ABSTRACT
The novel HLA alleles B*40:331, B*40:343, B*42:24, DRB1*01:74, DQB1*03:243, and DQB1*03:02:20 were identified in Brazilian individuals.
Subject(s)
Alleles , HLA-B Antigens/genetics , HLA-DQ beta-Chains/genetics , HLA-DRB1 Chains/genetics , Base Sequence , Brazil , Exons/genetics , Female , Histocompatibility Testing , Humans , Polymorphism, Single Nucleotide/geneticsABSTRACT
Novel allele, HLA-B*51:220 generated by a gene conversion event was identified in a Brazilian individual.
Subject(s)
Alleles , HLA-B Antigens/genetics , 5' Untranslated Regions/genetics , Base Sequence , Brazil , Exons/genetics , Humans , Introns/geneticsABSTRACT
Two novel alleles, HLA-A*02:643N and HLA-B*53:44, generated by different mechanisms, were identified in Brazilian individuals.
Subject(s)
Alleles , Exons , HLA Antigens/genetics , HLA-A2 Antigen/genetics , Polymorphism, Genetic , Tissue Donors , Adult , Base Sequence , Brazil , Codon/chemistry , Female , Gene Expression , Genotype , HLA Antigens/immunology , HLA-A2 Antigen/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Loss of Function Mutation , Male , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The HLA-B*50:48 allele differs from HLA-B*50:01:01 by one nucleotide substitution at position 130.
ABSTRACT
HLA-A*29:01:08 differs from A*29:01:01:01 by a single synonymous substitution at position 519, codon 149 GCGâGCA in exon 3.
Subject(s)
Alleles , Codon , HLA-A Antigens/genetics , Brazil , HumansABSTRACT
The HLA-DRB1*13:204 allele differs from HLA*13:64 by two nucleotide substitutions at positions 181 and 189 in the exon 2.
Subject(s)
Alleles , HLA-DRB1 Chains/genetics , Point Mutation , Registries , Base Sequence , Brazil , Codon , Exons , Genotype , HLA-DRB1 Chains/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Alignment , Sequence Analysis, DNA , Unrelated DonorsABSTRACT
Four novel HLA-B alleles, B*42:20, B*51:151, B*57:64 and B*58:42 were identified in Brazilian individuals.
Subject(s)
HLA-B Antigens/genetics , Histocompatibility Testing , Alleles , Bone Marrow Transplantation , Brazil , Epitopes, T-Lymphocyte/genetics , Female , Genotype , Humans , Male , Molecular Conformation , Polymerase Chain Reaction , Tissue DonorsABSTRACT
The HLA-A*80:03 allele differs from HLA*80:01:01:01 by two nucleotide substitutions at positions 559 and 560 in the exon 3.
Subject(s)
Alleles , HLA-A Antigens/genetics , Base Sequence , Brazil , Exons/genetics , Humans , Male , Molecular Sequence Data , Sequence AlignmentABSTRACT
The new HLA-DPB1*142:01 allele differs from DPB1*26:01:02 and DPB1*56:01 at codons 65 (I65>L65) and 35 (F35>Y35), respectively.