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1.
Sci Rep ; 14(1): 21714, 2024 Sep 17.
Article in English | MEDLINE | ID: mdl-39289392

ABSTRACT

The main purpose of this article is to study the generalized Kudryashov's equation with truncated M-fractional derivative, which is commonly used to describe the propagation of wide pulses in nonlinear optical fibers. By employing the complete discriminant system of fourth-order polynomials, various types of explicit solutions are systematically classified, which include periodic solutions, the trigonometric functions, the double-period solutions, and the elliptic function solutions. Additionally, a series of 2D, 3D, and contour plots are generated to visually depict the spatial distribution and evolution of various solutions. This not only advances the development of nonlinear equations in theory but also provides valuable guidance in practical applications.

2.
J Math Biol ; 83(5): 48, 2021 10 11.
Article in English | MEDLINE | ID: mdl-34635944

ABSTRACT

The chemical master equation (CME) is a fundamental description of interacting molecules commonly used to model chemical kinetics and noisy gene regulatory networks. Exact time-dependent solutions of the CME-which typically consists of infinitely many coupled differential equations-are rare, and are valuable for numerical benchmarking and getting intuition for the behavior of more complicated systems. Jahnke and Huisinga's landmark calculation of the exact time-dependent solution of the CME for monomolecular reaction systems is one of the most general analytic results known; however, it is hard to generalize, because it relies crucially on special properties of monomolecular reactions. In this paper, we rederive Jahnke and Huisinga's result on the time-dependent probability distribution and moments of monomolecular reaction systems using the Doi-Peliti path integral approach, which reduces solving the CME to evaluating many integrals. While the Doi-Peliti approach is less intuitive, it is also more mechanical, and hence easier to generalize. To illustrate how the Doi-Peliti approach can go beyond the method of Jahnke and Huisinga, we also find an explicit and exact time-dependent solution to a problem involving an autocatalytic reaction that Jahnke and Huisinga identified as not solvable using their method. Most interestingly, we are able to find a formal exact time-dependent solution for any CME whose list of reactions involves only zero and first order reactions, which may be the most general result currently known. This formal solution also yields a useful algorithm for efficiently computing numerical solutions to CMEs of this type.


Subject(s)
Algorithms , Gene Regulatory Networks , Computer Simulation , Probability , Stochastic Processes
3.
Math Biosci Eng ; 17(5): 5686-5708, 2020 08 28.
Article in English | MEDLINE | ID: mdl-33120573

ABSTRACT

Structured population models, which account for the state of individuals given features such as age, gender, and size, are widely used in the fields of ecology and biology. In this paper, we consider an age-structured population model describing the population of adults and juveniles. The model consists of a system of ordinary and neutral delay differential equations. We present an explicit solution to the model using a generalization of the Lambert W function called the r-Lambert W function. Numerical simulations with varying parameters and initial conditions are done to illustrate the obtained solution. The proposed method is also applied to an insect population model with long larval and short adult phases.


Subject(s)
Models, Biological , Adult , Humans
4.
Math Biosci Eng ; 15(4): 933-959, 2018 08 01.
Article in English | MEDLINE | ID: mdl-30380316

ABSTRACT

The main goal of this work is to clarify and quantify, by means of mathematical analysis, the role of structural viscoelasticity in the biomechanical response of deformable porous media with incompressible constituents to sudden changes in external applied loads. Models of deformable porous media with incompressible constituents are often utilized to describe the behavior of biological tissues, such as cartilages, bones and engineered tissue scaffolds, where viscoelastic properties may change with age, disease or by design. Here, for the first time, we show that the fluid velocity within the medium could increase tremendously, even up to infinity, should the external applied load experience sudden changes in time and the structural viscoelasticity be too small. In particular, we consider a one-dimensional poro-visco-elastic model for which we derive explicit solutions in the cases where the external applied load is characterized by a step pulse or a trapezoidal pulse in time. By means of dimensional analysis, we identify some dimensionless parameters that can aid the design of structural properties and/or experimental conditions as to ensure that the fluid velocity within the medium remains bounded below a certain given threshold, thereby preventing potential tissue damage. The application to confined compression tests for biological tissues is discussed in detail. Interestingly, the loss of viscoelastic tissue properties has been associated with various disease conditions, such as atherosclerosis, Alzheimer's disease and glaucoma. Thus, the findings of this work may be relevant to many applications in biology and medicine.


Subject(s)
Hydrodynamics , Models, Biological , Biomechanical Phenomena , Biophysical Phenomena , Elasticity , Humans , Mathematical Concepts , Nonlinear Dynamics , Porosity , Tissue Engineering , Viscosity
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