Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application.

Surface bacterial fouling has become an urgent global challenge that calls for resilient solutions. Despite the effectiveness in combating bacterial invasion, antibiotics are susceptible to causing microbial antibiotic resistance that threatens human health and compromises the medication efficacy. In nature, many organisms have evolved a myriad of surfaces with specific physicochemical properties to combat bacteria in diverse environments, providing important inspirations for implementing bioinspired approaches. This review highlights representative natural antibacterial surfaces and discusses their corresponding mechanisms, including repelling adherent bacteria through tailoring surface wettability and mechanically killing bacteria via engineering surface textures. Following this, we present the recent progress in bioinspired active and passive antibacterial strategies. Finally, the biomedical applications and the prospects of these antibacterial surfaces are discussed.

Critical evaluation of mechanism responsible for biomass abatement during electrochemical coagulation (EC) process: A critical review.

This is a first review paper that delineates fundamental disinfection mechanism undergoes during the simple electrochemical coagulation (EC) process. The elucidation of detailed mechanistic phenomenon of EC process involved would help to enhance the disinfection efficiency. In this context, the biomass (bacteria, virus and algae) abatement mechanism by EC is critically reviewed and rationalized based on the experimental demonstration performed from the recent decade. Whereas, the effect of most significant abiotic operating parameters, dissolved contents and bacteria cell wall composition on biomass reduction are explored in detail. From these analyses, physical removal and chemical inactivation routes are identified for bacteria abatement mechanism during the EC process using sacrificial electrodes. Which includes (i) enmeshment of microbial contaminants by EC flocs, (ii) sweeping flocculation is preferentially for destabilization of negatively charged biomass, and (iii) inactivation/attenuation of micro-organism cell walls by electrochemically induced reactive oxygen species (ROS) or direct interaction of electric field. Perhaps, the overall abatement mechanism attributes due to the aforementioned phenomenon endures independently and/or synergistically during the EC process. Nonetheless, to obtain better understanding of virus and algae abatement mechanism, we require more experimental investigation on algae and virus removal. Eventually, more intensive research efforts on biomass attenuation by EC are most important to reinforce this claim.

The Impact of Capsid Proteins on Virus Removal and Inactivation During Water Treatment Processes.

This study examined the effect of the amino acid composition of protein capsids on virus inactivation using ultraviolet (UV) irradiation and titanium dioxide photocatalysis, and physical removal via enhanced coagulation using ferric chloride. Although genomic damage is likely more extensive than protein damage for viruses treated using UV, proteins are still substantially degraded. All amino acids demonstrated significant correlations with UV susceptibility. The hydroxyl radicals produced during photocatalysis are considered nonspecific, but they likely cause greater overall damage to virus capsid proteins relative to the genome. Oxidizing chemicals, including hydroxyl radicals, preferentially degrade amino acids over nucleotides, and the amino acid tyrosine appears to strongly influence virus inactivation. Capsid composition did not correlate strongly to virus removal during physicochemical treatment, nor did virus size. Isoelectric point may play a role in virus removal, but additional factors are likely to contribute.