Subject(s)
Bilirubin/metabolism , Hyperbilirubinemia/metabolism , Crigler-Najjar Syndrome/genetics , Crigler-Najjar Syndrome/metabolism , Erythroblastosis, Fetal/metabolism , Humans , Hyperbilirubinemia, Hereditary/genetics , Hyperbilirubinemia, Hereditary/metabolism , Infant, Newborn , Jaundice, Chronic Idiopathic/genetics , Jaundice, Chronic Idiopathic/metabolism , Milk, Human/metabolism , SyndromeSubject(s)
Humans , Male , Female , Liver/anatomy & histology , Liver/physiology , Cholestasis , Bilirubin/metabolism , Hyperbilirubinemia, Hereditary/metabolism , Hepatitis, Viral, Human , Hepatitis, Chronic , Fatty Liver, Alcoholic , Fatty Liver , Liver Diseases, Parasitic , Liver Diseases, Alcoholic , Hypertension, Portal , Hepatic Encephalopathy , Hepatorenal Syndrome , Liver Cirrhosis, Biliary , Cholangitis, Sclerosing , Liver Neoplasms , TransplantsABSTRACT
Phenotyping of isoniazid acetylators in 19 Caucasoid patients with Gilbert's syndrome was achieved by evaluating the percentual of acetylisoniazid in the urine. The proportion of slow acetylators among the patients with Gilbert's syndrome was similar to those found among Caucasoids of control group. The conclusion was that Gilbert's syndrome doesn't interfere in the hepatic capacity of isoniazid acetylation.
Subject(s)
Gilbert Disease/metabolism , Hyperbilirubinemia, Hereditary/metabolism , Isoniazid/metabolism , Acetylation , Acetyltransferases/metabolism , Female , Humans , Isoniazid/analogs & derivatives , Isoniazid/urine , Liver/enzymology , Male , PhenotypeABSTRACT
Rotor's syndrome is a rare entity in our Country. We report here a case of this anomaly in a seventeen years old girl with jaundice from birth, normal biliary channels, elevated urinary coproporphyrins and retarded excretion of bromosulphalein with normal histology of the liver. The familiar study showed that the mother, but not the brothers, had a similar defect in excretion of bromosulphalein.