ABSTRACT
The aim of this trial was to implement a method to obtain a tool for analyses of tramadol and the main metabolite, o-desmethyltramadol (M1), in goat's plasma, and to evaluate the pharmacokinetics of these substances following intravenous (i.v.) and oral (p.o.) administration in female goats. The pharmacokinetics of tramadol and M1 were examined following i.v. or p.o. tramadol administration to six female goats (2 mg/kg). Average retention time was 5.13 min for tramadol and 2.42 min for M1. The calculated parameters for half-life, volume of distribution and total body clearance were 0.94+/-0.34 h, 2.48+/-0.58 L/kg and 2.18+/-0.23 L/kg/h following 2 mg/kg tramadol HCl administered intravenously. The systemic availability was 36.9+/-9.1% and half-life 2.67+/-0.54 h following tramadol 2 mg/kg p.o. M1 had a half-life of 2.89+/-0.43 h following i.v. administration of tramadol. Following p.o., M1 was not detectable.
Subject(s)
Analgesics, Opioid/pharmacokinetics , Goats/metabolism , Tramadol/analogs & derivatives , Tramadol/pharmacokinetics , Administration, Oral , Analgesics, Opioid/administration & dosage , Analgesics, Opioid/blood , Animals , Area Under Curve , Female , Injections, Intravenous/veterinary , Tramadol/administration & dosage , Tramadol/bloodABSTRACT
The authors report a case of schistosomiasis mansoni with intraspinal localization on a 39 year old man who presented neurologic manifestation likely a Brown-Séquard syndrome. Cerebrospinal fluid examination showed positive immunofluorescent test for schistosomiasis, and treatment was started at once.