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3.
BMJ Case Rep ; 17(2)2024 Feb 23.
Article En | MEDLINE | ID: mdl-38395468

The incidence of adrenal cysts is 0.06% and only 9% of these are true mesothelial cysts. Here, we present a case of a true mesothelial cyst together with a review of the literature. A female in her 30s presented to the surgical outpatient department complaining of right flank pain. Her contrast-enhanced CT scan revealed a 7.5×6.5×4.5 cm right adrenal gland cyst. The patient underwent a laparoscopic right adrenalectomy. Immunohistopathology revealed the cyst to be mesothelial in nature. The majority of true mesothelial adrenal cysts are benign, unilateral and more common in women. Any adrenal cyst diagnosed as a functional lesion or one that may be malignant or with a diameter of 5 cm or greater requires surgical care whereas smaller lesions can be managed conservatively. Laparoscopic adrenalectomy for an adrenal cyst of diameter greater than 6 cm is a safe and feasible procedure in expert hands if there is no invasion of surrounding tissue.


Adrenal Gland Diseases , Adrenal Gland Neoplasms , Cysts , Laparoscopy , Humans , Female , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/surgery , Adrenal Glands/diagnostic imaging , Adrenal Glands/surgery , Adrenal Glands/pathology , Cysts/diagnostic imaging , Cysts/surgery , Adrenal Gland Neoplasms/surgery , Adrenalectomy/methods
5.
Acta Gastroenterol Belg ; 86(3): 495-498, 2023.
Article En | MEDLINE | ID: mdl-37814568

Bilateral adrenal hemorrhage (BAH) is a rare condition that can lead to acute adrenal insufficiency and death if not recognized and treated promptly. We report the case of a 30-year-old male who presented to the emergency department with acute abdominal pain, nausea, and vomiting. On emergency room admission, the first abdominal CT revealed normal adrenal glands without enlargement, but with the development of hypotension and hypoglycemia, a second CT performed four days later showed enlargement due to hemorrhage in both adrenals. The diagnosis of BAH associated with acute adrenal insufficiency was retained. Prompt treatment with intravenous and oral corticosteroids resulted in successful conservative management. We describe the clinical, biological, radiological and etiological features of this condition based on a review of the literature.


Abdomen, Acute , Adrenal Gland Diseases , Adrenal Insufficiency , Male , Humans , Adult , Adrenal Gland Diseases/diagnosis , Adrenal Gland Diseases/diagnostic imaging , Adrenal Insufficiency/complications , Adrenal Insufficiency/diagnosis , Adrenal Insufficiency/drug therapy , Hemorrhage/etiology , Hemorrhage/complications , Abdominal Pain/diagnosis , Abdominal Pain/etiology , Acute Disease
6.
J Pak Med Assoc ; 73(6): 1317-1319, 2023 Jun.
Article En | MEDLINE | ID: mdl-37427641

Adrenal Gland Cysts are rare among all the pathologic cysts that occur in human beings; the pseudo-cyst variety even rarer. Adrenal pseudo-cysts are asymptomatic, non-functional, small, and incidentally discovered disease entities. Their clinical presentation is usually the result of their mass effects. Thanks to the advanced diagnostic technology, more such cases are being discovered timely and managed surgically, before life-threatening complications occur. Open surgical treatment remains the treatment of choice for giant cysts.


Adrenal Gland Diseases , Adrenal Gland Neoplasms , Cysts , Humans , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/surgery , Cysts/diagnostic imaging , Cysts/surgery , Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/diagnostic imaging , Adrenalectomy , Adrenal Glands/diagnostic imaging , Adrenal Glands/surgery , Adrenal Glands/pathology
8.
BMJ Case Rep ; 16(5)2023 May 04.
Article En | MEDLINE | ID: mdl-37142280

Cystic lesions of the adrenal glands are relatively uncommon and most of them are clinically silent. Though rarely associated with malignant changes, they may carry clinically detrimental consequences if misdiagnosed. Cystic adrenal lesions exhibit a broad histomorphological spectrum, ranging from pseudocysts, endothelial cysts, epithelial cysts and parasitic cysts. Here we present the case of a young woman with left-sided abdominal pain and contrast-enhanced CT showing a 10.4×7.7×7.8 cm fluid-filled left suprarenal lesion. The patient underwent exploratory laparotomy with cyst excision, and the histopathological examination of the specimen revealed a pseudocyst of the left adrenal gland. Despite being rare, usually benign and asymptomatic, the diagnosis and management of these cystic lesions of the adrenal glands are often unclear. Any functional lesion, potentially malignant lesion or lesion more than 5 cm deserves surgical management, whereas others can be managed conservatively.


Adrenal Gland Diseases , Epidermal Cyst , Female , Humans , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/surgery , Adrenal Glands/diagnostic imaging , Adrenal Glands/surgery , Adrenal Glands/pathology , Tomography, X-Ray Computed , Epidermal Cyst/pathology , Diagnosis, Differential
10.
Nat Rev Endocrinol ; 19(7): 398-406, 2023 07.
Article En | MEDLINE | ID: mdl-37095252

Adrenal cysts are rare lesions representing approximately 1-2% of adrenal incidentalomas. The majority of these rare lesions are benign. Rarely, phaeochromocytomas and adrenal malignant masses can present as cystic lesions and can occasionally be difficult to distinguish from benign cysts. Histologically, adrenal cysts are subdivided into pseudocysts, endothelial cysts, epithelial cysts and parasitic cysts. The radiological appearance of an adrenal cyst is generally similar to that of cysts in the kidney. They are thus well demarcated, usually rounded, with a thin wall and homogenous internal structure, low attenuating (<20 Hounsfield Units) on CT, low signalling on T1-weighted MRI sequences and high signalling on T2-weighted MRI sequences, and anechoic or hypoechoic on ultrasonography. Benign adrenal cysts have a slight female predominance and are usually diagnosed between the ages of 40 and 60. Most adrenal cysts are asymptomatic and are detected incidentally, although very large adrenal cysts can lead to mass effect symptoms, with surgery required to alleviate the symptoms. Thus, conservative management is usually recommended for asymptomatic cysts. However, when uncertainty exists regarding the benign nature of the cyst, additional work-up or follow-up is needed. The management of an adrenal cyst should preferably be discussed at an adrenal multidisciplinary team meeting.


Adrenal Gland Diseases , Adrenal Gland Neoplasms , Cysts , Pheochromocytoma , Humans , Female , Adult , Middle Aged , Male , Adrenal Gland Neoplasms/diagnostic imaging , Adrenal Gland Neoplasms/epidemiology , Tomography, X-Ray Computed , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/pathology , Pheochromocytoma/diagnostic imaging , Cysts/diagnostic imaging , Cysts/pathology , Diagnosis, Differential
15.
BMJ Case Rep ; 15(12)2022 Dec 12.
Article En | MEDLINE | ID: mdl-36524269

A woman in her 40s attended the hospital with worsening left upper abdominal dull aching pain for the past 6 months. Clinical examination and radiological investigations with ultrasonography and contrast-enhanced CT of the abdomen confirmed it to be a cystic lesion of the left adrenal of size 13 cm × 12 cm × 11 cm. With the possibility of an incidental malignancy due to large size, laparoscopic cyst excision meticulously without spillage of cyst content was possible due to preoperative planning. It was a difficult task to mobilise the cyst intact due to the thin wall to prevent accidental rupture and gross spillage of the cyst contents. The cyst wall sent for histopathological examination confirmed it to be an adrenal pseudocyst without any malignant focus. Adrenal pseudocysts are rare and mostly benign. However, the index of suspecting a malignancy should be high in large cysts, and meticulous dissection is warranted.


Adrenal Gland Diseases , Cysts , Laparoscopy , Female , Humans , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/surgery , Cysts/diagnostic imaging , Cysts/surgery , Adrenalectomy , Ultrasonography
16.
BMJ Case Rep ; 15(10)2022 Oct 07.
Article En | MEDLINE | ID: mdl-36207054

Antiphospholipid syndrome (APS) is an uncommon autoantibody-mediated condition characterised by acquired thrombophilia resulting in recurrent arterial and venous thrombosis. An inciting factor allows for the exposure of endothelial phospholipids, causing antigen formation and subsequent creation of antibodies. A woman in her 70s presented after vehicular trauma, suffering broken ribs, pneumothorax and incidentally discovered left adrenal haemorrhage. Two weeks later she presented with acute-onset abdominal pain and was found to have a right adrenal gland haemorrhage on CT imaging without interval trauma occurring. The patient had antiphospholipid antibody laboratory studies drawn and was given intravenous heparin with a bridge to warfarin at discharge. Laboratory results returned positive for lupus anticoagulant, beta-2 glycoprotein and anticardiolipin antibodies indicating triple positivity, with repeated laboratory tests positive in 12 weeks' time, confirming the diagnosis. Bilateral adrenal haemorrhage, rather than traditional venous thromboembolism, was the presenting pathology in this patient's diagnosis of APS.


Adrenal Gland Diseases , Antiphospholipid Syndrome , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/etiology , Antibodies, Anticardiolipin , Antibodies, Antiphospholipid , Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/diagnosis , Female , Glycoproteins , Hemorrhage/diagnostic imaging , Hemorrhage/etiology , Heparin , Humans , Lupus Coagulation Inhibitor , Phospholipids , Warfarin/therapeutic use
17.
BMC Pediatr ; 22(1): 248, 2022 05 05.
Article En | MEDLINE | ID: mdl-35513814

BACKGROUND: Neonatal adrenal hemorrhage (NAH) is an almost infrequent phenomenon (0.2-0.55%). Mechanical compression and alterations of venous pressure during delivery are considered the most probable explanations. Approximately 10% of the cases might have bilateral involvement. Clinical symptoms include abdominal mass, poor feeding, vomiting, prolonged jaundice, and anemia. Subgaleal hemorrhage (SGH) is one of the most clinically remarkable and potentially hazardous postnatal cranial injuries. CASE PRESENTATION: An early-term Iranian male neonate who was born through spontaneous vaginal delivery and experienced shoulder dystocia was diagnosed with bilateral NAH leading to adrenal insufficiency requiring glucocorticoid and mineralocorticoid supplementation. The SGH and jaundice were other postnatal complications. Serial monthly abdominal and brain ultrasound revealed complete regression of lesions after 70 days. However, after 16 months, the neonate has been still treated with hydrocortisone and fludrocortisone for the adrenal insufficiency diagnosis. He has a lower limit weight for age; however, developmental milestones have been appropriate for age. DISCUSSION AND CONCLUSION: Adrenal hemorrhage and SGH should be examined and looked for, particularly with proven evidence of difficult delivery and asphyxia in at-risk newborns. Clinical and ultrasound follow-up is mandatory for the assessment of hemorrhage resolution and conservative management. The early detection and treatment of adrenal insufficiency by laboratory examination is strongly recommended in bilateral cases. Furthermore, the early recognition of postnatal SGH to prevent clinical and neurological outcomes seems essential.


Adrenal Gland Diseases , Adrenal Insufficiency , Adrenal Gland Diseases/complications , Adrenal Gland Diseases/diagnostic imaging , Adrenal Insufficiency/complications , Female , Hematoma/complications , Hemorrhage/etiology , Humans , Infant, Newborn , Iran , Male , Pregnancy
18.
BMJ Case Rep ; 15(5)2022 May 06.
Article En | MEDLINE | ID: mdl-35523516

Spontaneous adrenal haemorrhage (SAH) is a rare condition. The incidence of adrenal haemorrhage in pregnancy is currently not known; however, an association with pregnancy has been reported.An acute presentation with severe back or flank pain should raise suspicion of this condition. Diagnosis is based on imaging. An ultrasound scan is a basic and readily available investigation in pregnancy to rule out renal and suprarenal pathology while CT or MRI scan can help to confirm the diagnosis. A multidisciplinary team (MDT) approach, involving the obstetric, anaesthetic, medical and endocrine team, is essential in management of this condition.We present a case of an SAH; managed conservatively, in an otherwise healthy and low-risk pregnant woman and describe the literature review on this rare condition, including pathophysiology and management.


Adrenal Gland Diseases , Pregnancy Complications , Adrenal Gland Diseases/diagnosis , Adrenal Gland Diseases/diagnostic imaging , Female , Flank Pain , Hemorrhage/diagnostic imaging , Hemorrhage/etiology , Hemorrhage/therapy , Humans , Magnetic Resonance Imaging/adverse effects , Pregnancy , Pregnancy Complications/diagnostic imaging , Pregnancy Complications/therapy
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