Seeking materials from nature for interrupting eye damage: Ultraviolet to blue light blocking clear cellulose films enabled by curcumin.

The harms caused by ultraviolet (UV) and blue light to eyes are attracting momentous concern due to growing exposure to artificial illumination and modern IT devices. Herein, a simple and eco-friendly adsorption approach was employed to integrate curcumin, a natural bioactive compound, into the cellulose substrate for the development of flexible and biodegradable filters capable of blocking harmful light. The curcumin/cellulose films demonstrate excellent UV-screening competence and photostability, with UV-A and UV-B screening ratios ranging from 92.8 % to 100 % and 89.2 % to 100 %, respectively. The films could block >96 % of blue light in the wavelength range of 400-500 nm. Meanwhile, the films maintain high transmittance (85.2-89.4 %) and low haze (2.0-2.7 %). The films can efficiently block blue light emanated from sunlight, light-emitting diodes, lighting systems, computer and mobile phone screens. Encouragingly, the incorporation of curcumin led to a substantial increase in the water contact angle, elevating it from 41.6 to 81.3°. Furthermore, the films exhibit excellent antimicrobial properties, biodegradability, and tensile strength in excess of 72 MPa. Therefore, these films fabricated entirely from natural resources have the potential to achieve practical applications such as food packaging and spectacle lens, especially suitable for electronic screen protectors.

Is there an intergenerational discrepancy in the comprehension and aesthetic preference regarding emoji usage? Evidence from WeChat.

Emojis are widely used on social media, blogs, and instant messaging to express users' feelings. However, in everyday interactions, the same emoji often has different interpretations and aesthetic preferences among different age groups. This can lead to communication barriers and misunderstandings. Based on social identity theory, this study uses WeChat, a social platform popular in China, to analyze intergenerational differences in emoji understanding and preferences through a questionnaire survey. The results indicate: (1) There are significant intergenerational differences in the usage habits, interpretation, and aesthetic preferences of emojis. (2) Middle-aged and elderly tend to interpret goodbye emoji symbols as simple emotional expressions, such as "goodbye" or "see you later," while younger-age groups lean towards more complex emotions and social intentions, such as "speechlessness" and "end of friendship." (3) Younger-age groups use emojis frequently and with a wide variety, whereas middle-aged and elderly groups use emojis less frequently and with limited variety. Younger individuals' aesthetic preferences for emojis lean towards humor, conflict, and narrative, whereas middle-aged and elderly groups prefer emojis with bright colors and everyday greetings typical of their generation. Based on research findings, we believe that social identity theory provides a framework for understanding how individuals establish their identities through interactions with specific social groups. This study is beneficial for identifying the comprehension and aesthetic biases in emoji usage across generations, sheds light on the broader implications of social identity theory in digital communication contexts, and promotes friendly social interactions in real-time communication applications.

Construction of multifunctional interface engineering on Cu-SSZ-13@Ce-MnOx/Mesoporous-silica catalyst for boosting activity, SO2 tolerance and hydrothermal stability.

Although small pore Cu-SSZ-13 catalysts have been successful as commercial catalysts for controlling NOx emissions from mobile sources, the challenges of high light-off temperature, SO2 tolerance and hydrothermal stability still need to be addressed. Here, we synthesized a multifunctional core-shell catalyst with Cu-SSZ-13 as the core phase and Ce-MnOx supported Mesoporous-silica (Meso-SiO2) as the shell phase via self-assembly and impregnation. The core-shell catalyst exhibited excellent low-temperature activity, SO2 tolerance and hydrothermal stability compared to the Cu-SSZ-13. The Ce-MnOx species dispersed in the shell are found to enhance both the acidic and oxidative properties of the core-shell catalyst. More critically, these species can rapidly activate NO and oxidize it to NO2, which allows the NH3-SCR reaction on the core-shell catalyst to be initiated in the shell phase. Meanwhile, Ce-MnOx species can react preferentially with SO2 as sacrifice components, effectively avoiding the sulfur inactivation of the copper active sites. Furthermore, the hydrophobic Meso-SiO2 shell provides an important barrier for the core phase, which reduces the loss of active species, acid sites and framework Al of the aged core-shell catalyst and mitigates the collapse of the zeolite framework. This work provides a new strategy for the design of novel and efficient NH3-SCR catalysts.

Nanoencapsulated MgBu2@ZIF-67 to Construct High Loading Mg-Co@C Nanocomposites: Breaking Through the Barrier of Room Temperature Onset Dehydrogenation.

The synergies of nanoconfinement and catalysis is an effective strategy to improve the kinetic and thermodynamic properties of Mg-based materials. However, obtaining Mg-based materials with high loading, anti-aggregation, and containing nanocatalysts to achieve dehydrogenation at room temperature remains a huge challenge. Herein, a novel and universal preparation strategy for Mg-Co@C nanocomposites with 9.5 nm Mg nanoparticles and 9.4 nm Co nanocatalysts embedded in carbon scaffold is reported. The 9.3 nm MgBu2 nanosheets precipitated by solvent displacement are encapsulated in ZIF-67 to prepare MgBu2@ZIF-67 precursors, then removing excess MgBu2 on the precursor surface and pyrolysis to obtain Mg-Co@C. It is worth noting that the Mg loading rate of Mg-Co@C is as high as rare 69.7%. Excitingly, the Mg-Co@C begins to dehydrogenate at room temperature with saturate capacity of 5.1 wt.%. Meanwhile, its dehydrogenation activation energy (Ea(des) = 68.8 kJ mol-1) and enthalpy (ΔH(des) = 61.6 kJ mol-1) significantly decrease compared to bulk Mg. First principles calculations indicate that the hydrogen adsorption energy on the Mg2CoH5 surface is only -0.681 eV. This work provides a universally applicable novel method for the preparation of nanoscale Mg-based materials with various nanocatalysts added, and provides new ideas for Mg-based materials to achieve room temperature hydrogen storage.

Dysregulated microRNAs and long non-coding RNAs associated with extracellular matrix stiffness.

Extracellular matrix (ECM) stiffness regulates development and homeostasis in vivo and affects both physiological and pathological processes. A variety of studies have demonstrated that mRNAs, such as Piezo1, integrin ß1, and Yes-associated protein (YAP)/tafazzin (TAZ), can sense the mechanical signals induced by ECM stiffness and transmit them from the extracellular space into the cytoplasm. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been reported to play important roles in various cellular processes. Therefore, the interactions between ncRNAs and ECM stiffness, as well as the underlying molecular mechanisms, have become intriguing. In this review, we summarize recent findings on miRNAs and lncRNAs that interact with ECM stiffness. Several miRNAs and lncRNAs are involved in the progression of liver cancer, breast cancer, osteosarcoma, and cardiovascular diseases under the regulation of ECM stiffness. Through these ncRNAs, cellular behaviors including cell differentiation, proliferation, adhesion, migration, invasion, and epithelial-mesenchymal transition (EMT) are affected by ECM stiffness. We also integrate the ncRNA signaling pathways associated with ECM stiffness, in which typical signaling pathways like integrin ß1/TGFß1, phosphatidylinositol-3 kinase (PI3K)/AKT, and EMT are involved. Although our understanding of the relationships between ncRNAs and ECM stiffness is still limited, further investigations may provide new insights for disease treatment. ECM-associated ncRNAs may serve as disease biomarkers or be targeted by drugs.

Design of Key Technologies for Elderly Public Network Services Based on Intelligent Recommendations.

As the world's population continues to increase, the proportion of elderly people is also rising. The existing elderly public service system is no longer able to meet the needs of the elderly for their daily lives. The elderly population is significantly less receptive to emerging matters than the younger population, resulting in the public elderly service system not being able to access the initial data of elderly users in a timely manner, which causes the system to make incorrect recommendations. Therefore, the elderly cannot enjoy all kinds of online services provided by the Internet platform. In order to solve this problem, an elderly intelligent recommendation method based on hybrid collaborative filtering is proposed. First, the data of elderly users and elderly service items are scored, and modelling is completed by a collaborative filtering algorithm. Then, the XGBoost model is combined to solve the optimal objective function, so that the recommended data set with the highest score in the nearest neighbour set is obtained. The experimental results show that the proposed hybrid algorithm effectively solves the cold start phenomenon that occurs when the elderly population uses the web to make recommendations for elderly services. In addition, the proposed hybrid algorithm has a higher recommendation footprint accuracy than other recommendation algorithms.

Efficient removal of heavy metal ions by diethylenetriaminepenta (methylene phosphonic) acid-doped hydroxyapatite.

Diethylenetriaminepenta (methylene phosphonic) acid (DTPMP) was first used as a dopant to modify hydroxyapatite and applied to remove Pb2+. The adsorption capacity of modified hydroxyapatite for Pb2+ can reach 2185.92 mg/g, which was 10.4 times that of commercial nanohydroxyapatite. The characterizations after adsorption of Pb2+ indicated the existence of chelation and the formation of the low bioavailability Pb10(PO4)6(OH)2. Moreover, the interaction of different components containing DTPMP, HAP, and pollutant Pb2+ was investigated by molecular dynamics (MD) simulation, which indicated that the organic-phosphonic group of DTPMP (PO3H-) had a stronger complex effect with calcium ions or lead ions than that of the inorganic-phosphate group of HAP (PO43-) with the two metal ions, which affected the crystallinity of HAP, and greatly improved the removal effect of DTPMP doped HAP composites for Pb2+ contaminants, the existence of amino groups can further enhance the affinity between DTPMP and HAP or lead ions. The chelation mechanism of DTPMP and Pb2+ was probed in depth by combining basin analysis, topology analysis of atoms in molecules (AIM), electron localization function (ELF) analysis, bond order density (BOD) & natural adaptive orbital (NAdO)analysis and orbital component analysis.

A vector whitefly endocytic receptor facilitates the entry of begomoviruses into its midgut cells via binding to virion capsid proteins.

Many circulative plant viruses transmitted by insect vectors are devastating to agriculture worldwide. The midgut wall of vector insects represents a major barrier and at the same time the key gate a circulative plant virus must cross for productive transmission. However, how these viruses enter insect midgut cells remains poorly understood. Here, we identified an endocytic receptor complex for begomoviruses in the midgut cells of their whitefly vector. Our results show that two whitefly proteins, BtCUBN and BtAMN, compose a receptor complex BtCubam, for which BtCUBN contributes a viral-binding region and BtAMN contributes to membrane anchorage. Begomoviruses appear to be internalized together with BtCubam via its interaction with the 12-19 CUB domains of BtCUBN via clathrin-dependent endocytosis. Functional analysis indicates that interruption of BtCUBN and BtAMN lead to reduction of virus acquisition and transmission by whitefly. In contrast, CUBN-begomovirus interaction was not observed in two non-competent whitefly-begomovirus combinations. These observations suggest a major role of the specific endocytic receptor in facilitating viral entry into vector midgut cells.

Functionalization of carbon nanomaterials by means of phytic acid for uranium enrichment.

A promising strategy for radionuclides immobilization on the functionalized carbon-based materials is a pursuing issue. Here, we developed phosphorylated hydrothermal carbon spheres (HCSs@PO4) through chemical-grafted method using phytic acid as a phosphorus source. When served as U(VI) scavenger from simulated environmental wastewater, the resulting HCSs@PO4 showed excellent adsorption capacity toward U(VI) (552.49 mg·g-1 at pH 5.0 and T = 298 K), outperforming that of HCSs (32.06 mg·g-1) and state-of the-art materials. A weak ionic strength-dependence of U(VI) enrichment with HCSs@PO4 was investigated by a series of pH experiments, indicating an inner-sphere surface complexation. Through thermodynamic study, high temperature promoted the adsorptive ability of HCSs@PO4 toward U(VI), revealing the endothermic and spontaneous nature. Additional selective adsorption applications were conducted to evaluate the ability of HCSs@PO4 to capture uranium fission byproducts and other radioactive ions. Analyses of characteristic means (FT-IR and XPS) revealed enhanced uptake performance of HCSs@PO4 originated from grafting abundant phosphate groups, which exhibited the stronger surface complexation toward U(VI) than sluggish hydroxyl and carboxyl groups. The findings herein highlighted a facile and powerful technique for the manufacture of phosphorylated carbon-based materials of radioactive wastewater remediation.

Implication of whitefly vesicle associated membrane protein-associated protein B in the transmission of Tomato yellow leaf curl virus.

Tomato yellow leaf curl virus (TYLCV) poses serious threat to tomato production worldwide, and the vector, Bemisia tabaci, plays a key role in the transmission of this virus. However, the molecular mechanisms underlying the transmission remain poorly understood. In this study, firstly, we identified the whitefly proteins that presumably interact with TYLCV coat protein (CP) using split-ubiquitin yeast two-hybrid system. Next, we conducted GST pull-down and immunofluorescence to examine the potential interaction between TYLCV CP and one of the proteins identified, namely vesicle associated membrane protein-associated protein B (VAPB), an protein abundantly expressed in whitefly midgut. Further experiments demonstrated that VAPB was significantly up-regulated upon virus acquisition, and silencing VAPB led to a significant increase of relative virus quantity in whitefly haemolymph and salivary glands, as well as an increase of TYLCV transmission efficiency. These findings indicate an important role of VAPB in the transmission of TYLCV by whiteflies.

Comparative proteomic analysis provides new insight into differential transmission of two begomoviruses by a whitefly.

BACKGROUND: Viruses in the genus Begomovirus (Family Geminiviridae) include many important economic plant viruses transmitted by whiteflies of the Bemisia tabaci species complex. In general, different begomoviruses may be acquired and transmitted by the same whitefly species with different efficiencies. For example, the species Mediterranean (MED) in this whitefly species complex transmits tomato yellow leaf curl virus (TYLCV) at a higher efficiency than papaya leaf curl China virus (PaLCuCNV). However, the proteomic responses of whitefly to the infection of different begomoviruses remain largely unknown. METHODS: We used iTRAQ-based proteomics coupled with RT-qPCR to investigate and compare responses of the MED whitefly to the infection of TYLCV and PaLCuCNV. RESULTS: Totally, 259, 395 and 74 differently expressed proteins (DEPs) were identified in the comparisons of TYLCV-infected vs. un-infected, PaLCuCNV-infected vs. un-infected, and TYLCV-infected vs. PaLCuCNV-infected whiteflies, respectively. These proteins appear associated with catabolic process, metabolic process, transport, defense response, cell cycle, and receptor. The comparisons of TYLCV-infected vs. un-infected and PaLCuCNV-infected vs. un-infected shared some similar DEPs, indicating possible involvement of laminin subunit alpha, dystroglycan, integrin alpha-PS2 and cuticle proteins in viral transport as well as the role of putative defense proteins 3 and PITH in anti-viral response. However, 20S proteasome subunits associated with regulation of virus degradation and accumulation were up-regulated in PaLCuCNV-infected but not in TYLCV-infected whiteflies, which may be related to the constraints of PaLCuCNV accumulation in MED. CONCLUSIONS: These findings provide valuable clues for unravelling the roles of some whitefly proteins in begomovirus transmission.

Comprehensive Evaluation of Soil Near Uranium Tailings, Beishan City, China.

To evaluate the impact of uranium tailings on soil composition and soil microbial, six soil samples at different distance from the uranium tailings (Beishan City, China) were collected for further analysis. Concentrations of radionuclides (238U and 232Th), heavy metals (Mn, Cd, Cr, Ni, Zn, and Pb) and organochlorine pesticide were determined by ICP-MS and GC, they were significantly higher than those of the control. And the Average Well Color Development as well as the Shannon, the Evenness, and the Simpson index were calculated to evaluate the soil microbial diversity. The carbon utilization model of soil microbial community was also analyzed by Biolog-eco. All results indicated that uranium tailings leaded to excessive radionuclides and heavy metals, and decreased the diversity of the soil microbial community. Our study will provide a valuable basis for soil quality evaluation around uranium tailing repositories and lay a foundation for the management and recovery of uranium tailings.

An experimental investigation on the speed of sand flow through a fixed porous bed.

In this study, we document several experiments that investigate the speed of the flow of fine sand through a fixed porous bed of packed glass beads under various conditions, including the height of the sand column (H) and porous bed (h) and the diameter of the glass beads (D) and sand grains (d). The experiments are conducted with glass beads packed at a constant density and sand at a different dry bulk density. The results show that the height of the sand does not affect the speed of the sand flow. The speed of the sand flow (v) decreases with an increase in h until h approaches a certain value. An equation [Formula: see text] is proposed, where a and k are the experimentally determined coefficients. Moreover, the flow of sand through a fixed porous bed could be regarded as parallel flow through multiple pipes, and therefore, the relationship between D and the number and diameter of pipes, N and D p, are discussed. Further investigations are needed for the result that the flow of sand through a porous bed or multiple parallel pipes cannot be simplified to flow through one orifice with a certain diameter.