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1.
Traffic Inj Prev ; : 1-9, 2024 Aug 09.
Article in English | MEDLINE | ID: mdl-39121372

ABSTRACT

OBJECTIVE: The objective of this study was to investigate the relationship between eye-catching effects and mental workload at highway tunnel entrances. Specifically, the study aimed to analyze drivers' eye blink behavior to gain a comprehensive understanding of how visual attraction at tunnel entrances affects cognitive workload. METHODS: 50 participants were recruited for the naturalistic driving experiment. Four different visually attractive driving scenarios (baseline, landscape-style architecture, tip slogan, and billboard) were selected. Eye-tracking technology was utilized to record and analyze the eye blink behavior of participating drivers. Various metrics, including blink frequency, blink duration, inter-blink interval, and pupil diameter after a blink, were measured and compared across different scenarios. RESULTS: The results of the study demonstrated significant differences in drivers' eye blink behavior across the different experimental scenarios, indicating the influence of visual attraction conditions on mental workload. The presence of eye-catching stimuli (landscape-style architecture, tip slogan, and billboard scenarios) at tunnel entrances resulted in decreased blink frequency, shorter blink duration, longer inter-blink intervals, and larger pupil diameter after a blink compared to when no specific eye-catching stimuli were present (baseline condition). These findings suggest that visual attractions capture drivers' attention, leading to increased cognitive workload and attentional demands. CONCLUSIONS: The findings of this study contribute to the existing literature on driver attention and mental workload, particularly in relation to eye-catching effect in tunnel environments. The presence of eye-catching stimuli at tunnel entrances can distract drivers and increase their mental workload, potentially compromising driving performance and safety. It is crucial for transportation authorities and designers to carefully consider the design and placement of visual attractions in tunnel entrances to minimize distraction and cognitive workload. By doing so, driving safety and performance can be enhanced in tunnel entrances.

2.
Bioorg Chem ; 152: 107744, 2024 Nov.
Article in English | MEDLINE | ID: mdl-39213799

ABSTRACT

Substrate access tunnel engineering is a useful strategy for enzyme modification. In this study, we improved the catalytic performance of Fe-type Nitrile hydratase (Fe-type NHase) from Pseudomonas fluorescens ZJUT001 (PfNHase) by mutating residue Q86 at the entrance of the substrate access tunnel. The catalytic activity of the mutant PfNHase-αQ86W towards benzonitrile, 2-cyanopyridine, 3-cyanopyridine, and 4-hydroxybenzonitrile was enhanced by 9.35-, 3.30-, 6.55-, and 2.71-fold, respectively, compared to that of the wild-type PfNHase (PfNHase-WT). In addition, the mutant PfNHase-αQ86W showed a catalytic efficiency (kcat/Km) towards benzonitrile 17.32-fold higher than the PfNHase-WT. Interestingly, the substrate preference of PfNHase-αQ86W shifted from aliphatic nitriles to aromatic nitrile substrates. Our analysis delved into the structural changes that led to this altered substrate preference, highlighting an expanded entrance tunnel region, theenlarged substrate-binding pocket, and the increased hydrophobic interactions between the substrate and enzyme. Molecular dynamic simulations and dynamic cross-correlation Matrix (DCCM) further supported these findings, providing a comprehensive explanation for the enhanced catalytic activity towards aromatic nitrile substrates.


Subject(s)
Hydro-Lyases , Nitriles , Pseudomonas fluorescens , Pseudomonas fluorescens/enzymology , Hydro-Lyases/metabolism , Hydro-Lyases/chemistry , Substrate Specificity , Nitriles/chemistry , Nitriles/metabolism , Molecular Structure , Biocatalysis , Protein Engineering
3.
Accid Anal Prev ; 202: 107600, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38663272

ABSTRACT

In China, visual guidance systems are commonly used in tunnels to optimize the visual reference system. However, studies focusing specifically on visual guidance systems in the tunnel entrance zone are limited. Hence, a driving simulation test is performed in this study to quantitatively evaluate the effectiveness of (i) visual guidance devices at different vertical positions (pavement and roadside) and (ii) a multilayer visual guidance system for regulating driving behavior in the tunnel entrance zone. Furthermore, the characteristics of driving behavior and their effects on traffic safety in the tunnel entrance zone are examined. Data such as the vehicle position, area of interest (AOI), throttle position, steering wheel angle, and lane center offset are obtained using a driving simulation platform and an eye-tracking device. As indicators, the first fixation position (FP), starting deceleration position (DP), average throttle position (TPav), number of deceleration stages (N|DS), gradual change degree of the vehicle trajectory (G|VT), and average steering wheel angle (SWAav) are derived. The regulatory effect of visual guidance devices on driving performance is investigated. First, high-position roadside visual guidance devices effectively reduce decision urgency and significantly enhance deceleration and lane-keeping performance. Specifically, the advanced deceleration performance (AD), smooth deceleration performance (SD), trajectory gradualness (TG), and trajectory stability (TS) in the tunnel entrance zone improve by 63%, 225%, 269%, and 244%, respectively. Additionally, the roadside low-position visual guidance devices primarily target the trajectory gradualness (TG), thus resulting in improvements by 80% and 448% in the TG and TS, respectively. Meanwhile, the pavement visual guidance devices focus solely on enhancing the TS and demonstrates a relatively lower improvement rate of 99%. Finally, the synergistic effect of these visual guidance devices facilitates the multilayer visual guidance system in enhancing the deceleration and lane-keeping performance. This aids drivers in early detection and deceleration at the tunnel entrance zone, reduces the urgency of deceleration decisions, promotes smoother deceleration, and improves the gradualness and stability of trajectories.


Subject(s)
Automobile Driving , Deceleration , Humans , China , Computer Simulation , Accidents, Traffic/prevention & control , Adult , Male , Eye-Tracking Technology , Female , Safety , Young Adult , Environment Design
4.
Traffic Inj Prev ; 25(5): 724-732, 2024.
Article in English | MEDLINE | ID: mdl-38634777

ABSTRACT

OBJECTIVE: This study aimed to investigate the effects of visual attraction in the entrance areas of highway tunnels on drivers' saccade behavior and driving safety, with the objective of providing insights for tunnel entrance design and driver education. METHODS: Fifty participants were recruited for the naturalistic driving experiment. Four different visually attractive driving scenarios (baseline, landscape-style architecture, tip slogan, and billboard) were selected. Eye-tracking technology was utilized to record and analyze the scanning behavior of participating drivers. Various metrics, including saccade duration, frequency, amplitude, velocity, and the peak-to-average ratio of saccade velocity (PARSV), were measured and compared across different scenarios. RESULTS: The results revealed different patterns of visual scanning dynamics among the four experimental scenarios, reflecting the different levels of visual-cognitive demands and situation awareness of drivers. The visual attraction in the tunnel entrance area resulted in prolonged saccade duration, increased saccade amplitude, reduced saccade frequency, and slower, less stable saccade velocity. Among these, drivers exhibited the most intricate and unstable scanning behavior, accompanied by the lowest level of situational awareness, particularly under the influence of visual attraction of tip slogan. CONCLUSIONS: The findings highlight the importance of considering visual attraction in tunnel entrance design. Minimizing unnecessary visual attraction can help reduce distractions and maintain driver attention, ultimately enhancing driving safety. Driver education programs should emphasize the significance of adapting to visual attraction at tunnel entrances to promote safer driving practices. Overall, this study contributes valuable insights into the effects of visual attraction on driver scanning behavior, facilitating the development of strategies to improve tunnel design and driver education.


Subject(s)
Attention , Automobile Driving , Eye-Tracking Technology , Saccades , Humans , Saccades/physiology , Male , Automobile Driving/psychology , Female , Adult , Young Adult , Attention/physiology , Environment Design
5.
Traffic Inj Prev ; 25(3): 499-509, 2024.
Article in English | MEDLINE | ID: mdl-38230899

ABSTRACT

OBJECTIVE: Traffic signs play a crucial role in ensuring road traffic safety, particularly in high-risk driving zones like the entrance zone of highway tunnels. However, the impact of traffic signs information volume (TSIV) on the performance of experienced and novice drivers in this specific zone remains unclear. This study aims to investigate the influence of TSIV on the visual sample entropy (SampEn) of both experienced and novice drivers in the entrance zone of highway tunnels. METHODS: A real vehicle driving trial was conducted with 60 participants approaching tunnels under various TSIV conditions. Fixation duration SampEn, saccade duration SampEn, and saccade amplitude SampEn were analyzed for both driver groups. RESULTS: As both driver groups approached the tunnel entrance, fixation duration SampEn, saccade duration SampEn, and saccade amplitude SampEn gradually increased. Initially, visual SampEn declined, followed by an increase as the TSIV level increased. The lowest value of visual SampEn was observed under the T3 TSIV condition (48.31 bits). Experienced drivers exhibited lower visual SampEn compared to novice drivers under similar TSIV conditions. CONCLUSIONS: TSIV and driving experience significantly influence the visual SampEn of drivers approaching the tunnel entrance. Optimal visual search patterns and performance were observed under the T3 TSIV condition (48.31 bits), which is critical for ensuring driving safety in the entrance zone of highway tunnels. Additionally, experienced drivers demonstrate better adaptation to tunnel environments and TSIV, while novice drivers may benefit from additional training to enhance their visual perception and performance.


Subject(s)
Automobile Driving , Humans , Accidents, Traffic/prevention & control , Entropy , Vision, Ocular , Visual Perception
6.
Traffic Inj Prev ; 25(2): 122-132, 2024.
Article in English | MEDLINE | ID: mdl-38019558

ABSTRACT

OBJECTIVE: The visual attraction of the freeway tunnel entrance zone will affect the driver's visual performance and visual workload, and then affect the driving safety. The purpose of this study is to explore the influence of different visual attraction conditions in the entrance zone of the freeway tunnel on driver's fixation behavior, and then evaluate the impact of eye-catching effect on driving safety. METHODS: Thirty-five participants were recruited for the naturalistic driving experiment. Four different visually attractive driving scenarios (baseline, landscape-style architecture, tip slogan, and billboard) were selected. Participants' fixation behavior data were collected using an eye-tracking device. The effects of the visual attraction conditions in the freeway tunnel entrance zones were analyzed on driver fixation duration, number of fixations, fixation deviation, and pupil diameter. RESULTS: The results demonstrated significant effects of different visual attractions in the entrance zone of the freeway tunnel on drivers' fixation behavior. Under the visual attraction of the billboard, drivers exhibited the most number of fixations. And under the visual attraction of tip slogan, drivers had the longest average fixation duration, the smallest horizontal fixation deviation, the largest vertical fixation deviation, and the highest pupil diameter and its coefficient of variation. CONCLUSIONS: It can be concluded that different visual attractions in the freeway tunnel entrance zone have different effects on the eye-catching effect of drivers, by influencing the fixation behavior characteristics of drivers. Billboard is most effective in capturing drivers' visual attention, and tip slogan requires greater attention allocation and visual cognitive effort from drivers, resulting in the highest visual cognitive workload. This study highlights the complex relationship between visual attraction and its performance on driver fixation behavior. The insights from this study can provide valuable references for the design and optimization of the visual environment in the entrance zone of freeway tunnels.


Subject(s)
Automobile Driving , Humans , Automobile Driving/psychology , Accidents, Traffic , Workload , Time Factors
7.
Sensors (Basel) ; 22(24)2022 Dec 12.
Article in English | MEDLINE | ID: mdl-36560097

ABSTRACT

Tunnels play an essential role in the transportation network. Tunnel entrances are usually buried at a shallow depth. In the event of an internal explosion, the blast pressure will cause severe damage or even collapse of the tunnel entrance, paralyzing the traffic system. Therefore, an accurate assessment of the damage level of tunnel entrances under internal blast loading can provide effective assistance for the anti-blast design of tunnels, post-disaster emergency response, and economic damage assessment. In this paper, four tunnel entrance specimens were designed and fabricated with a scale ratio of 1/5.5, and a series of field blast tests were carried out to examine the damage pattern of the tunnel entrances under internal explosion. Subsequently, static loading tests were conducted to obtain the maximum bearing capacity of the intact specimen and residual bearing capacities of the post-blast specimens. After that, an explicit non-linear analysis was carried out and a numerical finite element (FE) model of the tunnel entrance under internal blast loading was established by adopting the arbitrary Lagrangian-Eulerian (ALE) method and validated based on the data obtained from the field blast and static loading tests. A probabilistic vulnerability analysis of a typical tunnel entrance subjected to stochastic internal explosions (assuming various charge weights and detonation points) was then carried out with the validated FE model. For the purpose of damage assessment, the residual bearing capacity of the tunnel entrance was taken as the damage criterion. The vulnerability curves corresponding to various damage levels were further developed based on the stochastic data from the probabilistic vulnerability analysis. When the charge weight was 200 kg, the tunnel entrance exhibited slight or moderate damage, while the tunnel entrance suffered severe or even complete damage as the charge weight increased to 1000 kg. However, the tunnel entrance's probability of complete damage was less than 10% when the TNT charge weight did not exceed 1000 kg.

8.
Biochem Biophys Res Commun ; 575: 8-13, 2021 10 20.
Article in English | MEDLINE | ID: mdl-34454178

ABSTRACT

Nitrile hydratase (NHase) is able to bio-transform nitriles into amides. As nitrile hydration being an exothermic reaction, a NHase with high activity and stability is needed for amide production. However, the widespread use of NHase for amide bio-production is limited by an activity-stability trade-off. In this study, through the combination of substrate access tunnel calculation, residue conservative analysis and site-saturation mutagenesis, a residue located at the substrate access tunnel entrance of the thermophilic NHase from extremophile Caldalkalibacillus thermarum TA2. A1, ßLeu48, was semi-rationally identified as a potential gating residue that directs the enzymatic activity toward various pyridine and pyrazine nitriles. The specific activity of the corresponding mutant ßL48H towards 3-cyanopyridine, 2-cyanopyridine and cyanopyrazine were 2.4-fold, 2.8-fold and 3.1-fold higher than that of its parent enzyme, showing a great potential in the industrial production of high-value pyridine and pyrazine carboxamides. Further structural analysis demonstrated that the ßHis48 could form a long-lasting hydrogen bond with αGlu166, which contributes to the expansion of the entrance of substrate access tunnel and accelerate substrate migration.


Subject(s)
Bacillaceae/enzymology , Hydro-Lyases/metabolism , Nitriles/metabolism , Pyridines/metabolism , Recombinant Proteins/metabolism , Binding Sites , Hydro-Lyases/chemistry , Hydro-Lyases/isolation & purification , Hydrogen Bonding , Models, Molecular , Mutagenesis, Site-Directed/methods , Nitriles/chemistry , Protein Structural Elements , Pyridines/chemistry , Recombinant Proteins/genetics , Recombinant Proteins/isolation & purification , Structure-Activity Relationship
9.
Accid Anal Prev ; 157: 106145, 2021 Jul.
Article in English | MEDLINE | ID: mdl-34020757

ABSTRACT

The drastic changes of the space environment at the tunnel entrance can lead to frequent accidents with higher levels. The connected vehicle environment provides drivers with surrounding traffic information and improve their driving behavior by helping them make safe decisions efficiently. As such, this study is to examine the effects of the connected vehicle environment on driving behavior and safety at the tunnel entrance zone. To this end, this research simulates a connected vehicle environment and provides driving aids through the Human-Machine Interface (HMI). Secondly, 40 participants with diverse backgrounds drove the simulator under two different driving conditions: HMI-OFF (traditional driving environment) and HMI-ON (connected vehicle environment). Finally, indicators are selected from speed control, stability and urgency to analyze the impact of the connected vehicle environment on drivers' behaviors and safety at the warning zone and tunnel entrance zone. The results show that in the connected vehicle environment, the drivers' speed control in the warning zone is improved and their deceleration behavior is advanced. The driver's speed control and stability are improved while the danger level of the accident is reduced 100 m ahead of the tunnel entrance. Besides, the driver's speed control and stability have been both improved 300 m after the tunnel entrance. Overall, in the connected vehicle environment, the driver can recognize the tunnel in advance and adjust his driving speed in time to ensure his safety at the tunnel entrance. The results of this study play a critical role in the design and research of warning systems in a connected vehicle environment, and will also guide vehicle manufacturers in designing safety-related functions of automated vehicles. In this research, a connected vehicle environment test platform based on driving simulation technology is constructed and tested in specific tunnel entrance scenarios, which provides a reference for realizing active protection of vehicles at the tunnel entrance.


Subject(s)
Accidents, Traffic , Automobile Driving , Accidents, Traffic/prevention & control , Computer Simulation , Humans , Technology
10.
Article in English | MEDLINE | ID: mdl-32121272

ABSTRACT

The dark adaptation of drivers' eyes at a tunnel entrance seriously affects traffic safety. This can be improved by the design of tunnel lighting. Light-Emitting Diode (LEDs) have been applied as a new type of luminaire in tunnel lighting in recent years, but at present, there are few studies on the influence of color rendering of LEDs on tunnel traffic safety, and there is no explicit indicator for the selection of appropriate color rendering parameters in tunnel lighting specifications, which has aroused researchers' concern. In this article, several new color rendering evaluation indexes were compared, and as a result, it is considered that CRI2012 (a color difference-based color rendering index) is more suitable for evaluating the color rendering of LEDs used at tunnel entrances. The dark adaptation phenomenon was simulated in the laboratory. Four CRI2012s, three color temperatures and eight colored targets were used in the experiments. The results showed that yellow, silver and white can provide shorter reaction times, while red and brown lead to longer reaction times, which can provide a reference for the design of road and warning signs at tunnel entrances. The effect of target color on reaction time was greater than that of color rendering. Under most target colors, the higher the CRI2012, the shorter the reaction time. When designing the color rendering of the LEDs at a tunnel entrance, the value should thus be as large as possible (close to 100), and a lower color temperature value (about 2800 K) should be selected. This paper provides technical support for tunnel lighting design and a reference for tunnel lighting specifications, which is of significance to improve driving safety and avoid traffic accidents in highway tunnels.


Subject(s)
Automobile Driving , Color , Dark Adaptation , Lighting , Accidents, Traffic/prevention & control , Humans
11.
Article in English | MEDLINE | ID: mdl-31234339

ABSTRACT

At the entrance of a tunnel, reflection of sunlight from the surrounding environment and a lack of adequate lighting usually cause some vision problems. The purpose of this study is to optimize the lighting environment at the entrance of highway tunnels. Firstly, based on a highway tunnel in Zhejiang Province, the natural illumination intensity in different seasons and climate conditions inside and outside the tunnel entrance was analyzed by means of DIALux simulation software. Then the variation in illumination conditions with distance at the entrance of the tunnel was analyzed. Finally, based on the results above, this study proposes four solutions as follows: setting up a shading shed, auxiliary lighting facilities, decelerating reflective markings, and an adaptive dimming system.


Subject(s)
Sunlight , Automobile Driving , Computer Simulation , Humans , Research , Safety , Seasons , Software , Vision, Ocular
12.
Health Promot Perspect ; 8(4): 268-274, 2018.
Article in English | MEDLINE | ID: mdl-30479980

ABSTRACT

Background: The purpose of this study was to assess the contrast perception of obstacles in a tunnel entrance which was placed in Ilam Province, Iran. Methods: An obstacle with the reflection coefficient of 20% was mounted at the entrance of thetunnel and then, the car was placed near the tunnel entrance and the intrinsic luminance of the road (Lr,intrinsic) and obstacle (Lo,intrinsic) were measured inside the car using the luminance meter. Results: Intrinsic luminance of obstacle and road at the entrance of the tunnel were measured as 41 and 17 cd/m2, respectively. The contrast perception of obstacle in deriver's eyes and in the safe stopping distance (SSD) from the tunnel entrance was determined as 2.79 cd/m2. At the entrance of the studied tunnel, the contrast perception of obstacles with the reflection coefficient of 20% was lower than the minimum contrast perception (28%) recommended by International Commission on Illumination. Conclusion: The main conclusion that can be drawn from it, is that this obstacle in the SSD from the tunnel entrance cannot be conceived by the drivers, which may lead to higher rate of road traffic crashes.

13.
Springerplus ; 5: 538, 2016.
Article in English | MEDLINE | ID: mdl-27186502

ABSTRACT

INTRODUCTION: Driving environment in tunnels is quite different from the ordinary roadway sections, especially the entrance locations, which causes great difficulty in obtaining and interpreting information through fixations and saccades that are relevant to driving safety. Therefore, it is necessary to understand driver's visual behaviors while entering a tunnel so as to take the countermeasures for accident prevention. CASE DESCRIPTION: In order to identify the variation of driver's visual features during the process of tunnel entry, 18 participants were recruited to take part in a driving test conducted in real tunnel sections between Qipanguan toll and Jinshui toll of the G5 expressway in Shaanxi, China. During this test, the drivers' fixations, saccades and driving performances were captured for further analysis. DISCUSSION AND EVALUATION: The test data revealed that the driver's number of fixations, duration of fixations and number of saccades increased gradually at the transition zone. The number of fixations, duration of fixations and number of saccades then drop slightly until the end of the transition zone, and then rise just a little to a stable value after fully adapting to the driving conditions inside the tunnel. Meanwhile, the driver's number of saccades and saccade amplitude value decreased first, and then increased gradually until reaching a relatively stable value inside the tunnel. Additionally, drivers are more cautious at the transition zone, driving conservatively at lower speed, while decreasing their steering wheel angle and minimizing the vehicle's lateral deviation. Specially, novice drivers require a longer transition zone before tunnel entry compared to the experienced ones. Moreover, both novice and experienced drivers take more time to get prepared for tunnel entry while driving at night. CONCLUSION: Tunnel entrance section is far more dangerous, so drivers should be educated to get ready ahead for tunnel entry, drive cautiously at lower speed and pay full attention to the traffic flow conditions while driving through the tunnel, especially for the novice drivers in night tasks. Tunnel entrance is suggested to have easily identifiable frame design, with effective traffic signs placed at least 170 m before the entrance and gradually changeable LED lighting along the transition zone. All these suggestions provide insight into potential strategies for reducing and preventing traffic accidents and injuries at the tunnel locations.

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