Influência do selamento dentinário imediato com sistema adesivo universal na resistência de união / Influence of immediate dentin sealing on dentin bond strength with universal adhesive system

Resumo Introdução O selamento dentinário imediato consiste na aplicação imediata de um sistema adesivo sobre exposições dentinárias após o preparo dental e previamente aos procedimentos de moldagem. Objetivo O objetivo do estudo foi avaliar a influência do selamento dentinário imediato (SDI) na resistência adesiva do sistema adesivo universal (Single Bond Universal, 3M ESPE) em dentina, na forma de aplicação autocondicionante. Material e método 30 incisivos bovinos foram divididos em 3 grupos (n = 10): grupo S (Sem Selamento Dentinário Imediato), grupo SDI (Selamento Dentinário Imediato) e grupo SDIF (Selamento Dentinário Imediato + Resina Flow). A superfície vestibular foi desgastada com pontas diamantadas até a exposição superficial de dentina. A simulação da lama dentinária foi realizada com lixa d'água por 30s e a dentina tratada de acordo com o respectivo grupo. Para simulação da restauração provisória, foram cimentados blocos de resina bisacrílica com cimento de óxido de zinco. Após 7 dias, foi realizada a cimentação definitiva de blocos de resina com cimento resinoso dual (RelyX ARC, 3M ESPE). Os espécimes foram seccionados para obtenção de filetes de 1mm2 e submetidos ao teste de microtração, em uma máquina universal de ensaios (Instron). Os resultados foram tabulados e submetidos a Análise de Variância (ANOVA) e teste de Tukey a 5% de significância. Resultado Observaram-se maiores valores de resistência de união para o grupo SDIF (23,53 MPa), diferindo estatisticamente do Grupo S (17,65 MPa) (p=0,008). O grupo SDI apresentou valor médio de resistência de união (19,25 MPa), não diferindo estatisticamente dos grupos S (p=0,68) e SDIF (p=0,07). Conclusão Recomenda-se a técnica de selamento dentinário imediato seguido da uma camada de resina flow, em exposições dentinárias ocasionadas pelo preparo dental para restaurações indiretas.

Abstract Introduction Imediate dentin sealing (IDS) is a procedure where a dentin adhesive is applied on the exposed dentin surfaces after its preparation to indirect restorations and before impression procedures. Objective The objective of the study was to evaluate the effectiveness of the immediate dentin sealing technique (SDI) in adhesive resistance, using the Universal adhesive system (Single Bond Universal, 3M ESPE). Material and method 30 bovine incisors were selected and divided into 3 groups (n = 10): Groups S (Without Immediate Dentin Seal), SDI (Immediate Dentin Seal with Adhesive) and SDIF (Immediate Dentin Seal with Adhesive + Flow Resin). The vestibular surface was worn with diamond-tipped conical tips until superficial dentin exposure. The smear layer simulation was carried out with # 600 granulation sandpaper for 30s and the dentin was treated according to the respective group. To simulate the temporary restoration, blocks of bisacrylic resin were cemented with zinc oxide cement. After 7 days, the final cementation of resin blocks with dual resin cement (RelyX ARC, 3M ESPE) was carried out. The specimens were sectioned to obtain 1mm2 fillets and subjected to the microtensile test. Result The ANOVA test showed a statistical difference between the groups evaluated. Higher values of bond strength were observed for the SDIF group (23.53 MPa), differing statistically from Group S (17,65 MPa) (p = 0.008). The SDI group showed an average bond strength (19.25 MPa), which did not differ statistically from groups S (p = 0.68) and SDIF (p = 0.07). Conclusion Based on the results, it is recommended the immediate dental sealing technique with adhesive + flow resin in dental exposures caused in the dental preparation for indirect restorations.

Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin.

Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive physiology. In previous studies of adult mice, we detected that HEXr induced significantly reduced ovulation rate and significant correlation coefficients between sexual maturation and corporal weight in offspring. In this study, we investigated the effects of chronic HEXr administration on sperm concentration and functional activity, oestrous cyclicity and pregnancy index, in addition to the number of fetuses and its correlation with the number of corpora lutea. Adult Albino swiss mice were injected (sc) daily with HEXr: 100 µgkg(-1) day(-1) (HEXr D1) or 200 µgkg(-1) day(-1) (HEXr D2) for 53 days in males and 30 days in females. We detected a significantly decreased ratio in the number of fetuses per corpora lutea in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy, in addition to a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue. Although we did not find any significant effect on additional parameters evaluated in both genders, we propose certain effects of HEXr on the implantation process and/or early development of embryos and over the in vivo reproductive capability of males.

Reproductive performance of prepubertal Bos indicus heifers after progesterone-based treatments.

The objective was to evaluate the effects of exogenous progesterone (P4) on reproductive performance of prepubertal Bos indicus heifers. Prepubertal Nelore heifers (n = 589; 24.0 +/- 1.13 mo; 298.0 +/- 1.89 kg; body condition score of 3.2 +/- 0.26; mean +/- SEM) were randomly assigned to receive, between experimental Days -12 and 0: no treatments (CIDR0; n = 113); a new intravaginal insert (CIDR) containing 1.9 g of P4 (CIDR1; n = 237); or a similar insert previously used three times, with each use occurring for 9 d (CIDR4; n = 239). An additional treatment group was pubertal heifers given 12.5 mg dinoprost tromethamine im on Day 0 (PGF; n = 346), and used as controls for evaluation of conception rates. On Day 0, transrectal palpation was done for uterine score evaluation (UtS; 1-3 scale), blood samples were taken for serum P4 concentrations, and follicle diameter (FD) was measured. The breeding season started on Day 1 and consisted of AI after detection of estrus between Days 1 and 45, and exposure to bulls between Days 46 and 90. There were effects of treatment (P < 0.05) on serum concentrations of P4 on Day 0 (0.37 +/- 0.16, 2.31 +/- 0.11, and 1.20 +/- 0.11 ng/mL for CIDR0, CIDR1, and CIDR4, respectively; mean +/- SEM), FD on Day 0 (9.45 +/- 0.24, 9.72 +/- 0.17, and 11.42 +/- 0.16 mm), UtS on Day 0 (1.49 +/- 0.06, 1.88 +/- 0.04, and 2.24 +/- 0.04), estrus detection rates at 7 d (19.5, 42.6, and 38.3%) and 45 d (52.2, 72.1, and 75.3%) of the breeding season, and on pregnancy rates at 7 d (5.3, 14.3, and 18.4%), 45 d (27.4, 39.2, and 47.7%) and 90 d (72.6, 83.5, and 83.7%) of the breeding season. Conception rate 7 d after the start of the breeding season was greater (P < 0.05) in heifers from the CIDR4 (46.8%) and PGF (43.8%) groups than in the CIDR0 (27.3%) and CIDR1 (33.7%) groups. In conclusion, exogenous P4 hastened puberty and improved pregnancy rates at the beginning of the breeding season in prepubertal Bos indicus heifers. Furthermore, previously used CIDR inserts were better than new inserts.

The nutrition intervention improved adult human capital and economic productivity.

This article reviews key findings about the long-term impact of a nutrition intervention carried out by the Institute of Nutrition of Central America and Panama from 1969 to 1977. Results from follow-up studies in 1988-89 and 2002-04 show substantial impact on adult human capital and economic productivity. The 1988-89 study showed that adult body size and work capacity increased for those provided improved nutrition through age 3 y, whereas the 2002-04 follow-up showed that schooling was increased for women and reading comprehension and intelligence increased in both men and women. Participants were 26-42 y of age at the time of the 2002-04 follow-up, facilitating the assessment of economic productivity. Wages of men increased by 46% in those provided with improved nutrition through age 2 y. Findings for cardiovascular disease risk factors were heterogeneous; however, they suggest that improved nutrition in early life is unlikely to increase cardiovascular disease risk later in life and may indeed lower risk. In conclusion, the substantial improvement in adult human capital and economic productivity resulting from the nutrition intervention provides a powerful argument for promoting improvements in nutrition in pregnant women and young children.

A survey of patients with alcohol related problems in Carlton House, St. George's Grenada

Two years after the opening in Grenada of the Carlton House Alcoholism Treatment Centre, a review was conducted of the 45 persons admitted over a six-month period beginning February 1987, and a three month treatment outcome review was done. The review of admissions, using the CAGE questionnaire, shows findings similar to those in other hospital and field surveys in the Eastern Caribbean in terms of sex ratio (8 to 1), age of admission and age of first drink, social class distribution, choice of drink (rum) and a distribution of religious affiliation which reflects that of the population at large. Other characteristics of the Grenada study were that 25 of the 45 patients had first degree relatives who were alcoholic; half of the referrals were from a medical source, mainly the psychiatrist; although 1 in 12 general hospital admissions were diagnosed as suffering from alcoholism, only one fifth of these were referred to the Centre by physicians. One third of the patients had lost employment as a result of drinking. Treatment outcome was not improved by contact with Alcoholics Anonymous, but there was a better recovery rate among skilled than unskilled persons as judged by the number of relapses. Recommendations for improved staffing are made, as well as a plea for greater awareness of alcoholism on the part of physicians and surgeons (AU)