Subject(s)
Hyperpigmentation , Humans , Hyperpigmentation/pathology , Hyperpigmentation/etiology , Female , Male , AdultABSTRACT
A 19-year-old girl presented with symmetric and bilateral hyperpigmentation, an indurated lesion that initially appeared on the axillary fold at the age of 14, which then extended to the lower back, anterior aspect of both thighs, and popliteal fold. No hypertrichosis was observed (Figure 1).The patient was the youngest of the four children, born from the first-degree consanguineous marriage. She was born at full term and weighed 2,420 g at birth. No similar patient was present in the family. The patient experienced delayed motor acquisition and stature growth (3rd percentile) until the age of 4. Right hypoacusis was diagnosed at the age of 6. She developed hallux valgus, flexion contracture of the fin-gers and toes, barrel deformity of the anterior thorax, and recurrent fever. The laboratory tests, including fasting blood glucose, -triglycerides, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were normal. Her abdominal, pelvic, and transthoracic ultrasound scans were normal, with no hepatosplenomegaly, lymphadenopathy, or cardiac abnormalities. Histologic analysis demonstrated patchy acanthosis of the epidermis, with orthokeratotic hyperkeratosis. Keratinocyte hyperpigmentation and spongiosis at certain areas were observed with moder-ate inflammation because of the infiltration of lymphocytes, histiocytes, and plasma cells. Immunohistochemical analysis showed macrosialin (CD68+) and common gamma chain (γc) CD132. Germline mutations in the SLC29A3 gene were not analyzed. The patient was prescribed dermocorticoids with depigmentation therapy, which demonstrated moderate clinical evolution.
Subject(s)
Hyperpigmentation , Humans , Female , Morocco , Young Adult , Hyperpigmentation/pathology , Hyperpigmentation/diagnosis , Nucleoside Transport Proteins/genetics , Contracture/diagnosis , Hallux Valgus/pathology , Hallux Valgus/diagnosis , Hearing Loss, Sensorineural , HistiocytosisABSTRACT
This report describes a case of facial hyperpigmentation in a patient with Crohn's disease receiving adalimumab, a tumor necrosis factor (TNF)-alpha inhibitor. The onset of hyperpigmentation coincided with adalimumab administration, and its discontinuation resulted in significant improvement. Histopathological findings suggest a postinflammatory process at the dermo-epidermal junction. However, the precise mechanism remains unclear.
Subject(s)
Adalimumab , Crohn Disease , Hyperpigmentation , Humans , Adalimumab/adverse effects , Hyperpigmentation/chemically induced , Hyperpigmentation/pathology , Crohn Disease/drug therapy , Anti-Inflammatory Agents/adverse effects , Anti-Inflammatory Agents/therapeutic use , Female , Adult , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Face/pathology , MaleSubject(s)
Ferric Compounds , Maltose , Humans , Maltose/analogs & derivatives , Maltose/administration & dosage , Maltose/adverse effects , Ferric Compounds/administration & dosage , Ferric Compounds/adverse effects , Skin/pathology , Skin/drug effects , Hyperpigmentation/chemically induced , Hyperpigmentation/diagnosis , Hyperpigmentation/pathology , Female , Male , Administration, Intravenous , Middle Aged , Skin Pigmentation/drug effectsABSTRACT
Acquired circumscribed hyperpigmented patches and plaques have various differential diagnoses, including post-inflammatory hyperpigmentation and mycosis fungoides (MF). Leukomelanoderma is an uncommon cutaneous condition in which the pathogenesis is not fully elucidated. It has been reported that leukomelanoderma occurs after allergic contact dermatitis from hydroquinone or acute cutaneous graft-versus-host disease (1,2). Hyperpigmented MF is a cutaneous T-cell lymphoma with a frequent CD8+ phenotype (3). Herein, we report a case of leukomelanoderma clinically and histologically resembling hyperpigmented MF. A 55-year-old Japanese woman was referred to our department for evaluation of reticulate pigmentation with pruritic erythema on the face. She had used commercially available depigmenting cosmetic reagents for 20 years and ointment containing 10% hydroquinone for 3 months. Physical examination revealed diffuse hyperpigmentation and demarcated hypopigmented macules on the face and neck (Figure 1, a). Dermoscopy showed depigmented spots and reticulated plus dotted hyperpigmentation; it presented a pseudo-pigment network (Figure 1, b). Histological examination of a tissue specimen biopsied from the lesion showed superficial band-like lymphocytic infiltration in dermis accompanying single cells or small clusters in epidermis (Figure 1, c). Interface changes were observed together with melanophages in the dermis. Melan-A-positive melanocytes were absent. Immunohistochemical analysis demonstrated that the epidermotropic lymphocytes were CD3+CD7-, and they had predominance of CD8+ cells (Figure 1, d). These immunohistochemical results mimicked MF. However, PCR analysis of the T-cell receptor g-gene rearrangement was negative. Closed patch test result with hydroquinone (5% pet.) was graded D2 (+?) and D3 (+). Ten months after discontinuing cosmetic reagents and hydroquinone, the pigmentary changes showed improvement. The pathomechanism of leukomelanoderma is unclear. Although post-inflammatory pigmentation due to allergic or contact dermatitis together with direct depigmenting effects from hydroquinone use has been suggested (1), the immunophenotype of T-cells has not been examined. As observed in our patient, interface changes with melanophages, in addition to frequent CD8+ phenotype of the epidermotropism and dermal infiltrate of lymphocytes, were characteristic for hyperpigmented MF (3). Moreover, minimal CD7 expression was a specific finding for MF (4). T-cell receptor clonality was negative in our patient, but the clonality appears to be detected by PCR in up to 50% of the patients with early MF (3). In contrast, the closed patch test was positive for hydroquinone in our patient, and it is reported that CD8+ T-cells are recruited to the interphase between the epidermis and the dermis of the patients with allergic contact dermatitis (5). CD8+ T-cells might contribute to acute cutaneous graft-versus-host disease-like interface changes and destroy melanocytes in the leukomelanoderma lesion. Allergic contact dermatitis presenting as leukomelanoderma was thus suggested in our patient. However, further reports and studies are required to support this issue. Therefore, we considered it necessary to follow the patient, since MF was not absolutely eliminated.
Subject(s)
Hyperpigmentation , Mycosis Fungoides , Skin Neoplasms , Humans , Female , Middle Aged , Mycosis Fungoides/diagnosis , Mycosis Fungoides/pathology , Hyperpigmentation/pathology , Hyperpigmentation/diagnosis , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Diagnosis, DifferentialSubject(s)
Hyperpigmentation , Humans , Hyperpigmentation/pathology , Hyperpigmentation/diagnosis , Hyperpigmentation/metabolism , Hyperpigmentation/etiology , Female , ACTH Syndrome, Ectopic/diagnosis , ACTH Syndrome, Ectopic/etiology , Skin/pathology , Skin/metabolism , Adrenocorticotropic Hormone/metabolism , Adrenocorticotropic Hormone/blood , MaleSubject(s)
Cicatrix, Hypertrophic , Hyperpigmentation , Hypopigmentation , Humans , Cicatrix, Hypertrophic/pathology , Cicatrix, Hypertrophic/therapy , Cicatrix, Hypertrophic/etiology , Hypopigmentation/etiology , Hypopigmentation/pathology , Hyperpigmentation/etiology , Hyperpigmentation/pathology , Female , Intense Pulsed Light Therapy/methods , Male , Adult , Treatment Outcome , Child , Adolescent , InflammationABSTRACT
Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is a new acquired pigmentary disorder. Only a few cases have previously been reported in the Chinese population, in Chinese. To summarise the clinical, dermoscopic, and histopathological findings of DHGH in the English literature, to improve the recognition and management of this condition. This was a retrospective study to summarise the clinical, dermoscopic, and pathological findings of nine cases of DHGH. All nine patients with DHGH were female. The age at onset varied from 6 to 24 years (median 17 years). Patients were generally in good health without systemic disease. The lesions were often generalised to the trunk and extremities without any discomfort. Typical lesions were characterised by multiple uniform hypopigmented spots, 2-5 mm in diameter, irregularly distributed over diffuse hyperpigmentation. Dermoscopy revealed multiple blurred patchy areas of brownish pigmentation, sparse linear and dotted vessels, and perifollicular pigmentation on a white to bright white background, surrounded by brown hyperpigmentation. Histopathological findings included mild abnormal pigment of the epidermis, focal vacuolar degeneration of the basal cells, mild pigment incontinence and perivascular lymphocytic infiltration in the dermis. DHGH is a new entity with distinctive clinical manifestations that differ from those of other known pigmentary disorders. So far, DHGH has only been reported in the Chinese population. It may not be uncommon and has not received much attention due to the few reports. The aetiology and pathogenesis of DHGH are still unknown and require further investigation.
Subject(s)
Hyperpigmentation , Hypopigmentation , Humans , Female , Hyperpigmentation/pathology , Hypopigmentation/pathology , Retrospective Studies , Adolescent , Young Adult , Child , Dermoscopy , AdultSubject(s)
Atrophy , Humans , Atrophy/pathology , Skin/pathology , Male , Female , Hyperpigmentation/pathology , Hyperpigmentation/diagnosisABSTRACT
OBJECTIVES: Cutaneous diseases that disproportionately affect patients with darker pigmentation and their histologic features are historically understudied and undertreated. This review article aims to highlight the key clinical features, histopathology, and diagnostic pearls of several cutaneous diseases that commonly present in patients with darker pigmentation. METHODS: A literature search was conducted, and a list of cutaneous diseases that frequently affect patients with darker pigmentation was compiled. A group of experts expounded upon those that were most common or misdiagnosed according to scientific evidence and clinical practice. RESULTS: The diseases were divided into hypopigmented disorders, hyperpigmented disorders, scarring disorders, and alopecic disorders. Within each category, the etiology, clinical features, histopathology, and key histologic differential diagnoses are described and discussed. CONCLUSIONS: As many clinicians are taught that there are no effective treatment options or that these diseases are considered "cosmetic" in nature, patients often do not get a thorough medical workup or skin biopsy. This article aims to decrease the knowledge gap and serve as a resource for anyone involved in the care of patients with these cutaneous conditions.
Subject(s)
Skin Diseases , Skin Pigmentation , Humans , Skin Diseases/pathology , Skin Diseases/diagnosis , Pigmentation Disorders/pathology , Pigmentation Disorders/diagnosis , Diagnosis, Differential , Hyperpigmentation/pathology , Hyperpigmentation/diagnosisSubject(s)
Antineoplastic Agents , Hyperpigmentation , Imatinib Mesylate , Lentigo , Proto-Oncogene Proteins c-kit , Humans , Imatinib Mesylate/therapeutic use , Hyperpigmentation/genetics , Hyperpigmentation/chemically induced , Hyperpigmentation/pathology , Hyperpigmentation/drug therapy , Lentigo/genetics , Lentigo/pathology , Proto-Oncogene Proteins c-kit/genetics , Female , Male , Protein Kinase Inhibitors/adverse effects , Pyrimidines/therapeutic use , Adult , Middle AgedABSTRACT
The custom of oral tattooing is mainly performed in Ethiopia and Eritrea, and usually results in blue pigmentation of the maxillary gingiva in dentate individuals. However, its usefulness has not been explored in the forensic literature. The aim of this article is to provide a review of this custom and include an unusual case study involving persistent gingival pigmentation. Herein, this report describes a 43-year-old woman from Eritrea who presented with slight bluish hue of the edentulous maxillary ridge associated with cultural tattooing. Elucidation of the cause of subtle blue hyperpigmentation may be challenging as cultural tattooing typically fades with age. Timely recognition of this oral pseudopathologic process may serve as secondary evidence for forensic identification and possibly provide aid in localizing one's ethnogeographic origin.
Subject(s)
Tattooing , Humans , Female , Adult , Gingiva/pathology , Ethiopia , Hyperpigmentation/pathologySubject(s)
Hyperpigmentation , Lichen Planus , Humans , Lichen Planus/complications , Lichen Planus/pathology , Hyperpigmentation/pathology , Female , Male , Middle AgedABSTRACT
A woman in her 60s presented with oral lichen planus on hands and cheeks since childhood and also present in her parent and sibling. What is your diagnosis?
Subject(s)
Lichen Planus, Oral , Humans , Female , Lichen Planus, Oral/pathology , Lichen Planus, Oral/diagnosis , Middle Aged , Hyperpigmentation/pathology , Hyperpigmentation/diagnosis , Hyperpigmentation/etiologyABSTRACT
BACKGROUND: Inherited hyperpigmented skin disorders comprise a group of entities with considerable clinical and genetic heterogenicity. The genetic basis of a majority of these disorders remains to be elucidated. OBJECTIVES: This study aimed to identify the underlying gene for an unclarified disorder of autosomal-dominant generalized skin hyperpigmentation with or without glomuvenous malformation. METHODS: Whole-exome sequencing was performed in five unrelated families with autosomal-dominant generalized skin hyperpigmentation. Variants were confirmed using Sanger sequencing and a minigene assay was employed to evaluate the splicing alteration. Immunofluorescence and transmission electron microscopy (TEM) were used to determine the quantity of melanocytes and melanosomes in hyperpigmented skin lesions. GLMN knockdown by small interfering RNA assays was performed in human MNT-1 cells to examine melanin concentration and the underlying molecular mechanism. RESULTS: We identified five variants in GLMN in five unrelated families, including c.995_996insAACA(p.Ser333Thrfs*11), c.632 + 4delA, c.1470_1473dup(p.Thr492fs*12), c.1319G > A(p.Trp440*) and c.1613_1614insTA(Thr540*). The minigene assay confirmed that the c.632 + 4delA mutant resulted in abolishment of the canonical donor splice site. Although the number of melanocytes remained unchanged in skin lesions, as demonstrated by immunofluorescent staining of tyrosinase and premelanosome protein, TEM revealed an increased number of melanosomes in the skin lesion of a patient. The GLMN knockdown MNT-1 cells demonstrated a higher melanin concentration, a higher proportion of stage III and IV melanosomes, upregulation of microphthalmia-associated transcription factor and tyrosinase, and downregulation of phosphorylated p70S6â K vs. mock-transfected cells. CONCLUSIONS: We found that loss-of-function variants in GLMN are associated with generalized skin hyperpigmentation with or without glomuvenous malformation. Our study implicates a potential role of glomulin in human skin melanogenesis, in addition to vascular morphogenesis.
A group of skin conditions known as 'inherited hyperpigmented skin disorders' includes some diseases with different clinical and genetic traits. The genetic basis of the majority of these diseases is not understood. To identify the gene responsible for a disease that causes darker patches of skin (hyperpigmentation) with or without the abnormal growth of blood vessels and the presence of cells named glomus cells (a glomuvenous malformation), we used genetic techniques called whole-exome sequencing and Sanger sequencing in five unrelated families with this disease. We also used a technique called a 'minigene assay' to evaluate genetic alterations in a gene called GLMN, which encodes a protein called glomulin. Immunofluorescence and transmission electron microscopy (TEM) were used to determine the number of pigment-producing cells (called melanocytes) and melanosomes (where the pigment melanin is synthesized, stored and transported) in hyperpigmented skin lesions. We identified five different variants of the GLMN gene in five unrelated families. Although the number of melanocytes remained unchanged in skin lesions, TEM revealed an increased number of melanosomes. By 'switching off' the GLMN gene, we found that skin cells produced more pigment, as well as the proteins MITF and tyrosinase; they also showed a decrease in the phosphorylated protein p-p70S6â K. Overall, we found that loss-of-function mutations in GLMN caused skin hyperpigmentation with or without abnormal blood vessels. The results suggest there could be a potential role of the protein glomulin in human skin colour and blood vessel changes.
Subject(s)
Exome Sequencing , Hyperpigmentation , Melanocytes , Pedigree , Humans , Hyperpigmentation/genetics , Hyperpigmentation/pathology , Female , Male , Melanocytes/metabolism , Adult , Loss of Function Mutation , Glomus Tumor/genetics , Glomus Tumor/pathology , Melanosomes/genetics , Child , Melanins/metabolism , Adolescent , Skin/pathology , Skin/blood supply , Middle Aged , Paraganglioma, Extra-Adrenal , Adaptor Proteins, Signal TransducingSubject(s)
Hyperpigmentation , Scalp , Humans , Hyperpigmentation/diagnosis , Hyperpigmentation/pathology , Skin/pathologySubject(s)
Hyperpigmentation , Lichen Planus , Humans , Administration, Cutaneous , Hyperpigmentation/drug therapy , Hyperpigmentation/diagnosis , Hyperpigmentation/pathology , Lichen Planus/drug therapy , Lichen Planus/pathology , Lichen Planus/diagnosis , Pyrroles/administration & dosage , Pyrroles/therapeutic use , Skin/pathology , Skin/drug effects , Treatment OutcomeABSTRACT
BACKGROUND: The H syndrome is an autosomal recessive disease characterized by hyperpigmentation, hypertrichosis and sensorineural hearing loss. METHODS: A mutation in the coding of the human equilibrative nucleoside transporter 3 (hENT3) within the SLC29A3 gene on chromosome 10q22 leads to the manifestation of this disease. In this report, we present two cases of H syndrome. RESULTS: The first patient exhibits hyperpigmentation, hypogonadism, Type 1 diabetes mellitus, arthritis and osteoporosis. The second patient experiences hyperpigmentation, hypertrichosis, osteopenia and hypogonadism. CONCLUSION: Our objective is to broaden the clinical spectrum of H syndrome, highlighting the involvement of arthritis, hyperinflammation and low bone mineral density in individuals with this disorder.