Síndrome de quilomicronemia: aspectos genéticos y revisión de la literatura / Chylomicronemia syndrome: genetic aspects and literature review

Chylomicronemia syndrome is a metabolic condition characterized by severe hypertriglyceridemia and fasting chylomicronemia, secondary to an alteration in the ability to metabolize triglycerides. It can respond to different etiologies, the most frequent being multifactorial. Familial chylomicronemia syndrome, on the other hand, represents an infrequent cause of chylomicronemia syndrome, showing an autosomal recessive inheritance pattern. It's caused by pathogenic variants in genes related to chylomicron's metabolism, mainly LPL1 gene. One of the main associated risks is the occurrence of acute pancreatitis, which can also have a recurrent course. The primary therapy goal in patients with this condition is prevention of pancreatitis and related comorbidities. The treatment basis consists in reduce chylomicron formation by restriction of dietary fat, in association with physical activity and pharmacologic therapy. It is important to distinguish the etiology of chylomicronemia syndrome since it has repercussions in terms of response to treatment, complications, and recurrence risk. (AU)

Gemfibrozil en el manejo de las dislipidemias / Genfibrozil in the management of hyperlipidemia

Propósito: evaluar la eficacia del Gemfibrozil en pacientes con Dislipidemias. Material y Métodos: Se estudiaron un total de 30 pacientes que consultaron la Emergencia de Adultos del Hospital Central de Valencia y el Centro Médico Lara, durante el lapso de tiempo comprendido entre enero a septiembre de 1992 por presentar dislipidemias

Hiperlipoproteinemias / Hyperlipoproteinemias

Os autores revisam o metabolismo das lipoproteínas plasmáticas e a fisiopatologia das hiperlipoproteínas primárias e secundárias. Säo descritos o quadro clínico e o manejo terapêutico de cada classe clínica