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1.
BMJ Open Ophthalmol ; 9(1)2024 Jul 31.
Article in English | MEDLINE | ID: mdl-39089733

ABSTRACT

BACKGROUND: In 2020, almost 100 million people were blind or visually impaired from cataract. Cataract surgery is a cost-effective treatment for cataracts. In Nigeria, twice as many women are cataract blind as men. Cataract surgical rate (CSR, the number of cataract operations per million population per year in a defined geographical location) is an output indicator of cataract surgical services. The recommended target CSR for sub-Saharan Africa is 1000/year. The aim of this study was to assess the CSR in men and women in Imo state, Nigeria. METHODS: A retrospective review of cataract surgery undertaken in all eye health facilities in Imo State in 2019. Data collected included the type and location of facilities, patient demographics and the number and type of cataract operations performed in each facility. The CSR was calculated overall, in men and women, and in younger and older women. RESULTS: The CSR overall was 330/million and was slightly higher in women (347/million) than in men (315/million) (p<0.001). More elderly women (≥65 years) accessed cataract surgery through outreach than men and younger women (OR 1.5 (95% CI 1.03 to 2.22, p=0.03) and 1.6 (95% CI 1.07 to 2.44, p=0.02)), respectively. CONCLUSION: The overall CSR in Imo state was approximately one-third of that recommended for sub-Saharan Africa. Although the CSR was higher in women than in men, considerably higher CSRs are needed in women to address their higher burden of cataract blindness. Operational and intervention science research are needed, to identify and evaluate interventions which address demand and supply barriers to accessing cataract surgery, particularly for elderly women.


Subject(s)
Cataract Extraction , Cataract , Humans , Cataract Extraction/statistics & numerical data , Nigeria/epidemiology , Female , Male , Retrospective Studies , Aged , Middle Aged , Cataract/epidemiology , Gender Equity , Adult , Health Services Accessibility/statistics & numerical data , Sex Distribution , Aged, 80 and over , Blindness/epidemiology , Blindness/etiology
2.
BMC Prim Care ; 25(1): 250, 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38987673

ABSTRACT

BACKGROUND: The purpose of this study was to quantify how much of the burden of visual impairment (VI) and unmet need in Talagang, identified by Rapid Assessment of Avoidable Blindness (RAAB) survey data, has been addressed by Community Eye Health (CEH) programme efforts. METHODS: A RAAB survey was carried out in November 2018, with 2,824 participants in Talagang Tehsil, Punjab, Pakistan, aged 50 and over. Census data were used to extrapolate survey data to the population. Alongside this, a CEH programme was launched, consisting of community eye screening, and onward referral to rural health centres, secondary or tertiary ophthalmological services, as required. This health intervention aimed to address the eye care needs surfaced by the initial survey. From 2018 to 2022, 30,383 people aged 50 or over were screened; 14,054 needed referral to further steps of the treatment pathway and more detailed data collection. Programme data were compared to estimates of population unmet needs. Main outcome measures were prevalence of VI, and proportion of need met by CEH Programme, by cause and level of VI. RESULTS: Among those aged 50 and over, 51.0% had VI in at least one eye. The leading causes were cataract (46.2%) and uncorrected refractive error (URE) (25.0%). In its first four years, the programme reached an estimated 18.3% of the unmet need from cataract, and 21.1% of URE, equally in both men and women. CONCLUSIONS: Robustly collected survey and programme data can improve eye health planning, monitoring and evaluation, address inequities, and quantify the resources required for improving eye health. This study quantifies the time required to reach eye health needs at the community level.


Subject(s)
Blindness , Humans , Pakistan/epidemiology , Blindness/epidemiology , Blindness/prevention & control , Blindness/etiology , Middle Aged , Female , Male , Aged , Prevalence , Refractive Errors/epidemiology , Refractive Errors/diagnosis , Health Services Needs and Demand , Cataract/epidemiology , Vision Screening/methods , Referral and Consultation/statistics & numerical data
3.
Eye (Lond) ; 38(11): 2070-2082, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38965321

ABSTRACT

BACKGROUND: We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD). METHODS: We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness ( < 3/60) caused by AMD, stratified by age, region, and year. RESULTS: In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%. CONCLUSIONS: The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.


Subject(s)
Blindness , Global Health , Macular Degeneration , Visual Acuity , Visually Impaired Persons , Humans , Blindness/epidemiology , Blindness/etiology , Macular Degeneration/epidemiology , Prevalence , Visually Impaired Persons/statistics & numerical data , Vision, Low/epidemiology , Aged , Female
4.
Eye (Lond) ; 38(11): 2083-2101, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38965322

ABSTRACT

BACKGROUND: Uncorrected refractive error (URE) is a readily treatable cause of visual impairment (VI). This study provides updated estimates of global and regional vision loss due to URE, presenting temporal change for VISION 2020 METHODS: Data from population-based eye disease surveys from 1980-2018 were collected. Hierarchical models estimated prevalence (95% uncertainty intervals [UI]) of blindness (presenting visual acuity (VA) < 3/60) and moderate-to-severe vision impairment (MSVI; 3/60 ≤ presenting VA < 6/18) caused by URE, stratified by age, sex, region, and year. Near VI prevalence from uncorrected presbyopia was defined as presenting near VA < N6/N8 at 40 cm when best-corrected distance (VA ≥ 6/12). RESULTS: In 2020, 3.7 million people (95%UI 3.10-4.29) were blind and 157 million (140-176) had MSVI due to URE, a 21.8% increase in blindness and 72.0% increase in MSVI since 2000. Age-standardised prevalence of URE blindness and MSVI decreased by 30.5% (30.7-30.3) and 2.4% (2.6-2.2) respectively during this time. In 2020, South Asia GBD super-region had the highest 50+ years age-standardised URE blindness (0.33% (0.26-0.40%)) and MSVI (10.3% (8.82-12.10%)) rates. The age-standardized ratio of women to men for URE blindness was 1.05:1.00 in 2020 and 1.03:1.00 in 2000. An estimated 419 million (295-562) people 50+ had near VI from uncorrected presbyopia, a +75.3% (74.6-76.0) increase from 2000 CONCLUSIONS: The number of cases of VI from URE substantively grew, even as age-standardised prevalence fell, since 2000, with a continued disproportionate burden by region and sex. Global population ageing will increase this burden, highlighting urgent need for novel approaches to refractive service delivery.


Subject(s)
Blindness , Global Health , Refractive Errors , Visual Acuity , Visually Impaired Persons , Humans , Blindness/epidemiology , Blindness/etiology , Refractive Errors/epidemiology , Refractive Errors/physiopathology , Prevalence , Visually Impaired Persons/statistics & numerical data , Visual Acuity/physiology , Male , Middle Aged , Female , Vision, Low/epidemiology , Adult , Sex Distribution , Aged , Age Distribution
5.
Am J Case Rep ; 25: e943112, 2024 Jul 15.
Article in English | MEDLINE | ID: mdl-39054886

ABSTRACT

BACKGROUND Myelin oligodendrocyte glycoprotein (MOG)-associated disease (MOGAD) is a recently described inflammatory demyelinating disease of the central nervous system (CNS), which needs to be distinguished from aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) and multiple sclerosis (MS). CASE REPORT A 42-year-old woman presenting with loss of vision due to optic neuritis was admitted to the Naval Medical Center in October 2022. She had optic disc edema, blurred visual margins, optic disc pallor, and deficient visual field in both eyes. Cranial magnetic resonance imaging (MRI) showed bilateral optic nerve thickening, tortuosity, and swelling, especially on the right side. Orbital MRI T2 sequence showed the typical "double track sign" change. The titers of MOG-IgG in CSF and serum were 1: 1 (+) and 1: 32 (+) separately, so MOGAD was diagnosed. The primary treatment was intravenous methylprednisolone for 2 weeks, after which the blurred vision improved and MRI showed the optic nerve lesions disappeared. She was discharged and oral corticosteroids were tapered gradually, and 1 month later, the symptom had vanished without recurrence, cranial MRI was normal, and MOG-IgG in CSF and serum were negative. Low-dose oral corticosteroids were continued for 6 months, with no relapse and normal cranial MRI, so we stopped corticosteroid therapy. At 1-year follow-up, the symptoms had not recurred. CONCLUSIONS A 42-year-old woman presented with loss of vision due to optic neuritis and positive antibody testing for MOG. MOGAD was diagnosed, and timely immunotherapy was effective.


Subject(s)
Myelin-Oligodendrocyte Glycoprotein , Optic Neuritis , Humans , Female , Optic Neuritis/etiology , Optic Neuritis/diagnosis , Adult , Myelin-Oligodendrocyte Glycoprotein/immunology , Methylprednisolone/therapeutic use , Magnetic Resonance Imaging , Immunotherapy/adverse effects , Blindness/etiology
6.
S Afr Med J ; 114(6): e1616, 2024 May 31.
Article in English | MEDLINE | ID: mdl-39041505

ABSTRACT

Neuromyelitis optica spectrum of disorders is a rare cause of optic neuritis in children. It is a critical diagnosis requiring urgent management, with delays carrying both life- and sight-threatening complications. Most of the published literature on this entity is in adult patients, with only a few case reports to guide management in the paediatric population. The purpose of this article is to shareour experience in the management of this condition in a child, and thus hopefully add to the limited body of knowledge currently available.


Subject(s)
Aquaporin 4 , Biomarkers , Gastroenteritis , Immunoglobulin G , Neuromyelitis Optica , Humans , Neuromyelitis Optica/diagnosis , Neuromyelitis Optica/immunology , Neuromyelitis Optica/blood , Aquaporin 4/immunology , Gastroenteritis/complications , Gastroenteritis/diagnosis , Immunoglobulin G/blood , Biomarkers/blood , Female , Child , Acute Disease , Magnetic Resonance Imaging , Optic Neuritis/diagnosis , Optic Neuritis/immunology , Blindness/etiology , Male
7.
S Afr Med J ; 114(6b): e1309, 2024 Jun 24.
Article in English | MEDLINE | ID: mdl-39041534

ABSTRACT

BACKGROUND: Preventable blindness is a global public health problem. In South Africa (SA) the prevalence of blindness is increasing, with a higher proportion of cataracts than the global norm, and a large rural population with limited access to specialised eye-care services. OBJECTIVE: To determine the level of knowledge regarding preventable blindness and treatment options within a rural and urban population. SETTING: Rural and urban areas in the Eastern Cape, SA. METHODS: A descriptive cross-sectional study was conducted among 309 participants. Questionnaires were administered by fieldworkers at the different sites. Proportions were calculated and χ2 tests done to determine whether there was any significant relationship between the categorical variables. Data analysis was done using Stata version 15. RESULTS: Participants were almost equally distributed among the urban (49.2%) and rural areas (50.8%). Both groups had a similar composition of males and females. Most participants had completed high school. The results showed a statistically significant difference between the urban and rural participants' knowledge about the causes of blindness: refractive error χ 2 (1, N=30) = 8.20, p<0.05, and cataract χ2 (1, N=28) = 8.64, p<0.05. The top two differences in the views between urban and rural participants regarding symptoms associated with eye problems (p<0.05) were: 'people who need spectacles have double vision', χ2 (1, N=122) = 28.19; and 'people who need spectacles squint their eyes', χ2 (1, N=124) = 17.37. The majority of urban participants reported opting to go to a private optometrist for eye health services, while the majority of rural participants would go to a pharmacy. Both groups were aware of the role of ageing in blindness. CONCLUSION: Urban participants in this study appeared to be more knowledgeable than rural participants about the causes and symptoms of blindness and its treatment options. These findings should provide some value to those who provide primary healthcare services in rural areas as there is a clear opportunity for patient education and health promotion regarding the causes and symptoms of these common preventable causes of blindness. Addressing this knowledge gap regarding the causes and symptoms of blindness and the treatment options is a critical first step for awareness programmes in rural areas. Without this, there will be little demand for any treatment or service. Future studies are needed to understand which health promotion interventions are effective in preventable blindness in rural populations.


Subject(s)
Blindness , Health Knowledge, Attitudes, Practice , Rural Population , Urban Population , Humans , South Africa/epidemiology , Male , Female , Cross-Sectional Studies , Blindness/prevention & control , Blindness/epidemiology , Blindness/etiology , Adult , Middle Aged , Surveys and Questionnaires , Young Adult , Aged , Cataract/epidemiology , Adolescent , Refractive Errors/therapy , Refractive Errors/epidemiology
9.
BMJ Case Rep ; 17(7)2024 Jul 05.
Article in English | MEDLINE | ID: mdl-38969394

ABSTRACT

A diabetic woman in her fifties presented with a sudden onset of failing vision and diplopia involving the right eye for two days, along with fever and headache. Radiological investigations revealed right sphenoid sinusitis along with inflammation around the right orbital apex and optic nerve. Functional endoscopic sinus surgery, with orbital and optic nerve decompression improved the ocular movements, but not the visual acuity. Histopathology was suggestive of a granulomatous inflammatory lesion, and high-resolution computed tommography (HRCT) of the thorax revealed lung lesions suggestive of an old tubercular infection, and antitubercular treatment (ATT) was then initiated.At the end of two months of ATT, there was complete resolution of ophthalmoplegia, relative afferent pupillary defect, direct and consensual light reflex however, failure of improvement in her visual acuity, indicated damage to the optic nerve.Extrapulmonary tuberculosis involving an isolated sphenoid sinus is rare and elusive. Prompt radiological investigations, followed by orbital decompression and ATT, provide the best possible outcomes.


Subject(s)
Antitubercular Agents , Blindness , Ophthalmoplegia , Sphenoid Sinus , Humans , Female , Middle Aged , Antitubercular Agents/therapeutic use , Sphenoid Sinus/diagnostic imaging , Ophthalmoplegia/etiology , Ophthalmoplegia/diagnosis , Blindness/etiology , Sphenoid Sinusitis/complications , Sphenoid Sinusitis/diagnosis , Sphenoid Sinusitis/diagnostic imaging , Tomography, X-Ray Computed , Decompression, Surgical , Tuberculosis/complications , Tuberculosis/diagnosis
10.
Pan Afr Med J ; 47: 164, 2024.
Article in English | MEDLINE | ID: mdl-39036015

ABSTRACT

Optic neuritis is a rare presentation of vitamin B12 deficiency. We describe a 33-year-old female patient living with HIV presenting with progressive loss of vision for 1 week. She had a history of severe peripheral neuropathy that was managed with vitamin B12-containing tablets approximately three years before presenting with progressive loss of vision. On examination, she had no perception of light in the left eye and no perception of hand motion in the right eye. The fundus in her left eye had mild blurring of disc margins. Results from tests done showed a haemoglobin of 12.9g/dl, MCV 101fl, a serum vitamin B12 of 78pmol/l, and cytomegalovirus (CMV) test showed no active disease. She was diagnosed with optic neuritis and started on 30 mg tablets of prednisolone for 1 week with slight improvement. She was then started on vitamin B12 injections 1 mg daily for 10 days and thereafter, monthly for 6 months. She reported gradual improvement and regained her sight after 5 months treatment of with Vitamin B12 injections. Ophthalmic manifestations of vitamin B12 deficiency are not common and may present without haematological signs therefore, a high index of suspicion is required for early diagnosis and management of vitamin B12 deficiency.


Subject(s)
Alkynes , Anti-HIV Agents , Benzoxazines , Blindness , Cyclopropanes , HIV Infections , Optic Neuritis , Vitamin B 12 Deficiency , Vitamin B 12 , Humans , Female , Adult , Vitamin B 12 Deficiency/diagnosis , Vitamin B 12 Deficiency/drug therapy , Vitamin B 12 Deficiency/complications , Vitamin B 12/administration & dosage , HIV Infections/complications , HIV Infections/drug therapy , Benzoxazines/administration & dosage , Benzoxazines/adverse effects , Anti-HIV Agents/administration & dosage , Anti-HIV Agents/adverse effects , Blindness/etiology , Cyclopropanes/administration & dosage , Optic Neuritis/diagnosis , Optic Neuritis/drug therapy , Prednisolone/administration & dosage , Glucocorticoids/administration & dosage
11.
Sci Rep ; 14(1): 16638, 2024 07 18.
Article in English | MEDLINE | ID: mdl-39025892

ABSTRACT

The purpose of this study was to examine how demographics, etiology, and clinical examination findings are related to visual outcomes in subjects with open globe injury (OGI) across a large and generalizable sample. A retrospective cohort analysis was performed using data collected from the electronic medical records of four tertiary university centers for subjects with OGI presenting from 2018 to 2021. Demographic information, injury mechanisms, clinical exam findings, visual acuity (VA) at presentation and most recent follow-up were recorded. In subjects with bilateral OGIs, only right eyes were included. A modified ocular trauma score (OTS) using presenting VA, the presence of perforating injury, OGI, and afferent pupillary defect was calculated. The risk of subjects' demographic characteristics, ocular trauma etiology, clinical findings and modified OTS on the presence of monocular blindness at follow-up were assessed using univariable and multivariable regression models. 1426 eyes were identified. The mean age was 48.3 years (SD: ± 22.4 years) and the majority of subjects were men (N = 1069, 75.0%). Univariable analysis demonstrated that subjects of Black race were 66% (OR: 1.66 [1.25-2.20]; P < 0.001) more likely to have monocular blindness relative to White race at follow-up. OTS Class 1 was the strongest predictor of blindness (OR: 38.35 [21.33-68.93]; P < 0.001). Based on multivariable analysis, lower OTS category (OTS Class 1 OR: 23.88 [16.44-45.85]; P < 0.001) moderately predicted visual outcomes (R2 = 0.275, P < 0.001). OGI has many risks of poor visual outcome across patient groups that vary by demographic category, mechanism of injury, and clinical presentation. Our findings validate that a modified OTS remains a strong predictor of visual prognosis following OGI in a large and generalizable sample.


Subject(s)
Eye Injuries, Penetrating , Visual Acuity , Humans , Male , Female , Middle Aged , Adult , Retrospective Studies , Eye Injuries, Penetrating/epidemiology , Eye Injuries, Penetrating/complications , Aged , Blindness/etiology , Blindness/epidemiology , Young Adult , Adolescent
12.
Int Ophthalmol ; 44(1): 234, 2024 Jun 19.
Article in English | MEDLINE | ID: mdl-38896279

ABSTRACT

PURPOSE: As the epidemiological and burden trends of glaucoma are changing, it is extremely necessary to re-investigate geographical differences and trends. Here we use data from the 2019 Global burden of Disease, which aims to report the prevalence and disability-adjusted life years of glaucoma injury to assess the latest epidemiological models and trends from 1990 to 2019. METHOD: Annual case numbers, age-standardized rates of prevalence, DALYs, and their estimated annual percentage changes (EAPCs) for glaucoma between 1990 and 2019 were derived from the GBD 2019 study. The relationship between glaucoma disease burden and social demographic index (SDI) was also investigated in this study. RESULTS: In 2019, there were 7.47 million prevalent cases and 0.75 million DALYs cases, which increased by 92.53% and 69.23% compared with 1990 respectively. The global age-standardized rate of prevalence (ASPR) and age-standardized rate of DALYs (ASDR) decreased during 1990-2019 (EAPC = - 0.55 and - 1, respectively). In 2019, the highest ASPR and ASDR of Glaucoma were all observed in Mali, whereas the lowest occurred in Taiwan (Province of China). In terms of gender, males were more likely to suffer from glaucoma than females, especially the elderly. CONCLUSIONS: The global prevalence and DALYs of glaucoma had an absolute increase during the past 30 years. The disease burden caused by glaucoma is closely related to socioeconomic level, age, gender, and other factors, and these findings provide a basis for policymakers from the perspective of social management.


Subject(s)
Glaucoma , Global Burden of Disease , Global Health , Humans , Glaucoma/epidemiology , Prevalence , Female , Male , Middle Aged , Aged , Adult , Age Distribution , Disability-Adjusted Life Years , Sex Distribution , Quality-Adjusted Life Years , Adolescent , Aged, 80 and over , Young Adult , Child , Cost of Illness , Blindness/epidemiology , Blindness/etiology
13.
J Glob Health ; 14: 04100, 2024 Jun 14.
Article in English | MEDLINE | ID: mdl-38867671

ABSTRACT

Background: Asia accounts for more than half of the world's population and carries a substantial proportion of the global burden of blindness and vision impairment. Characterising this burden, as well as its causes and determinants, could help with devising targeted interventions for reducing the occurrence of blindness and visual impairment. Methods: Using the Global Burden of Disease Study 2019 database, we retrieved data on the number of disability-adjusted life years (DALYs); crude and age-standardised rates; and the prevalence (with 95% uncertainty intervals (95%UIs)) of blindness and vision loss due to six causes (age-related macular degeneration, cataracts, glaucoma, near-vision impairment, refractive error, and other vision loss) for Asian countries for the period between 1990 and 2019. We defined DALYs as the sum of the years lost due to disability and years of life lost, and calculated age-standardised figures for the number of DALYs and prevalence by adjusting for population size and age structure. We then evaluated the time trend of the disease burden and conducted subgroup analyses by gender, age, geographic locations, and socio-demographic index (SDI). Results: In 2019, the DALYs and prevalence of blindness and vision loss had risen by 90.1% and 116% compared with 1990, reaching 15.84 million DALYs (95% UI = 15.83, 15.85) and 506.71 million cases (95% UI = 506.68, 506.74). Meanwhile, the age-standardised rate of DALYs decreased from 1990 to 2019. Cataracts, refractive error, and near vision impairment were the three most common causes. South Asia had the heaviest regional disease burden (age-standardised rate of DALYs = 517 per 100 000 population; 95% UI = 512, 521). Moreover, the burden due to cataracts ranked high in most Asian populations. Being a woman; being older; and having a lower national SDI were factors associated with a greater vision loss burden. Conclusions: The burden due to vision loss remains high in Asian populations. Cataracts, refractive error, and near vision loss were the primary causes of blindness and vision loss. Greater investment in ocular disease prevention and care by countries with lower socioeconomic status is needed, as well as specific strategies targeting cataract management, women and the elderly.


Subject(s)
Blindness , Disability-Adjusted Life Years , Global Burden of Disease , Humans , Blindness/epidemiology , Blindness/etiology , Female , Male , Aged , Middle Aged , Asia/epidemiology , Adult , Aged, 80 and over , Prevalence , Young Adult , Adolescent , Child , Child, Preschool , Infant , Cataract/epidemiology , Cataract/complications , Vision, Low/epidemiology , Refractive Errors/epidemiology , Refractive Errors/complications
14.
Eye (Lond) ; 38(11): 2047-2057, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38937557

ABSTRACT

OBJECTIVES: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by diabetic retinopathy and their proportion of the total number of vision-impaired individuals. METHODS: Data from population-based studies on eye diseases between 1980 to 2018 were compiled. Meta-regression models were performed to estimate the prevalence of blindness (presenting visual acuity <3/60) and moderate or severe vision impairment (MSVI; <6/18 to ≥3/60) attributed to DR. The estimates, with 95% uncertainty intervals [UIs], were stratified by age, sex, year, and region. RESULTS: In 2020, 1.07 million (95% UI: 0.76, 1.51) people were blind due to DR, with nearly 3.28 million (95% UI: 2.41, 4.34) experiencing MSVI. The GBD super-regions with the highest percentage of all DR-related blindness and MSVI were Latin America and the Caribbean (6.95% [95% UI: 5.08, 9.51]) and North Africa and the Middle East (2.12% [95% UI: 1.55, 2.79]), respectively. Between 2000 and 2020, changes in DR-related blindness and MSVI were greater among females than males, predominantly in the super-regions of South Asia (blindness) and Southeast Asia, East Asia, and Oceania (MSVI). CONCLUSIONS: Given the rapid global rise in diabetes and increased life expectancy, DR is anticipated to persist as a significant public health challenge. The findings emphasise the need for gender-specific interventions and region-specific DR healthcare policies to mitigate disparities and prevent avoidable blindness. This study contributes to the expanding body of literature on the burden of DR, highlighting the need for increased global attention and investment in this research area.


Subject(s)
Blindness , Diabetic Retinopathy , Global Health , Visually Impaired Persons , Humans , Blindness/epidemiology , Blindness/etiology , Diabetic Retinopathy/epidemiology , Prevalence , Visually Impaired Persons/statistics & numerical data , Visual Acuity/physiology , Male , Female , Sex Distribution
15.
J Craniofac Surg ; 35(5): 1449-1455, 2024.
Article in English | MEDLINE | ID: mdl-38838361

ABSTRACT

Facial fractures and their historical link to potential blindness have been well-documented, often attributed to optic canal injuries or retinal vascular occlusion. This dire consequence can result from both direct and indirect ocular trauma, including retrobulbar hemorrhage. Traumatic orbital compression can manifest in various forms, such as hematomas, fractured bone fragments, and emphysema, all posing a significant threat to vision, necessitating immediate intervention. In this study, 9 clinical cases of traumatic orbital compression are presented, each characterized by distinct etiologies. The study delves into traumatic orbital compressive syndromes, underscoring the critical imperative of early recognition and treatment to prevent vision loss. Orbital compression, whether from edema, hematoma, or emphysema, collectively culminates in elevated intraorbital pressure and the potential for optic nerve ischemia. Through the presentation of these 9 clinical cases, the article emphasizes the pressing need for timely intervention in addressing orbital compressive syndromes to avert vision loss. Various surgical techniques are elucidated, highlighting the pivotal role of expeditious medical intervention. This article offers invaluable insights into the diagnosis, management, and outcomes of traumatic orbital compressive syndromes.


Subject(s)
Orbital Diseases , Humans , Male , Adult , Female , Middle Aged , Orbital Diseases/etiology , Orbital Diseases/therapy , Orbital Diseases/surgery , Retrobulbar Hemorrhage/etiology , Orbital Fractures/surgery , Orbital Fractures/complications , Hematoma/etiology , Treatment Outcome , Emphysema/etiology , Emphysema/therapy , Edema/etiology , Syndrome , Aged , Tomography, X-Ray Computed , Blindness/etiology , Decompression, Surgical/methods
17.
Harefuah ; 163(5): 305-309, 2024 May.
Article in Hebrew | MEDLINE | ID: mdl-38734944

ABSTRACT

INTRODUCTION: Ocular inflammation, uveitis, represents over 40 distinct diseases, caused by infectious or non-infectious etiologies. Non-infectious uveitis may be related to systemic autoimmune diseases. Most uveitis patients are of working age, and prolonged disease may affect their independence and ability to work. Uveitis has various clinical manifestations and may result in the development of ocular complications and vision loss. Uveitis accounts for 10-15% of blindness in the developed world. Autoimmune diseases are increasing globally and often involve the eyes. Most cases occur in young active people and therefore any ocular changes have a longer effect. Symptoms may be mild but they might be severe, even blindness. It accounts for 10% to 15% of all causes of blindness among people of working age in the developed world. OBJECTIVES: To describe the ocular manifestation of uveitis related to systemic autoimmune diseases. We will describe ocular signs related to the disease and discuss the treatment approach to prevent the development of ocular complications and vision loss. METHODS: Review of clinical findings and treatment approach to non-infectious uveitis. CONCLUSIONS: Ocular involvement is commonly found in many autoimmune diseases. The severity of ocular disease varies between cases and complications may result in vision loss. Early diagnosis and treatment may prevent the development of ocular complications, maintaining visual acuity and patient independence.


Subject(s)
Autoimmune Diseases , Uveitis , Visual Acuity , Humans , Autoimmune Diseases/diagnosis , Uveitis/etiology , Uveitis/diagnosis , Blindness/etiology , Severity of Illness Index , Early Diagnosis
18.
Harefuah ; 163(5): 310-314, 2024 May.
Article in Hebrew | MEDLINE | ID: mdl-38734945

ABSTRACT

INTRODUCTION: Corneal disease is among the leading reversible causes of blindness worldwide. Corneal transplantation is a successful and curative treatment for most of these cases. However, in certain indications it is not amendable for standard corneal transplantation, the only available option to restore functional vision is keratoprosthesis (KPro) implantation. KPros may also offer an alternative to the global shortage of donor corneas, limiting the access to transplantations. However, current KPros face many challenges, including surgical complexity that requires skilled surgeons and vast resources as well as unique surgical and post-operative complications. Although several artificial corneas have been proposed over the years, two implants are mostly used in the clinical setting today. The first, the Boston KPro, consists of a front plate with an optical stem and a back plate snapped together with donor corneal tissue in-between, which is then sutured to the patient's cornea. The second, the Osteo-odonto-keratoprosthesis (OOKP), uses biological tissue of the alveolar bone to support an optical cylinder within the eye. The indications, surgical techniques, and complication profile of the two procedures are different and will be discussed in this review. Extensive research continues to improve the accessibility and technological developments of KPros in the search for a potential breakthrough in the treatment of these difficult cases.


Subject(s)
Cornea , Corneal Diseases , Corneal Transplantation , Prostheses and Implants , Humans , Corneal Diseases/surgery , Corneal Transplantation/methods , Cornea/surgery , Artificial Organs , Blindness/etiology , Postoperative Complications
19.
Harefuah ; 163(5): 298-304, 2024 May.
Article in Hebrew | MEDLINE | ID: mdl-38734943

ABSTRACT

INTRODUCTION: Glaucoma is a progressive optic neuropathy and is the leading cause of preventable irreversible blindness worldwide. Glaucoma causes progressive visual field loss and can have significant implications on the patient's quality of life. Lowering intraocular pressure (IOP) is the only treatment proven to prevent vision loss from glaucoma. It is achieved using medication, laser treatment and surgery. The treatment paradigm of glaucoma has been one whereby surgical intervention has been left for advanced cases due to a variety of reasons, mainly concerning safety and long term success. The past two decades have seen a paradigm shift towards earlier IOP lowering interventions using a wide array of different technologies in the laser and surgical spaces. This review aims to understand the background to this paradigm shift, its necessity, and its potential impact on the vision and life of glaucoma patients.


Subject(s)
Glaucoma , Intraocular Pressure , Laser Therapy , Quality of Life , Humans , Glaucoma/therapy , Glaucoma/surgery , Intraocular Pressure/physiology , Laser Therapy/methods , Blindness/etiology , Blindness/prevention & control , Visual Fields/physiology , Disease Progression , Optic Nerve Diseases/etiology , Optic Nerve Diseases/therapy
20.
PLoS One ; 19(5): e0294371, 2024.
Article in English | MEDLINE | ID: mdl-38776330

ABSTRACT

PURPOSE: To determine the prevalence and causes of blindness and visual impairment among adults in Kogi, Nigeria. METHODS: A Rapid assessment of avoidable blindness (RAAB) protocol was used with additional tools measuring disability and household wealth to measure the prevalence of blindness and visual impairment (VI) and associations with sex, disability, wealth, cataract surgical coverage and its effectiveness. RESULTS: Age- and sex-adjusted all-cause prevalence of bilateral blindness was 3.6% (95%CI 3.0-4.2%), prevalence of blindness among people living with additional, non-visual disabilities was 38.3% (95% CI 29.0-48.6%) compared to 1.6% (95%CI 1.2-2.1%; [Formula: see text] = 771.9, p<0.001) among people without additional disabilities. Cataract was the principal cause of bilateral blindness (55.3%). Cataract surgical coverage (CSC) at visual acuity (VA) 3/60 was 48.0%, higher among men than women (53.7% vs 40.3%); 12.0% among people with non-visual disabilities; 66.9% among people without non-visual disabilities, being higher among people in the wealthiest two quintiles (41.1%) compared to the lowest three (24.3%). Effective Cataract Surgical Coverage at Visual Acuity 6/60 was 31.0%, higher among males (34.9%) than females (25.5%), low among people with additional, non-visual disabilities (1.9%) compared to people with no additional disabilities (46.2%). Effective CDC was higher among people in the wealthiest two quintiles (411%) compared to the poorest three (24.3%). Good surgical outcome (VA>6/18) was seen in 61 eyes (52.6%) increasing to 71 (61.2%) eyes with best correction. Cost was identified as the main barrier to surgery. CONCLUSION: Findings suggest there exists inequalities in eye care with women, poorer people and people with disabilities having a lower Cataract Surgical Coverage, thereby, underscoring the importance of eye care programs to address these inequalities.


Subject(s)
Blindness , Humans , Nigeria/epidemiology , Male , Female , Blindness/epidemiology , Blindness/etiology , Middle Aged , Prevalence , Aged , Adult , Cataract/epidemiology , Cataract/complications , Cataract Extraction/statistics & numerical data , Visual Acuity , Adolescent , Young Adult , Aged, 80 and over , Disabled Persons/statistics & numerical data
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