COVID-19 fatalities, latitude, sunlight, and vitamin D.

BACKGROUND: Since Vitamin D is known to be vital in regulating the immune system, and sunlight UV radiation exposure on the skin produces Vitamin D and UV intensity is highest nearest the equator, a study was done to examine the correlation between the latitude and COVID-19 fatality rates for countries. METHODS: Eighty-eight countries were selected based on their likelihood of providing reliable data. Using death rates/million for each country from the "worldometer" website, a correlation analysis was done between death rates and a country's latitude. RESULTS: A highly significant, positive correlation was found between lower death rates and a country's proximity to the equator (Pearson r = 0.40 P < .0001, 2-tailed t test). The R squared of 0.16 means that 16% of the variation in death rates among nations is accounted for by the latitude of the country. Evidence is presented suggesting a direct correlation between sunlight exposure and reduced mortality. DISCUSSION: This study is the first to document a statistically significant correlation between a country's latitude and its COVID-19 mortality and is consistent with other research regarding latitude, Vitamin D deficiency, and COVID-19 fatalities. Limitations of this study are noted. CONCLUSIONS: Further research is needed to confirm the correlation between latitude and COVID-19 fatalities, and to determine the optimum amounts of safe sunlight exposure and/or vitamin D oral supplementation to reduce COVID-19 fatalities in populations that are at high risk for vitamin D deficiency.

Effects of vitamin D deficiency on intraocular pressure values obtained by ocular response analyzer.

PURPOSE: To compare corneal biomechanical properties measured with ocular response analyzer (ORA) and intraocular pressure (IOP) measurements in patients with vitamin D deficiency and in healthy cases. METHODS: One hundred and twenty eyes of 120 subjects (between the ages of 19 and 78) who applied to university's outpatient clinic were evaluated: 41 lacks of vitamin D (Group 1), 39 insufficient vitamin D (Group 2) and 40 controls (Group 3). Corneal hysteresis, corneal resistance factor, Goldmann-correlated IOP and corneal compensated IOP of patients were measured by ORA. RESULTS: The mean ages were 48.9 ± 12.1, 52.8 ± 13.6 and 52.1 ± 13.9 in groups 1, 2 and 3, respectively (p = 0.370). Mean IOPcc values were 16.5 ± 3.6 (8.1-27.3), 16.7 ± 2.7 (12.0-22.7) and 16.3 ± 3.3 (10.8-27.4) mmHg (p = 0.889); mean IOPg values were 16.8 ± 5.0 (6.5-39.5), 16.3 ± 2.9 (10.3-23.0) and 15.9 ± 3.2 (10.0-26.0) mmHg (p = 0.539); mean CH values were 10.8 ± 1.9 (8.3-19.0), 11.4 ± 1.6 (6.9-14.0) and 11.2 ± 1.5 (7.5-13.2) (p = 0.257); mean CRF values were 10.5 ± 2.7 (7.4-25.0), 11.1 ± 1.5 (6.8-13.5) and 10.5 ± 1.2 (7.7-12.8) (p = 0.282) in groups 1, 2 and 3, respectively. There was no statistical difference between the groups in terms of IOPcc, IOPg CH and CRF. However, mean CH values were found less in the lack of vitamin D group. CONCLUSION: The CH values were lower, and the IOPg values were higher in cases of vitamin D deficiency. Corneal biomechanical differences in patients with lack of vitamin D were not statistically significant.