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1.
In. Soeiro, Alexandre de Matos; Leal, Tatiana de Carvalho Andreucci Torres; Accorsi, Tarso Augusto Duenhas; Gualandro, Danielle Menosi; Oliveira Junior, Múcio Tavares de; Caramelli, Bruno; Kalil Filho, Roberto. Manual da residência em cardiologia / Manual residence in cardiology. Santana de Parnaíba, Manole, 2 ed; 2022. p.545-547, tab.
Monography in Portuguese | LILACS | ID: biblio-1352997
2.
J Cardiovasc Electrophysiol ; 30(11): 2448-2452, 2019 11.
Article in English | MEDLINE | ID: mdl-31502385

ABSTRACT

INTRODUCTION: There are conflicting data regarding the efficacy of implantable cardioverter-defibrillator (ICD) in Chagas disease (CD) patients. This study aims to evaluate the short-term outcome after ICD for secondary prevention, in a population where CD is a prevalent cause of heart failure (HF). METHODS AND RESULTS: Consecutive patients with HF and reduced left ventricular ejection fraction (LVEF), who underwent ICD implantation for secondary prevention of SCD. Clinical and demographic data were collected to investigate mortality predictors at 1 year. During the study period, 117 patients underwent ICD implantation, of which 108 were included. The most frequent causes of HF was CD: 52 (48.1%) and ischemic cardiomyopathy: 20 (18.5%). Chagas and non-Chagas patients were well balanced-male: 32 (61.5%) vs 38 (67.9%), P = .548; age: 59.2 (±10.9) vs 56.8 (±13.4), P = .681; and LVEF: 34.1 (±0.2) vs 31.3 (±8.7), P = .064, respectively. At the mean follow-up of 15.7 months, overall mortality occurred in 14 (12.9%) patients, with a higher incidence in patients with CD cardiomyopathy, 11 (21.2%) vs 3 (5.4%), P = .021 (log-rank). In the multivariate analysis, CD remained as an independent predictor for death (hazard ratio: 4.62, confidence interval [95% CI]: 1.27-16.81, P = .021). CONCLUSION: CD was associated with a poor short-term outcome in patients with HF submitted to ICD implantation for secondary prevention when compared with other HF etiologies. In this specific HF population, ICD indication should be individualized, considering the worst prognosis of these patients.


Subject(s)
Chagas Cardiomyopathy/therapy , Defibrillators, Implantable , Electric Countershock/instrumentation , Heart Failure/therapy , Secondary Prevention/instrumentation , Adult , Aged , Brazil/epidemiology , Chagas Cardiomyopathy/diagnosis , Chagas Cardiomyopathy/mortality , Chagas Cardiomyopathy/physiopathology , Electric Countershock/adverse effects , Electric Countershock/mortality , Female , Heart Failure/diagnosis , Heart Failure/mortality , Heart Failure/physiopathology , Humans , Incidence , Male , Middle Aged , Prevalence , Retrospective Studies , Risk Assessment , Risk Factors , Stroke Volume , Time Factors , Treatment Outcome , Ventricular Function, Left
3.
Biomed Eng Online ; 18(1): 96, 2019 Sep 13.
Article in English | MEDLINE | ID: mdl-31519192

ABSTRACT

BACKGROUND: Considering the clinical importance of the ventricular fibrillation and that the most used therapy to reverse it has a critical side effect on the cardiac tissue, it is desirable to optimize defibrillation parameters to increase its efficiency. In this study, we investigated the influence of stimuli duration on the relationship between pacing threshold and defibrillation probability. RESULTS: We found out that 0.5-ms-long pulses had a lower ratio of defibrillation probability to the pacing threshold, although the higher the pulse duration the lower is the electric field intensity required to defibrillate the hearts. CONCLUSION: The appropriate choice of defibrillatory shock parameters is able to increase the efficiency of the defibrillation improving the survival chances after the occurrence of a severe arrhythmia. The relationship between pulse duration and the probability of reversal of fibrillation shows that this parameter cannot be underestimated in defibrillator design since different pulse durations have different levels of safety.


Subject(s)
Electric Countershock/methods , Heart/physiopathology , Animals , Electric Countershock/adverse effects , Male , Myocytes, Cardiac/pathology , Probability , Rats , Rats, Wistar , Safety , Time Factors
4.
Int J Cardiovasc Imaging ; 35(9): 1587-1596, 2019 Sep.
Article in English | MEDLINE | ID: mdl-30993507

ABSTRACT

Atrial fibrillation (AF) is the most common arrhythmia in humans. After successful cardioversion, there is a recurrence of 60% due to atrial remodeling, and it has been shown that the global peak atrial longitudinal strain (GPALS) is decreased in these subjects. The aim of this study was to evaluate the predictive value of GPALS for AF recurrence. A prospective cohort of patients with persistent (PnVAF) and long standing persistent non-valvular AF (LSPnVAF) which underwent electrical cardioversion was evaluated with standard echocardiographic variables and GPALS quantification. The primary endpoint was AF recurrence at 6 months. We included PnVAF (n = 50, aged 68.4 ± 10.2 years, female 46%, lasted AF 6 months) and LSPnVAF (n = 81, aged 66.5 ± 13.1 years, female 36%, lasted AF 18 months). At 6 months there were a 68% of recurrence of AF in PnVAF and 53% in LSPnVAF group. GPALS was lower in recurrence 7.8 ± 2.0% versus 21.2 ± 8.9% (p < 0.001) for PnVAF and 7.3 ± 2.7% versus 20.7 ± 7.6% (p < 0.001) in LSPnVAF. GPALS ≤ 10.75% discriminates recurrence at 6 months with a sensitivity of 85%, specificity 99%, PPV 85%, NPV 90%, LR + 8.5 and LR- 0.17. The independent predictors of recurrence in PnVAF were GPALS ≤ 10.75% HR 8.89 [(2.2-35.7), p < 0.01] meanwhile in LSPnVAF were age HR 1.039 [(1.007-1.071), p = 0.01], and GPALS ≤ 10.75% HR 28.1 [(7.2-109.1), p < 0.001]. In subjects with PnVAF and LSPnVAF with successful electrical cardioversion, GPALS ≤ 10.75% predicts arrhythmia recurrence at 6-month follow-up.


Subject(s)
Atrial Fibrillation/therapy , Atrial Function, Left , Echocardiography, Doppler, Pulsed/methods , Electric Countershock/adverse effects , Heart Atria/diagnostic imaging , Image Interpretation, Computer-Assisted/methods , Myocardial Contraction , Aged , Atrial Fibrillation/diagnostic imaging , Atrial Fibrillation/physiopathology , Biomechanical Phenomena , Female , Heart Atria/physiopathology , Humans , Male , Middle Aged , Predictive Value of Tests , Recurrence , Reproducibility of Results , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome
5.
Laryngoscope ; 129(8): 1949-1953, 2019 08.
Article in English | MEDLINE | ID: mdl-30444012

ABSTRACT

OBJECTIVES/HYPOTHESIS: Upper airway stimulation has demonstrated marked improvements in apnea-hypopnea index, oxygen desaturation index, and quality-of-life measures in patients with moderate to severe obstructive sleep apnea (OSA) who cannot tolerate continuous positive airway pressure. Cardiac arrhythmias are common in patients with OSA and can require electrical cardioversion. We describe the first four reported cases of hypoglossal nerve stimulator (HGNS) dysfunction after electrical cardioversion and illustrate our operative approach to device troubleshooting and repair. STUDY DESIGN: Retrospective case series. METHODS: A retrospective review of 201 HGNS implantations performed at two academic institutions revealed four cases of HGNS device dysfunction after electrical cardioversion requiring surgical revision. Preoperative and postoperative device performance metrics and electrical cardioversion specifications were retrospectively assessed and compiled for this case series. The senior authors (R.J.S., M.S.B.) detail operative planning and approach for HGNS implantable pulse generator (IPG) replacement. RESULTS: At least two patients with HGNS device dysfunction had received cardioversion via anterolateral electrode pad placement. Three patients had received multiple shocks. All four patients experienced a change in device functionality or complete cessation of functionality after electrocardioversion. Operatively, each patient required replacement of the IPG, with subsequent intraoperative interrogation revealing proper device functionality. CONCLUSION: Counseling for patients with HGNS undergoing external electrical cardioversion should include possible device damage and need for operative replacement. Anteroposterior electrode pad placement should be considered for patients with HGNS who require electrocardioversion. Operative replacement of an HGNS system damaged by electrocardioversion begins with IPG replacement and intraoperative device interrogation. LEVEL OF EVIDENCE: 4 Laryngoscope, 129:1949-1953, 2019.


Subject(s)
Arrhythmias, Cardiac/therapy , Electric Countershock/adverse effects , Electric Stimulation Therapy/instrumentation , Equipment Failure , Implantable Neurostimulators , Sleep Apnea, Obstructive/therapy , Aged , Arrhythmias, Cardiac/etiology , Female , Humans , Hypoglossal Nerve , Male , Quality of Life , Retrospective Studies , Sleep Apnea, Obstructive/complications
6.
Braz J Cardiovasc Surg ; 32(6): 498-502, 2017.
Article in English | MEDLINE | ID: mdl-29267613

ABSTRACT

INTRODUCTION: The implantable cardioverter defibrillator had been increasing the survival of patients at high risk for sudden cardiac death. The subcutaneous implantable cardioverter defibrillator was developed to mitigate the complications inherent to lead placement into cardiovascular system. OBJECTIVE: To report the initial experience of 18 consecutive cases of subcutaneous implantable cardioverter defibrillator implantation showing the indications, potential pitfalls and perioperative complications. METHODS: Between September 2016 and March 2017, 18 patients with indication for primary and secondary prevention of sudden cardiac death, with no concomitant indication for artificial cardiac pacing, were included. RESULTS: The implantation of the subcutaneous implantable cardioverter defibrillator successfully performed in 18 patients. It was difficult to place the subcutaneous lead at the parasternal line in two patients. One patient returned a week after the procedure complaining about an increase in pain intensity at pulse generator pocket site, which was associated with edema, temperature rising and hyperemia. Two patients took antialgic medication for five days after surgery. A reintervention was necessary in one patient to replace the lead in order to correct inappropriate shocks caused by myopotential oversensing. CONCLUSION: In our initial experience, although the subcutaneous implantable cardioverter defibrillator implantation is a less-invasive, simple-accomplishment procedure, it resulted in a bloodier surgery perhaps requiring an operative care different from the conventional. Inappropriate shock by oversensing is a reality in this system, which should be overcame in order not to become a limiting issue for its indication.


Subject(s)
Cardiac Pacing, Artificial/methods , Death, Sudden, Cardiac/prevention & control , Defibrillators, Implantable , Electric Countershock/instrumentation , Secondary Prevention/instrumentation , Ventricular Fibrillation/therapy , Death, Sudden, Cardiac/etiology , Defibrillators, Implantable/adverse effects , Electric Countershock/adverse effects , Female , Humans , Male , Middle Aged , Pacemaker, Artificial , Treatment Outcome , Ventricular Fibrillation/complications
7.
Rev. bras. cir. cardiovasc ; Rev. bras. cir. cardiovasc;32(6): 498-502, Nov.-Dec. 2017. tab, graf
Article in English | LILACS | ID: biblio-897968

ABSTRACT

Abstract Introduction: The implantable cardioverter defibrillator had been increasing the survival of patients at high risk for sudden cardiac death. The subcutaneous implantable cardioverter defibrillator was developed to mitigate the complications inherent to lead placement into cardiovascular system. Objective: To report the initial experience of 18 consecutive cases of subcutaneous implantable cardioverter defibrillator implantation showing the indications, potential pitfalls and perioperative complications. Methods: Between September 2016 and March 2017, 18 patients with indication for primary and secondary prevention of sudden cardiac death, with no concomitant indication for artificial cardiac pacing, were included. Results: The implantation of the subcutaneous implantable cardioverter defibrillator successfully performed in 18 patients. It was difficult to place the subcutaneous lead at the parasternal line in two patients. One patient returned a week after the procedure complaining about an increase in pain intensity at pulse generator pocket site, which was associated with edema, temperature rising and hyperemia. Two patients took antialgic medication for five days after surgery. A reintervention was necessary in one patient to replace the lead in order to correct inappropriate shocks caused by myopotential oversensing. Conclusion: In our initial experience, although the subcutaneous implantable cardioverter defibrillator implantation is a less-invasive, simple-accomplishment procedure, it resulted in a bloodier surgery perhaps requiring an operative care different from the conventional. Inappropriate shock by oversensing is a reality in this system, which should be overcame in order not to become a limiting issue for its indication.


Subject(s)
Humans , Male , Female , Middle Aged , Ventricular Fibrillation/therapy , Electric Countershock/instrumentation , Cardiac Pacing, Artificial/methods , Death, Sudden, Cardiac/prevention & control , Defibrillators, Implantable/adverse effects , Secondary Prevention/instrumentation , Pacemaker, Artificial , Ventricular Fibrillation/complications , Electric Countershock/adverse effects , Treatment Outcome , Death, Sudden, Cardiac/etiology
8.
J Am Heart Assoc ; 4(10): e002185, 2015 Oct 09.
Article in English | MEDLINE | ID: mdl-26452987

ABSTRACT

BACKGROUND: Targeted automated external defibrillator (AED) programs have improved survival rates among patients who have an out-of-hospital cardiac arrest (OHCA) in US airports, as well as European and Japanese railways. The Sao Paulo (Brazil) Metro subway carries 4.5 million people per day. A targeted AED program was begun in the Sao Paulo Metro with the objective to improve survival from cardiac arrest. METHODS AND RESULTS: A prospective, longitudinal, observational study of all cardiac arrests in the Sao Paulo Metro was performed from September 2006 through November 2012. This study focused on cardiac arrest by ventricular arrhythmias, and the primary endpoint was survival to hospital discharge with minimal neurological impairment. A total of 62 patients had an initial cardiac rhythm of ventricular fibrillation. Because no data on cardiac arrest treatment or outcomes existed before beginning this project, the first 16 months of the implementation was used as the initial experience and compared with the subsequent 5 years of full operation. Return of spontaneous circulation was not different between the initial 16 months and the subsequent 5 years (6 of 8 [75%] vs. 39 of 54 [72%]; P=0.88). However, survival to discharge was significantly different once the full program was instituted (0 of 8 vs. 23 of 54 [43%]; P=0.001). CONCLUSIONS: Implementation of a targeted AED program in the Sao Paulo Metro subway system saved lives. A short interval between arrest and defibrillation was key for good long-term, neurologically intact survival. These results support strategic expansion of targeted AED programs in other large Latin American cities.


Subject(s)
Cardiopulmonary Resuscitation/instrumentation , Death, Sudden, Cardiac/prevention & control , Defibrillators , Electric Countershock/instrumentation , Out-of-Hospital Cardiac Arrest/therapy , Railroads , Urban Health Services , Ventricular Fibrillation/therapy , Aged , Brazil , Cardiopulmonary Resuscitation/adverse effects , Cardiopulmonary Resuscitation/mortality , Electric Countershock/adverse effects , Electric Countershock/mortality , Emergency Medical Services , Female , Humans , Longitudinal Studies , Male , Middle Aged , Out-of-Hospital Cardiac Arrest/diagnosis , Out-of-Hospital Cardiac Arrest/mortality , Out-of-Hospital Cardiac Arrest/physiopathology , Patient Admission , Patient Discharge , Program Evaluation , Prospective Studies , Recovery of Function , Risk Factors , Time Factors , Time-to-Treatment , Transportation of Patients , Treatment Outcome , Ventricular Fibrillation/diagnosis , Ventricular Fibrillation/mortality , Ventricular Fibrillation/physiopathology
9.
JACC Cardiovasc Interv ; 8(7): 984-90, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26088516

ABSTRACT

OBJECTIVES: This study aimed to assess 6-month outcomes in patients with implantable cardioverter-defibrillators (ICDs) undergoing renal sympathetic denervation (RSD) for refractory ventricular arrhythmias (VAs). BACKGROUND: ICDs are generally indicated for patients at high risk of malignant VAs. Sympathetic hyperactivity plays a critical role in the development, maintenance, and aggravation of VAs. METHODS: A total of 10 patients with refractory VA underwent RSD. Underlying conditions were Chagas disease (n = 6), nonischemic dilated cardiomyopathy (n = 2), and ischemic cardiomyopathy (n = 2). Information on the number of ventricular tachycardia (VT)/ventricular fibrillation (VF) episodes and device therapies (antitachycardia pacing/shocks) in the previous 6 months as well as 1 and 6 months post-treatment was obtained from ICD interrogation. RESULTS: The median number of VT/VF episodes/antitachycardia pacing/shocks 6 months before RSD was 28.5 (range 1 to 106)/20.5 (range 0 to 52)/8 (range 0 to 88), respectively, and was reduced to 1 (range 0 to 17)/0 (range 0 to 7)/0 (range 0 to 3) at 1 month and 0 (range 0 to 9)/0 (range 0 to 7)/0 (range 0 to 3) at 6 months afterward, respectively. There were no major procedure-related complications. Two patients experienced sustained VT within the first week; in both cases, no further episodes occurred during follow-up. Two patients were nonresponders: 1 with persistent idioventricular rhythm and 1 with multiple renal arteries and incomplete ablation. Three patients died during follow-up. None of the deaths was attributed to VA. CONCLUSIONS: In patients with ICDs and refractory VAs, RSD was associated with reduced arrhythmic burden with no procedure-related complications. Randomized controlled trials investigating RSD for treatment of refractory VAs in patients with increased sympathetic activity are needed.


Subject(s)
Defibrillators, Implantable , Electric Countershock/instrumentation , Kidney/blood supply , Renal Artery/innervation , Sympathectomy/methods , Tachycardia, Ventricular/therapy , Ventricular Fibrillation/therapy , Aged , Brazil , Catheter Ablation/adverse effects , Electric Countershock/adverse effects , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Factors , Sympathectomy/adverse effects , Tachycardia, Ventricular/diagnosis , Tachycardia, Ventricular/physiopathology , Time Factors , Treatment Outcome , Ventricular Fibrillation/diagnosis , Ventricular Fibrillation/physiopathology
10.
RELAMPA, Rev. Lat.-Am. Marcapasso Arritm ; 28(1): 19-22, jan.-mar.2015.
Article in Portuguese | LILACS, Sec. Est. Saúde SP | ID: lil-773027

ABSTRACT

O soco precordial, descrito na década de 1960, tem sua utilidade questionada nas bradiarritmiase pode gerar taquiarritmias. Apresentamos o caso de paciente do sexo masculino, com 24 anos de idade, semantecedentes cardiovasculares relevantes e com história de palpitações recorrentes desde os 17 anos, que, apóscardioversão elétrica durante monitorização para realização de ablação por cateter, apresentou assistolia por mais de30 segundos, mantido com punho percussão, cujo registro pode demonstrar a eficácia em induzir a despolarizaçãoventricular. Duas considerações são relevantes nesse contexto: 1) presença de assistolia pós-cardioversão, compoucos relatos na literatura, relacionada a disfunção sinusal ou a uso de fármacos (que não é o caso de nossorelato, que pode ter sido induzida pelo reflexo vagal produzido pela cardioversão elétrica); e 2) impacto precordial,que produz aumento da pressão ventricular, distensão miocárdica, ativação dos canais iônicos e consequentedespolarização, gerando batimentos eficazes, capazes de manter a estabilidade hemodinâmica. A cardioversãoelétrica pode induzir a assistolia e o soco precordial pode ser útil na assistolia.


The use of precordial thump, described in the 60s, has been questioned in the management ofbradyarrhythmias and due the potential to generate tachyarrhythmias. We present the case of a 24-years-old malepatient, without relevant cardiovascular history, with recurrent palpitations since the age of 17, who after electricalcardioversion during monitoring for a catheter ablation procedure, developed asystole for over 30 seconds, treatedby precordial thump, whose recording demonstrates its effectiveness in inducing ventricular depolarization. Tworelevant considerations in ventricular depolarization induction: 1) the presence of asystole after cardioversionwith few reports in the literature attributed to sinus node dysfunction or drug therapy (which is not the caseof our patient, that may have been induced by the vagal reflexes produced by electrical cardioversion); and 2)the precordial impact, that increases ventricular pressure, myocardial stretch, activation of ion channels andsubsequent depolarization, generating effective beats, capable of maintaining hemodynamic stability. Electricalcardioversion may induce asystole and the precordial thump may be helpful in asystole.


Subject(s)
Humans , Male , Adult , Electric Countershock/adverse effects , Heart Arrest/diagnosis , Tachycardia, Atrioventricular Nodal Reentry/therapy , Echocardiography , Electrocardiography , Propofol/adverse effects
11.
Cardiol J ; 21(4): 397-404, 2014.
Article in English | MEDLINE | ID: mdl-24293165

ABSTRACT

BACKGROUND: The aim of this study was to compare the outcome of 3 months vs. 18 months of amiodarone treatment after atrial fibrillation (AF) conversion in patients who experienced the first episode of persistent AF. METHODS: We included 51 patients who experienced the first episode of persistent AF receiving amiodarone (600 mg) daily for 4-6 weeks. If AF persisted, electrical cardioversion (ECV) was performed. All patients received amiodarone (200 mg daily) for 3 months and then were randomized to amiodarone (Group I) or placebo (Group II) and followed for 15 months. The control group comprised 9 untreated patients undergoing ECV. Treatment effectiveness was evaluated using a Bayesian model. RESULTS: Eighteen months after AF reversion, 22 (81.5%) patients in Group I, 13 (54.2%) patients in Group II, and 1 (11.1%) patient in the control group remained in sinus rhythm. No differences were found between Group I patients who required ECV and Group II patients. Sinus rhythm was preserved in all Group I patients when it was achieved during amiodarone administration. Limiting adverse effects occurred in 3 (11.1%) patients in Group I. CONCLUSIONS: In patients regaining sinus rhythm after the first episode of persistent AF, a 3-month amiodarone treatment after reversion is a reasonable option for rhythm control.


Subject(s)
Amiodarone/administration & dosage , Anti-Arrhythmia Agents/administration & dosage , Atrial Fibrillation/therapy , Electric Countershock , Heart Conduction System/drug effects , Heart Rate/drug effects , Aged , Aged, 80 and over , Argentina , Atrial Fibrillation/diagnosis , Atrial Fibrillation/physiopathology , Bayes Theorem , Combined Modality Therapy , Disease-Free Survival , Double-Blind Method , Drug Administration Schedule , Echocardiography, Doppler , Electric Countershock/adverse effects , Electrocardiography, Ambulatory , Female , Heart Conduction System/physiopathology , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Recurrence , Time Factors , Treatment Outcome
12.
Europace ; 15(7): 957-62, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23376978

ABSTRACT

AIMS: Implantable cardioverter-defibrillators (ICDs) are now a first-line option for prevention of sudden death in Chagas disease (ChD). However, efficacy and safety of ICD treatment in ChD remains controversial. The aim of our study was to compare clinical outcome after ICD implantation in ChD and non-ChD patients. METHODS AND RESULTS: The study population consists of patients who received ICD implantation in a tertiary Reference Center for ChD in Brazil. The primary endpoint of the study was appropriate therapy (appropriate shocks or anti-tachycardia pacing); the secondary endpoint was the event-free survival defined as absence of death or appropriate therapy. One hundred and thirty-five [corrected] patients were followed for the median time of 266 days. Sixty-five patients had ChD. Appropriate ICD therapy occurred in 32 (49.2%) ChD and in 19 (27.1%) non-ChD patients (P=0.005). Ventricular tachycardia occurred in 27 (42%) ChD and in 16 (23%) non-ChD (P = 0.01) patients. There was a statistically significant difference in event-free survival between the group of patients with and without ChD (P=0.004). The median event-free survival was 230 days (95% confidence interval, CI: 113-347) in patients with ChD and 549 days (95% CI: 412-687) in non-ChD patients. Chagas disease double the risk of the patient to have appropriate therapy (hazard ratio, HR = 2.2, 95% CI = 1.2-4.3, P = 0.02) and appropriate therapy or death (HR = 2.2, 95% CI = 1.2-4.2, P = 0.01) in multivariate analysis. There were 16 deaths (11.8%) with 8 deaths in each group and five inappropriate shocks (3.7%) with one in ChD patients (1.6%). CONCLUSION: The higher frequency of appropriate ICD therapy and the shorter event-free survival in ChD patients are consistent with the presence of an arrhythmogenic substrate that characterizes this cardiomyopathy.


Subject(s)
Arrhythmias, Cardiac/prevention & control , Chagas Cardiomyopathy/therapy , Death, Sudden, Cardiac/prevention & control , Defibrillators, Implantable , Electric Countershock/instrumentation , Aged , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/mortality , Brazil , Chagas Cardiomyopathy/complications , Chagas Cardiomyopathy/diagnosis , Chagas Cardiomyopathy/mortality , Death, Sudden, Cardiac/etiology , Disease-Free Survival , Electric Countershock/adverse effects , Electric Countershock/mortality , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Multivariate Analysis , Proportional Hazards Models , Retrospective Studies , Risk Factors , Tertiary Care Centers , Time Factors , Treatment Outcome
13.
Rev. chil. med. intensiv ; 27(3): 177-183, 2012. ilus, tab
Article in Spanish | LILACS | ID: biblio-831355

ABSTRACT

El manejo del paciente con descargas frecuentes será dependientedel número de las descargas recibidas, de si estas sonapropiadas o no, de la condición clínica preexistente yposterior a las descargas, de los factores gatillantes que seidentifiquen y corrijan y de la colaboración de un equipomultidisciplinario, encabezado por el médico de urgencias yposteriormente el Intensivista de turno, la asesoría de uncardiólogo electrofisiólogo y personal del equipo de psiquiatría...


The management of patients with frequent shocks episodeswill be dependent on the number of shocks received,appropriate and inappropriate shocks episodes, pre-existingmedical condition and after shock, triggering factors areidentified and corrected and the collaboration of a multidisciplinaryteam, led by the emergency physician and later theintensivist, the advice of a cardiologist and electrophysiologist,and psychiatry team personnel...


Subject(s)
Humans , Anti-Arrhythmia Agents/therapeutic use , Electric Countershock/adverse effects , Defibrillators, Implantable/adverse effects
14.
Clinics (Sao Paulo) ; 65(3): 291-6, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20360920

ABSTRACT

OBJECTIVES: Cold exposure induces glycogen and lipid depletion in the liver and the adrenal gland, respectively. However, no previous study has determined the effects of electrical countershock on those tissues. We aimed to evaluate the effects of electrical countershock on lipid depletion in the adrenal gland and on glycogen depletion in the liver. METHODS: We used 40 male Wistar rats divided into four groups: the control group, in which the animals were subjected to a resting period of seven days; the electrical discharge group, in which the animals were subjected to a resting period followed by administration of ten 300-mV electrical discharges; the electrical post-discharge group, in which the animals received ten electrical shocks (300 mV) followed by rest for seven consecutive days; and the cold stress group, in which the animals were subjected to a resting period and were then exposed to -8 degrees C temperatures for four hours. All animals underwent a laparotomy after treatment. The lipid and glycogen depletions are presented using intensity levels (where + = low intensity and ++++ = high intensity, with intermediate levels in between). RESULTS: The rats exposed to the cold stress presented the highest glycogen and lipid depletion in the liver and the adrenal gland, respectively. Furthermore, we noted that the electrical countershock significantly increased lipid depletion in the adrenal gland and glycogen depletion in the liver. One week after the electrical countershock, the liver and adrenal gland profiles were similar to that of the control group. CONCLUSION: Electrical countershock immediately increased the glycogen depletion in the liver and the lipid depletion in the adrenal gland of rats.


Subject(s)
Adrenal Glands/metabolism , Electric Countershock/adverse effects , Hypothermia, Induced/adverse effects , Lipid Metabolism/physiology , Liver Glycogen/metabolism , Liver/metabolism , Animals , Male , Models, Animal , Random Allocation , Rats , Rats, Wistar , Statistics, Nonparametric
15.
Clinics ; Clinics;65(3): 291-296, 2010. ilus, tab
Article in English | LILACS | ID: lil-544008

ABSTRACT

OBJECTIVES: Cold exposure induces glycogen and lipid depletion in the liver and the adrenal gland, respectively. However, no previous study has determined the effects of electrical countershock on those tissues. We aimed to evaluate the effects of electrical countershock on lipid depletion in the adrenal gland and on glycogen depletion in the liver. METHODS: We used 40 male Wistar rats divided into four groups: the control group, in which the animals were subjected to a resting period of seven days; the electrical discharge group, in which the animals were subjected to a resting period followed by administration of ten 300-mV electrical discharges; the electrical post-discharge group, in which the animals received ten electrical shocks (300 mV) followed by rest for seven consecutive days; and the cold stress group, in which the animals were subjected to a resting period and were then exposed to -8ºC temperatures for four hours. All animals underwent a laparotomy after treatment. The lipid and glycogen depletions are presented using intensity levels (where + = low intensity and ++++ = high intensity, with intermediate levels in between). RESULTS: The rats exposed to the cold stress presented the highest glycogen and lipid depletion in the liver and the adrenal gland, respectively. Furthermore, we noted that the electrical countershock significantly increased lipid depletion in the adrenal gland and glycogen depletion in the liver. One week after the electrical countershock, the liver and adrenal gland profiles were similar to that of the control group. CONCLUSION: Electrical countershock immediately increased the glycogen depletion in the liver and the lipid depletion in the adrenal gland of rats.


Subject(s)
Animals , Male , Rats , Adrenal Glands/metabolism , Electric Countershock/adverse effects , Hypothermia, Induced/adverse effects , Lipid Metabolism/physiology , Liver Glycogen/metabolism , Liver/metabolism , Models, Animal , Random Allocation , Rats, Wistar , Statistics, Nonparametric
16.
Arq Bras Cardiol ; 86(3): 191-7, 2006 Mar.
Article in Portuguese | MEDLINE | ID: mdl-16612445

ABSTRACT

OBJECTIVE: Evaluate, based on the evolution of new biochemical markers of cardiac damage, if electrical cardioversion (ECV) causes myocardial injury. METHODS: Seventy-six patients (P) submitted to elective ECV for atrial fibrillation or atrial flutter were evaluated. Creatine phosphokinase (CPK), CK-MB activity, CK-MB mass, myoglobin and cardiac troponin I (cTnI) were measured before, and 6 and 24 hours after ECV. RESULTS: ECV was successful in 58 P (76.3%). Cumulative energy (CE) was up to 350 joules (J) in 36 P, from 500 to 650 J in 20 P and from 900 to 960 J in 20 P; the mean energy delivered being 493 J (+/- 309). The levels of cTnI remained within normal limits in all 76 P. The increase of cumulative energy led to an elevation of CPK levels (> p value = 0.007), CK-MB activity (> p value = 0.002), CK-MB mass (> p value = 0.03), and myoglobin (> p value = 0.015). A positive correlation between the cumulative energy and CPK peaks was observed (r = 0.660; p < 0.001), CK-MB activity (r = 0.429; p < 0.0001), CK-MB mass (r = 0.265; p = 0.02), and myoglobin (r = 0.684; p < 0.0001), as well as between the number of shocks and the CPK peaks (r = 0.770; p < 0.001), CK-MB activity (r = 0.642; p < 0.0001), CK-MB mass (r = 0.430; p < 0.0001), and myoglobin (r = 0.745; p < 0.0001). CONCLUSION: ECV does not cause myocardial injury detectable by cTnI measurement. Elevations of CPK, CK-MB activity, CK-MB mass and myoglobin result from skeletal muscle injury and are positively correlated with the CE delivered or with the number of shocks.


Subject(s)
Creatine Kinase, MB Form/blood , Electric Countershock/adverse effects , Heart Injuries/etiology , Myoglobin/blood , Troponin I/blood , Analysis of Variance , Atrial Fibrillation/therapy , Atrial Flutter/therapy , Biomarkers/blood , Female , Heart Injuries/blood , Humans , Male , Middle Aged , Time Factors
17.
Arq. bras. cardiol ; Arq. bras. cardiol;86(3): 191-197, mar. 2006. tab, graf
Article in Portuguese | LILACS, Sec. Est. Saúde SP | ID: lil-424261

ABSTRACT

OBJETIVO: Avaliar, através da evolução dos novos marcadores bioquímicos de injúria cardíaca, se a cardioversão elétrica (CVE) causa lesão miocárdica. MÉTODOS: Foram avaliados 76 pacientes (P) submetidos a CVE eletiva de fibrilação atrial ou flutter atrial. Medidas de creatinafosfoquinase (CPK), CKMB-atividade e dosagem de CKMB-massa (M), mioglobina e troponina I cardíaca (cTnI) foram determinadas antes e após 6 e 24 horas da CVE. RESULTADOS: A CVE resultou um sucesso em 58 P (76,3 por cento). A carga cumulativa (CC) foi de até 350 joules (J) em 36 P, de 500 a 650 J em 20 P e de 900 a 960 J em 20 P, com energia média aplicada de 493 J (± 309). A cTnI permaneceu dentro da normalidade nos 76 P. Com o aumento da CC, ocorreu elevação de CPK (> valor de p = 0,007), CKMB-atividade (> valor de p = 0,002), CKMB-M (> valor de p = 0,03) e mioglobina (> valor de p = 0,015). Correlação positiva foi observada entre a CC e picos de CPK (r = 0,660; p < 0,001), CKMB-atividade (r = 0,429; p < 0,0001), CKMB-M (r = 0,265; p = 0,02) e mioglobina (r = 0,684; p < 0,0001). Correlação também positiva ocorreu entre o número de choques e picos de CPK (r = 0,770; p < 0,001), CKMB-atividade (r = 0,642; p < 0,0001), CKMB-M (r = 0,430; p < 0,0001) e mioglobina (r = 0,745; p < 0,0001). CONCLUSÃO: A CVE não causa lesão miocárdica detectável pela dosagem da cTnI. Elevações de CPK, CKMB-atividade, CKMB-M e mioglobina são decorrentes de lesão do músculo esquelético, estando correlacionadas positivamente com a CC aplicada ou com o número de choques.


Subject(s)
Female , Humans , Male , Middle Aged , Creatine Kinase, MB Form/blood , Electric Countershock/adverse effects , Heart Injuries/etiology , Myoglobin/blood , Troponin I/blood , Analysis of Variance , Atrial Fibrillation/therapy , Atrial Flutter/therapy , Biomarkers/blood , Heart Injuries/blood , Time Factors
18.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 15(3): 268-280, maio-jun. 2005. ilus
Article in Portuguese | LILACS, Sec. Est. Saúde SP | ID: lil-426795

ABSTRACT

O suporte básico da vida, em sua essência, visa ao atendimento imediato da parada cardiorespiratória. O reconhecimento da parada cardiorespiratória, a realização de manobras de ressuscitação cardiopulmonar e de desfibrilação precoce assim como a chegada do suporte avançado estão diretamente relacionados com a sobrevida. A participação da população leiga no atendimento da parada cardiorespiratória é de fundamental importância, assim como a participação médica. As cidades e comunidades, em nosso país, precisam se empenhar para desenvolver métodos populacionais de esclarecimento e incentivo à busca por informações precisas do tratamento da parada cardiorespiratória. O mesmo deve ser observado na atividadae desportiva. Ressaltam-se as principais modificações nas novas diretrizes em emergências e ressuscitação em suporte básico de vida.


Subject(s)
Male , Female , Humans , Electric Countershock/adverse effects , Heart Arrest/complications , Resuscitation/methods , Death, Sudden/prevention & control
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