Tumor de Brenner maligno y embarazo. Caso clínico: revisión de la bibliografía / Malignant Brenner tumor and pregnancy. Case report: Literature review

Resumen ANTECEDENTES: La asociación del tumor de Brenner con el embarazo es excepcional: solo hay cuatro casos reportados, ninguno maligno. CASO CLÍNICO: Paciente de 33 años, con antecedente de un embarazo que finalizó mediante parto y sin contratiempos, sin antecedentes médico-quirúrgicos de interés. En la ecografía de la décima segunda semana se registró una imagen sonoluscente de paredes lisas, de 41 mm, dependiente del ovario izquierdo. Durante la cesárea se practicó la tumorectomía. El estudio histológico describió una neoplasia epitelial de células transicionales, con áreas benignas, proliferativas e infiltrativas, compatible con un tumor de Brenner maligno. Se trató con cirugía radical de cáncer de ovario y quimioterapia coadyuvante. CONCLUSIONES: Es importante tener en mente al tumor de Brenner maligno como diagnóstico de exclusión ante tumoraciones de rápido y gran crecimiento durante el embarazo. En todas las ecografías de seguimiento del embarazo es indispensable valorar los anejos.

Abstract BACKGROUND: The association between Brenner tumor and pregnancy is extremely rare. Only four well-documented cases of benign Brenner tumor during pregnancy have been reported but nonmalignant. CLINICAL CASE: A 33-year-old female patient, with a history of a pregnancy that ended in delivery and without setbacks, with no medical or surgical history of interest. In the ultrasound scan of the twelfth week, a 41 mm smooth-walled sonoluscent image was recorded in the left ovary. Lumpectomy was performed during cesarean section. Histological study described a transitional cell epithelial neoplasm, with benign, proliferative and infiltrative areas, compatible with a malignant Brenner tumor. She was treated with radical ovarian cancer surgery and adjuvant chemotherapy. CONCLUSION: It is important to keep malignant Brenner's tumor in mind as a diagnosis of exclusion in the presence of rapidly and rapidly growing tumors during pregnancy. It is very important to evaluate the appendages in all follow-up ultrasounds during pregnancy.

Radioactive seed localization versus wire localization for lumpectomies: a comparison of outcomes.

OBJECTIVE: The purpose of this study was to compare outcomes of radioactive seed localization (RSL) versus wire localization using surgical margin size, reexcision and reoperation rates, specimen size, radiology resource utilization, and cosmesis as measures. MATERIALS AND METHODS: Patients who underwent RSL before segmental mastectomy from April 1, 2011, to March 1, 2012, for biopsy-proven cancer were selected. Each was matched using tumor size, type, and surgeon to a wire localization control case, resulting in 232 cases. Width of the closest surgical margin, reexcision rate, and reoperation rate were compared as were the ratios of tumor volume to initial surgical specimen volume and tumor volume to all surgically excised volume (including reexcisions and reoperations). Cosmetic outcome was analyzed by comparison of Harvard scores and specimen volume with breast volume. Radiology resource utilization was compared before and after RSL implementation. RESULTS: No significant differences between methods were found in closest surgical margin (RSL mean, 0.45 cm; wire localization mean, 0.45 cm; p=0.972), reexcision rate (RSL mean, 21.1%; wire localization mean, 26.3%; p=0.360), reoperation rate (RSL, 11.4%; wire localization, 12.7%; p=0.841), ratio of the tumor volume to initial surgical specimen volume (RSL mean, 0.027; wire localization mean, 0.028; p=0.886), ratio of the tumor volume to total volume resected (RSL mean, 0.024; wire localization mean, 0.024; p=0.997), or in clinical or computed cosmesis scores (clinical p=0.5; calculated p=0.060). There was a 34% increase in scheduled biopsy slot utilization, 50% savings in time spent scheduling, and a 4.1-day average decrease in biopsy wait time after RSL institution. CONCLUSION: RSL is an acceptable alternative to wire localization and offers significant improvements in workflow.

Cirugía oncoplástica de la mama: primera experiencia en el Instituto Nacional de Enfermedades Neoplásicas / Oncoplastic surgery of the breast: first experience at the Instituto Nacional de Enfermedades Neoplasicas

Introducción: la cirugía oncoplástica de la mama es una técnica quirúrgica que ha tenido mucha difusión durante los últimos años. Su empleo está extendiándose rápidamente en diferentes centros alrededor del mundo. El objetivo de este estudio fue describir los resultados en un grupo de pacientes sometidos a cirugía oncoplástica de la mama y compararlos con un grupo sometido a tumorectomía. Métodos: Revisamos y comparamos las características y resultados del tratamiento del grupo sometido a cirugía oncoplástica (n=78) versus los del grupo sometido a tumorectomía (n=68) en el Instituto Nacional de Enfermedades Neoplásicas en el año 2012. Se usaron estadísticas descriptivas y las comparaciones se realizaron con las pruebas t-student y chi-cuadrado. Resultados Las características basales, incluyendo la distribución de las lesiones en los cuadrantes mamarios, fueron similares. Hubo diferencia significativa en el número de ampliación de márgenes dentro de sala de operaciones (53,7% vs 34,9%, para cirugía oncoplástica vs tumorectomía respectivamente; P=0,007), en el volumen de la pieza quirúrgica (325 cm3 vs 151,9 cm3 para la cirugía oncoplástica vs tumorectomía, respectivamente; P=0,033); asimismo se encontraron tendencias estadísticas con respecto a la tasa de reoperaciones (12,8% vs 25,4% para la cirugía oncoplástica vs tumorectom¡a, respectivamente; P=0,056). Conclusiones: la cirugía oncoplástica es un método tan seguro como la tumorectomía, con mejores resultados en términos de procedimientos quirúrgicos adicionales y puede implementarse en las principales Instituciones del país.

Introduction: Breast oncoplastic surgery is a surgical technique that has been quite spread in recent years while their use is spreading rapidly in different facilities around the world. The aim of this study was to describe the results in a group of patients undergoing oncoplastic breast surgery and compare the results with a group of patients undergoing lumpectomy. Methods: we reviewed the features and results of treatment of a group of patients undergoing oncoplastic surgery (n=78) against the results of a group that underwent lumpectomy (n=68) at the Instituto Nacional de Endermedades Neopl sicas in 2012. Descriptive statistics were used and comparisons were done with the Student's t-test and chi square test when appropriate. Results Baseline characteristics were similar between groups, including the distribution of lesions in breast quadrants. In the volume of the surgical specimen (151.9 cm3 vs 325 cm3; significant differences in the number of margin expansion in operating room (P=0.007 and 53.7% vs 34.9% for lumpectomy vs oncoplastic surgery, respectively) were found lumpectomy vs oncoplastic surgery, respectively, P=0.033) and also statistical trends were found with respect to the rate of reoperations (12.8% vs 25.4 % for lumpectomy vs oncoplastic surgery, respectively, P=0.056). Conclusions: oncoplastic surgery is as safe as lumpectomy with better results in terms of additional surgical procedures and may be implemented in the major institutions of the country.

Patrones oncoplásticos en el tratamiento conservador del cáncer de mama y lesiones de riesgo / Ncoplastic patterns in the conservative treatment of breast cancer and high risk lesions

Objetivo: Demostrar la eficacia de la utilización de patrones oncoplásticos por el cirujano de la mama en la realización de la tumorectomía adecuada con resultados cosméticos satisfactorios en el Centro Clínico Familia, Puerto Ordaz. Pacientes y método: Estudio prospectivo en pacientes con cáncer de mama o lesiones benignas de riesgo entre septiembre 2009 y diciembre 2011, en quienes la tumorectomía convencional ocasionaría acentuados defectos cosméticos y ésto determinado por tamaño, localización, relación volumen tumor/mama, multicentricidad y/o bilateralidad de la lesión. Resultados: Se operaron 11 pacientes. Ocho pacientes con cáncer. Carcinoma infiltrante: siete pacientes (63,7%), carcinoma lobulillar in situ: un paciente (9%), y con hiperplasia ductal atípica: tres pacientes (28,1%). El patrón oncoplástico más utilizado fue la mamoplastia vertical de pedículo inferior de rama única: seis paciente (54,5%). La mamoplastia vertical de pedículo superior de rama única y la técnica de Grisotti: dos pacientes (18%), respectivamente. La mamoplastia circunareolar un caso (9%). Se practicó biopsia del ganglio centinela en cinco pacientes, sin complicaciones atribuibles a la inyección de azul patente subareolar. Los resultados cosméticos fueron satisfactorios. Una paciente presentó discreta asimetría de altura de complejo areola ­ pezón y otra paciente un hematoma que se drenó ambulatoriamente. Conclusión: Los patrones oncoplásticos son técnicas quirúrgicas eficaces en el tratamiento conservador del cáncer de mama logrando la extirpación oncológica con excelentes resultados cosméticos. Estos procedimientos pueden ser practicados por el cirujano de la mama sin entrenamiento formal en cirugía plástica, pero sí fundamentado en una minuciosa planificación y técnicas sin excesiva complejidad(AU)

Objective: To demonstrate the effectiveness of oncoplastic techniques by the breast surgeon performing the lumpectomy with satisfactory cosmetic outcomes, at the Centro Clínico Familia, Puerto Ordaz. Patients and method: A prospective study in patients with breast cancer and risk lesions, between September 2009 - December 2011, in whom conventional lumpectomy would cause cosmetic defect and this was determined by the size, location, and relation tumor/breast volume, multicentric or bilateral lesion. Results: Eleven patients were operated. Eight with diagnosed breast cancer. Invasive carcinoma: seven patients (63.7%), lobular in situ carcinoma: one patient (9%) and with atypical ductal hyperplasia: three patients (28.1%). The oncoplastic technique more used was the vertical mamoplasty with inferior single branch pedicle: six patients (54.5%). The vertical mammoplasty with superior branch single pedicle and Grisotti´s technique: two patients (18%) respectively. periareolar mamoplasty: one case (9%). Sentinel lymph node biopsy was performed on five patients without complications due to the subareolar injection of patent blue. The cosmetic results were satisfactory. One patient presented a little asymmetry of height of complex areola - nipple and another patient presented a hematoma that was drained ambulatory. Conclusion: Oncoplastic techniques are effective surgical techniques in the conservative treatment of breast cancer and allow extensive resection with excellent cosmetic results. These procedures can be performed by the breast surgeon without formal training in plastic surgery, but based on a thorough planning of techniques without excessive complexity(AU)