ABSTRACT
This paper aims to report clinical, laboratory, radiographic, and pathological features in a case of cervical vertebral stenotic myelopathy (CVSM) affecting a 4-month-old Nelore calf for the first time. During physical examination, the calf could stand if assisted when lifting by the tail but fallen to the ground when trying to walk. Attempts to flex and extend the neck to the right side failed. Radiographs findings consisted of reduced intervertebral spaces, and misalignments between the endplates, more evident between the C3 and C4 vertebrae, resulting in narrowing of the spinal canal and compression of the spinal cord. Grossly, C4 showed cranial articular surface malformation, abnormal metaphyseal growth plate development, reduced vertebral body size and deformity. Histologically, C4 showed an abnormal vertebral bone development characterized by moderate replacement of trabecular bone by fibrous tissues, multifocal areas of dystrophic hyaline cartilage development, and cartilaginous growth failure along the metaphyseal growth plate. Cervical spinal cord within the stenotic vertebral canal showed swollen neurons with central chromatolysis, areas of Wallerian degeneration, and necrotic debris. In contrast with the well-known Wobbler syndrome in horses, the etiology of CVSM in cattle remains undetermined, and further genetic and pathological studies must be conducted to elucidate it.
ABSTRACT
El síndrome de Pai se describe como la presencia de 3 anomalías congénitas: fisura de labio medial, pólipos cutáneos nasales y faciales, y lipoma pericallosal. La expresión clínica es variable. El desarrollo neuromadurativo suele ser normal. Existen 42 casos descritos en la literatura. Se proponen distintos tipos de herencia, pero, hasta la actualidad, no existe un gen asignado para esta patología. Se presentan dos pacientes con síndrome de Pai, uno de ellos con hallazgos clínicos aún no descritos (defectos de segmentación vertebral y osteoma coroideo).
Pai syndrome is a very rare congenital disorder characterized by medial cleft lip, nasal and facial cutaneous polyps, and pericallosal lipoma. Broad phenotypic variability exists in this condition. Neurodevelopment is usually normal. Up to date 42 cases have been reported in the literature. Different types of inheritance have been proposed, but most cases are sporadic. No gene has been identified. We report two cases with Pai syndrome, one of them with novel clinical findings as vertebral segmentation defects and choroidal osteoma.
Subject(s)
Humans , Female , Infant , Skin Diseases/diagnosis , Coloboma/diagnosis , Nasal Polyps/diagnosis , Cleft Lip/diagnosis , Agenesis of Corpus Callosum/diagnosis , Lipoma/diagnosis , PhenotypeABSTRACT
Pai syndrome is a very rare congenital disorder characterized by medial cleft lip, nasal and facial cutaneous polyps, and pericallosal lipoma. Broad phenotypic variability exists in this condition. Neurodevelopment is usually normal. Up to date 42 cases have been reported in the literature. Different types of inheritance have been proposed, but most cases are sporadic. No gene has been identified. We report two cases with Pai syndrome, one of them with novel clinical findings as vertebral segmentation defects and choroidal osteoma.
El síndrome de Pai se describe como la presencia de 3 anomalías congénitas: fisura de labio medial, pólipos cutáneos nasales y faciales, y lipoma pericallosal. La expresión clínica es variable. El desarrollo neuromadurativo suele ser normal. Existen 42 casos descritos en la literatura. Se proponen distintos tipos de herencia, pero, hasta la actualidad, no existe un gen asignado para esta patología. Se presentan dos pacientes con síndrome de Pai, uno de ellos con hallazgos clínicos aún no descritos (defectos de segmentación vertebral y osteoma coroideo).
Subject(s)
Agenesis of Corpus Callosum/diagnosis , Cleft Lip/diagnosis , Coloboma/diagnosis , Lipoma/diagnosis , Nasal Polyps/diagnosis , Skin Diseases/diagnosis , Female , Humans , Infant , PhenotypeABSTRACT
This paper aims to describe the macroscopic aspects of disease and radiological findings related to spina bifida in a newborn cat. A female cat was seen in labor at a veterinary clinic in Teresina-PI. By performing the ultrasound test it was possible detect the presence of three fetuses aged approximately 62 days and decreased heart rate. The patient underwent surgery immediately to cesarean section with ovariohysterectomy. One of the newborn cat showed changes consistent with spina bifida. The owner opted for the newborn cat euthanasia because is not known effective treatment for the case. There are insufficient researchs on the embryonic development aimed at prevention and treatment of these anomalies. These studies are necessary to ensure a good prognosis for patients.
Este trabalho tem como objetivo descrever os aspectos macroscópicos da doença e os achados radiológicos relacionados à espinha bÃfida em um neonato felino. Uma fêmea felina foi atendida em trabalho de parto numa clÃnica veterinária em Teresina-PI. Ao realizar o exame ultrassonográfico foi possÃvel detectar a presença de três fetos com idade aproximada de 62 dias e com batimentos cardÃacos diminuÃdos. A paciente foi submetida imediatamente à cirurgia cesariana com ovariossalpingohisterectomia. Um dos neonatos apresentava alterações compatÃveis com espinha bÃfida. A proprietária optou pela eutanásia do neonato por não se conhecer um tratamento eficaz para o caso. Ainda são escassas as pesquisas sobre o desenvolvimento embrionário voltadas para prevenção e tratamento dessas anomalias. Estas pesquisas são necessárias a fim de garantir um bom prognóstico aos pacientes portadores.
ABSTRACT
This paper aims to describe the macroscopic aspects of disease and radiological findings related to spina bifida in a newborn cat. A female cat was seen in labor at a veterinary clinic in Teresina-PI. By performing the ultrasound test it was possible detect the presence of three fetuses aged approximately 62 days and decreased heart rate. The patient underwent surgery immediately to cesarean section with ovariohysterectomy. One of the newborn cat showed changes consistent with spina bifida. The owner opted for the newborn cat euthanasia because is not known effective treatment for the case. There are insufficient researchs on the embryonic development aimed at prevention and treatment of these anomalies. These studies are necessary to ensure a good prognosis for patients.
Este trabalho tem como objetivo descrever os aspectos macroscópicos da doença e os achados radiológicos relacionados à espinha bífida em um neonato felino. Uma fêmea felina foi atendida em trabalho de parto numa clínica veterinária em Teresina-PI. Ao realizar o exame ultrassonográfico foi possível detectar a presença de três fetos com idade aproximada de 62 dias e com batimentos cardíacos diminuídos. A paciente foi submetida imediatamente à cirurgia cesariana com ovariossalpingohisterectomia. Um dos neonatos apresentava alterações compatíveis com espinha bífida. A proprietária optou pela eutanásia do neonato por não se conhecer um tratamento eficaz para o caso. Ainda são escassas as pesquisas sobre o desenvolvimento embrionário voltadas para prevenção e tratamento dessas anomalias. Estas pesquisas são necessárias a fim de garantir um bom prognóstico aos pacientes portadores.