Infecções odontogênicas - patogênese e repercussões sistêmicas: revisão de literatura / Odontogenic infections pathogenesis and systemic repercussions

A região de cabeça e pescoço pode ser acometida por doenças infecciosas de origem não odontogênica ou odontogênica - sendo essa geralmente de causa endodôntica. A saúde bucal faz parte do sistema corporal de um indivíduo, desse modo, a negligência com seus cuidados gera um impacto sistêmico. Sendo assim, o objetivo do presente trabalho é analisar o desenvolvimento das infecções odontogênicas desde a necrose pulpar às possíveis repercussões sistêmicas, como: Angina de Ludwing, Mediastinite Necrosante, Fasceíte Necrosante, Endocardite Bacteriana, Sinusite do Seio Maxilar e Osteomielite. É de suma importância que o profissional cirurgião dentista conheça a patogênese dessas infecções, para que este seja capaz de elaborar um diagnóstico precoce e preciso, bem como saiba utilizar os protocolos de prevenção e condutas, a fim de evitar graves complicações sistêmicas. A partir dessa elucidação, será possível evitar o adoecimento do corpo gerado por uma doença da cavidade oral.

The head and neck region can be affected by infectious diseases of non-odontogenic or odontogenic origin - the latter usually having an endodontic cause. Oral health is part of an individual's body system, thus, neglecting its care generates a systemic impact. Therefore, the aim of this study is to analyze the development of odontogenic infections from pulpal necrosis to possible systemic repercussions, such as: Ludwing's Angina, Necrotizing Mediastinitis, Necrotizing Fasciitis, Bacterial Endocarditis, Maxillary Sinusitis and Osteomyelitis. It is extremely important that the dental surgeon knows the pathogenesis of these infections, so that he is able to make an early and accurate diagnosis, as well as know how to use prevention protocols and conducts, in order to avoid serious systemic complications. From this elucidation, it will be possible to avoid the illness of the body generated by a disease of the oral cavity.

Nutritional and laboratory assessment as predictors of hospitalization time, severity of the underlying disease and mortality in dogs / Avaliação nutricional e laboratorial como preditores do tempo de hospitalização, gravidade da doença de base e mortalidade em cães

In medicine, prognosis is defined as a prediction based on a patient's diagnosis and therapeutic possibilities, including the duration and severity of illness, and death rate. The prognostic indices used in human medicine, or even the few standardized indices for veterinary medicine, are not widespread or routinely applied in small animal clinics. Thus, this study aimed to identify commonly used variables in routine clinical practice that may be useful as prognostic markers, correlating specifically with length of stay (LOS), disease severity, and mortality. This study included 246 routine dogs from a teaching veterinary hospital in southern Brazil who underwent analyses for nutritional status (NS) (by anamnesis, physical, and laboratory examinations), hematological examinations, and several serum biochemical parameters. Frequencies, means and standard deviations of the variables, correlation analyses and comparative analyses (Kruskal-Wallis at α = 5%) were calculated. The following relevant markers of disease severity in dogs were considered: presence of malnutrition, including history of hyporexia, anorexia, body condition score (BCS) ≤3 and muscle mass score (MMS≤2); low values of transferrin (TF), total iron binding capacity (TIBC) and anemia; high values of transferrin saturation (TS), lactate and C-Reactive Protein (CRP)/albumin ratio. In animals without systemic diseases or with mild-to-moderate systemic diseases, low albumin values, CRP/albumin ratio, and hyporexia were indicators of a long LOS. In animals with critical systemic diseases, low body mass index (BMI) and hemoglobin (HGB) values were indicators of a short LOS (secondary to high mortality). Mortality indicators in sick dogs included hypoalbuminemia and high urea concentration. In conclusion, the observation of these alterations, especially when they occur simultaneously, helps in determining the prognosis in dogs from a hospital population in an objective, practical, and accessible manner.(AU)

Prognóstico é definido na medicina, como uma predição baseada no diagnóstico do paciente e nas possibilidades terapêuticas, acerca da duração da enfermidade, gravidade da doença e taxa de óbito. Os índices de prognóstico utilizados em medicina humana ou mesmo os poucos padronizados para medicina veterinária não são muito difundidos ou aplicados na clínica de pequenos animais. Dessa forma, esta pesquisa objetivou identificar variáveis de uso comum na rotina clínica que possam ser úteis como marcadoras de prognóstico, se correlacionando, especificamente como o tempo de internamento (TI), gravidade de doença e mortalidade. Para tal, foram avaliados 246 cães da rotina de um hospital veterinário escola do sul do Brasil, estudados em relação ao estado nutricional (EN) (por anamnese, exame físico e laboratorial), exames hematológicos e diversos parâmetros bioquímicos séricos. Foram calculadas as frequências, médias e desvios-padrões das variáveis, análises de correlação e análises comparativas (Kruskal-Wallis em α = 5%). Foram considerados marcadores relevantes de gravidade de doença em cães: presença de desnutrição, incluindo histórico de hiporexia, anorexia, escore de condição corporal (ECC) ≤3 e escore de massa muscular (EMM≤2); baixos valores de transferrina (TF), da capacidade total de ligação ao ferro (CTLF) e anemia; além de valores elevados de índice de saturação da transferrina (IST), lactato e da relação PCR/albumina. Nos animais sem doenças sistêmicas ou com doenças sistêmicas discretas a moderadas, os indicadores de elevado TI foram: baixos valores de albumina, relação Proteína-C-Reativa (PCR)/Albumina e hiporexia. Nos animais com doenças sistêmicas críticas, os indicadores de baixo TI (secundários a alta mortalidade) foram: baixos valores de índice de massa corporal (IMC) e hemoglobina (HB). Os indicadores de mortalidade em cães doentes foram: hipoalbuminemia e elevada concentração de ureia. Conclui-se que a constatação dessas alterações, especialmente quando ocorrem simultaneamente, embasa a determinação do prognóstico em cães de uma população hospitalar, de maneira objetiva, prática e acessível.(AU)

Diabetes, periodontitis, and cardiovascular disease: towards equity in diabetes care.

Type 2 diabetes and its associated cardiovascular risk is an escalating epidemic that represents a significant public health burden due to increased morbidity and mortality, disproportionately affecting disadvantaged communities. Poor glycaemic control exacerbates this burden by increasing retinal, renal, and cardiac damage and raising healthcare costs. This predicament underscores the urgent need for research into cost-effective approaches to preventing diabetes complications. An important but often overlooked strategy to improve metabolic control in diabetic patients is the treatment of periodontitis. Our aim is to assess whether the inclusion of periodontitis treatment in diabetes management strategies can effectively improve metabolic control, and to advocate for its inclusion from an equity perspective. We conducted a comprehensive review of the literature from 2000 to 2023. We analyzed the pathophysiological links between periodontitis, diabetes, and atherosclerotic cardiovascular disease, all of which have inflammation as a central component. We also examined the inequalities in health care spending in this context. Our findings suggest that incorporating routine screening and treatment of periodontitis into national health programs, with coordinated efforts between physicians and dentists, is a cost-effective measure to improve metabolic control, reduce complications and improve the overall quality of life of people with diabetes.

End of life decisions in immunocompromised patients with acute respiratory failure.

PURPOSE: To identify patient, disease and organizational factors associated with decisions to forgo life-sustaining therapies (DFLSTs) in critically ill immunocompromised patients admitted to the intensive care unit (ICU) for acute respiratory failure. MATERIAL AND METHODS: We performed a secondary analysis of the international EFRAIM prospective study, which enrolled 1611 immunocompromised patients with acute respiratory failure admitted to 68 ICUs in 16 countries between October 2015 and June 2016. Multivariate logistic analysis was performed to identify independent predictors of DFLSTs. RESULTS: The main causes of immunosuppression were hematological malignancies (50%) and solid tumor (38%). Patients had a median age of 63 yo (54-71). A pulmonologist was involved in the patient management in 38% of cases. DFLSTs had been implemented in 28% of the patients. The following variables were independently associated with DFLSTs: 1) patient-related: older age (OR 1.02 per one year increase, 95% confidence interval(CI) 1.01-1.03,P < 0.001), poor performance status (OR 2.79, 95% CI 1.98-3.93, P < 0.001); 2) disease-related: shock (OR 2.00, 95% CI 1.45-2.75, P < 0.001), liver failure (OR 1.59, 95% CI 1.14-2.21, P = 0.006), invasive mechanical ventilation (OR 1.79, 95% CI 1.31-2.46, P < 0.001); 3) organizational: having a pulmonologist involved in patient management (OR 1.85, 95% CI 1.36-2.52, P < 0.001), and the presence of a critical care outreach services (OR 1.63, 95% CI 1.11-2.38, P = 0.012). CONCLUSIONS: A DFLST is made in one in four immunocompromised patient admitted to the ICU for acute respiratory failure. Involving a pulmonologist in patient's management is associated with less non beneficial care.

Vacunación contra SARS-CoV-2 en pacientes con esclerosis sistémica en Argentina: preferencias, acceso y adherencia al plan de vacunación / Vaccination against SARS-CoV-2 in patients with systemic sclerosis in Argentina: preferences, access and adherence to the vaccination plan

Introducción: en pacientes con enfermedades reumatológicas autoinmunes se recomienda la aplicación sistemática y secuencial de una serie de vacunas para la prevención de enfermedades transmisibles. El objetivo de este estudio fue estimar la proporción de pacientes con esclerosis sistémica (ES) que recibieron vacunación contra el coronavirus (SARS-CoV-2). Materiales y métodos: se envió una encuesta anónima por correo electrónico o contacto por WhatsApp desde mayo a septiembre de 2021, con preguntas para evaluar la adherencia al esquema de vacunación recomendado en pacientes con enfermedades reumatológicas, así como temores, preferencias y adherencia al esquema de vacunación contra el SARS-CoV-2. Resultados: se incluyeron 295 pacientes con ES. El 68,81% estaba vacunado contra el SARS-CoV-2 con al menos una dosis, de los cuales el 48,7% tenía dos dosis. El 84,75% refirió conversar con su médico sobre su esquema de vacunación general. Solo el 5,4% tenía las cuatro vacunas. El 93,56% manifestó voluntad de vacunarse contra el SARS-CoV-2; el 56,27% prefirió la vacuna Sputnik V. El 7,46% manifestó su voluntad de no vacunarse. Los factores que influyeron en la adherencia a la vacunación, con mayor frecuencia, fueron el miedo a contraer la infección por SARS-CoV-2 (86,1%) y las reacciones adversas (23,05%). Conclusiones: destacamos el hecho de que solo 6 meses después de que se dispusiera la vacunación contra el SARS-CoV-2, la mitad de los pacientes con ES tenía el esquema recomendado completo.

Introduction: in patients with autoimmune rheumatic diseases, the systematic and sequential application of a series of vaccines is recommended for the prevention of communicable diseases. The objective was to estimate the proportion of patients with systemic sclerosis (SSc) who received vaccination against coronavirus (SARS-CoV-2). Materials and methods: since may to september 2021, an anonymous survey was sent by email or messaging app, containing questions to assess adherence to the recommended vaccination schedule in patients with rheumatic diseases, as well as fears, preferences and adherence to vaccination schedule against SARS-CoV-2. Results: 295 patients with SSc were included. 68.81% were vaccinated for SARS-CoV-2 with at least one dose, 48.7% of this group had two doses. 84.75% reported talking to their doctor about their general vaccination schedule. Only 5.4% had all four vaccines. 93.56% expressed willingness to be vaccinated against SARS-CoV-2, 56.27% preferred the Sputnik V vaccine. 7.46% expressed their willingness to not be vaccinated. The factors that most frequently influenced adherence to vaccination were fear of contracting SARS-CoV-2 infection (86.1%) and adverse reactions (23.05%). Conclusions: we highlight the fact that only 6 months after vaccination against SARS-CoV-2 became available, half of the patients with SSc had the full recommended schedule.

Registro de datos sobre riesgo quirúrgico en historias clínicas de Estomatología General Integral / Recording surgical risk data in comprehensive dental care medical records

Introducción: La atención estomatológica integral al paciente de riesgo quirúrgico resulta un reto en la actualidad. El profesional de la estomatología necesita herramientas que permita profundizar en los riesgos quirúrgicos, entre esas herramientas puede contarse la correcta confección de historia clínica. Objetivo: Describir el comportamiento de la confección de historia clínica en los pacientes de riesgo quirúrgico en la Clínica Estomatológica "Salvador Allende". Métodos: Se revisaron 108 historias clínicas de todos los pacientes de riesgo quirúrgico ingresados en la consulta de estomatología general integral en el archivo de la Clínica "Salvador Allende" del municipio Cerro, La Habana, correspondientes a un periodo de tres meses. Resultados: Un 41,6 por ciento de pacientes presentó hipertensión arterial, seguidos de pacientes con dos o más enfermedades (37,0 por ciento). El 56,4 por ciento de las historias clínicas abordó sobre el uso de medicamentos para la enfermedad de base, los restantes acápites tuvieron bajos porcentajes en relación con el completamiento de la información. El 79,6 por ciento de los pacientes de riesgo recibieron tratamiento quirúrgico. Conclusiones: La enfermedad de riesgo más frecuente es la hipertensión arterial seguida por los pacientes con dos o más enfermedades. No se recogen los datos necesarios en la atención del paciente de riesgo quirúrgico y las propuestas plasmadas permitirán realizar cualquier ejercicio de la profesión de manera más eficaz y con menor riesgo(AU)

Introduction: Comprehensive dental care of surgical risk patients is a current challenge. Dental care professionals should have access to tools allowing them to expand their knowledge about possible surgical risks. Appropriately developed medical records are an example of such tools. Objective: To describe the process of development of medical records of surgical risk patients at Salvador Allende dental clinic. Methods: A total 108 medical records were reviewed, corresponding to all the surgical risk patients admitted to the general comprehensive dental care service of Salvador Allende dental clinic in the municipality of Cerro, Havana, in a three months' period. Results: Of the patients studied, 41.6 percent had arterial hypertension, followed by patients with two or more conditions (37.0 percent). It was found that 56.4 percent of the medical records contained information about the use of drugs for the underlying condition. The remaining items exhibited low percentages of data completion. 79.6 percent of the risk patients received surgical treatment. Conclusions: The most common risk condition is arterial hypertension, followed by patients with two or more diseases. The data required for the care of surgical risk patients are not recorded. The proposals put forth will make it possible to perform any professional practice in a more effective manner and with a lower level of risk(AU)

Pathways Linking Oral Bacteria, Nitric Oxide Metabolism, and Health.

Nitrate-reducing oral bacteria have gained a lot of interest due to their involvement in nitric oxide (NO) synthesis and its important cardiometabolic outcomes. Consortia of nitrate-metabolizing oral bacteria associated with cardiometabolic health and cognitive function have been recently identified. Longitudinal studies and clinical trials have shown that chronic mouthwash use is associated with increased blood pressure and increased risk for prediabetes/diabetes and hypertension. Concurrently, recent studies are beginning to shed some light on the complexity of nitrate reduction pathways of oral bacteria, such as dissimilatory nitrate reduction to ammonium (DNRA), which converts nitrite into ammonium, and denitrification, which converts nitrite to NO, nitrous oxide, and dinitrogen. These pathways can affect the composition and metabolism of the oral microbiome; consequently, salivary nitrate and nitrite metabolism have been proposed as targets for probiotics and oral health. These pathways could also affect systemic NO levels because NO generated through denitrification can be oxidized back to nitrite in the saliva, thus facilitating flux along the NO3--NO2--NO pathway, while DNRA converts nitrite to ammonium, leading to reduced NO. It is, therefore, important to understand which pathway predominates under different oral environmental conditions, since the clinical consequences could be different for oral and systemic health. Recent studies show that oral hygiene measures such as tongue cleaning and dietary nitrate are likely to favor denitrifying bacteria such as Neisseria, which are linked with better cardiometabolic health. A vast body of literature demonstrates that redox potential, carbon-to-nitrate ratio, and nitrate-to-nitrite ratio are key environmental drivers of the competing denitrification and DNRA pathways in various natural and artificial ecosystems. Based on this information, a novel behavioral and microbial model for nitric oxide metabolism and health is proposed, which links lifestyle factors with oral and systemic health through NO metabolism.

The oral microbiota: a literature review for updating profesional s in dentistry-Part II / La microbiota oral: una revisión de literatura para la actualización de profesionales en odontología-Parte II

ABSTRACT: In the first part of this literature review, published in October 2019 in this journal, we summarized the conceptual background of the oral microbiota, and the main methods used in microbiology to characterize oral organisms. We also presented the most studied bacteria species in the oral microbiota. In this second part, we will discuss the evidence regarding the biological plausibility linking the oral microbiota dysbiosis and systemic diseases, as well as the main factors and mechanisms suspected in this association.

RESUMEN: En la primera parte de esta revisión de literatura, publicada en esta revista en octubre de 2019, se resumieron los antecedentes conceptuales de la microbiota oral y describieron los principales métodos utilizados en microbiología para caracterizar los microorganismos orales. Asimismo, se presentaron las especies bacterianas mejor estudiadas de la microbiota oral. En esta segunda parte, se explorará la plausibilidad biológica que vincularía la disbiosis de la microbiota oral y las enfermedades sistémicas, así como las características que podrían influenciar la composición de la microbiota oral.

Desarrollo de la habilidad "diagnóstico" de manifestaciones oftalmológicas en la carrera de Medicina

RESUMEN Introducción: El creciente aumento en el índice de enfermedades sistémicas y su relación con algunas manifestaciones oftalmológicas, impone un reto al ejercicio de la Medicina en la Atención Primaria de Salud y a la Educación Médica Superior cubana en la actualidad. Objetivo: Elevar la preparación metodológica del colectivo docente de la asignatura Oftalmología para el desarrollo de la habilidad "diagnóstico" de manifestaciones oftalmológicas presentes en algunas enfermedades sistémicas. Método: Se utilizó un muestro censal, en el departamento de Oftalmología del Hospital General Docente "Dr. Agostinho Neto", de Guantánamo, realizado durante el curso académico 2019- 2020, constituido por los 21 docentes de ese colectivo docente. En correspondencia, se utilizaron métodos teóricos y empíricos. Resultados: Se identificó que los profesores del colectivo de la asignatura Oftalmología fueron capaces de significar el valor de la relación entre los profesores, los estudiantes y el grupo, como componentes personales del proceso de enseñanza-aprendizaje y comprender que el marco de relaciones interpersonales entre ellos, se establece sobre la base de las categorías, actividad y comunicación. En cuanto a los componentes didácticos no personales, los docentes manifestaron, tanto en entrevistas en profundidad como en las grupales, que este tipo de preparación metodológica, fue muy útil para su desempeño docente-asistencial. Conclusiones: La preparación metodológica realizada es pertinente y se contextualiza a las potencialidades e insuficiencias didácticas-metodológicas identificadas en dicho colectivo docente para el desarrollo de la habilidad "diagnóstico" de manifestaciones oftalmológicas presentes en algunas enfermedades sistémicas: cerebrovasculares, cardiovasculares, neoplasias y respiratorias.

ABSTRACT Introduction: The growing increase in the rate of systemic diseases and their relationship with some ophthalmologic manifestations, imposes a challenge to the practice of medicine in Primary Health Care and to Cuban Higher Medical Education at present. Objective: To increase the methodological preparation for the teaching staff of Ophthalmology subject in order to develop the skill "diagnosis" of ophthalmologic manifestations present in some systemic diseases. Method: A census sample was applied in the Ophthalmology department at the Hospital General Docente "Dr. Agostinho Neto", in Guantánamo. This census was carried out during the academic year 2019-2020, constituted by the 21 professors of that teaching group. Correspondingly, theoretical and empirical methods were used. Results: It was identified that the professors of the Ophthalmology subject group were able to understand the value of the relationship between professors, students and the group, as personal components of the teaching-learning process and to understand that the framework of interpersonal relationships among them it´s established on the basis of categories, activity and communication. As for the non-personal didactic components, professors stated, both in in-depth and group interviews, that this type of methodological preparation was very useful for their teaching-assistance performance. Conclusions: The methodological preparation carried out was appropriate and it is contextualized to the didactic-methodological potentialities and insufficiencies identified in this teaching group for the development of the skill "diagnosis" of ophthalmologic manifestations present in some systemic diseases: cerebrovascular, cardiovascular, neoplasias and respiratory diseases.

RESUMO Introdução: O crescente aumento do índice de doenças sistêmicas e sua relação com algumas manifestações oftalmológicas, impõe um desafio à prática da Medicina na Atenção Primária à Saúde e à Educação Médica Superior cubana na atualidade. Objetivo: Levantar a preparação metodológica do grupo de ensino da disciplina de Oftalmologia para o desenvolvimento da capacidade "diagnóstico" das manifestações oftalmológicas presentes em algumas doenças sistêmicas. Método: Foi utilizada uma amostra censitária no serviço de Oftalmologia do Hospital General Docente "Dr. Agostinho Neto", de Guantánamo, realizada durante o ano letivo 2019-2020, composta por 21 professores deste grupo de ensino. Correspondentemente, métodos teóricos e empíricos foram usados. Resultados: Identificou-se que os professores do grupo disciplinar de Oftalmologia conseguiram significar o valor da relação entre professores, alunos e grupo, como componentes pessoais do processo ensino-aprendizagem e compreender que o arcabouço das relações interpessoais entre eles, é estabelecido com base em categorias, atividade e comunicação. Quanto aos componentes didáticos não pessoais, os professores afirmaram, tanto em entrevistas em profundidade como em entrevistas em grupo, que este tipo de preparação metodológica foi muito útil para a sua atuação docente-assistencial. Conclusões: O preparo metodológico realizado é pertinente e contextualizado às potencialidades e insuficiências didático-metodológicas identificadas no referido grupo de ensino para o desenvolvimento da capacidade "diagnóstico" de manifestações oftalmológicas presentes em algumas doenças sistêmicas: cerebrovasculares, cardiovasculares, neoplasias e respiratórias.

Periodontal Inflammation and Systemic Diseases: An Overview.

Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

Oral Manifestations in Patients with COVID-19: A 6-Month Update.

This is the first update of the previously published living systematic review that summarized evidence on the prevalence of oral signs and symptoms in patients with COVID-19. Hitherto, 183 studies were included, reporting data from 64,876 patients with COVID-19 worldwide. The overall prevalence of taste disorders was 38% (95% CI = 22% to 56%, I2 = 98%). Hypogeusia, dysgeusia, and ageusia were also evaluated by a meta-analysis, and the pooled prevalence was 34% for hypogeusia, 33% for dysgeusia, and 26% for ageusia. Taste disorders were associated with a positive COVID-19 test (odds ratio [OR] = 7.54, 95% CI = 5.24 to 10.86, I2 = 93%, P < 0.00001), showing high certainty of evidence. However, the association between taste disorders and mild/moderate severity of COVID-19 (OR = 1.63, 95% CI = 1.33 to 1.99, I2 = 69%, P < 0.0001) and female patients with COVID-19 (OR = 1.77, 95% CI = 1.26 to 2.48, I2 = 79%, P = 0.001) presented low certainty of evidence. Xerostomia was a new feature of this update, and the pooled data demonstrated a prevalence of 43% (95% CI = 36% to 50%, I2 = 71%) in patients with COVID-19. Regarding oral mucosal lesions, the most common clinical pattern was aphthous like, followed by herpes-like lesions, candidiasis, glossitis/depapillation/geographic tongue, parotitis, and angular cheilitis. Oral lesions were more frequent in the tongue, lips, and palate, presenting miscellaneous clinical aspects that are more likely to represent coinfections. Therefore, the reanalysis of current evidence suggests the triad xerostomia, taste dysfunction, and oral mucosal lesions as common manifestations in patients with COVID-19. However, these outcomes are under discussion, and more studies will be necessary to confirm their association with direct SARS-CoV-2 infection in the oral cavity.

Curso optativo de riesgo quirúrgico para estudiantes de pregrado de la carrera de estomatología / Elective course on surgical risk for undergraduate dental medicine students

Introducción: Los pacientes de riesgo quirúrgico presentan enfermedades asociadas que deben considerarse durante el tratamiento estomatológico. Investigaciones realizadas revelan la existencia de deficiencias durante la atención estomatológica a este tipo de paciente y que el tema debe ser reforzado durante el pregrado. Objetivos: Exponer las generalidades del curso optativo de atención estomatológica integral al paciente de riesgo quirúrgico y los criterios emitidos por sus participantes. Métodos: Se realizó una investigación descriptiva de corte pedagógico para exponer las características más importantes del curso. Se tuvieron en cuenta las siguientes variables: temas, objetivos, sistema de conocimientos y de habilidades. Se aplicó la técnica de Positivo, Negativo, Interesante a todos los participantes del curso. Resultados: El curso implementado contó con cinco temas: el primero dedicado a las generalidades y las características particulares en la confección de historia clínica; el segundo y tercero, a las enfermedades de riesgo quirúrgico y los tratamientos estomatológicos; el cuarto, al uso de medicamentos para la enfermedad sistémica y las posibles interacciones; y el quinto, a experiencias clínicas. Los estudiantes aportaron criterios positivos, negativos e interesantes. Conclusiones: El curso diseñado ofrece conocimientos y habilidades al estudiante que no se proporcionan en las asignaturas de pregrado, lo cual permite una mejor atención estomatológica integral a los pacientes de riesgo quirúrgico. Los estudiantes participantes del curso optativo aportaron criterios favorables sobre su estructura, pertinencia y valor científico(AU)

Introduction: Surgical risk patients have associated diseases that must be considered during dental treatment. Some research carried out have revealed the existence of deficiencies during dental care for this type of patients, a reason why the issue must be strengthened during undergraduate studies. Objective: To present the generalities of an elective course of comprehensive dental care for patients at surgical risk and the criteria issued by its participants. Methods: A descriptive research with a pedagogical nature was carried out to expose the most important characteristics of the course. The following variables were taken into account: topics, objectives, knowledge system and skills system. The positive-negative-interesting technique was applied to all the course participants. Results: The implemented course had five topics: the first was dedicated to generalities and particular characteristics in the preparation of a clinical record; the second and third courses, to surgical risk diseases and dental treatments; the fourth course, to the use of drugs for systemic diseases and possible interactions; and the fifth, to clinical experiences. The students provided positive, negative and interesting criteria. Conclusions: The designed course offers knowledge and skills to the student that are not provided in undergraduate subjects, which allows better comprehensive dental care to patients at surgical risk. The students participating in the elective course provided favorable criteria about the course's structure, relevance and scientific value(AU)

Childhood Acute Leukemias in Developing Nations: Successes and Challenges.

PURPOSE OF REVIEW: Acute leukemias represent a tremendous threat to public health around the globe and the main cause of death due to disease in scholar age children from developing nations. Here, we review their current status in Mexico, as a paradigm of study, and the major challenges to control systemic diseases like childhood cancer. RECENT FINDINGS: A unique molecular epidemiology, late/low precision diagnosis, limited access to treatment, toxicity associated with therapy, continuous exposure to environmental risk factors, and the high frequency of early relapses are some of the factors cooperating to low rates of survival in low-to-medium-income countries. Deliberative dialogues and exhaustive programs have emerged as promising means of advancing evidence-informed policy, by providing a structured forum for key stakeholders to integrate scientific and pragmatic knowledge about complex health concerns. A system-wide strategy based on the comprehensive leukemia identity is essential for a meaningful decline in early childhood mortality.

Oral Manifestations in Patients with COVID-19: A Living Systematic Review.

This living systematic review aims to summarize evidence on the prevalence of oral signs and symptoms in patients with COVID-19. The review was reported per the PRISMA checklist, and the literature search was conducted in 6 databases and in gray literature. Studies published in any language mentioning oral symptoms and signs in patients with COVID-19 were included. The risk of bias was assessed by the Joanna Briggs Institute appraisal tools. The certainty of evidence was evaluated through GRADE assessment. After a 2-step selection, 40 studies were included: 33 cross-sectional and 7 case reports. Overall, 10,228 patients (4,288 males, 5,770 females, and 170 unknown) from 19 countries were assessed. Gustatory impairment was the most common oral manifestation, with a prevalence of 45% (95% CI, 34% to 55%; I2 = 99%). The pooled eligible data for different taste disorders were 38% for dysgeusia and 35% for hypogeusia, while ageusia had a prevalence of 24%. Taste disorders were associated with COVID-19 (odds ratio [OR], 12.68; 95% CI, 6.41 to 25.10; I2 = 63%; P < 0.00001), mild/moderate severity (OR, 2.09; 95% CI, 1.25 to 3.49; I2 = 66%; P = 0.005), and female patients (OR, 1.64; 95% CI, 1.23 to 2.17; I2 = 70%; P = 0.0007). Oral mucosal lesions presented multiple clinical aspects, including white and erythematous plaques, irregular ulcers, small blisters, petechiae, and desquamative gingivitis. Tongue, palate, lips, gingiva, and buccal mucosa were affected. In mild cases, oral mucosal lesions developed before or at the same time as the initial respiratory symptoms; however, in those who required medication and hospitalization, the lesions developed approximately 7 to 24 d after onset symptoms. Therefore, taste disorders may be common symptoms in patients with COVID-19 and should be considered in the scope of the disease's onset and progression. Oral mucosal lesions are more likely to present as coinfections and secondary manifestations with multiple clinical aspects (PROSPERO CRD42020184468).

El glaucoma y las enfermedades sistémicas con compromiso vascular / Glaucoma and systemic diseases of vascular involvement

La presión intraocular es considerada el único factor causal potencialmente modificable con el propósito de prevenir la ceguera por glaucoma. Esta es una enfermedad multifactorial y, aunque es el factor de riesgo más importante en su desarrollo, la reducción de sus valores no garantiza el cese de la progresión del daño glaucomatoso. El glaucoma primario de ángulo abierto y el glaucoma de presión normal comparten factores de riesgo similares en la patogénesis y se pueden clasificar en categorías mecánicas y vasculares. La evidencia científica actual ha logrado demostrar que existe una importante asociación entre las enfermedades sistémicas con compromiso vascular, como la migraña, la apnea obstructiva del sueño, la hipotensión arterial de diferentes causas, la hipertensión arterial, la enfermedad cerebrovascular, la cardiopatía isquémica y la diabetes mellitus con los hallazgos a nivel ocular en pacientes con neuropatía óptica glaucomatosa. Esta correlación orienta a considerar estas enfermedades en conjunto para que cada profesional dedicado a la salud visual considere siempre imprescindible la evaluación de los aspectos que vinculan estas enfermedades para actuar en consecuencia. Se realiza una búsqueda sobre el glaucoma y las enfermedades sistémicas con compromiso vascular(AU)

Intraocular pressure is considered to be the only potentially modifiable causative factor to prevent glaucoma blindness. However, glaucoma is a multifactorial disease, and true as it is that its main risk factor is intraocular pressure, its reduction does not ensure cessation of the progress of glaucomatous damage. Primary open angle glaucoma and normal pressure glaucoma share similar pathogenetic risk factors, and may be classified as mechanical or vascular. According to current scientific evidence, an important association exists between systemic diseases with vascular involvement, such as migraine, obstructive sleep apnea, arterial hypotension of various causes, arterial hypertension, cerebrovascular disease, ischemic heart disease and diabetes mellitus, and ocular findings in patients with glaucomatous optic neuropathy. In view of this correlation, these diseases should be considered jointly, so that visual health professionals always bear in mind the evaluation of their common characteristics and act in consequence. A search was carried out on glaucoma and systemic diseases with vascular compromise(AU)

Pseudoexfoliación ocular: un signo de alerta temprana de enfermedades sistémicas / Ocular pseudoexfoliation: an early warning signal in systemic diseases

El síndrome pseudoexfoliativo es una enfermedad relacionada con la edad, que afecta a la población mayor de 60 años y tiene una distribución mundial. Se caracteriza por la producción y la acumulación progresiva de un material fibrilar extracelular a nivel de las distintas estructuras del ojo, con repercusiones significativas sobre la salud ocular de los pacientes y, además, conduce a complicaciones quirúrgicas. El material pseudoexfoliativo no solo se encuentra en el globo ocular, sino en distintas partes del organismo, como el corazón, los pulmones, el cerebro y los vasos sanguíneos, por lo que algunos estudios sugieren la relación de este síndrome con ciertas afecciones cardíacas. Se presenta un paciente de 74 años de edad, negro, con antecedentes de hipertensión arterial, que se ingresa por pérdida brusca de la visión de ambos ojos, acompañado de dolor. Al examen oftalmológico, después del tratamiento hipotensor, se constató material pseudoexfolitivo y cristalino subluxado a cámara vítrea. Se diagnosticó glaucoma pseudoexfoliativo, disfunción asintomática del miocardio, hiperlipidemia, ateroma en la aorta abdominal e hipoacusia neurosensorial severa. Existen estudios que sugieren relación del síndrome pseudoexfoliativo con ciertas enfermedades y factores de riegos vasculares con alto impacto en la morbimortalidad a nivel mundial(AU)

Pseudoexfoliation syndrome is an aging-related disease of worldwide distribution affecting people aged over 60 years. It is characterized by progressive production and accumulation of extracellular fibrillar material in the different structures of the eye, with significant impacts on the patients' ocular health. It may also lead to surgical complications. Pseudoexfoliative material is not only found in the eyeball, but also in various parts of the body, such as the heart, the lungs, the brain and blood vessels, this being the reason why some studies suggest a relationship to certain heart conditions. A case is presented of a male black 74-year-old patient with a history of arterial hypertension, admitted due to sudden vision loss in both eyes, accompanied by pain. The ophthalmological examination performed after hypotensive treatment confirmed the presence of pseudoexfoliative material and crystalline subluxated to the vitreous chamber. The diagnosis was pseudoexfoliation glaucoma, asymptomatic myocardial dysfunction, hyperlipidemia, abdominal aorta atheroma and severe neurosensory hypoacusis. Some studies suggest a relationship between pseudoexfoliation syndrome and certain vascular diseases and risk factors with a high impact on worldwide morbidity and mortality(AU)

Emergencias médicas en la atención odontológica: pacientes "de riesgo" y/o "en riesgo" / Medical emergencies in dental care: 'risk' and/or 'at risk' patients

En medicina, los pacientes de riesgo son aquellos que, al momento de la consulta, presentan antecedentes y/o pa- decimientos que implican una mayor probabilidad de sufrir complicaciones, como personas inmunodeprimidas o con en- fermedades crónicas, ya sean cardíacas, pulmonares, renales, hepáticas, sanguíneas o metabólicas (por ejemplo, diabetes). Estos pacientes se encuentran en riesgo en el caso de prác- ticas que puedan exacerbar o provocar reacciones adversas a raíz de su padecimiento. En la actualidad, el grupo poblacional vulnerable ha au- mentado a partir de nuevos tratamientos médicos que han per- mitido mejorar padecimientos sistémicos severos y prolongar la esperanza de vida. Ante pacientes "de riesgo" o "en riesgo", el odontólogo debe estar alerta y actualizado, a fin de evitar provocar alteraciones sistémicas y de reaccionar pronta y eficazmente, en caso de ser necesario, ante las urgencias médicas que se presenten (AU)

In medicine, risk patients are those who at the consulta- tion have a history and/or conditions that could cause a great- er possibility of a complication; such as immunosuppressed, chronic heart, pulmonary, kidney, liver, blood or metabolic diseases (for example, diabetes).These patients are at risk during procedures that could in- crease or cause inadequate reactions due to their conditions. Currently, the vulnerable population group has increased since newest medical treatments have emerged; allowing se- vere systemic ailments to improve and prolong life expectancy. With risk or at-risk patients, the dentist must be alert and up-to-date to avoid systemic alterations and react promptly and efficiently if necessary in any medical emergency that might take place (AU)

Prevalencia de derrame pericárdico en enfermedades sistémicas.

INTRODUCTION: The presence of 50 mL of fluid or more in the pericardial sac is known as pericardial effusion. OBJECTIVE: To determine the prevalence of pericardial effusion in patients with systemic diseases. METHOD: Echocardiographic studies performed at the National Medical Center Siglo XXI Specialty Hospital Cardiology Department between 2006 and 2016 were reviewed. According to Weitzman's criteria, pericardial effusion was classified as mild, < 10 mm, moderate, 10 to 20 mm and severe, > 20 mm. RESULTS: In total, 10,653 studies were reviewed; the prevalence of pericardial effusion was 3.5 % (380), in 209 women (55 %, 45.9 ± 19.0 years) and 171 men (45 %, 41.9 ± 18.5 years). Etiology was uremic in 227 (59.7 %), lymphatic drainage reduction in 73 (15.8 %), autoimmune diseases in 30 (7.9 %), neoplastic in 26 (6.8 %), infectious in 19 (5 %), idiopathic in 14 (3.7 %), hypothyroidism in two (0.5 %), iatrogenic in one (0.3 %) and post-infarction in one (0.3 %). Severity was mild in 87 (22.9 %), moderate in 147 (38.7 %) and severe in 146 (38.4 %). CONCLUSIONS: The prevalence of pericardial effusion was 3.5% in patients with systemic diseases.

INTRODUCCIÓN: La presencia de 50 mL o más de líquido dentro del saco pericárdico se denomina derrame pericárdico. OBJETIVO: Determinar la prevalencia de derrame pericárdico en pacientes con enfermedades sistémicas. MÉTODO: Se revisaron los estudios ecocardiográficos efectuados en el Servicio de Cardiología del Hospital de Especialidades del Centro Médico Nacional Siglo XXI, entre 2006 y 2016. Conforme los criterios de Weitzman, el derrame pericárdico se clasificó en ligero, < 10 mm, moderado de 10 a 20 mm y severo, > 20 mm. RESULTADOS: Se revisaron 10 653 estudios; la prevalencia del derrame pericárdico fue de 3.5 % (380), 209 mujeres (55 %, 45.9 ± 19.0 años) y 171 hombres (45 %, 41.9 ± 18.5 años). La etiología fue urémica en 227 (59.7 %), reducción del drenaje linfático en 73 (15.8 %), enfermedades autoinmunes en 30 (7.9 %), neoplásicas en 26 (6.8 %), infecciosas en 19 (5 %), idiopáticas en 14 (3.7 %), hipotiroidismo en dos (0.5 %), iatrogénica en uno (0.3 %) y posinfarto en uno (0.3 %). La severidad fue ligera en 87 (22.9 %), moderada en 147 (38.7 %) y severa en 146 (38.4 %). CONCLUSIONES: La prevalencia de derrame pericárdico fue de 3.5 % en pacientes con enfermedades sistémicas.

Prevalence of pericardial effusion in systemic diseases / Prevalencia de derrame pericárdico en enfermedades sistémicas

Abstract Introduction: The presence of 50 ml of fluid or more in the pericardial sac is known as pericardial effusion. Objective: To determine the prevalence of pericardial effusion in patients with systemic diseases. Method: Echocardiographic studies performed at the National Medical Center Siglo XXI Specialty Hospital Cardiology Department between 2006 and 2016 were reviewed. According to Weitzman's criteria, pericardial effusion was classified as mild, < 10 mm, moderate, 10 to 20 mm and severe, > 20 mm. Results: In total, 10,653 studies were reviewed; the prevalence of pericardial effusion was 3.5 % (380), in 209 women (55 %, 45.9 ± 19.0 years) and 171 men (45 %, 41.9 ± 18.5 years). Etiology was uremic in 227 (59.7 %), lymphatic drainage reduction in 73 (15.8 %), autoimmune diseases in 30 (7.9 %), neoplastic in 26 (6.8 %), infectious in 19 (5 %), idiopathic in 14 (3.7 %), hypothyroidism in two (0.5 %), iatrogenic in one (0.3 %) and post-infarction in one (0.3 %). Severity was mild in 87 (22.9 %), moderate in 147 (38.7 %) and severe in 146 (38.4 %). Conclusions: The prevalence of pericardial effusion was 3.5% in patients with systemic diseases.