Search | VHL Regional Portal

Complete Myeloperoxidase Deficiency: Beware the "False-Positive" Dihydrorhodamine Oxidation.

Milligan, Ki Lee; Mann, Daphne; Rump, Amy; Anderson, Victoria L; Hsu, Amy P; Kuhns, Douglas B; Zerbe, Christa S; Holland, Steven M.

J Pediatr ; 176: 204-6, 2016 09.

Article in English | MEDLINE | ID: mdl-27301573

ABSTRACT

Myeloperoxidase deficiency is the most common inherited phagocyte disorder (1:2000) and causes an abnormal dihydrorhodamine oxidation test, which also is seen in chronic granulomatous disease. A patient with Candida meningitis and low dihydrorhodamine oxidation signal was diagnosed with chronic granulomatous disease but actually had compound heterozygous myeloperoxidase deficiency.

Subject(s)

Granulomatous Disease, Chronic/diagnosis , Metabolism, Inborn Errors/diagnosis , Diagnosis, Differential , False Positive Reactions , Humans , Male , Oxidation-Reduction , Rhodamines/metabolism , Young Adult

Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment.

Fernandez-Boyanapalli, Ruby F; Falcone, Emilia Liana; Zerbe, Christa S; Marciano, Beatriz E; Frasch, S Courtney; Henson, Peter M; Holland, Steven M; Bratton, Donna L.

J Allergy Clin Immunol ; 136(5): 1399-1401.e3, 2015 Nov.

Article in English | MEDLINE | ID: mdl-26386811

Subject(s)

Granulomatous Disease, Chronic/drug therapy , Hypoglycemic Agents/administration & dosage , Macrophages/drug effects , Mitochondria/metabolism , Phagocytosis , Thiazolidinediones/administration & dosage , Adolescent , Adult , Animals , Cells, Cultured , Child , Disease Models, Animal , Female , Granulomatous Disease, Chronic/immunology , Humans , Inflammation Mediators/metabolism , Macrophages/immunology , Male , Mice , Middle Aged , PPAR gamma/metabolism , Phagocytosis/drug effects , Pioglitazone , Reactive Oxygen Species/metabolism , Young Adult

ABSTRACT

Subject(s)

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL