Advancements in addressing drug dependence: A review of promising therapeutic strategies and interventions.

Substance dependence represents a pervasive global concern within the realm of public health. Presently, it is delineated as a persistent and recurrent neurological disorder stemming from drug-triggered neuroadaptations in the brain's reward circuitry. Despite the availability of various therapeutic modalities, there has been a steady escalation in the mortality rate attributed to drug overdoses. Substantial endeavors have been directed towards the exploration of innovative interventions aimed at mitigating cravings and drug-induced repetitive behaviors. Within this review, we encapsulate the most auspicious contemporary treatment methodologies, accentuating meta-analyses of efficacious pharmacological and non-pharmacological approaches: including gabapentin, topiramate, prazosin, physical exercise regimens, and cerebral stimulation techniques.

Do steroid abusers have more temporomandibular joint symptoms? A study with 97 bodybuilders.

OBJECTIVES: Anabolic androgenic steroids (AAS) are derivatives of testosterone, used to treat gonadal disturbances, performance enhancement, and aesthetic purposes. AAS abuse can lead to side effects, including androgenic, cardiovascular, and liver disturbances, effects on libido, gynecomastia, and behavioral effects. There is a hypothesis that some joint tissues may be targets for sex hormones, and the use of AAS without medical follow-up may exacerbate temporomandibular joint problems in patients seeking performance and aesthetics. METHODS: In this study, a cross-sectional survey was conducted on AAS abusers who voluntarily presented themselves for clinical evaluation. Patients were subdivided by sex and age group, and the length of AAS use and symptoms such as headache, tinnitus, and temporomandibular joint pain were evaluated. RESULTS: It was observed that drug usage is related to symptoms. CONCLUSION: The results suggest that AAS use without medical follow-up may exacerbate temporomandibular joint problems, especially in patients with low estrogen levels.

Prenatal and postnatal cocaine exposure enhances the anxiety- and depression-like behaviors in rats during cocaine withdrawal.

Prenatal drug exposure is a public health problem, which results in profound behavioral problems during childhood and adolescence, mainly represented by an increase in the risk of cocaine abuse at an early age. In rodents, prenatal and postnatal cocaine exposure enhanced locomotor activity and cocaine- or nicotine-induced locomotor sensitization. Various authors consider that the adverse emotional states (anxiety and depression) that occur during cocaine withdrawal are the main factors that precipitate, relapse, and increase chronic cocaine abuse, which could increase the risk of relapse of cocaine abuse. Therefore, the objective of this study was to characterize anxiety- and depression-like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal in rats born to females exposed prenatally and postnatally to cocaine. A group of pregnant female Wistar rats were administered daily from day GD0 to GD21 with cocaine (cocaine preexposure group), and another group of pregnant female rats was administered daily with saline (saline preexposure group). Of the litters resulting from the cocaine-pre-exposed and saline-pre-exposed pregnant female groups, only the male rats were used for the recording of the anxiety- and depression-like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal The study found that prenatal and postnatal cocaine exposure dose-dependent enhanced anxiety- and depression-like behaviors. This suggests that prenatal and postnatal cocaine exposure can result in enhanced vulnerability to cocaine abuse in young and adult humans.

Polarization of HIV-1- and CMV-Specific IL-17-Producing T Cells among People with HIV under Antiretroviral Therapy with Cannabis and/or Cocaine Usage.

OBJECTIVE: This study evaluated the influence of cannabis and/or cocaine use in human immunodeficiency virus (HIV)- and cytomegalovirus (CMV)-specific T-cell responses of people with HIV (PWH). RESULTS: There was a higher percentage of IL-17-producing HIV-Gag-specific CD8+ T-cells in all drug users than that in PWH non-drug users. Stratifying the drug-user groups, increased percentages of IL-17-producing HIV-Gag-specific CD4+ and CD8+ T-cells were found in PWH cannabis plus cocaine users compared to PWH non-drug users. In response to CMV, there were higher percentage of IL-17-producing CMV-specific CD8+ T-cell in PWH cocaine users than that in PWH non-drug users. Considering all drug users together, there was a higher percentage of SEB-stimulated IL-17-producing CD4+ T-cells than that in PWH non-drug users, whereas cannabis users had higher percentages of IL-17-producing CD4+ T-cells compared to non-drug users. METHODS: Cryopreserved peripheral blood mononuclear cells from 37 PWH undergoing antiretroviral therapy (ART) using cannabis (10), cocaine (7), or cannabis plus cocaine (10) and non-drug users (10) were stimulated with HIV-1 Gag or CMV-pp65 peptide pools, or staphylococcal enterotoxin B (SEB) and evaluated for IFN-γ- and/or IL-17A-producing CD4+ and CD8+ T-cells using flow cytometry. CONCLUSIONS: Cannabis plus cocaine use increased HIV-specific IL-17 producing T-cells and cocaine use increased IL-17 CMV-specific CD8+ T-cell responses which could favor the inflammatory conditions associated with IL-17 overproduction.

Biperiden reverses the increase in 50-kHz ultrasonic vocalizations but not the increase in locomotor activity induced by cocaine.

Cocaine use disorder (CUD) is a worldwide public health problem, associated with severe psychosocial and economic impacts. Currently, no FDA-approved treatment is available for CUD. However, an emerging body of evidence from clinical and preclinical studies suggests that biperiden, an M1 muscarinic receptor antagonist, presents potential therapeutic use for CUD. These studies have suggested that biperiden may reduce the reinforcing effects of cocaine. It is well established that rodents emit 50-kHz ultrasonic vocalizations (USV) in response to natural rewards and stimulant drugs, including cocaine. Nonetheless, the effects of biperiden on the cocaine-induced increase of 50-kHz USV remains unknown. Here, we hypothesized that biperiden could antagonize the acute effects of cocaine administration on rat 50-kHz USV. To test this hypothesis, adult male Wistar rats were divided into four experimental groups: saline, 5 mg/kg biperiden, 10 mg/kg cocaine, and biperiden/cocaine (5 and 10 mg/kg, i.p., respectively). USV and locomotor activity were recorded in baseline and test sessions. As expected, cocaine administration significantly increased the number of 50-kHz USV. Biperiden administration effectively antagonized the increase in 50-kHz USV induced by cocaine. Cocaine administration also increased the emission of trill and mixed 50 kHz USV subtypes and this effect was antagonized by biperiden. Additionally, we showed that biperiden did not affect the cocaine-induced increase in locomotor activity, although biperiden administration per se increased locomotor activity. In conclusion, our findings indicate that administering biperiden acutely reduces the positive affective effects of cocaine, as demonstrated by its ability to inhibit the increase in 50-kHz USV.

Thermocoagulation in Multiple Targets to Treat Obsessive-Compulsive Disorder Associated with Drug Addiction: Case Report / Termocoagulação de múltiplos alvos para tratar transtorno obsessivo-compulsivo associado à drogadição: Relato de caso

Substance-related disorders are chronic psychiatric conditions defined by substance abuse, and they compromise patients both clinically and functionally. Currently, pharmacotherapy, behavioral therapy, or an association of both are the treatments of choice for obsessive-compulsive disorder associated with drug addiction. However, the refractoriness to treatment, as a result of the high failure rates of these approaches, has led to the need to develop surgical techniques to treat severe cases of substance-related disorders. In the present article, we report the case of a patient who underwent neurosurgery through the stereotactic technique after refractoriness to the conventional treatment for drug addiction. The patient showed sustained improvement in his addiction to drugs. Despite the numerous reports on the effectiveness and applicability of neurosurgery in psychiatric disorders, some concerns regarding stereotactic surgery as a treatment for drug addiction still remain, especially in relation to its efficacy, safety, and ethical implications.

Transtornos relacionados ao uso de substâncias são condições psiquiátricas crônicas definidas pelo abuso de substâncias, que deixam o paciente comprometido clínica e funcionalmente. Atualmente, a farmacoterapia, a terapia comportamental ou a associação de ambas são os tratamentos de escolha para o transtorno obsessivo-compulsivo associado ao vício em drogas. Contudo, a refratariedade ao tratamento, resultante das altas taxas de fracasso dessas abordagens, tornou necessário o desenvolvimento de técnicas cirúrgicas para tratar casos graves de transtornos relacionados ao uso de substâncias. Neste artigo, relatamos o caso de um paciente submetido a neurocirurgia pela técnica estereotáxica após fracasso do tratamento convencional para drogadição. O paciente apresentou melhora sustentada do vício em drogas. Apesar dos inúmeros relatos sobre a eficácia e a aplicabilidade da neurocirurgia em transtornos psiquiátricas, ainda existem certa preocupação a respeito da cirurgia estereotáxica como tratamento para a drogadição, principalmente em relação à sua eficácia, segurança e implicações éticas.

Cuidado transcultural em maternidades a puérperas e neonatos expostos a substâncias psicoativas no pré-natal / Cross-Cultural Care In Maternities To Puerpera And Newborns Exposed To Psychoactive Substances In Prenatal

O abuso de substâncias psicoativas pela mulher no período pré-natal tem chamado a atenção para a necessidade de práticas de cuidado materno-neonatal que sejam culturalmente competentes. Desta forma, este estudo teve como objetivo relatar limitações e potencialidades de cuidado transcultural ao binômio mãe usuária de álcool ou outras drogas e seu neonato, observadas no dia a dia da maternidade. Trata-se de uma pesquisa qualitativa de natureza exploratória, descritiva, com perspectiva etnográfica sobre o cuidado prestado ao binômio mãe usuária de álcool ou outras drogas e seu neonato, realizada entre 2018 e 2020 em maternidades. Os dados foram obtidos por meio de observação participante e entrevistas às puérperas e profissionais de saúde, discutindo-os à luz da Teoria de Madeleine Leininger. As limitações e potencialidades do cuidado focaram no acolhimento, na comunicação entre os profissionais e as pacientes, na identificação de sinais de dependência e abstinência na puérpera, nas orientações em saúde e na rotina de avaliação neonatal. A compreensão cultural e o vínculo etnográfico permitiram uma relação de confiança, de busca de conhecimento e de construção coletiva para o efetivo cuidado culturalmente congruente frente às limitações encontradas.

The abuse of psychoactive substances by women during the prenatal period has called attention to the need for culturally competent maternal-neonatal care practices. Thus, this study aimedto report limitations and potentialities of cross-cultural care to the binomial mother who uses alcohol or other drugs and her newborn, observed in the daily life of the maternity ward. It is qualitative research of exploratory, descriptive nature, with ethnographic perspective on the care provided to the binomial mother who uses alcohol or other drugs and her newborn, conducted between 2019 to 2020 in maternity hospitals. The data were obtained through participant observation and interviews to puerperae and health professionals, discussing them in the light of Madeleine Leininger's Theory. The limitations and potentialities of care focused on the reception, communication between professionals and patients, identification of signs of dependence and abstinence in puerperae, health guidelines, and routine neonatal evaluation. The cultural understanding and the ethnographic bond allowed a relationship of trust, search for knowledge, and collective construction for the effective culturally congruent care in face of the limitations found.

"Louco sim, drogado não": o imaginário de profissionais da saúde mental / "Crazies over junkies": The collective imagination of mental health professionals

Considerando que as práticas clínicas se baseiam tanto em conhecimentos científicos como em crenças e valores nem sempre conscientes, este estudo objetiva investigar o imaginário coletivo de profissionais de saúde mental sobre o paciente psiquiátrico, na perspectiva da psicologia psicanalítica concreta. Justifica-se, portanto, desde o interesse em aperfeiçoar a qualidade do atendimento, tendo em vista tanto o benefício dos pacientes, como a melhoria das condições de exercício profissional. A partir de uma entrevista psicológica coletiva, articulada ao redor do uso do Procedimento de Desenhos-Estórias com Tema, abordamos sete profissionais de nível superior que trabalham em equipamento de saúde mental. A consideração do material permitiu a produção interpretativa de dois campos de sentido afetivo-emocional: "Sofredores psicóticos" e "Impostores dependentes". O quadro geral apresenta a coexistência de visões solidárias e éticas diante do psicótico com visões preconceituosas e hostis em relação ao dependente químico. Esse contraste se baseia sobretudo na dificuldade em perceber que a base motivacional do uso da droga seria o sofrimento emocional. Como um todo, esse cenário permite pensar que a reforma psiquiátrica gerou transformações que promovem acolhimento, mas que ainda permanecem estigmas a serem superados.

Considering that clinical practices are based both on scientific knowledge and on beliefs and values that are not always conscious, this study aims to investigate the collective imagination of mental health professionals about the psychiatric patient, from the perspective of psychoanalytic concrete psychology. The importance of this study lies on the interest in improving the quality of care, considering both the benefit of patients and the improvement of professional practice conditions. Based on a collective psychological interview, articulated around the use of the Thematic Story-Drawing Procedure, we approached seven higher education professionals who work in mental health service. Consideration of the material allowed the interpretative production of two affective-emotional fields of meaning: "Psychotic sufferers" and "Dependent impostors". The overall picture shows the coexistence of sympathetic and ethical views toward the mentally psychotic with prejudiced and hostile views toward the drug-dependent. This contrast is mainly based on the difficulty in realizing that the motivational basis for drug use would be emotional suffering. As a whole, this scenario allows us to conclude that the psychiatric reform has brought about transformations that promote acceptance, but that stigmas to be overcome still remain.

Early discharge predictors among inpatients crack cocaine users.

INTRODUCTION: High rates of early hospital discharge are often observed in crack cocaine users and are related to adverse outcomes and increased public spending. This study evaluated clinical and sociodemographic factors associated with early treatment discharge among crack users. METHODS: The sample comprised 308 men diagnosed with crack cocaine use disorder (crack only), aged 18 to 65 years, admitted between 2013 and 2017 to a male-only hospital unit to treat substance use disorders. Sociodemographic and clinical data were obtained using the Addiction Severity Index, 6th version, and a Sociodemographic Questionnaire. RESULTS: Early discharge (within 7 days) was significantly associated with lack of own income, insufficient family support, being single, and recent homelessness. Regarding drug use, lower treatment retention was related to younger age of crack use onset, recent alcohol use, and nicotine use. Factors such as age, skin color, and educational level showed no relation to the outcome. CONCLUSION: Our findings suggest that presence of characteristics verifiable at the time of admission may be related to crack users' treatment retention. Identification of these factors can contribute to target interventions in order to improve treatment adherence in crack cocaine users.

Early discharge predictors among inpatient crack cocaine users

Abstract Introduction High rates of early hospital discharge are often observed in crack cocaine users and are related to adverse outcomes and increased public spending. This study evaluated clinical and sociodemographic factors associated with early treatment discharge among crack users. Methods The sample comprised 308 men diagnosed with crack cocaine use disorder (crack only), aged 18 to 65 years, admitted between 2013 and 2017 to a male-only hospital unit to treat substance use disorders. Sociodemographic and clinical data were obtained using the Addiction Severity Index, 6th version, and a Sociodemographic Questionnaire. Results Early discharge (within 7 days) was significantly associated with lack of own income, insufficient family support, being single, and recent homelessness. Regarding drug use, lower treatment retention was related to younger age of crack use onset, recent alcohol use, and nicotine use. Factors such as age, skin color, and educational level showed no relation to the outcome. Conclusion Our findings suggest that presence of characteristics verifiable at the time of admission may be related to crack users' treatment retention. Identification of these factors can contribute to target interventions in order to improve treatment adherence in crack cocaine users.

Gender differences in progression to crack-cocaine use and the role of sexual and physical violence.

OBJECTIVE: This study aimed to evaluate whether progression from first drug use to crack-cocaine use differs according to gender, and whether the report of sexual or physical violence impacts the time of progression. METHODS: We interviewed 896 crack-cocaine users (548 men; 348 women) from addiction treatment units. Cox regression models evaluated the time of progression from first drug use to crack use. We analyzed gender differences according to the absence or presence of sexual or physical violence, also considering whether violence, when present, had occurred before or after the onset of crack use. RESULTS: Women presented a faster progression to crack use regardless of exposure to sexual or physical violence (p < 0.05). Compared to unexposed men, there was a similar progression for men exposed to sexual or physical violence before the first use of crack (p = 0.167 and p = 0.393, respectively). In both genders, we observed a faster progression among individuals exposed to these types of violence after the onset of crack use (p < 0.01). CONCLUSIONS: We found a faster progression to crack use among women and among individuals exposed to sexual and physical violence after the onset of crack use. These results encourage differentiated treatment strategies, focused on gender and individual characteristics.

Construção simbólica frente à falha do recurso à droga na psicose / Construction symbolique face à l'échec de la consommation de drogue dans la psychose / Symbolic construction on the failure of drug use in psychosis

A inserção de psicanalistas em instituições da rede de saúde mental, em especial nos dispositivos de atenção a usuários de álcool e outras drogas, amplia a discussão sobre o diagnóstico estrutural frente ao uso de substâncias psicoativas. O recurso às drogas na psicose pode operar como uma tentativa de estabilização ao localizar no real da substância os efeitos da invasão do real dos sintomas psicóticos. O objetivo deste artigo é discutir, a partir de um caso clínico, a possibilidade de construção simbólica frente à falha deste recurso. O caso analisado pela teoria lacaniana demonstra que o uso de drogas pode ser capturado pelo processo de desorganização pulsional. Discute-se a função do sonho na psicose e sua relação com a construção delirante. O endereçamento transferencial ao analista, por outro lado, permite que o discurso sobre as drogas em sua dimensão significante opere como uma forma de construção simbólica para a amarração dos registros

L'insertion despsychanalystes dans les établissements du réseau d'assistance de la santé mentale, notamment dans les dispositifs de prise en charge des usagers d'alcool et d'autres drogues, élargit la réflexion sur le diagnostic structurel face à l'usage de substances psychoactives. L'usage de drogues dans la psychose peut opérer comme une tentative de stabilisation en situant dans le réel de la substance les effets de l'envahissement du réel des symptômes psychotiques. L'objectif de cet article est de discuter, a partir d'un cas clinique, de la possibilité d'une construction symbolique face à l'échec de cette ressource. Le cas, pour la théorie lacanienne, démontre que la consommation de drogues peut être capturée par le processus de désorganisation de la pulsion. Les rêves sont discutés a partir du délire et de sa fonction dans la psychose. L'adresse du transfert à l'analyste, au contraire, permet au discours sur la drogue dans sa dimension signifiante d'opérer comme une forme de construction symbolique pour nouer les registres.

The insertion of psychoanalysts in institutions of the mental health network, especially in spaces dedicated to the care of users of alcohol and other drugs, broadens the discussion on the structural diagnosis in the face of psychoactive substance use. The use of drugs in psychosis can operate as an attempt at stabbilization by locating in the real of the substance the effects of the invasion of the real of psychotic symptoms. The objective of this article is to discuss, based on a clinical case, the possibility of symbolic construction when facing the failure of this resource. The case demonstrates through lacan´s theory that drug use can be captured by the process of disorganization of the drive. The function of dream in psychosis is discussed through its relation to delusion. The transferential addre to the analyst, on the other hand, allows the discourse about drugs in its signifying dimension to operate as a form of symbolic construction for tying the registers

Gender differences in progression to crack-cocaine use and the role of sexual and physical violence

Objective: This study aimed to evaluate whether progression from first drug use to crack-cocaine use differs according to gender, and whether the report of sexual or physical violence impacts the time of progression. Methods: We interviewed 896 crack-cocaine users (548 men; 348 women) from addiction treatment units. Cox regression models evaluated the time of progression from first drug use to crack use. We analyzed gender differences according to the absence or presence of sexual or physical violence, also considering whether violence, when present, had occurred before or after the onset of crack use. Results: Women presented a faster progression to crack use regardless of exposure to sexual or physical violence (p < 0.05). Compared to unexposed men, there was a similar progression for men exposed to sexual or physical violence before the first use of crack (p = 0.167 and p = 0.393, respectively). In both genders, we observed a faster progression among individuals exposed to these types of violence after the onset of crack use (p < 0.01). Conclusions: We found a faster progression to crack use among women and among individuals exposed to sexual and physical violence after the onset of crack use. These results encourage differentiated treatment strategies, focused on gender and individual characteristics.

Considerações sobre parcerias amorosas e excessos em algumas mulheres toxicômanas / Considerations about loving partnerships and excesses in some drug addicts women / Consideraciones sobre enlaces amorosos y excesos en algunas mujeres toxicómanas

Pensar no sujeito atravessado pelo fenômeno toxicômano implica em legitimar paradoxais formas de se colocar na vida. Esse sujeito, sendo produto e efeito de políticas econômicas vigentes, incita tentativas sociais de controle que denunciam a falta de saber lidar com a questão. Já sendo difícil pensar nessa condição em geral, a questão torna-se ainda mais problemática quando se consideram subgrupos como o de mulheres. Entre 2000 e 2016, por exemplo, ocorreu um aumento de 656% do encarceramento feminino, com alta representatividade de crimes relacionados às drogas. Atentando-se a esses fenômenos e à transferência com a psicanálise, que mostra o quanto a figura da mulher se faz apreendida desde Freud como um enigma, propõe-se neste artigo compartilhar recortes de reverberações de uma pesquisa resultante da experiência com um grupo de mulheres em um Centro de Atenção Psicossocial - álcool e outras drogas (CAPS AD). Para realização do grupo, foi constituído um espaço em que essas mulheres pudessem falar sobre seus impasses no encontro com o feminino e com o laço social, sendo ambos particularmente atravessados por objetos tóxicos. Essa pesquisa resultou em elaborações sobre curiosas e sintomáticas parcerias que essas mulheres estabeleciam ao longo da vida, levando-nos a refletir sobre o quanto a toxicomania pode aproximar-se de um semblante de existência para algumas delas. Na direção da ética da psicanálise, reforça-se com este trabalho a emergência do singular diante de globalizadas respostas e propõe-se a potencialização da escuta nele realizada para outros espaços de cuidado e acolhimento, principalmente espaços da saúde pública.

Think about the subject traversed by the drug addiction phenomenon implies in legitimize paradoxical ways of living life. If before some substances existed as a contact means with deities through members authorized by certain groups, in modernity are inaugurated new ways of use that become these substances known as "drugs". The addicted subject, being product and effect of current economic policies, awake social attempts of control that denounce the lack of know how to deal with the issue. Already being difficult to think about this, when considering subgroups such as women, the question becomes even more problematic. Between 2000 and 2016, there was a 656% increase in female incarceration, with a high proportion of drug-related crimes. In view of these phenomena and transference with psychoanalysis, that shows how the women figure is understood since Freud as an enigma, we propose this work by excerpts from a clinical experience and research with a women group in a Psychosocial Care Center - alcohol and other drugs (CAPS AD). To this, it was offered a space in which these women could talk about the impasses of the encounter with the feminine and the social bond, being in particular crossed by toxic objects. This work resulted in elaborations about curious and symptomatic partnerships that these women established throughout their lives, leading us to reflect on how much drug addiction can approach a semblant of existence for some of them. In direction of psychoanalytic ethics, the emergence of singular is reinforced in the face of globalized responses, and it is proposed to potentialize the listening like in this work in other care and embracement places, especially public spaces.

Pensar en el sujeto atravesado por el fenómeno de la toxicomanía requiere legitimar formas paradójicas de ponerse en la vida. Este sujeto, siendo producto y efecto de las políticas económicas actuales, incita a intentos de control social que denuncian la falta de saber cómo tratar el problema. Siendo difícil pensar en esta condición en general, al considerar subgrupos como de las mujeres, la cuestión se vuelve aún más problemática. Entre 2000 y 2016, por ejemplo, hubo un aumento de 656% del encarcelamiento femenino, con una alta representatividad de delitos relacionados con las drogas. Teniendo en cuenta estos fenómenos y una transferencia con el psicoanálisis, que muestra lo cuánto se comprende la figura de la mujer como un enigma desde Freud, este artículo se propone con el fin de compartir recortes de reverberaciones de una investigación resultante de la experiencia de los autores con un grupo de mujeres en un Centro de Atención Psicosocial - alcohol y otras drogas (CAPS AD). Para esto, se ofreció un espacio en que estas mujeres podían hablar de los impases del encuentro con lo femenino y con el vínculo social, siendo en particular atravesadas por objetos tóxicos. Este trabajo dio lugar a elaboraciones sobre curiosos y sintomáticos enlaces que estas mujeres establecieron en sus vidas, lo que nos llevó a reflexionar sobre como la adicción a las drogas puede acercarse a un semblante de existencia para algunas de ellas. En la dirección de la ética del psicoanálisis, refuérzanos con este trabajo la emergencia del singular frente a las respuestas globalizadas y proponemos potencializar la escucha realizada a otros espacios de atención y tratamiento, principalmente espacios públicos.

Dinâmicas do gozo e a clínica das toxicomanias / The dynamics of jouissance and clinical care for drug addiction / La dinámica del goce y la clínica de drogadicción

RESUMO Este estudo teve por objetivo realizar uma pesquisa teórica em psicanálise sobre a clínica da toxicomania. Trata-se pesquisa teórica em psicanálise, visando a novos encadeamentos conceituais a respeito do tema. O consumo, que se apresenta como toxicômano, é atribuído a um gozo mortífero, dinâmica que visa à satisfação total das pulsões do Sujeito. Concluímos ao longo desse escrito que as dinâmicas de gozo representadas pelo Suplemento e Suplência possuem uma análise diferencial para a compreensão do consumo de drogas. Sugerimos, como contraponto, que o movimento de Alienação e Separação, metaforizado pela dinâmica do Fort-Da, é de grande valia na condução do processo clínico para o tratamento desse Sujeito.

ABSTRACT This study aimed to conduct theoretical research in psychoanalysis on the clinical care for drug addiction. It is theoretical research in psychoanalysis, aiming at new conceptual chains on the theme. The consumption that presents itself as drug addiction is attributed to a deadly enjoyment, a dynamic that aims at the total satisfaction of the individual's drives. We concluded how the dynamics of jouissance represented by Replacement and Supplement play a differential role in comprehending drug consumption. We suggest, as a counterpoint, that the Alienation and Separation movement, which worked as a metaphor in the Fort-Da dynamic, is of great value in conducting the clinical process for the treatment of these individuals.

RESUMEN Este estudio tuvo como objetivo realizar una investigación teórica en psicoanálisis sobre una clínica de drogadicción. Se trata de una investigación teórica en psicoanálisis, apuntando a nuevas cadenas conceptuales sobre el tema. El consumo que se presenta como drogadicto se atribuye a un goce mortal, dinámica que apunta a la satisfacción total de los impulsos del Sujeto. Concluimos a lo largo de este artículo cómo la dinámica del goce representada por el Suplemento y el Reemplazo tiene un papel diferencial en la comprensión del consumo de drogas. Sugerimos, como contrapunto, que el movimiento de Alienación y Separación, metaforizado por la dinámica Fort-Da, es de gran valor en la conducción del proceso clínico para el tratamiento de estos sujetos.

m-CF3-substituted diphenyl diselenide attenuates all phases of morphine-induced behavioral locomotor sensitization in mice.

BACKGROUND: Behavioral sensitization, thought to underlie some aspects of drug dependence, is typically measured as increased locomotion in response to repeated administration of a drug. The study aimed to investigate the (m-CF3-PhSe)2 effects on the acquisition, withdrawal, and re-exposure phases of morphine-induced behavioral locomotor sensitization. METHODS: Swiss male mice were treated with saline or morphine at 10 mg/kg twice a day for 3 days; those of the morphine group were kept in the morphine withdrawal period (5 days). On day 9, mice were re-exposed to morphine. (m-CF3-PhSe)2 (10 mg/kg) or vehicle was administered at all phases of morphine protocol, and mice performed locomotor activity test. Oxidative stress markers and the levels of opioid, dopamine, and glutamate receptors were determined in samples of the cerebral cortex. (m-CF3-PhSe)2 administered at all phases of protocol attenuated morphine-induced locomotor sensitization. RESULTS: Mice exposed to morphine showed reduced weight gain and increased locomotor activity, but (m-CF3-PhSe)2 treatment attenuates the weight gain and behavioral hyperlocomotion effects. (m-CF3-PhSe)2, independent of the administration phase, modulated the increase of opioidergic (MOR, DOR, KOR) and glutamatergic (NMDA 2A and 2B) protein contents and attenuated redox imbalance in the cerebral cortex of mice exposed to morphine. However, (m-CF3-PhSe)2 did not modulate cortical protein levels of dopaminergic (D1 and D2) receptors in the acquisition phase of morphine-induced locomotor sensitization protocol. CONCLUSION: (m-CF3-PhSe)2 was effective against the behavioral and molecular alterations caused by morphine at all phases of locomotor sensitization.

Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats / Óleo de copaíba (Copaifera reticulata) reduz consumo voluntário de álcool em ratos

Copaiba oleoresin, extracted from the Copaifera reticulata tree, has been used as a remedy in popular medicine in the Brazilian Amazon for various purposes, including reducing drug abuse. Yet no studies evaluated the effect of repeated administration of copaiba oil on alcohol consumption in animals. To evaluate this effect, we divided adult male Wistar rats into a) an alcohol group in which the animals had free access to choose between two bottles: one containing alcohol solution (20%) and another containing vehicle solution (0.2% saccharin); and b) a control group with access to two bottles containing vehicle solution. Rats were free to drink 24 h per day, for 35 days. Daily alcohol consumption and weekly body weight gain and food intake were monitored. From day 22, half of the rats in each group received 600 mg kg-1 copaiba oleoresin and the other received vehicle, subcutaneously, once a day, for three days. On day 35, rats were evaluated in an open-field test. The results showed that copaiba oil decreased voluntary alcohol intake and preference between days 2 and 6 after the last administration. Copaiba treatment also decreased the food intake and body weight gain in both alcohol and control groups without changing behaviors in the open-field test. Therefore, copaiba oil was able to reduce voluntary alcohol consumption in rats and could be tested in humans as an adjuvant to treat alcohol use disorder.(AU)

O óleo extraído da árvore copaíba, Copaifera reticulata, tem sido usado na medicina popular na Amazônia brasileira para diversos fins, incluindo abuso de drogas. Contudo, não há estudos avaliando o efeito da administração repetida do óleo de copaíba sobre o consumo de álcool em animais. Para avaliar esse efeito, dividimos ratos Wistar machos adultos em dois grupos: a) um grupo álcool, no qual os animais tinham livre acesso a duas garrafas: uma contendo solução alcoólica (20%) e outra contendo solução veículo (sacarina 0,2%); e b) um grupo controle com acesso a duas garrafas contendo solução veículo. Os ratos podiam beber livremente, 24 horas por dia, durante 35 dias. O consumo diário de álcool, bem como o ganho de peso corporal semanal e a ingestão de alimentos foram monitorados. A partir do dia 22, metade dos ratos de cada grupo recebeu 600 mg kg-1 de óleo de copaíba e a outra metade recebeu veículo, por via subcutânea, uma vez ao dia, durante três dias. No dia 35, os ratos foram testados em teste de campo aberto. Os resultados mostraram que o óleo de copaíba diminuiu a ingestão voluntária e a preferência por álcool entre os dias 2 e 6 após a última administração. O tratamento com óleo de copaíba também diminuiu a ingestão alimentar e o ganho de peso corporal em ambos os grupos álcool e controle, sem alterar o comportamento no teste de campo aberto. Portanto, o óleo de copaíba foi capaz de reduzir o consumo voluntário de álcool em ratos e poderia ser testado em humanos como um adjuvante para tratar transtorno de uso de álcool.(AU)

Influence of COVID-19 Pandemic Uncertainty in Negative Emotional States and Resilience as Mediators against Suicide Ideation, Drug Addiction and Alcoholism.

This research uses structural equation modeling to determine the influence of uncertainty due to the COVID-19 pandemic as an independent variable in the negative emotional states and resilience (as mediating variables) vs. drug addiction, alcoholism, and suicide ideation as dependent variables in 5557 students from a public state university in Northern Mexico. The five variables are related through eight hypotheses and tested using partial least squares. We used an adapted questionnaire sent by email in May 2020. Findings show that uncertainty facing the COVID-19 pandemic had a direct and significant influence on negative emotional states and a significant inverse effect on resilience; in the trajectory, drug addiction and alcoholism, and suicide ideation are explained.