Variations in head tilt during the acquisition of CBCT scans and their effects on effective radiation dose.

OBJECTIVES: This study evaluated the impact of variations in anteroposterior and lateral tilts of patients' head on radiation-weighted doses to organs/tissues and effective doses using three different cone beam computed tomography machines. METHODS: An anthropomorphic phantom was used to estimate radiation doses in three CBCT machines (OP300, Eagle X 3D, and Eagle Edge). Thermoluminescent dosimeters were placed in regions corresponding to pre-stablished organ/tissues. CBCT examinations from the posterior mandible and anterior maxilla regions were acquired, with three different anteroposterior angulations (0°, 30°, and 45°), and from the posterior mandible in three different lateral angulations (0°, 20° to the left, and 20° to the right side). Radiation-weighted doses for each organ/tissue and effective doses were calculated for each machine and angulation. RESULTS: For the posterior mandible acquisitions, anteroposterior angulations of the head at 30° and 45° yielded a reduction in effective doses in all three devices. A 20° tilt to the right side resulted in lower doses than to the left (same side as the FOV). For the anterior maxilla, increased anteroposterior angulation was associated with reduction in effective dose in two devices. CONCLUSION: Effective doses are lower when small FOV CBCT exams of the posterior mandible and anterior maxilla are acquired with increased anteroposterior head angulation at 30° and 45°. For FOV in the posterior mandible, a 20° lateral tilt towards the side opposite to the FOV also yields lower effective doses. The main contribution to these dose reductions is the decrease in dose to salivary glands.

Physiological and clinical effects of trunk inclination adjustment in patients with respiratory failure: a scoping review and narrative synthesis.

BACKGROUND: Adjusting trunk inclination from a semi-recumbent position to a supine-flat position or vice versa in patients with respiratory failure significantly affects numerous aspects of respiratory physiology including respiratory mechanics, oxygenation, end-expiratory lung volume, and ventilatory efficiency. Despite these observed effects, the current clinical evidence regarding this positioning manoeuvre is limited. This study undertakes a scoping review of patients with respiratory failure undergoing mechanical ventilation to assess the effect of trunk inclination on physiological lung parameters. METHODS: The PubMed, Cochrane, and Scopus databases were systematically searched from 2003 to 2023. INTERVENTIONS: Changes in trunk inclination. MEASUREMENTS: Four domains were evaluated in this study: 1) respiratory mechanics, 2) ventilation distribution, 3) oxygenation, and 4) ventilatory efficiency. RESULTS: After searching the three databases and removing duplicates, 220 studies were screened. Of these, 37 were assessed in detail, and 13 were included in the final analysis, comprising 274 patients. All selected studies were experimental, and assessed respiratory mechanics, ventilation distribution, oxygenation, and ventilatory efficiency, primarily within 60 min post postural change. CONCLUSION: In patients with acute respiratory failure, transitioning from a supine to a semi-recumbent position leads to decreased respiratory system compliance and increased airway driving pressure. Additionally, C-ARDS patients experienced an improvement in ventilatory efficiency, which resulted in lower PaCO2 levels. Improvements in oxygenation were observed in a few patients and only in those who exhibited an increase in EELV upon moving to a semi-recumbent position. Therefore, the trunk inclination angle must be accurately reported in patients with respiratory failure under mechanical ventilation.

The Characterization of a Novel PrMADS11 Transcription Factor from Pinus radiata Induced Early in Bent Pine Stem.

A novel MADS-box transcription factor from Pinus radiata D. Don was characterized. PrMADS11 encodes a protein of 165 amino acids for a MADS-box transcription factor belonging to group II, related to the MIKC protein structure. PrMADS11 was differentially expressed in the stems of pine trees in response to 45° inclination at early times (1 h). Arabidopsis thaliana was stably transformed with a 35S::PrMADS11 construct in an effort to identify the putative targets of PrMADS11. A massive transcriptome analysis revealed 947 differentially expressed genes: 498 genes were up-regulated, and 449 genes were down-regulated due to the over-expression of PrMADS11. The gene ontology analysis highlighted a cell wall remodeling function among the differentially expressed genes, suggesting the active participation of cell wall modification required during the response to vertical stem loss. In addition, the phenylpropanoid pathway was also indicated as a PrMADS11 target, displaying a marked increment in the expression of the genes driven to the biosynthesis of monolignols. The EMSA assays confirmed that PrMADS11 interacts with CArG-box sequences. This TF modulates the gene expression of several molecular pathways, including other TFs, as well as the genes involved in cell wall remodeling. The increment in the lignin content and the genes involved in cell wall dynamics could be an indication of the key role of PrMADS11 in the response to trunk inclination.

Comparison of mesiodistal angulations of premolars and molars in anterior open bite subjects with different sagittal malocclusions: A retrospective study.

INTRODUCTION: Mesiodistal angulation of premolars and molars can be altered by forces of open bite malocclusion. The aim of this study was to compare the mesiodistal angulations of the posterior teeth in class I, II, and III individuals with anterior open bite (AOB) versus individuals with harmonious occlusion. METHODS: This comparative cross-sectional study used 299 lateral head radiographs of individuals with permanent dentition. There were 4 groups (harmonious occlusion [n=89], Class I open bite [OB] [n=75], Class II OB [n=66], and Class III OB [n=69]). Premolar (1UPM, 2UPM) and molar (1UM, 2UM) angulations were measured relative to the occlusal plane and the palatal or mandibular plane by a trained and calibrated evaluator. ANOVA and Scheffe tests were used for statistical analyses (P<0.05). RESULTS: The mesial angulation of the upper premolars showed greater angulation of between approximately 2° and 5° in the OB groups compared to the harmonious occlusion group (P<0.05). Only in the Class II OB group did the first and second upper molars show distal angulation in relation to the palatal plane (1UM 81.85°±5.42°; 2UM 75.32±7.4°) (P<0.05). The Class III OB group presented the greatest distal angulations of the lower premolars and molars (between 3° to 5° of difference, P<0.05) in relation to those of the harmonious occlusion group. CONCLUSIONS: The upper first premolars in all the AOB groups and the lower second premolars in the Class II OB group had greater mesioangulation. Additionally, the upper molars of the Class II OB group and the lower molars of the Class III OB group showed distoangulation compared with the molars in the group with harmonious occlusion.

Effect of Reducing the Size and Number of Faces of Polyhedral Specimen on Wood Characterization by Ultrasound.

The complete characterization of wood, with the determination of the 12 elastic constants that represent its orthotropy, is greatly relevant in applications employing structural calculation software programs. Ultrasound allows for such characterization with relative simplicity when compared to other methods. The polyhedron is considered the most appropriate specimen format for allowing the 12 constants to be calculated with a single specimen, and the traditionally used one is the 26-sided polyhedron, which, to be produced manually with more precision in directing the main directions of the wood, needs larger faces. The accuracy of this technique tends to be reduced when increasing the growth rings' inclination since the waves deviate from the main directions of orthotropy. This research aimed to verify whether it is possible to reduce the polyhedra dimension without affecting the results of the elastic parameters obtained in wood characterization by ultrasound. The results indicate that the dimension of the polyhedron can be reduced without prejudice to the results of the elastic parameters obtained by the ultrasound test and that, in the manual production process of the specimen, the best way to make this reduction is to eliminate the faces unused in the test, changing the polyhedron to 18 faces instead of 26. Reducing the number of faces simplifies the manufacturing process and thus increases the possibility of producing specimens with straighter growth rings and better-directed symmetry axes.

Buildings' Biaxial Tilt Assessment Using Inertial Wireless Sensors and a Parallel Training Model.

Applications of MEMS-based sensing technology are beneficial and versatile. If these electronic sensors integrate efficient processing methods, and if supervisory control and data acquisition (SCADA) software is also required, then mass networked real-time monitoring will be limited by cost, revealing a research gap related to the specific processing of signals. Static and dynamic accelerations are very noisy, and small variations of correctly processed static accelerations can be used as measurements and patterns of the biaxial inclination of many structures. This paper presents a biaxial tilt assessment for buildings based on a parallel training model and real-time measurements using inertial sensors, Wi-Fi Xbee, and Internet connectivity. The specific structural inclinations of the four exterior walls and their severity of rectangular buildings in urban areas with differential soil settlements can be supervised simultaneously in a control center. Two algorithms, combined with a new procedure using successive numeric repetitions designed especially for this work, process the gravitational acceleration signals, improving the final result remarkably. Subsequently, the inclination patterns based on biaxial angles are generated computationally, considering differential settlements and seismic events. The two neural models recognize 18 inclination patterns and their severity using an approach in cascade with a parallel training model for the severity classification. Lastly, the algorithms are integrated into monitoring software with 0.1° resolution, and their performance is verified on a small-scale physical model for laboratory tests. The classifiers had a precision, recall, F1-score, and accuracy greater than 95%.

Methyl esters of 23,24-Dinor-5α-cholan-22-oic acids as brassinosteroid Analogues. Synthesis, evaluation of plant growth promoting activity and Molecular docking.

Five new brassinosteroid analogues were synthetized from 3ß-acetoxy-23,24-dinorchol-4-en-22-oic acid. All the obtained compound showed significant activity in the Rice Lamina Inclination Test. Interestingly the effects of the methyl ester of 3ß-hydroxy-6-oxo-23,24-dinorcholan-22-oic acid (14) at concentrations of 1 × 10-7 and 1 × 10-6 M proved to be higher than those produced by brassinolide. In silico Molecular Docking and Induced fit docking (IFD) simulations for the compounds with the highest biological activity data were carried out to investigate the binding mode interactions into the brassinolide-binding groove which revealed that the compound 14 had high binding energy values and a good affinity.

The Reverse Shoulder Arthroplasty Angle in MRI: Impact of the Articular Cartilage in the Estimated Inclination of the Inferior Glenoid.

Purpose: To describe the reverse shoulder arthroplasty angle (RSA angle) in magnetic resonance imaging (MRI) and compare the angle formed using bony landmarks (Bony RSA angle or B-RSA angle) with another angle formed using the cartilage margin as reference (Cartilage RSA angle or C-RSA angle). Methods: Adult patients with a shoulder MRI obtained in our hospital between July 2020 and July 2021 were included. The C-RSA angle and B-RSA angle were measured. All images were independently assessed by 4 evaluators. Intraclass correlation coefficient (ICC) was determined for the B-RSA and C-RSA to evaluate interobserver agreement. Results: A total of 61 patients were included with a median age of 59 years (17-77). C-RSA angle was significantly higher than B-RSA (25.4° ± 0.7 vs 19.5° ± 0.7, respectively) with a P-value <.001. The overall agreement was considered "good" for C-RSA (ICC = 0.74 [95% CI 0.61-0.83]) and "excellent" for B-RSA angle (ICC = 0.76 [95% CI 0.65-0.85]). Conclusions: C-RSA angle is significantly higher than B-RSA angle. In cases without significant glenoid wear neglecting to account for the remaining articular cartilage at the inferior glenoid margin may result in superior inclination of standard surgical guides.

Asociación entre la inclinación sagital del incisivo central superior y el ángulo nasolabial en ortodoncia / Association between the sagittal inclination of the maxillary central incisor and the nasolabial angle in orthodontics

Objetivo: determinar si existe asociación entre la inclinación del incisivo central superior y el ángulo naso-labial de Legan. Materiales y métodos: se utilizaron las telerradiografías laterales de cráneo de 20 pacientes entre 18 y 39 años, obtenidas al inicio y final de su tratamiento ortodóncico, para un análisis cefalométrico. El total de medidas obtenidas se ordenó en dos tiempos. Tiempo 1 (T1) incluyó la medición del ángulo plano biespinal-eje mayor del incisivo superior (AiT1) y del ángulo naso-labial (AnlT1) en las radiografías tomadas previo al tratamiento y tiempo 2 (T2) incluyó la medición de los mismos ángulos en las radiografías tomadas al finalizar el tratamiento (AiT2 y AnlT2 respectivamente). Los datos obtenidos fueron tabulados y analizados estadísticamente. Resultados: la muestra presentó distribución normal, por lo que se aplicó el test de correlación de Pearson, para determinar si existía asociación entre ambas variables (Ai y Anl) en T1 y T2, obteniendo como resultado un valor de R=0,5. Conclusión: no existe asociación estadística entre la variación en la inclinación del incisivo central superior y el Ángulo naso-labial de Legan.

Aim: to determine if there is an association between the inclination of the upper central incisor and the nasolabial Legan angle. Materials and methods: lateral head radiographs of 20 patients between 18 and 39 years old, obtained at the beginning and end of their orthodontic treatment, were used for a cephalometric analysis. The total of measurements obtained was ordered in two times. Time 1 (T1) included the measurement of the bispinal plane angle-major axis of the upper incisor (AiT1) and the nasolabial angle (AnlT1) in the radiographs taken before treatment and time 2 (T2) included the measurement of the same angles, in the radiographs taken at the end of the treatment (AiT2 and AnlT2 respectively). The data obtained were tabulated and statistically analyzed. Results: the sample presented a normal distribution. So, the Pearson correlation test was applied to determine if there was an association between both variables (Ai and Anl) in T1 and T2, obtaining a value of R=0.5 as a result. Conclusion: there is no statistical association between the variation in the inclination of the upper central incisor and the nasolabial Angle of Legan.

Radiographic findings in the coxofemoral joint of Australian Cattle Dogs / Achados radiográficos em articulação coxofemoral de cães da raça Australian Cattle Dog

Australian Cattle Dogs (ACD) are medium-sized animals widely used in fieldwork for managing cattle and sheep. There needs to be more information about the conditions these dogs can develop despite being well-characterized animals since the beginning of the 20th century. Hip dysplasia (HD) is a developmental abnormality between the femoral head and the acetabular fossa, which can be debilitating. However, the available literature has no studies on the prevalence of this condition in dogs of this breed. This study aimed to evaluate radiographs of ACD qualitatively and quantitatively. For this purpose, 49 dogs considered healthy without clinical signs of HD were radiographically assessed, and the animals were classified as dysplastic (D) and non-dysplastic (ND). A frequency of 46.9% of dysplastic dogs was observed, with males being more affected. The cortical index (CI) and angle of inclination (AI) could not differentiate D from ND animals; only the Norberg angle (NA) was effective in this differentiation. No correlation was observed between AI, CI, and AN.(AU)

Os cães da raça Autralian Cattle Dog (ACD) são animais de porte médio, muito utilizados no trabalho de campo para manejo de gado e ovelha. Apesar de serem animais bem caracterizados desde o início do século XX, há poucas informações sobre afecções que esses cães podem desenvolver. A displasia coxofemoral (DCF) é uma anormalidade do desenvolvimento entre a cabeça do fêmur e a fossa acetabular podendo ser debilitante. Contudo, não há estudos, na literatura disponível, sobre a prevalência desta afecção em cães dessa raça. O objetivo deste trabalho foi avaliar qualitativamente e quantitativamente radiografias de cães da raça ACD. Para tanto, foram avaliados radiograficamente 49 cães considerados hígidos e sem sinais clínicos de DCF. Os animais foram classificados em displásicos (D) e não displásicos (ND). Observou-se a frequência de 46,9% de cães displásicos, sendo os machos mais acometidos. O índice cortical (IC) e o ângulo de inclinação (AI) não foram capazes de diferenciar os animais D dos ND, apenas o ângulo de Norberg (AN) foi eficaz nessa diferenciação. Não houve correlação entre AI, IC e AN.(AU)

A predictive model for the critical shoulder angle based on a three-dimensional analysis of scapular angular and linear morphometrics.

BACKGROUND: The purpose of this study was to define the features of scapular morphology that are associated with changes in the critical shoulder angle (CSA) by developing the best predictive model for the CSA based on multiple potential explanatory variables, using a completely 3D assessment. METHODS: 3D meshes were created from CT DICOMs using InVesalius (Vers 3.1.1, RTI [Renato Archer Information Technology Centre], Brazil) and Meshmixer (3.4.35, Autodesk Inc., San Rafael, CA). The analysis included 17 potential angular, weighted linear and area measurements. The correlation of the explanatory variables with the CSA was investigated with the Pearson's correlation coefficient. Using multivariable linear regression, the approach for predictive model-building was leave-one-out cross-validation and best subset selection. RESULTS: Fifty-three meshes were analysed. Glenoid inclination (GI) and coronal plane angulation of the acromion (CPAA) [Pearson's r: 0.535; -0.502] correlated best with CSA. The best model (adjusted R-squared value 0.67) for CSA prediction contained 10 explanatory variables including glenoid, scapular spine and acromial factors. CPAA and GI were the most important based on their distribution, estimate of coefficients and loss in predictive power if removed. CONCLUSIONS: The relationship between scapular morphology and CSA is more complex than the concept of it being dictated solely by GI and acromial horizontal offset and includes glenoid, scapular spine and acromial factors of which CPAA and GI are most important. A further investigation in a closely defined cohort with rotator cuff tears is required before drawing any clinical conclusions about the role of surgical modification of scapular morphology. LEVEL OF EVIDENCE: Level 4 retrospective observational cohort study with no comparison group.

Inclinations of greenhouse farmers in Turkey toward agricultural insurance / Inclinações de agricultores de estufas em Turquia rumo ao seguro agrícola

This study is explored the reasons why greenhouse farmers take out and do not take out agricultural insurance as well as the farmers' inclinations toward agricultural insurance and the factors that affect them so that agricultural insurance can be improved. In this context, three districts of Antalya where greenhouse farming is intensively carried out, namely Aksu, Serik and Kumluca, were selected as the research location, and face-to-face interviews were conducted with 200 farmers, 100 of which had agricultural insurance and 100 of which did not. The farms were divided into two groups, namely, those with and without insurance, according to the data obtained. The potential statistical relationship between some selected features of the farms under study and the farmers with and without insurance was identified by chi-square test. Furthermore, the inclinations, views and opinions of farmers with and without agricultural insurance concerning agricultural insurance were evaluated using a Likert scale. Among the reasons why farmers take out agricultural insurance are insuring their crop, avoiding any potential loss, securing their income and presence of disaster risk. The main reasons why farmers do not take out agricultural insurance is the registration and share problems of their lands.

O objetivo deste estudo é explorar as razões pelas quais os agricultores de estufas contratam e não realizam seguro agrícola, bem como as inclinações dos agricultores em relação ao seguro agrícola e os fatores que os afetam para que o seguro agrícola possa ser melhorado. Nesse contexto, três distritos de Antália, onde a agricultura de efeito estufa é intensamente realizada, foram selecionados como local de pesquisa, Aksu, Serik e Kumluca. Foram realizadas entrevistas presenciais com 200 agricultores, dos quais 100 tinham seguro agrícola e os outros 100 não. As fazendas foram divididas em dois grupos, com e sem seguro, de acordo com os dados obtidos. A relação estatística potencial entre algumas características selecionadas das fazendas em estudo e os agricultores com e sem seguro foi identificada pelo teste do qui-quadrado. Além disso, as inclinações, e opiniões dos agricultores com e sem seguro agrícola, em relação ao seguro agrícola, foram avaliadas usando uma escala Likert. Entre as razões pelas quais os agricultores fazem um seguro agrícola, estão assegurando sua colheita, sua renda, presença de risco de desastre e evintando possíveis perdas. A principal entre as razões pelas quais os agricultores não fazem seguro agrícola é o registro e o compartilhamento de problemas de suas terras.

Change in crown inclination accompanying initial tooth alignment with round archwires

ABSTRACT Objective: To evaluate, in-vitro, the change in crown inclination that occurs during orthodontic leveling and alignment using different archwire-bracket-ligation combinations. Materials and Methods: Four archwire types were tested: (1) 0.012-in stainless steel and (2) 0.0155-in stainless steel multi-stranded, (3) 0.012-in nitinol Orthonol® and (4) 0.012-in nitinol Thermalloy®. Combinations with five types of 0.022-in slot orthodontic brackets were tested: SmartClipTM and Time3® self-ligating brackets, Mini-Taurus® and Victory SeriesTM conventional brackets, and Synergy® conventional-low friction bracket. Conventional brackets were ligated with both stainless steel and elastomeric ligatures. The simulated malocclusion comprised 2.0mm gingival and 2.0mm labial displacements of a maxillary right central incisor. Rotation around the Y-axis (representing labio-palatal inclination) was measured for the different archwire-bracket-ligation combinations. Results: The largest rotation was measured whith Orthonol® and Thermalloy® wires when combined with SmartClipTM brackets (8.07±0.24º and 8.06±0.26º, respectively) and with Synergy® brackets ligated with stainless steel ligatures (8.03±0.49º and 8.0±0.37º, respectively). The lower rotation was recorded when Thermalloy®, multi-stranded, and Orthonol® wires were ligated with elastomeric rings to Mini-Taurus® brackets (1.53±0.18º, 1.65± 0.23º and 1.70±0.28º, respectively) and to Victory SeriesTM brackets (1.68± 0.78º, 2.92± 1.40º and 1.74±0.46º, respectively). Conclusions: All archwire-bracket-ligation combinations produced lingual crown inclination; however, lower changes were observed when the conventional brackets were ligated with elastomeric rings. The multi-stranded archwire produced less rotation with nearly every bracket-ligation combination, compared to the other archwires. The effect of the archwire-bracket-ligation combination on tooth inclination during leveling and alignment should be considered during planning treatment mechanics.

RESUMO Objetivo: Avaliar, in vitro, as mudanças na inclinação das coroas dentárias que acontecem durante o alinhamento e nivelamento usando diferentes combinações de arcos/braquetes/ligaduras. Material e Métodos: Foram usados quatro tipos de arcos ortodônticos: (1) 0,012" de aço inoxidável, (2) 0,0155" de aço multifilamentado, (3) Orthonol® 0,012" de nitinol e (4) Thermalloy® 0,012" de nitinol. Esses arcos foram combinados com cinco tipos de braquetes ortodônticos com slot 0,022": braquetes autoligáveis SmartClipTM e Time3®, braquetes convencionais Mini-Taurus® e Victory SeriesTM, e braquetes convencionais de baixo atrito Synergy®. Os braquetes convencionais receberam ligaduras de aço ou elastoméricas. A má oclusão simulada foi composta por um deslocamento do incisivo central superior direito em 2 mm para a cervical e 2 mm para a vestibular. A rotação ao redor do eixo Y (representando a inclinação vestibulolingual) foi medida para as diferentes combinações de arco/braquete/ligadura. Resultados: A maior rotação foi medida quando os arcos Orthonol® e Thermalloy® foram usados com os braquetes SmartClipTM (8,07±0,24º e 8,06±0,26º, respectivamente) e com os braquetes Synergy® com ligaduras metálicas (8,03±0,49º e 8,0±0,37º, respectivamente). A menor rotação foi vista quando os arcos Thermalloy®, multifilamentado e Orthonol® foram presos por ligaduras elastoméricas aos braquetes Mini-Taurus® (1,53±0,18º, 1,65±0,23º e 1,70±0,28º, respectivamente) e aos braquetes Victory SeriesTM (1,68±0,78º, 2,92±1,40º e 1,74±0,46º, respectivamente). Conclusões: todas as combinações arco-braquete-ligadura produziram inclinação palatina da coroa. Entretanto, as menores mudanças foram observadas quando os braquetes convencionais receberam ligaduras elastoméricas. O arco multifilamentado produziu menor rotação com quase todas as combinações braquete-ligadura, em comparação aos outros arcos. O efeito da combinação arco-braquete-ligadura na inclinação dentária durante o alinhamento e nivelamento deve ser considerado durante o planejamento da mecânica dos tratamentos.

A Talk between Flavonoids and Hormones to Reorient the Growth of Gymnosperms.

Plants reorient the growth of affected organs in response to the loss of gravity vector. In trees, this phenomenon has received special attention due to its importance for the forestry industry of conifer species. Sustainable management is a key factor in improving wood quality. It is of paramount importance to understand the molecular and genetic mechanisms underlying wood formation, together with the hormonal and environmental factors that affect wood formation and quality. Hormones are related to the modulation of vertical growth rectification. Many studies have resulted in a model that proposes differential growth in the stem due to unequal auxin and jasmonate allocation. Furthermore, many studies have suggested that in auxin distribution, flavonoids act as molecular controllers. It is well known that flavonoids affect auxin flux, and this is a new area of study to understand the intracellular concentrations and how these compounds can control the gravitropic response. In this review, we focused on different molecular aspects related to the hormonal role in flavonoid homeostasis and what has been done in conifer trees to identify molecular players that could take part during the gravitropic response and reduce low-quality wood formation.

Synthesis of New Brassinosteroid 24-Norcholane Type Analogs Conjugated in C-3 with Benzoate Groups.

The metabolism of brassinosteroid leads to structural modifications in the ring skeleton or the side alkyl chain. The esterification and glycosylation at C-3 are the most common metabolic pathways, and it has been suggested that conjugate brassinosteroids are less active or inactive. In this way, plants regulate the content of active brassinosteroids. In this work, the synthesis of brassinosteroid 24-norcholane type analogs conjugated at C-3 with benzoate groups, carrying electron donor and electron attractant substituents on the aromatic ring, is described. Additionally, their growth-promoting activities were evaluated using the Rice Lamina Inclination Test (RLIT) and compared with that exhibited by brassinolide (used as positive control) and non-conjugated analogs. The results indicate that at the lowest tested concentrations (10-8-10-7 M), all analogs conjugated at C-3 exhibit similar or higher activities than brassinolide, and the diasteroisomers with S configuration at C-22 are the more active ones. Increasing concentration (10-6 M) reduces the biological activities of analogs as compared to brassinolide.

Synthesis of New Steroidal Carbamates with Plant-Growth-Promoting Activity: Theoretical and Experimental Evidence.

A priority of modern agriculture is to use novel and environmentally friendly plant-growth promoter compounds to increase crop yields and avoid the indiscriminate use of synthetic fertilizers. Brassinosteroids are directly involved in the growth and development of plants and are considered attractive candidates to solve this problem. Obtaining these metabolites from their natural sources is expensive and cumbersome since they occur in extremely low concentrations in plants. For this reason, much effort has been dedicated in the last decades to synthesize brassinosteroids analogs. In this manuscript, we present the synthesis and characterization of seven steroidal carbamates starting from stigmasterol, ß-sitosterol, diosgenin and several oxygenated derivatives of it. The synthesis route for functionalization of diosgenin included epoxidation and epoxy opening reactions, reduction of carbonyl groups, selective oxidation of hydroxyl groups, among others. All the obtained compounds were characterized by 1H and 13C NMR, HRMS, and their melting points are also reported. Rice lamina inclination test performed at different concentrations established that all reported steroidal carbamates show plant-growth-promoting activity. A molecular docking study evaluated the affinity of the synthesized compounds towards the BRI1-BAK1 receptor from Arabidopsis thaliana and three of the docked compounds displayed a binding energy lower than brassinolide.

Medición del Ángulo de Inclinación del Ligamento Cruzado Anterior (LCA). Serie de Casos / Anterior Cruciate Ligament (ACL) Inclination angle measurement. Case Series

Introducción La evaluación de la inclinación del ligamento cruzado anterior(LCA) es útil tanto en pacientes que no han sido llevados a procedimientos reconstructivos para aclarar dudas diagnósticas ante la sospecha de una lesión parcial como para el planeamiento quirúrgico; y en el postoperatorio para evaluar la calidad y efectividad al restaurar las inserciones anatómicas del ligamento. Sin embargo en nuestro medio no existe un referente local de medición ni un entrenamiento en la toma de la misma. Objetivo Medir el ángulo de inclinación del LCA en rodillas sanas de nuestra población, utilizando técnicas de medición por resonancia magnética (RM) entre junio del 2013 y junio del 2017. Métodos Estudio descriptivo tipo serie de casos, se incluyeron los pacientes sometidos a RM en el servicio de radiología de nuestro hospital que fueron leídas como normales. Las mediciones del ángulo de inclinación se tomaron en los planos sagital, coronal y axial. Resultados Se incluyeron 91 pacientes (45% (n=41) Hombres / 55% (n=50) Mujeres). Se encontró un ángulo de inclinación del LCA en el plano sagital con una media de 45.31 (DE: 5.39), en el plano coronal de 70.68 (DE:5.79) y 68.49 (DE:5.61) en el plano axial, sin encontrarse diferencias imagenológicas segmentados por sexo, edad o lateralidad. Discusión No se aprecian diferencias en las imágenes de RM en el ángulo de inclinación en ninguno de los tres planos entre hombres y mujeres, tampoco respecto a lateralidad o grupos de edad. Se obtuvieron resultados que aún no están descritos en la literatura; los obtenidos son similares a los reportados en la literatura

Background The evaluation of the inclination of the anterior cruciate ligament (ACL) is useful to clarify diagnostic doubts in patients who have not been taken to reconstructive procedures and to evaluate the quality and effectiveness of restoring the anatomical attachments of the ligament. after an ACL surgery reconstruction. However, in our environment there is no local measurement reference or training in measuring it inclination angle. The aim of the study is to measure the inclination angle of the ACL in healthy knees of our population, using magnetic resonance (MRI) measurement techniques. Methods A Case Series study was performed, including patients who underwent to knee MRI between June 2013 and June 2017 that were read as normal. Inclination angle measurements of the ACL were taken in the sagittal, coronal, and axial planes. Results 91 patients were included (45% (n=41) Men / 55% (n=50) Women). An ACL inclination angle was found in the sagittal plane with a mean of 45.31 (SD: 5.39), in the coronal plane of 70.68 (SD: 5.79) and 68.49 (SD: 5.61) in the axial plane, with no imaging differences found. segmented by sex, age or laterality. Discussion There are no differences in the MRI images in the angle of inclination in any of the three planes between men and women, neither with regard to laterality or age groups. Results were obtained that have not yet been described in the literature; those obtained are similar to those reported in the literature

Reliability of Spinopelvic Measurements That May Influence the Cup Position in Total Hip Arthroplasty.

BACKGROUND: Spinopelvic pathology has been identified as a potential risk factor for instability after total hip arthroplasty. Spinopelvic radiographic parameters used to diagnose spinopelvic disease may also impact optimal cup placement. The purpose of this study was to assess the arthroplasty surgeon accuracy in making spinopelvic measurements. METHODS: Five fellowship-trained or in-training arthroplasty surgeons reviewed 44 lateral lumbar radiographs in two sessions. All evaluators were instructed how to perform measurements but had little experience in doing so. Traditional measurements included the pelvic tilt (PT), pelvic incidence (PI), and sacral slope (SS), and novel measurements included the acetabular ante-inclination (AI) and pelvic femoral angle. Surgeon measurements were compared with those made by experienced engineers. intraclass coefficients (ICCs) were calculated and interpreted. RESULTS: The interobserver reliability for 4 of 5 of the spinopelvic parameters was good to excellent (ICC >0.75) with the highest reliability seen for PI measurement (ICC = 0.939). Only moderate interobserver reliability was observed for AI measurement (ICC = 0.559). Intraobserver reliability was the highest for the PI and SS, ranging from moderate to good (ICC, 0.718 to 0.896). The lowest intraobserver reliability was seen for the AI (ICC range, 0.026 to 0.545) and pelvic femoral angle (ICC range, 0.035 to 0.828). Surgeon measurements of PT and SS were compared with engineer measurements with extremely poor correlation observed (ICC <0 for all). CONCLUSION: Surgeon intraobserver and interobserver reliability in making novel radiographic measurements was low compared with traditional radiographic measurements. Surgeon reliability in making traditional measurements of the PT and SS was very poor compared with experienced assessors using software-based measurements.

Novel bendable abutments as a solution to correct unfavorable implant inclination. A clinical report.

OBJECTIVE: This clinical case report describes a novel bendable abutment as a prosthetic solution for implants presenting with an unfavorable inclination. CLINICAL CONSIDERATIONS: A metal-ceramic screw-retained single crown was made on this novel bendable abutment in a patient presenting with a pronounced buccal inclination of an implant. A plastic reference guide is used to define the correct inclination and then this inclination is transferred to the abutment using a specific bending device at the same appointment. CONCLUSIONS: Bendable abutments can be used as a solution to correct unfavorable implant inclinations. This abutment can be customized at the same appointment considering a case-specific inclination rather than conventional pre-angled abutments. CLINICAL SIGNIFICANCE: Bendable abutments can be customized according to each case specificities while conventional pre-angled abutments may not be adequate for all patients. Also, the abutment customization could be easily done by dentists at their own practices using a specific bending device with hand pressure only, saving time, and the need to order pre-angled abutments or having it in stock.

Características anatomorradiográficas de los terceros molares en adolescentes de la enseñanza preuniversitaria / Anatomo-radiographic characteristics of third molars in senior high school students

RESUMEN Introducción: Las retenciones dentarias afectan al 17 % de los pacientes a nivel mundial y están consideradas actualmente como un síndrome, en que los terceros molares ocupan el primer lugar y cuya extirpación quirúrgica deviene la intervención más comúnmente practicada por los cirujanos maxilofaciales. Objetivo: Describir las características anatomorradiográficas de los terceros molares, así como su posible relación con variables epidemiológicas de interés. Métodos: Se realizó un estudio observacional, descriptivo y transversal en escolares del Instituto Preuniversitario "Antonio Alomá Serrano", perteneciente al área de salud del Policlínico Docente Asistencial "José Martí" de Santiago de Cuba, durante el período comprendido desde mayo de 2016 hasta febrero de 2017. Se utilizaron radiografías panorámicas indicadas a estos pacientes, en las que se efectuaron el análisis y la clasificación. Resultados: La mayoría de los dientes se encontraban en clase I (52,6 por ciento), clase C (51,9 por ciento), posición C (82,2 por ciento), verticales (47,7 por ciento) y sin aproximación sinusal (89,5 por ciento). Además se observaron relaciones significativas entre la edad y el color de la piel con respecto al espacio retromolar y la inclinación dentaria de este grupo molar, y entre el sexo y la inclinación. Conclusiones: Los terceros molares son los dientes con mayor variabilidad en cuanto a posición e inclinación intraósea y en edades avanzadas se logra suficiente espacio retromolar y verticalización en la mayoría de ellos(AU)

ABSTRACT Introduction: Tooth impaction affects 17 % of patients worldwide. It is currently considered to be a syndrome in which third molars occupy the first place. Surgical removal is the most common intervention performed by maxillofacial surgeons. Objective: Describe the anatomo-radiographic characteristics of third molars and their possible relationship to epidemiological variables of interest. Methods: A cross-sectional observational descriptive study was conducted of students from Antonio Alomá Serrano Senior High School, from the health area of José Martí University Polyclinic in Santiago de Cuba, from May 2016 to February 2017. The study was based on panoramic radiographs, which were analyzed and classified. Results: Most teeth were class I (52.6 percent), class C (51.9 percent), position C (82.2 percent), vertical (47.7 percent) and without sinus approach (89.5 percent). Significant relationships were found between age and skin color with respect to retromolar space and tooth inclination of this molar group, and between sex and inclination. Conclusions: Third molars are the teeth showing the greatest variability in terms of intraosseous inclination and position. In advanced ages most of them achieve enough retromolar space and verticalization(AU)