Post-extubation laryngitis in children: diagnosis, management and follow-up.

OBJECTIVES: To describe the occurrence of post-extubation laryngitis, analyze its one-year evolution, and correlate laryngeal lesions with clinical outcomes. METHODS: Retrospective study including children up to 13 years old at a tertiary hospital between March 2020 and March 2022 with diagnosis of post-extubation laryngitis confirmed by endoscopic examination. Exclusion criteria were prior history of intubation or anatomical airway abnormalities. Medical records were reviewed to characterize patients, underlying diagnosis, laryngeal lesions, treatment, and outcomes at 12-month follow-up. RESULTS: The study included 38 endoscopically confirmed post-extubation laryngitis cases, corresponding to 86.4% of suspected cases. The mean age was 13.24 months, and 60.5% were male. Acute respiratory failure was the leading cause of intubation. Initial treatment was clinical, and initial diagnosis was defined by nasopharynoglaryngoscopy and/or Microlaryngoscopy and Bronchoscopy (MLB) findings. Initial diagnostic MLB was performed in 65.7% of the patients. Approximately half (53%) of the patients exhibited moderate or severe laryngeal lesions. When compared to mild cases, these patients experienced a higher rate of extubation failures (mean of 1.95 vs. 0.72, p = 0.0013), underwent more endoscopic procedures, and faced worse outcomes, such as the increased need for tracheostomy (p = 0.0001) and the development of laryngeal stenosis (p = 0.0450). Tracheostomy was performed in 14 (36.8%) children. Patients undergoing tracheostomy presented more extubation failures and longer intubation periods. Eight (21%) developed laryngeal stenosis, and 17 (58.6%) had complete resolution on follow-up. CONCLUSION: Post-extubation laryngitis is a frequent diagnosis among patients with clinical symptoms or failed extubation. The severity of laryngeal lesions was linked to a less favorable prognosis observed at one-year follow-up. Otolaryngological evaluation, follow-up protocols, and increased access to therapeutic resources are essential to manage these children properly. LEVEL OF EVIDENCE: Level 4.

Infecciones fúngicas en otorrinolaringología: revisión de la literatura / Fungal infections in otolaryngology: literature review

Ante el aumento a nivel mundial de condiciones inmunosupresoras, la incidencia de enfermedades fúngicas que afectan órganos y sistemas propios del estudio otorrinolaringológico va en alza. Entre estas patologías es posible encontrar la candidiasis orofaríngea, laringitis fúngica, otomicosis, y distintos tipos de rinosinusitis. El estudio de los aspectos clínicos, agentes causantes y mecanismos patogénicos de estas enfermedades será fundamental para la práctica médica de los tiempos por venir.

With the worldwide increase of immunosuppressive conditions, the incidence of fungal diseases affecting organs and systems of otorhinolaryngological study is on the rise. Among these pathologies it is possible to find oropharyngeal candidiasis, fungal laryngitis, otomycosis, and different types of rhinosinusitis. The study of the clinical aspects, causative agents and pathogenic mechanisms of these diseases will be fundamental for the medical practice of the times to come.

Manifestaciones laríngeas de COVID-19 / Laryngeal manifestations of COVID-19

Introducción: la infección por COVID-19 afecta el tracto aerodigestivo superior a través de la enzima convertidora de angiotensina 2 (ECA2) y/o la proteasa transmembrana serina 2 (TMPRSS2). Sus manifestaciones agudas y secuelas han sido muy variadas y no todas están relacionadas con la intubación orotraqueal. El objetivo es describir las características sociodemográficas, clínicas y los hallazgos endoscópicos de los pacientes con síntomas laringofaríngeos posteriores a una infección por SARS-CoV-2 evaluados en el Hospital Militar Central y Hospital Universitario Clínica San Rafael entre marzo de 2020 y marzo de 2022. Materiales y métodos: estudio observacional de corte transversal con datos sociodemográficos, comorbilidades, necesidad de intubación orotraqueal, variedad de síntomas y sus hallazgos endoscópicos. Resultados: se recolectaron datos de 118 pacientes; la edad media fue de 51 años ± 14,4. El síntoma más frecuente fue la disfonía (69,5 %), seguido de la disnea (39,8 %). El 58,9 % requirió intubación orotraqueal y, de estos, la manifestación más frecuente fue disfonía por tensión muscular (DTM) y estenosis subglótica-traqueal. En el 41,1 % restante su hallazgo más frecuente fue la laringitis irritativa. Conclusiones: la COVID-19 tiene múltiples manifestaciones laringofaríngeas en relación con su mecanismo de infección e invasión en los tejidos de esta zona, de tipo inflamatorio y estructural, y no todos están relacionados con la intubación.

Introduction: COVID 19 infection affects the upper aerodigestive tract through angiotensin-converting enzyme 2 (ACE2) and/or Transmembrane serine protease 2 (TMPRSS2). Its acute manifestations and sequelae have been very varied, and not all of them are related to orotracheal intubation. The objective is to describe the sociodemographic and clinical characteristics and the endoscopic findings of patients with laryngopharyngeal symptoms after SARS-CoV-2 infection evaluated at the Hospital Militar Central and Hospital Universitario Clínica San Rafael between March 2020 and March 2022. Methods: Cross-sectional observational study, obtaining sociodemographic data, comorbidities, need for orotracheal intubation, variety of symptoms and their endoscopic findings. Results: 118 patients were collected; the mean age was 51 years ± 14.4. The most frequent symptom was dysphonia (69.5%), followed by dyspnea (39.8%). 58.9% required orotracheal intubation and of these the most frequent manifestation was muscular tension dysphonia (MTD) and subglottictracheal stenosis. In the remaining 41.1%, the most frequent finding was irritative laryngitis. Conclusions: COVID-19 has multiple laryngopharyngeal manifestations in relation to its mechanism of infection and invasion in the tissues of this area, as an inflammatory and structural type, and not all of them are related to intubation.

Laryngeal Mucous Membrane Pemphigoid as an Immune-related Adverse Effect of Pembrolizumab Treatment.

Pembrolizumab is an immune checkpoint inhibitor (ICI) approved for multiple indications in a variety of malignancies. Although generally well tolerated, the potential for significant adverse effects, specifically immune related adverse effects (irAEs) needs to be taken into consideration. Several cases of bullous pemphigoid have been reported as a cutaneous adverse effect of ICIs since 2015, and there are recent reports of mucous membrane pemphigoid (MMP). We present the case of an 84-year-old male with metastatic urothelial carcinoma on treatment with pembrolizumab, who developed laryngeal mucous membrane pemphigoid as an irAE. The diagnosis was based on patient's clinical history and serologic testing, and supported by symptomatic improvement after ICI discontinuation and immunosuppression. Pembrolizumab-induced MMP is a newly described and infrequent irAE, requiring early suspicion and close monitoring for its diagnosis and management.

Management of laryngopharyngeal reflux in Brazil: a national surveys / Manejo do refluxo laringofaríngeo no Brasil: pesquisa nacional

Abstract Introduction: Studies assessing the management of laryngopharyngeal reflux by otolaryngologists have reported an important heterogeneity regarding the definition, diagnosis, and treatment, which leads to discrepancies in the management of the patient. Information about the current knowledge and practices of Brazilian otolaryngologists in laryngopharyngeal reflux is lacking. Objective: To investigate the trends in management of laryngopharyngeal reflux disease among Brazilian otolaryngologists. Methods: A survey was sent by email to the members of the Brazilian Association of Otolaryngology-Head Neck Surgery. This survey has initially been conducted by the laryngopharyngeal reflux study group of young otolaryngologists of the International Federation of Otolaryngological Societies. Results: According to the survey responders, the prevalence of laryngopharyngeal reflux was estimated to be 26.8% of patients consulting in otolaryngology and the most common symptoms were globus sensation, throat clearing, cough and stomach acid reflux. Nasal obstruction, Eustachian tube dysfunction, acute and chronic otitis media, vocal fold nodules and hemorrhage were considered not associated with laryngopharyngeal reflux by the majority of responders. About 2/3 of Brazilian otolaryngologists based the diagnosis of laryngopharyngeal reflux on the assessment of both symptoms and findings and a positive response to empiric therapeutic trials. Proton pump inhibitor utilized once or twice daily, was the most commonly used therapeutic scheme. Only 21.4% of Brazilian otolaryngologists have heard about nonacid and mixed laryngopharyngeal reflux and the awareness about the usefulness of multichannel intraluminal impedance pH monitoring (MII-pH) was minimal; 30.5% of responders did not consider themselves as well-informed about laryngopharyngeal reflux. Conclusion: Although the laryngopharyngeal reflux-related symptoms, main diagnostic and treatment approaches referred by Brazilian otolaryngologists are consistent with the literature, the survey identified some limitations, such as the insufficient awareness of the role of laryngopharyngeal reflux in many otolaryngological conditions and of the possibility of non-acid or mixed reflux in refractory cases. Future studies are needed to establish international recommendations for the management of laryngopharyngeal reflux disease.

Resumo Introdução: Estudos que avaliaram o manejo do refluxo laringofaríngeo por otorrinolaringologistas mostraram uma importante heterogeneidade em relação à definição, diagnóstico e tratamento, o que leva a discrepâncias no tratamento do paciente. Faltam informações sobre o conhecimento e as práticas atuais dos otorrinolaringologistas brasileiros sobre o refluxo laringofaríngeo. Objetivo: Investigar as tendências no manejo da doença do refluxo laringofaríngeo entre os otorrinolaringologistas brasileiros. Método: O questionário foi enviado por e-mail aos membros da Associação Brasileira de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço. Esta pesquisa foi inicialmente conduzida pelo LPR Study Group of Young Otolaryngologists da International Federation of Otolaryngological Societies. Resultados: De acordo com os respondentes da pesquisa, a prevalência de refluxo laringofaríngeo foi estimada em 26,8% dos pacientes consultados e os sintomas mais comuns foram sensação de globus, pigarro, tosse e refluxo de ácido estomacal. Obstrução nasal, disfunção da trompa de Eustáquio, otite média aguda e crônica, nódulos nas pregas vocais e hemorragia foram considerados como não associados ao refluxo laringofaríngeo pela maioria dos respondentes. Cerca de 2/3 dos otorrinolaringologistas brasileiros basearam o diagnóstico de refluxo laringofaríngeo na avaliação dos sintomas e achados e na resposta positiva a testes terapêuticos empíricos. Inibidores de bomba de prótons uma ou duas vezes ao dia foi o esquema terapêutico mais usado. Somente 21,4% dos otorrinolaringologistas brasileiros já ouviram falar sobre refluxo laringofaríngeo não ácido e misto e o conhecimento sobre a utilidade do monitoramento de pH por impedância intraluminal multicanal foi mínimo; 30,5% dos respondentes não se consideraram tão bem informados sobre o refluxo laringofaríngeo. Conclusão: Embora os sintomas relacionados ao refluxo laringofaríngeo e as principais abordagens diagnósticas e terapêuticas referidas pelos otorrinolaringologistas brasileiros sejam consistentes com a literatura, a pesquisa identificou algumas limitações, como o conhecimento insuficiente do papel do refluxo laringofaríngeo em diversas condições otorrinolaringológicas e da possibilidade de refluxo não ácido ou misto em casos refratários. Estudos futuros são necessários para estabelecer recomendações internacionais para o manejo de doença do refluxo laringofaríngeo.

Management of laryngopharyngeal reflux in Brazil: a national survey.

INTRODUCTION: Studies assessing the management of laryngopharyngeal reflux by otolaryngologists have reported an important heterogeneity regarding the definition, diagnosis, and treatment, which leads to discrepancies in the management of the patient. Information about the current knowledge and practices of Brazilian otolaryngologists in laryngopharyngeal reflux is lacking. OBJECTIVE: To investigate the trends in management of laryngopharyngeal reflux disease among Brazilian otolaryngologists. METHODS: A survey was sent by email to the members of the Brazilian Association of Otolaryngology-Head Neck Surgery. This survey has initially been conducted by the laryngopharyngeal reflux study group of young otolaryngologists of the International Federation of Otolaryngological Societies. RESULTS: According to the survey responders, the prevalence of laryngopharyngeal reflux was estimated to be 26.8% of patients consulting in otolaryngology and the most common symptoms were globus sensation, throat clearing, cough and stomach acid reflux. Nasal obstruction, Eustachian tube dysfunction, acute and chronic otitis media, vocal fold nodules and hemorrhage were considered not associated with laryngopharyngeal reflux by the majority of responders. About 2/3 of Brazilian otolaryngologists based the diagnosis of laryngopharyngeal reflux on the assessment of both symptoms and findings and a positive response to empiric therapeutic trials. Proton pump inhibitor utilized once or twice daily, was the most commonly used therapeutic scheme. Only 21.4% of Brazilian otolaryngologists have heard about nonacid and mixed laryngopharyngeal reflux and the awareness about the usefulness of multichannel intraluminal impedance pH monitoring (MII-pH) was minimal; 30.5% of responders did not consider themselves as well-informed about laryngopharyngeal reflux. CONCLUSION: Although the laryngopharyngeal reflux-related symptoms, main diagnostic and treatment approaches referred by Brazilian otolaryngologists are consistent with the literature, the survey identified some limitations, such as the insufficient awareness of the role of laryngopharyngeal reflux in many otolaryngological conditions and of the possibility of non-acid or mixed reflux in refractory cases. Future studies are needed to establish international recommendations for the management of laryngopharyngeal reflux disease.

Correlación diagnóstica entre fibrolaringoscopia y videoendoscopia digestiva alta en pacientes con reflujo gastroesofágico y reflujo laringofaríngeo / Diagnostic Correlation Between Fiberlaringoscopy and Upper Gastrointestinal Video Endoscopy in Patients with Gastroesophagic Reflux and Laryngopharyngeal Reflux

Introducción: el reflujo laringofaríngeo (RLF) se origina por el flujo retrógrado de contenido gástrico hacia la faringe, pero es una entidad diferente de la enfermedad por reflujo gastroesofágico (ERGE). El objetivo del estudio fue determinar la correlación entre los signos endoscópicos de la fibrolaringoscopia y la videoendoscopia digestiva alta (VEDA). Material y métodos: estudio observacional, retrospectivo y analítico. Se incluyeron pacientes que consultaron por sintomatología de RLF y ERGE. Los hallazgos visualizados por fibrolaringoscopia flexible, VEDA y biopsia de mucosa gástrica de cada paciente se compararon con la prueba de chi-cuadrado (χ²). Se consideró significativo un valor de p ≤ 0,05. Resultados: se incluyeron 318 pacientes entre 18 y 84 años. Se encontró que el 100 % de los pacientes con esofagitis tenía laringitis (p = 0,001); el 100 % de los pacientes con hernia hiatal tenían RLF (p = 0,001); el 97 % de los pacientes con Helicobacter pylori en la mucosa gástrica tenían RLF (p = 0.001). El 71 % de los pacientes con hernia hiatal tenían esofagitis (p = 0,001). Se encontró una asociación lineal entre la edad y la hernia hiatal con la edad y el RLF (p = 0,03). Conclusiones: en este estudio, los signos encontrados en la fibrolaringoscopia tuvieron una asociación estadística con la VEDA. Aproximadamente el 90 % de los pacientes con signos de laringitis tuvo una correlación con algún grado de esofagitis, esófago de Barrett, hernia hiatal y Helicobacter pylori. También se encontró que la laringitis por RLF y la hernia hiatal se relacionaron directamente con el incremento de la edad.

Introduction: Laryngopharyngeal reflux (LPR) is caused by the retrograde flow of gastric contents towards the pharynx, but it is a different entity from gastroesophageal reflux disease (GERD). The objective of the study was to determine the relationship between the endoscopic signs of fiber laryngoscopy and upper gastrointestinal video endoscopy. Material and methods: Observational, retrospective and analytical study. Patients who consulted for LPR and GERD symptoms were included. The findings visualized by flexible fiber laryngoscopy, upper gastrointestinal video endoscopy and gastric mucosal biopsy of each patient were compared with the Chi-square (χ²) test. A value of p ≤ 0.05 is estimated significantly. Results: 318 patients between 18 and 84 years old were included. A relationship was found in 100% of the patients with esophagitis had laryngitis (p = 0.001); 100% of the patients with hiatal hernia had LPR (p = 0.001); 97% of patients with Helicobacter pylori in the gastric mucosal have LPR (p= 0.001); 71% of patients with hiatal hernia had esophagitis (p = 0.001). A linear association was found between age and hiatal hernia with age and LPR. (p = 0.03). Conclusions: In this study, the signs found in fiber laryngoscopy had a statistical association with the upper gastrointestinal video endoscopy. Approximately 90% of patients with signs of laryngitis had correlation with some degree of esophagitis, Barrett's esophagus, hiatal hernia and Helicobacter pylori. It was also found that LPR and hiatal hernia were directly related to increasing age

Validation of the Brazilian Portuguese Version of the Reflux Finding Score.

INTRODUCTION: Laryngopharyngeal reflux (LPR) poses a diagnostic challenge. Clinical diagnosis, based on suggestive symptoms and laryngoscopic signs of inflammation, should be acceptable, as long as diligent differential diagnosis is sought. In order to minimize subjectivity, a number of diagnostic instruments have been proposed, being the most common the Reflux Symptom Index and the Reflux Finding Score (RFS). The latter has been translated into several languages including Portuguese, but it still has not been properly validated in this language. OBJECTIVE: To validate the Brazilian Portuguese version of the RFS. MATERIAL AND METHOD: For validity and internal consistency, 172 adults were studied (106 with LPR and 66 healthy controls). Flexible transnasal laryngoscopy images were randomly examined twice by each of the two experienced otolaryngologists with a 72-hour interval. Strict exclusion criteria were applied to avoid other possible known causes of chronic laryngitis. For assessment of reproducibility and temporal stability, a random sample of 108 subjects (53 patients and 55 controls) were tested and retested. RESULTS: A statistically significant difference was observed in the mean RFS between patients with LPR (10.26 ± 3.58) and controls (5.52 ± 1.34) (P < 0.001). The interclass correlation coefficient comparing test and retest for both raters was high (R1 = 0.956; R2 =  0.948). CONCLUSION: The Brazilian Portuguese version of the RFS proved to be a reliable and reproducible instrument for the diagnosis of LPR with a sensitivity of 82.08%, a specificity of 93.94%, a positive predictive value of 95.60%, and a negative predictive value was 76.54%.

Sensitivity, Specificity, and Reproducibility of the Brazilian Portuguese Version of the Reflux Symptom Index.

INTRODUCTION: The diagnosis of laryngopharyngeal reflux is controversial. There is currently no gold standard, so it relies mainly on suspicious clinical symptoms and videolaryngoscopic findings. Unfortunately these signs and symptoms are common to other causes of chronic laryngitis. Scoring systems have been proposed to reduce subjectivity in clinical diagnosis. The most widely used and accepted is the Reflux Symptom Index, which has already been translated into over 10 other languages. OBJECTIVE: Study the psychometric properties of the Brazilian Portuguese version of the Reflux Symptom Index (Índice de Sintomas de Refluxo - ISR). METHODS: One hundred and fifty-four adults, 88 with laryngopharyngeal reflux and 66 healthy controls, were studied over a 6-month period, responding to the ISR after thoroughly investigated on possible other causes of chronic laryngitis and the presence of gastroesophageal disease. Test and retest reliability was addressed by reapplying the score to a random subgroup of 101 subjects. RESULTS: The ISR of subjects was significantly higher than that of controls (Student t test for independent samples, P < 0.001). The ISR also showed high temporal stability and reproducibility (ICC of 0.988 with a confidence interval of 0.982-0.992). The ISR at a cutoff of 13 points presented a sensitivity of 78.4%, a specificity of 95.4%, a false negative of 4.55%, a false positive of 21.59%, a positive predictive value of 95.83%, and a negative predictive value of 86.93%. CONCLUSION: The ISR proved to be a valid and reliable diagnostic tool.

Arytenoid chondritis in two calves / Condrite aritenóide em duas bezerras

Although, calf diphtheria and necrotic laryngitis are common infections in the oral cavitys soft tissues, arytenoid chondritis is addressed as a serious but rarely diagnosed complication in cattle. This paper aimed to describe clinical, laboratory, imaging, and pathological findings in two calves with arytenoid chondritis. A 2-month-old Jersey calf and a 3-month-old Girolando calf presented 40-days history of respiratory distress. In the former, oral endoscopy revealed enlarged and immobile arytenoids with major involvement of the left arytenoid, causing severe distortion and partial obstruction of the rima glottidis. In the latter, latero-lateral radiography of the head revealed radiolucent areas and thickening at the level of the larynx to the dorsal trachea. Pathological examination of one calf showed neutrophilic multifocal inflammatory infiltrate and areas of necrosis in the cricoarytenoid cartilage, surrounded by abscessation. Definitive diagnosis of arytenoid chondritis in these two calves was established on the basis of clinical, laboratory, imaging (endoscopy and radiography), and pathological findings. Daily and careful observation of the herds and the use of ancillary diagnostic methods allowed the early diagnosis of the disease, and accurate diagnosis can improve prognosis and increase treatment success rate.(AU)

Embora a difteria em bezerros e a laringite necrótica sejam infecções comuns nos tecidos moles da cavidade oral, a condrite aritenoide é considerada uma complicação grave, mas raramente diagnosticada em bovinos. Este trabalho tem como objetivo descrever os achados clínicos, laboratoriais, de imagem e patológicos em duas bezerras apresentando condrite aritenoide. Uma bezerra Jersey de dois meses de idade e uma bezerra Girolando de três meses de idade apresentavam dificuldades respiratórias por 40 dias. Na primeira, a endoscopia oral revelou aritenoides aumentadas e imóveis, com grande envolvimento da aritenoide esquerda, causando distorção grave e obstrução parcial de rima glottidis. Na segunda, a radiografia látero-lateral da cabeça revelou áreas radioluscentes e espessamento ao nível da laringe até a traqueia dorsal. O exame patológico de uma bezerra revelou infiltrado inflamatório multifocal neutrofílico e áreas de necrose na cartilagem cricoaritenóide, circundadas por abscessos. O diagnóstico definitivo de condrite aritenoide nessas duas bezerras foi estabelecido com base nos achados clínicos, laboratoriais, de imagem (endoscopia e radiografia) e patológicos. O monitoramento diário e minucioso dos rebanhos e o uso de métodos auxiliares de diagnóstico permitem o diagnóstico precoce da enfermidade, sendo que o diagnóstico preciso pode melhorar o prognóstico e aumentar a taxa de sucesso do tratamento.(AU)

Arytenoid chondritis in two calves / Condrite aritenóide em duas bezerras

ABSTRACT: Although, calf diphtheria and necrotic laryngitis are common infections in the oral cavity's soft tissues, arytenoid chondritis is addressed as a serious but rarely diagnosed complication in cattle. This paper aimed to describe clinical, laboratory, imaging, and pathological findings in two calves with arytenoid chondritis. A 2-month-old Jersey calf and a 3-month-old Girolando calf presented 40-days history of respiratory distress. In the former, oral endoscopy revealed enlarged and immobile arytenoids with major involvement of the left arytenoid, causing severe distortion and partial obstruction of the rima glottidis. In the latter, latero-lateral radiography of the head revealed radiolucent areas and thickening at the level of the larynx to the dorsal trachea. Pathological examination of one calf showed neutrophilic multifocal inflammatory infiltrate and areas of necrosis in the cricoarytenoid cartilage, surrounded by abscessation. Definitive diagnosis of arytenoid chondritis in these two calves was established on the basis of clinical, laboratory, imaging (endoscopy and radiography), and pathological findings. Daily and careful observation of the herds and the use of ancillary diagnostic methods allowed the early diagnosis of the disease, and accurate diagnosis can improve prognosis and increase treatment success rate.

RESUMO: Embora a difteria em bezerros e a laringite necrótica sejam infecções comuns nos tecidos moles da cavidade oral, a condrite aritenoide é considerada uma complicação grave, mas raramente diagnosticada em bovinos. Este trabalho tem como objetivo descrever os achados clínicos, laboratoriais, de imagem e patológicos em duas bezerras apresentando condrite aritenoide. Uma bezerra Jersey de dois meses de idade e uma bezerra Girolando de três meses de idade apresentavam dificuldades respiratórias por 40 dias. Na primeira, a endoscopia oral revelou aritenoides aumentadas e imóveis, com grande envolvimento da aritenoide esquerda, causando distorção grave e obstrução parcial de rima glottidis. Na segunda, a radiografia látero-lateral da cabeça revelou áreas radioluscentes e espessamento ao nível da laringe até a traqueia dorsal. O exame patológico de uma bezerra revelou infiltrado inflamatório multifocal neutrofílico e áreas de necrose na cartilagem cricoaritenóide, circundadas por abscessos. O diagnóstico definitivo de condrite aritenoide nessas duas bezerras foi estabelecido com base nos achados clínicos, laboratoriais, de imagem (endoscopia e radiografia) e patológicos. O monitoramento diário e minucioso dos rebanhos e o uso de métodos auxiliares de diagnóstico permitem o diagnóstico precoce da enfermidade, sendo que o diagnóstico preciso pode melhorar o prognóstico e aumentar a taxa de sucesso do tratamento.

Correlación entre la sintomatología y los hallazgos laringoscópicos en pacientes con cuadro clínico de reflujo faringolaríngeo en un hospital nacional de tercer nivel / Correlation between symptoms and laryngoscopy findings in patients with clinical symptoms of pharyngolaryngeal reflux in a national tertiary care hospital

Objetivo: correlacionar la sintomatología de reflujo faringolaríngeo y los hallazgos laringoscópicos, mediante el índice de síntomas de reflujo y el puntaje de hallazgos de reflujo, en pacientes de consulta externa del servicio de Otorrinolaringologia del Hospital Nacional Arzobispo Loayza. Material y métodos: estudio transversal. Participaron 94 pacientes con sintomatología de reflujo faringolaríngeo, con criterios de laringoscopia, que acudieron a consultorio externo, desde setiembre del 2017 hasta abril del 2018. Se evaluó la sintomatología mediante el índice de síntomas de reflujo (ISR) y, los hallazgos de laringoscopia por medio del puntaje de hallazgos de reflujo (RFS). La correlación entre los puntajes de estos dos índices fue evaluada mediante uso del Tau-b de Kendall. Resultados: todos los casos presentaron síntomas como disfonía, tos y carraspera; mientras que a la laringoscopia el 97,9% de pacientes presentaron eritema de aritenoides, y el 87,2%, edema de bandas ventriculares. Todos los casos tuvieron un puntaje de 15,5 en el ISR y 82 casos tuvieron un puntaje de PHR mayor a 7 con un promedio de 8,6. Se encontró una correlación fuertemente positiva entre los puntajes de ISR y PHR, con un coeficiente de correlación Tb=0,866. Conclusiones: existe una correlación fuerte positiva entre los puntajes del índice de síntomas y el puntaje de hallazgos de RFL, en pacientes del Hospital Nacional Arzobispo Loayza durante setiembre del 2017 hasta abril del 2018.

Objective: to correlate the symptoms of pharyngolaryngeal reflux and laryngoscopy findings using the reflux symptom index and the score for reflux findings, in outpatients of the Ear, Nose, and Throat (ENT) service in Arzobispo Loayza National Hospital. Material and Methods: this is a cross-sectional study. Ninety-four patients with symptoms compatible with pharyngolaryngeal reflux participated, with criteria for performing laryngoscopy, came to our outpatient clinic from September 2017 up to April 2018. Symptoms were assessed using the reflux symptom index (RSI), and laryngoscopy findings were assessed using the reflux findings score (RFS). We assessed the correlation between these two scores using Kendall's Tau-b. Results: all patients presented with dysphonia, cough, and scratchy throat; laryngoscopy findings were as follows: 97.9% patients showed arythenoid erythema, and 87.2% showed ventricular band edema. All cases had a 15.5 score in the RSI scale, and 82 cases had a higher than 7 score in the RFS scale, the average value was 8.6. A strongly positive correlation was found between the two scales. Conclusions: there is a strong correlation between the symptom index score and the reflux findings score in patients from Arzobispo Loayza National Hospital since September 2017 up to April 2018.

Revealing the needs of children with tracheostomies.

INTRODUCTION: Small children with tracheostomy are at potential risk and have very specific needs. International literature describes the need for tracheostomy in 0.5% to 2% of children following intubation. Reports of children submitted to tracheostomy, their characteristics and needs are limited in developing countries and therefore there is a lack of health programs and government investment directed to medical and non-medical care of these patients. The aim of this study was to describe the characteristics of these children and identify problems related to or caused by the tracheostomy. METHODS: A retrospective cohort study was performed based on a common database applied in four high complexity healthcare facilities to children submitted to tracheostomy from January 2013 to December 2015. Data concerning children's demographics, indication for tracheostomy, early and late complications related to tracheostomy, airway diagnosis, comorbidities and decannulation rates are reported. Patients who did not present a complete database or had a follow-up of less than six months were excluded. RESULTS: A total of 160 children submitted to tracheostomy during the three-year period met the criteria and were enrolled in this study. Median age at tracheostomy was 6.9 months (ranging from 1 month to 16 years, interquartile range of 26 months). Post-intubation laryngitis was the most frequent indication (48.8%). Comorbidities were frequent: neurologic disorders were reported in 40%, pulmonary pathologies in 26.9% and 20% were premature infants. Syndromic children were 23.1% and the most frequent was Down's syndrome. The most common early complication was infection that occurred in 8.1%. Stomal granulomas were the most frequent late complication and occurred in 16.9%. Airway anomalies were frequently diagnosed in follow-up endoscopic evaluations. Subglottic stenosis was the most frequent airway diagnosis and occurred in 29.4% of the cases followed by laryngomalacia, suprastomal collapse and vocal cord paralysis. Decannulation was achieved in 22.5% of the cases in the three-year period. The main cause for persistent tracheostomy was the need for further treatment of airway pathology. Mortality rate was 18.1% during this period but only 1.3% were directly related to the tracheostomy, the other deaths were a consequence of other comorbidities. CONCLUSION: Tracheostomies were performed mostly in very small children and comorbidities were very common. Once a tracheostomy was performed in a child in most cases it was not removed before a year. The most common early complication was stoma infection followed by accidental decannulation. The most frequent late complication was granuloma and suprastomal collapse. Airway abnormalities were very frequent in this population and therefore need to be assessed before attempting decannulation.

Cânula nasal de alto fluxo pós-extubação traqueal em criança com obstrução de vias aéreas superiores: relato de caso / High-flow nasal cannula post-tracheal extubation in a child with upper airway obstruction: case report

RESUMO Objetivo: Relatar o caso de um lactente que necessitou de intubação traqueal no setor de emergência pediátrica por conta de laringite aguda grave e que, após a extubação traqueal programada, fez uso, com sucesso, da cânula nasal de alto fluxo, a qual, possivelmente, evitou a falha da extubação traqueal. Descrição do caso: Paciente masculino, 8 meses de idade, admitido no pronto atendimento de pediatria com desconforto respiratório agudo por causa de obstrução alta de vias aéreas secundária à laringite aguda grave. Foi imediatamente intubado e encaminhado para a unidade de terapia intensiva (UTI) pediátrica. Apresentou falha de extubação em função de edema importante de laringe evidenciado por broncoscopia, o que contraindicou a extubação. Na segunda tentativa de extubação, o paciente apresentou desconforto respiratório, melhorando após uso da cânula nasal de alto fluxo, com redução da frequência cardíaca e respiratória, possibilitando a extubação com sucesso. Comentários: O uso da cânula nasal de alto fluxo foi eficaz e apresentou boa resposta nesse paciente com laringite aguda, sugerindo ser um possível adjuvante para o tratamento, evitando-se a piora do quadro respiratório e da necessidade de reintubação.

ABSTRACT Objective: To report a case of a patient who required tracheal intubation in a pediatric emergency department due to acute laryngitis and that, after the planned extubation, has successfully used the high-flow nasal cannula, which possibly prevented extubation failure. Case description: A male 8-month-old child was admitted to the pediatric emergency room with acute respiratory distress due to a high airway obstruction secondary to severe acute laryngitis. He was immediately intubated and referred to the pediatric intensive care unit. He presented extubation failure due to a significant laryngeal edema evidenced by bronchoscopy. In the second attempt to extubate, he presented respiratory distress, but, after the use of the high-flow nasal cannula, he became stable, reducing the heart and respiratory frequencies, and the extubation was successful. Comments: The use of the high-flow nasal cannula was effective and presented good response in this patient with acute laryngitis, suggesting that it is a possible adjuvant for the treatment, avoiding worsening respiratory conditions and the need for reintubation.

Correlación diagnostica entre fibronasolaringoscopía y video endoscopia digestiva alta en pacientes con reflujo gastroesofágico y reflujo faringolaríngeo / Diagnostic correlation between fibronasolaringoscopy and upper gastrointestinal endoscopy video in patients with gastroesophagic reflux and faringolaryngeal reflux

RESUMEN: El reflujo faringolaríngeo. Se origina por el flujo retrógrado de contenido gástrico hacia la faringe, pero existen factores, capaces de perpetuarlo: disfunción del esfínter esofágico, tiempo de exposición y sensibilidad del tejido al material refluido, estos elementos permiten considerar al reflujo faringolaríngeo como una entidad diferente del reflujo gastroesofágico. OBJETIVO: Encontrar una correlación entre los signos endoscópicos de pacientes con síntomas por reflujo gastroesofágico y reflujo faringolaringeo a través de los hallazgos de la fibrolaringoscopía flexible y video endoscopia digestiva alta. Además de identificar la distribución epidemiológica de los pacientes participantes. MATERIAL Y MÉTODOS: Estudio observacional, retrospectivo y analítico. Se incluyeron pacientes que consultaron al servicio de Otorrinolaringología y Gastroenterología de la Clínica Universitaria Reina Fabiola Córdoba Argentina, por sintomatología de reflujo faringolaríngeo y gastroesofágico. Entre mayo/2016 y mayo/2017. Los hallazgos de reflujo faringolaríngeo por fibrolaringoscopía flexible y de esofagitis por video endoscopia digestiva alta de cada paciente se compararon con la prueba de Chi cuadrado. Se consideró significativo un valor de p ≤0.05. RESULTADOS: Se incluyeron 49 pacientes entre 7 y 80 años; de éstos, el 45% son de género masculino, y 55% femenino. El 100% de los pacientes presentaron criterios fibrolaringoscópicos diagnósticos de reflujo faringolaríngeo, por el contrario, la video endoscopia digestiva alta mostró que solo el 55% de los pacientes tenían signos de esofagitis (p= 0.24). CONCLUSIONES: En este estudio, no se observó una correlación diagnóstica entre los signos de la fibrolaringoscopía y video endoscopia digestiva alta en relación al diagnóstico de reflujo faringolaríngeo y esofagitis. No se encontró una diferencia entre ambos géneros y los signos de reflujo faringolaríngeo y esofagitis. La frecuencia de las manifestaciones otorrinolaringológicas del reflujo faringolaríngeo se relaciona directamente con el incremento de la edad; sobre todo, la cuarta década de la vida. (AU)

OBJECTIVE: Find a correlation between the endoscopic signs of patients with symptoms due to gastroesophagic reflux and faringolaryngeal reflux through the findings of fiber-optic laryngoscopy and upper gastrointestinal endoscopy. In addition, identify the epidemiological distribution of the participant's patients. MATERIALS AND METHODS: Observational, retrospective and analytical study of patients who have consulted the service of Otorhinolaryngology and Gastroenterology of the Reina Fabiola University Clinic, due to symptomatology of pharyngolaryngeal reflux and gastroesophageal reflux. Between May/2016 and May/2017. The findings of pharyngolaryngeal reflux by fiber-optic laryngoscopy and esophagitis by upper gastrointestinal endoscopy of each patient were compared with the Chi square test. A value of p ≤0.05 was considered significant. RESULTS: We included 49 patients between 7 and 80 years old; 45% of them were male and 55% were female. 100% of the patients had fiber-optic laryngoscopy diagnostic criteria of pharyngolaryngeal reflux. In contrast, upper digestive endoscopy showed that only 55% of the patients had signs of esophagitis (p = 0.24). CONCLUSIONS: In this study, wasn´t observed a diagnostic correlation between the signs of fiber-optic laryngoscopy and upper gastrointestinal endoscopy in relation to the diagnosis of pharyngolaryngeal reflux and esophagitis. We did not find a difference between both genders and signs of esophageal pharyngolaryngeal reflux. The frequency of otorhinolaryngological manifestations of pharyngolaryngeal reflux is directly related to the increase in age. (AU)

Deglutição em pacientes com laringite / Swallowing in patients with laryngitis

ABSTRACT BACKGROUND: Dysphagia is described as a complaint in 32% of patients with laryngitis. OBJECTIVE: The objective of this investigation was to evaluate oral and pharyngeal transit of patients with laryngitis, with the hypothesis that alteration in oral-pharyngeal bolus transit may be involved with dysphagia. METHODS: Videofluoroscopic evaluation of the swallowing of liquid, paste and solid boluses was performed in 21 patients with laryngitis, 10 of them with dysphagia, and 21 normal volunteers of the same age and sex. Two swallows of 5 mL liquid bolus, two swallows of 5 mL paste bolus and two swallows of a solid bolus were evaluated in a random sequence. The liquid bolus was 100% liquid barium sulfate and the paste bolus was prepared with 50 mL of liquid barium and 4 g of food thickener (starch and maltodextrin). The solid bolus was a soft 2.2 g cookie coated with liquid barium. Durations of oral preparation, oral transit, pharyngeal transit, pharyngeal clearance, upper esophageal sphincter opening, hyoid movement and oral-pharyngeal transit were measured. All patients performed 24-hour distal esophageal pH evaluation previous to videofluoroscopy. RESULTS: The evaluation of 24-hour distal esophageal pH showed abnormal gastroesophageal acid reflux in 10 patients. Patients showed longer oral preparation for paste bolus and a faster oral transit time for solid bolus than normal volunteers. Patients with laryngitis and dysphagia had longer preparation for paste and solid boluses, and a faster oral transit time with liquid, paste and solid boluses. CONCLUSION: A longer oral preparation for paste and solid boluses and a faster transit through the mouth are associated with dysphagia in patients with laryngitis.

RESUMO CONTEXTO: Disfagia é uma queixa presente em 32% dos pacientes com laringite. OBJETIVO: O objetivo desta investigação foi avaliar o trânsito oral e faríngeo de pacientes com laringite, com a hipótese de que a alteração no trânsito do bolo pela boca e faringe pode estar envolvida com a queixa de disfagia. MÉTODOS: A avaliação videofluoroscópica da deglutição de bolos líquido, pastoso e sólido foi realizada em 21 pacientes com laringite, 10 deles com disfagia e 21 voluntários normais da mesma idade e sexo. Duas deglutições de 5 mL de bolo líquido, duas deglutições de bolo pastoso e duas deglutições de bolo sólido foram avaliadas em sequência casual definida por sorteio. Bolo líquido foi sulfato de bário 100%, e o bolo pastoso foi preparado com 50 mL de bário líquido e 4 g de espessante alimentar (amido e maltodextrina). O bolo sólido foi 2,2 g de uma bolacha macia embebida em bário líquido. A duração da preparação oral, trânsito oral, trânsito faríngeo, depuração da faringe, abertura do esfíncter superior do esôfago, movimento do hióide e do trânsito oral-faríngeo foram medidas. Precedendo a videofluoroscopia todos pacientes realizaram exame de pHmetria de 24 horas. RESULTADOS: O registro do pH intraesofágico distal revelou resultado anormal em 10 pacientes. Pacientes com laringite apresentaram maior duração da preparação oral para bolo pastoso e um tempo de trânsito oral mais rápido para bolo sólido. Os pacientes com laringite e disfagia tiveram uma preparação oral mais longa para bolo pastoso e sólido e tempo de trânsito oral menor com bolos líquido, pastoso e sólido. CONCLUSÃO: Preparação oral mais longa para bolos pastoso e sólido e trânsito mais rápido através da boca são situações associadas com a presença de disfagia em pacientes com laringite.

Tuberculosis en otorrinolaringología. Reporte de 3 casos / Tuberculosis in otolaryngology. Report of 3 cases / Tuberculose em otorrinolaringología. Relatório de 3 casos

La tuberculosis extrapulmonar suele ser una presentación poco frecuente. Aunque la vía respiratoria alta es la vía de entrada del Mycobacterium tuberculosis, su afectación es rara (menos del 2%), siendo la localización ótica, laríngea y nasofaríngea de carácter excepcional, pudiéndose presentar tanto de forma primaria como secundaria a una lesión pulmonar. Se describen tres formas de presentación de tuberculosis extrapulmonar, resaltando la importancia de su sospecha clínica; fundamental para el diagnóstico. Se reporta un caso de tuberculosis laríngea como presentación primaria; un caso de tuberculosis faríngea como presentación secundaria y un caso de presentación ótica en un paciente inmunocomprometido. Debido al aumento en los últimos años de esta enfermedad es necesario tenerla presente como diagnóstico diferencial. Se destacan las dificultades en su detección, ya que no existen características exclusivas de la tuberculosis. La importancia del diagnóstico precoz radica en que es una enfermedad con buena evolución si es tratada oportunamente.

Extrapulmonary tuberculosis is usually an uncommon presentation. Although the upper respiratory tract is the entry route of the Mycobacterium tuberculosis, its involvement is rare (less than 2%), being the otic, laryngeal and nasopharyngeal localization exceptional, being able to present both primary and secondary to a lung injury. Three forms of presentation of extrapulmonary tuberculosis are described highlighting the importance of their clinical suspicion; fundamental for the diagnosis. A case of laryngeal tuberculosis is reported as primary presentation; a case of pharyngeal tuberculosis as a secondary presentation and a case of otic presentation in an immunocompromised patient. Due to the increase in recent years of this disease it is necessary to keep it in mind as a differential diagnosis. The difficulties in its detection are highlighted, since there are no exclusive characteristics of tuberculosis. The importance of early diagnosis lies in the fact that it is a disease with good evolution if it is treated opportunely.

A tuberculose extrapulmonar é geralmente uma apresentação incomum. Embora a via aérea superior é o Mycobacterium tuberculosis porta de entrada, o seu envolvimento é rara (menos do que 2%), a localização ótica, da laringe e da nasofaringe excepcional, sendo possível que tanto na forma primária como secundária à lesão do pulmão. Três formas de apresentação da tuberculose extrapulmonar são descritas, destacando a importância de sua suspeita clínica; fundamental para o diagnóstico. Um caso de tuberculose laríngea é relatado como apresentação primária; um caso de tuberculose faríngea como apresentação secundária e um caso de apresentação ótica em paciente imunocomprometido. Devido ao aumento nos últimos anos desta doença é necessário ter isto em mente como um diagnóstico diferencial. As dificuldades em sua detecção são destacadas, uma vez que não existem características exclusivas da tuberculose. A importância do diagnóstico precoce reside no fato de ser uma doença com boa evolução se tratada oportunamente.

Substernal goiter and laryngopharyngeal reflux

ABSTRACT Objective This study aims to compare the prevalence of laryngopharyngeal reflux signs between two groups of patients undergoing thyroidectomy for voluminous goiter: substernal goiters and voluminous cervical goiter without thoracic extension. Subjects and methods A retrospective case-control study was performed with data retrieved of the charts of the patients submitted to thyroidectomies occurred at a tertiary care center (Head and Neck Surgery Department, University of São Paulo Medical School) between 2010 and 2014. The selected thyroidectomies were allocated in two groups for study: patients with substernal goiters and patients with voluminous cervical goiter without thoracic extension. Cervical goiters were selected by ultrasonography mensuration. Clinical criterion was used to define substernal goiter. Results The average thyroid volume in patients with substernal goiter was significantly greater than the average volume in patients with only cervical goiter (p < 0.001). The prevalence of signs of reflux laryngitis at laryngoscopy was significantly greater in substernal goiter patients (p = 0.036). Moreover, substernal goiter was considered as the unique independent variable for high reflux laryngitis signs at laryngoscopy (OR = 2.75; CI95%: 1.05-7.20; p = 0.039) when compared to only cervical goiter patients. Conclusion This study shows a significant association between substernal goiters and signs of laryngopharyngeal reflux at preoperative laryngoscopy. Therefore, when compared with voluminous cervical goiters, the substernal goiters increase the chance of reflux laryngitis signs in patients.

Correlación diagnóstica entre fibronasolaringoscopía y videoendoscopía digestiva alta en pacientes con reflujo gastroesofágico y reflujo faringolaríngeo / Diagnostic correlation between fibronasolaringoscopy and upper gastrointestinal endoscopy video in patients with gastroesophagic reflux and faringolaryngeal reflux / Correlação do diagnóstico entre fibronasolaringoscopia eendoscopia digestiva alta em pacientes com refluxo gastroesofágico e refluxo faringolaríngeo

Introducción: el reflujo faringolaríngeo se origina por el flujo retrógrado de contenido gástrico hacia la faringe, pero existen factores capaces de perpetuarlo: disfunción del esfínter esofágico, tiempo de exposición y sensibilidad del tejido al material refluido, estos elementos permiten considerar al reflujo faringolaríngeo como una entidad diferente del reflujo gastroesofágico. Material y método: Estudio observacional, retrospectivo y analítico. Se incluyeron pacientes que consultaron al servicio de Otorrinolaringología y Gastroenterología de la Clínica Universitaria Reina Fabiola Córdoba Argentina, por sintomatología de reflujo faringolaríngeo y gastroesofágico. Entre mayo/2016 y mayo/2017. Los hallazgos de reflujo faringolaríngeo por fibrolaringoscopía flexible y de esofagitis por videoendoscopía digestiva alta de cada paciente se compararon con la prueba de Chi cuadrado. Se consideró significativo un valor de p ≤0,05. Resultados: Se incluyeron 49 pacientes entre 7 y 80 años; de éstos, el 45% son de género masculino, y 55% femenino. El 100% de los pacientes presentaron criterios fibrolaringoscópicos diagnósticos de reflujo faringolaríngeo; por el contrario, la videoendoscopía digestiva alta mostró que solo el 55% de los pacientes tenían signos de esofagitis (p= 0,24). Conclusiones: En este estudio no se observó una correlación diagnóstica entre los signos de la fibrolaringoscopía y videoendoscopía digestiva alta en relación al diagnóstico de reflujo faringolaríngeo y esofagitis. No se encontró una diferencia entre ambos géneros y los signos de reflujo faringolaríngeo y esofagitis. La frecuencia de las manifestaciones otorrinolaringológicas del reflujo faringolaríngeo se relaciona directamente con el incremento de la edad; sobre todo, la cuarta década de la vida.

Introduction: pharyngolaryngeal reflux. Its etiology, the retrograde flow of gastric contents towards the pharynx would be the origin, but there are factors, capable of perpetuating it: dysfunction of the esophageal sphincter, time of exposure and sensitivity of the tissue to the refluxed material, which allows pharyngolaryngeal reflux to be considered as a different entity from gastroesophageal reflux. Material and method: Observational, retrospective and analytical study of patients who have consulted the service of Otorhinolaryngology and Gastroenterology of the Reina Fabiola University Clinic, due to symptomatology of pharyngolaryngeal reflux and gastroesophageal reflux. Between May/2016 and May/2017. The findings of pharyngolaryngeal reflux by fiber-optic laryngoscopy and esophagitis by upper gastrointestinal endoscopy of each patient were compared with the Chi square test. A value of p ≤0.05 was considered significant. Results: We included 49 patients between 7 and 80 years old; 45% of them were male and 55% were female. 100% of the patients had fiber-optic laryngoscopy diagnostic criteria of pharyngolaryngeal reflux. In contrast, upper digestive endoscopy showed that only 55% of the patients had signs of esophagitis (p = 0.24). Conclusions: In this study, wasn´t observed a diagnostic correlation between the signs of fiber-optic laryngoscopy and upper gastrointestinal endoscopy in relation to the diagnosis of pharyngolaryngeal reflux and esophagitis. We did not find a difference between both genders and signs of esophageal pharyngolaryngeal reflux. The frequency of otorhinolaryngological manifestations of pharyngolaryngeal reflux is directly related to the increase in age.

Introdução: o refluxo faringolaríngeo. Sua etiologia é o fluxo retrógrado de conteúdo gástrico para a faringe, mas existem fatores capazes de perpetuá- lo: disfunção do esfíncter esofágico, tempo de exposição e sensibilidade do tecido ao material refluído, o que permite considerar o refluxo faringolaríngeo como uma entidade diferente do refluxo gastroesofágico. Material e métodos: Estudo observacional, retrospectivo e analítico de amostra de pacientes que consultaram o serviço de Otorrinolaringologia e Gastroenterologia da Clínica Universitária Reina Fabiola, devido à sintomatologia de refluxo faringolaríngeo e refluxo gastroesofágico, entre maio/2016 e maio/2017. Os achados do refluxo faringolaríngeo por fibrolaringoscopia flexível e esofagite por endoscopia digestiva alta de cada paciente foram comparados com o teste do chi-quadrado. Um valor de p ≤ 0,05 foi considerado significativo. Resultados: Foram estudados 49 pacientes entre 7 e 80 anos; destes, 45% do sexo masculino e 55% do sexo feminino. 100% os pacientes apresentavam critérios fibrolaringoscópicos para refluxo faringolaríngeo. Em contraste, a endoscopia digestiva alta mostrou que apenas 55% dos pacientes apresentavam sinais de esofagite (p = 0,24). Conclusões: Neste estudo, não foi observada correlação diagnóstica entre os sinais de fibrolaringoscopia e endoscopia digestiva alta em relação ao diagnóstico de refluxo faringolaríngeo e esofagite. Não foi encontrada diferença entre os sexos e os sinais de refluxo faringoaríngeo e esofagite. A freqüência das manifestações otorrinolaringoló- gicas do refluxo faringolaríngeo está diretamente relacionada ao aumento de idade.

Laringitis fúngica en pacientes inmunocompetentes / Fungal laryngitis in immunocompetent patients

Introducción: La laringitis fúngica es una patología poco planteada en pacientes inmunocompetentes, sin embargo se debería tener en consideración en el diagnóstico diferencial de leucoplaquias en estos pacientes, más aún con factores predisponentes como reflujo faringolaríngeo, tabaquismo crónico y/o uso de corticoides. Objetivo: Presentar una serie de casos de pacientes inmunocompetentes con diagnóstico clínico de laringitis fúngica y tratamiento antimicótico empírico. Describir la asociación con factores predisponentes claves. Material y método: Estudio retrospectivo que incluyó a 11 pacientes con diagnóstico clínico de laringitis fúngica por correlación de la clínica, factores predisponentes y hallazgos en la videoestroboscopía laríngea (leucoplaquias múltiples en los pliegues vocales) sumado a la respuesta a tratamiento empírico con fluconazol oral. Se realizó además una revisión de la literatura disponible hasta el año 2015. Resultados: Todos los diagnósticos fueron clínicos correlacionando síntomas con hallazgo de leucoplaquias características en la laringe. El principal factor asociado fue el reflujo faringolaríngeo (91%) seguido por uso de corticoides (55%). Todos los pacientes fueron tratados con un esquema empírico de fluconazol oral por 14-21 días. El 100% de los pacientes respondió de forma exitosa al uso de este fármaco con remisión de los síntomas y de las lesiones laríngeas. Conclusión: El diagnóstico clínico y tratamiento con fluconazol oral como tratamiento de primera línea generarían buena tasa de respuesta, siempre que se correlacionen los síntomas y signos del paciente con los hallazgos encontrados en la laringe.

Introduction: The fungal laryngitis is an unusual disease in immunocompetent patients, however should take into consideration in the differential diagnosis of leukoplakias, especially in patients with predisposing factors such as pharyngolaryngeal reflux, use of inhaled, oral or intravenous corticosteroids. Aim: Describe a series of cases of fungal laryngitis in immunocompetent patients with clinical diagnosis and empirical antifungal treatment. In addition, finding the association with predisposing factors keys. Material and method: Retrospective study of 11 patients with diagnosis of fungal laryngitis according to clinical presentation, predisposing factors and findings in the laryngeal videostroboscopy (vocal folds leukoplakias) joined the response to empirical treatment with oral fluconazole. Also an extensive literature review was conducted until 2015. Results: The main predisposing factor was the pharyngolaryngeal reflux (91%) followed by use of corticosteroids (55%). All patients were treated empirically with fluconazole for 14-21 days. 100% of patients responded successfully, with remission of symptoms and laryngeal lesions. Conclusion: Clinical diagnosis and treatment with fluconazole as first-line treatment generate good response rate, provided that the patient's symptoms and signs with the findings in the larynx are correlated.