ABSTRACT
Tin oxide is a promising channel material, offering the advantages of being low-cost and environmentally friendly and having a wide band gap. However, despite the high electron mobility of SnO2 in bulk, the corresponding thin-film transistors (TFTs) generally exhibit moderate performance, hindering their widespread application. Herein, we proposed a codoping strategy to improve both the electrical property and the stability of SnO2 TFTs. A comparative analysis between doped and undoped SnO2 was conducted. It is observed that taking advantage of the difference in ionic radii between two dopants (indium and gallium) and the tin ions in the host lattice can effectively reduce impurity-induced strain. Additionally, we investigated the effect of codoping content on SnO2 TFTs. The optimal codoped SnO2 (TIGO) TFTs demonstrate high performance, featuring a field-effect mobility of 15.9 cm2/V·s, a threshold voltage of 0.2 V, a subthreshold swing of 0.5 V/decade, and an on-to-off current ratio of 2.2 × 107. Furthermore, the devices show high stability under both positive and negative bias stress conditions with a small threshold voltage shift of 1.8 and -1.2 V, respectively. Utilizing the TIGO TFTs, we successfully constructed a resistor-loaded unipolar inverter with a high gain of 10.76. This study highlights the potential of codoped SnO2 TFTs for advanced applications in electronic devices.
ABSTRACT
BACKGROUND: Giardia lamblia (syn. G. intestinalis, G. duodenalis) is a primitive opportunistic protozoon, and one of the earliest differentiated eukaryotes. Despite its primitive nature, G. lamblia has a sophisticated cytoskeleton system, which is closely related to its proliferation and pathogenicity. Meanwhile, α giardin is a G. lamblia-specific cytoskeleton protein, which belongs to the annexin superfamily. Interestingly, G. lamblia has 21 annexin-like α giardins, i.e., more than higher eukaryotes. The functional differences among α giardin members are not fully understood. METHODS: We took α-4 giardin, a member of α giardin family, as a research object. A morpholino-mediated knockdown experiment was performed to identify the effect of α-4 giardin on G. lamblia trophozoites biological traits. A yeast two-hybrid cDNA library of G. lamblia strain C2 trophozoites was screened for interaction partners of α-4 giardin. Co-immunoprecipitation and fluorescent colocalization confirmed the relationship between G. lamblia EB1 (gEB1) and α-4 giardin. RESULTS: α-4 Giardin could inhibit the proliferation and adhesion of G. lamblia trophozoites. In addition, it interacted with G. lamblia EB1 (gEB1). CONCLUSIONS: α-4 Giardin was involved in proliferation and adhesion in G. lamblia trophozoites, and EB1, a crucial roles in mitosis, was an interacting partner of α-4 giardin.
Subject(s)
Cytoskeletal Proteins , Giardia lamblia , Protozoan Proteins , Trophozoites , Giardia lamblia/metabolism , Giardia lamblia/genetics , Protozoan Proteins/metabolism , Protozoan Proteins/genetics , Trophozoites/metabolism , Cytoskeletal Proteins/metabolism , Cytoskeletal Proteins/genetics , Protein Binding , Two-Hybrid System TechniquesABSTRACT
Given the digitalization trends within the field of engineering, we propose a practical approach to engineering digitization. This method is established based on a physical sandbox model, camera equipment and simulation technology. We propose an image processing modeling method to establish high-precision continuous mathematical models of transmission towers. The calculation of the wind field is realized by using wind speed calculations, a load-wind-direction-time algorithm and the Continuum-Discontinuum Element Method (CDEM). The sensitivity analysis of displacement- and acceleration-controlled transmission tower loads under two different wind direction conditions is conducted. The results show that the digital model exhibits a proportional relationship with the physical dimensions of the transmission tower model. The error between the numerical simulation results and the experimental results falls within a reasonable range. Nodes at higher positions of the transmission tower experience significantly higher forces compared to those at lower positions, and the structural forms with larger windward projected areas yield similar simulation results. The proposed digital twin system can help monitor the performance of structural bodies and assess the disaster degree in extreme conditions. It can guide specific maintenance and repair tasks.