Surface matches prevail over distant analogs during retrieval.

Laboratory studies using a reception paradigm have found that memory items sharing similar entities and relations with a working memory cue (surface matches) are easier to retrieve than items sharing only a system of abstract relations (structural matches). However, the naturalistic approach has contended that the observed supremacy of superficial similarity could have originated in a shallow processing of somewhat inconsequential stories, as well as in the inadvertent inclusion of structural similarity during the construction of surface matches. We addressed the question of which kind of similarity dominates retrieval through a hybrid paradigm that combines the ecological validity of the naturalistic production paradigm with the experimental control of the reception paradigm. In Experiment 1 we presented participants with a target story that maintained either superficial or structural similarities with two popular movies that had received a careful processing prior to the experimental session. Experiment 2 replicated the same procedure with highly viralized public events. In line with traditional laboratory results, surface matches were significantly better retrieved than structural matches, confirming the supremacy of superficial similarities during retrieval.

Cheminformatic characterization of natural products from Panama.

In this work, we discuss the characterization and diversity analysis of 354 natural products (NPs) from Panama, systematically analyzed for the first time. The in-house database was compared to NPs from Brazil, compounds from Traditional Chinese Medicine, natural and semisynthetic collections used in high-throughput screening, and compounds from ChEMBL. An analysis of the "global diversity" was conducted using molecular properties of pharmaceutical interest, three molecular fingerprints of different design, molecular scaffolds, and molecular complexity. The global diversity was visualized using consensus diversity plots that revealed that the secondary metabolites in the Panamanian flora have a large scaffold diversity as compared to other composite databases and also have several unique scaffolds. The large scaffold diversity is in agreement with the broad range of biological activities that this collection of NPs from Panama has shown. This study also provided further quantitative evidence of the large structural complexity of NPs. The results obtained in this study support that NPs from Panama are promising candidates to identify selective molecules and are suitable sources of compounds for virtual screening campaigns.

Cannabinoid Type†1 Receptor (CB1) Ligands with Therapeutic Potential for Withdrawal Syndrome in Chemical Dependents of Cannabis sativa.

Cannabis sativa withdrawal syndrome is characterized mainly by psychological symptoms. By using computational tools, the aim of this study was to propose drug candidates for treating withdrawal syndrome based on the natural ligands of the cannabinoid type 1 receptor (CB1). One compound in particular, 2-n-butyl-5-n-pentylbenzene-1,3-diol (ZINC1730183, also known as stemphol), showed positive predictions as a human CB1 ligand and for facile synthetic accessibility. Therefore, ZINC1730183 is a favorable candidate scaffold for further research into pharmacotherapeutic alternatives to treat C. sativa withdrawal syndrome.