Subject(s)
Anxiety Disorders , Humans , Anxiety Disorders/diagnosis , Anxiety Disorders/drug therapyABSTRACT
Chronic pruritus associated with underlying malignancy can greatly hinder a patient's quality of life. The severity is variable and patients frequently fail traditional first line therapies. We report a patient with diffuse, chronic pruritus secondary to peripheral T Cell Lymphoma (PTCL) who had same day response to mirtazapine after a litany of other agents were unsuccessful.
Subject(s)
Antidepressive Agents, Tricyclic/therapeutic use , Lymphoma, T-Cell, Peripheral/complications , Mirtazapine/therapeutic use , Pruritus/drug therapy , Aged , Humans , Male , Pruritus/etiology , Quality of Life , Treatment OutcomeSubject(s)
Hypnotics and Sedatives/therapeutic use , Sleep Initiation and Maintenance Disorders/diagnosis , Sleep Initiation and Maintenance Disorders/drug therapy , Antidepressive Agents/pharmacokinetics , Antidepressive Agents/therapeutic use , Benzodiazepines/pharmacokinetics , Benzodiazepines/therapeutic use , Chronic Disease , Cognitive Behavioral Therapy/methods , Cognitive Behavioral Therapy/trends , Humans , Hypnotics and Sedatives/pharmacokinetics , Plant Preparations/pharmacokinetics , Plant Preparations/therapeutic use , Receptors, Melatonin/agonists , Sleep Initiation and Maintenance Disorders/metabolismABSTRACT
Remeron (Mirtazapine) is an antidepressant drug which exerts its action by blocking presynaptic α-2-adrenergic receptors and postsynaptic serotonin types 2 and 3 receptors. In this in vitro analysis, human peripheral blood lymphocytes was treated by remeron (10, 25, 40 and 55 µg/mL) for 24 hours and 48 hours periods, then it was attempted to study of genotoxic and cytotoxic effects of the substance on human peripheral blood lymphocytes by some tests such as sister chromatid exchange (SCE), chromosomal abnormalities (CA) and micronucleus (MN) tests. Also proliferating effect of the substance was investigated. Remeron didn't significantly cause chromosomal abnormalities and sister chromatid exchange while caused micronucleus at 40 µg/mL concentration and 24 h periodic time and increased proliferation index of the both 24 and 48 hours treated cells was decreased in a concentration manner. Also, exposing to the remeron for 24 and 48 hours leaded to a decrease in mitotic index and nucleus division index in the cells by concentration dependent manner. These findings showed that remeron did not have significantly genotoxic effects on human peripheral blood lymphocytes while it showed cytotoxic effects on the cells, which is the first report on genotoxic and cytotoxic properties of remeron.
Subject(s)
Adrenergic alpha-Antagonists/toxicity , Lymphocytes/drug effects , Mianserin/analogs & derivatives , Micronuclei, Chromosome-Defective/chemically induced , Serotonin Antagonists/toxicity , Sister Chromatid Exchange/drug effects , Adult , Cell Proliferation/drug effects , Cells, Cultured , Dose-Response Relationship, Drug , Female , Humans , Lymphocytes/pathology , Male , Mianserin/toxicity , Micronucleus Tests , Mirtazapine , Mitosis/drug effects , Mitotic Index , Risk Assessment , Time Factors , Young AdultABSTRACT
Hiccups are defined as involuntary contractions of the diaphragm and intercostal muscles. Most instances of hiccups are self-limiting, but intractable hiccups can sometimes lead to multiple problems including exhaustion. A 56-year-old female visited our psychiatric department due to persistent hiccups and insomnia. Initially, she was unsuccessfully managed using conservative methods, i.e., holding her breath, drinking water, inducing a gag reflex, and orally administering haloperidol. We administered Remeron Soltab(R), and the hiccups disappeared. We conclude that mirtazapine is a useful in the treatment for persistent hiccups.
Subject(s)
Female , Humans , Middle Aged , Contracts , Diaphragm , Drinking Water , Haloperidol , Hiccup , Intercostal Muscles , Mianserin , Reflex , Sleep Initiation and Maintenance DisordersABSTRACT
Since many antidepressants can cause sexual dysfunction, the aim of this study was to follow-up sexual functions during mirtazapine (RemeronSolTab®) treatment. One hundred and two (44 male and 58 female) outpatients with major depression were recruited to this prospective, observational, non-interventional study. The screening was followed by three visits, during which the 17-HAMD, CGI and 9-BDI scales were used. The change of sexual life was monitored by a self-completing questionnaire, based on the modified Psychotropic-Related Sexual Dysfunction Questionnaire. During the treatment both the depression rating scales and the CGI have shown a significant improvement and significant amelioration of previous sexual problems was found; patients were evaluating their sexual life better and better. Our results indicated that mirtazapine is an effective tool for depressed patients who suffer from sexual dysfunction.