ABSTRACT
BACKGROUND: The aim of the study was to assess positivity nonsentinel lymph nodes in patients with macro, micro and submicrometastases in sentinel lymph nodes and find predictive factors of positivity nonsentinel lymph nodes. Study was conducted at the Department of Surgery in Pardubice, Pilsen, Ostrava and Zlín. MATERIAL AND METHODS: Sentinel lymph nodes were assessed based on standards of Czech Pathological Society. Detection of sentinel lymph nodes was performed based on radionavigation or combination of radionavigation and blue dye method. RESULTS: In group N1 (macrometastases) there was found positivity of nonsentinel lymph nodes in 50% (45 from 90 patients). In group N1 Mi (micrometastases) there was found positivity of nonsentinel lymph nodes in 26.7% (16 from 60 patients). In group NO I+ (sub-micrometastases) there was found positivity of nonsentinel lymph nodes in 6.7% (1 from 15 patients). Predictive factors were size of metastasis, number of positive sentinel lymph nodes and grading. Size of tumor was not found to be a predictive factor of positivity nonsentinel lymph nodes. DISCUSSION: High positivity of nonsentinel lymph nodes in pacients with macro and micrometastases in sentinel lymph nodes advocates to perform axillary lymph nodes dissection. Due to small number of patients with submicrometastases it is not possible to assess if axillary dissection is necessary or not. Predictive factors of positivity of nonsentinel lymph nodes are size of metastasis in sentinel lymph nodes, number of positive sentinel lymph nodes and grading. Size of tumor was not found to be a predictive factor due to small tumors in the study. In spite of this it is necessary to consider it like a predictive factor of positivity nonsentinel lymph nodes. CONCLUSION: In patients with macro and micrometastases it is necessary to perform axillary dissection. In patients with submicrometastases in sentinel lymph nodes it is necessary to consider predictive factors.
Subject(s)
Breast Neoplasms/pathology , Lymph Node Excision , Lymph Nodes/pathology , Axilla , Female , Humans , Lymphatic Metastasis , Prognosis , Sentinel Lymph Node BiopsyABSTRACT
The aim of this study was to analyze the possibilities of various types of stent modeling and to develop some new models. A brief survey of basic properties of stents and a list of basic designs of stents is presented. Two approaches to stent modeling were identified. Structural mechanics is the theoretical background of our analytical model of a spiral stent. The finite element method was also used. The measurement equipment for model evaluation was developed.
Subject(s)
Models, Theoretical , Stents , Computer Simulation , Finite Element Analysis , Materials Testing , Prosthesis Design , Prosthesis Failure , Stress, Mechanical , Time FactorsABSTRACT
The parasitic thermovoltage can influence the temperature measurement during hyperthermia using the miniature multithermocouple probes with a common wire. It was noticed that, when a thermocouple junction is placed in a sharp thermal gradient, a parasitic thermovoltage is added to the voltage of all remaining thermocouples situated in the direction to the tip of the probe. This article gives the theoretical explanation, experimental verification, and practical elimination of this phenomenon.
Subject(s)
Hyperthermia, Induced/instrumentation , Thermometers , Biophysical Phenomena , Biophysics , Humans , Thermodilution/instrumentationABSTRACT
In this work various types of programs which can be used in a learning and teaching process are analysed. Also the procedure of creating software for CAL is studied and the procedure, that is the most suitable one for developing CAL is suggested here. Also recommended properties of software for teaching and learning medical biophysics are described. General characteristics and types of authoring tools are discussed in this work and a set of authoring tools is described in more details. Conclusions are documented and demonstrated by program Blood Circulation. For development of this program the authoring system Authorware 3.5 was selected. The program is organized as a hypertext with possibility to find words, with a list of the last visited pages, and with an on line help system. This program works with a text, graphics, interactive animated schemes and with interactive equations. In the program it is possible to test the level of knowledge by means of solving problems or multiply choice test.
Subject(s)
Biophysics/education , Computer-Assisted Instruction , SoftwareABSTRACT
Article deals with some possibilities of the combination of the shape memory and another physical properties of nitinol (Ti-Ni alloy) for application in the medicine. The thermoelectric properties of originally developed miniature thermocouple probe with the shape memory are described in details. The shape memory effect of the thermocouple is based on the use of the combination of the metals nitinol and constantan.
Subject(s)
Alloys , Biophysical Phenomena , Biophysics , ThermodynamicsABSTRACT
The computer controlled apparatus for invasive measurement of temperature profile of biological systems based on original miniature multithermocouple probe is described in this article. The main properties of measuring system were verified by using the original testing device.
Subject(s)
Signal Processing, Computer-Assisted , ThermometersABSTRACT
Teaching programs and possibilities of creating them are discussed. A teaching program the Frequency Analysis written in the C++ language is described. Principle of harmonic analysis and FFT is explained.
