Equal rates of bone healing and reduced surgical time with iliac crest allograft compared to autograft in medial opening wedge high tibial osteotomy: a randomized controlled clinical trial.

INTRODUCTION: Iliac crest autograft is frequently used to fill in bone defects after osteotomies. Nonetheless, surgery for bone autograft procurement is associated with morbidity and pain at the donor site. Alternatives to it have been explored, but there is no consensus to guide their application as a routine practice in several orthopedic procedures. Thus, this study was designed to compare the efficacy and safety between iliac crest autograft and allograft in medial opening wedge high tibial osteotomy. MATERIALS AND METHODS: Forty-seven patients with a symptomatic unilateral genu varum and an indication for high tibial osteotomy were randomly assigned to receive either autograft or allograft to fill the osteotomy site. Operative time, bone healing, and complication rates (delayed union, nonunion, superficial and deep infection, loss of correction, and hardware failure) were recorded after a one-year follow-up. Data were expressed as Mean ± Standard Deviation and considered statistically significant when p < 0.05. RESULTS: The time to radiologic union was similar between both groups (Allograft: 2.38 ± 0.97 months vs. Autograft: 2.45 ± 0.91 months; p = 0.79). Complication rates were also similar in both groups, with one infection in the allograft group and two in the autograft group, two delayed unions in the allograft group, and three in the autograft group. The operative time differed by 11 min between the groups, being lower in the allograft group (Allograft: 65.4 ± 15.1 min vs. Autograft: 76.3 ± 15.2 min; p = 0.02). CONCLUSION: Iliac crest allografts can be safely and effectively used in medial opening wedge high tibial osteotomy as it promotes the same rates of bone union as those achieved by autologous grafts, with the benefits of a shorter operative time. TRIAL REGISTRATION NUMBER: U1111-1280-0637 1 December 2022, retrospectively registered.

[The morbidity of the posterior iliac crest bone graft harvesting could be an overestimated fact. Study in patients with open posterolateral lumbar fusion]. / La morbilidad del sitio donante de injerto de cresta ilíaca posterior podría ser un hecho sobreestimado. Estudio en pacientes con fusión lumbar posterolateral abierta.

INTRODUCTION: spinal fusion is used to treat, among other pathologies, the degenerative intervertebral disc disease. Autologous iliac crest bone grafting is the golden standard treatment for increasing the rate of fusion; however, it isn't free of complications. OBJECTIVES: to investigate whether patients who have posterior iliac crest graft harvesting and are blinded to the donor site, can identify from which side the graft was harvested, and whether the intensity of this pain is related to the amount of graft obtained. MATERIAL AND METHODS: prospective, experimental, randomized and comparative, single-blind study. Adult patients who underwent primary instrumented open posterolateral lumbar fusion with autologous iliac crest bone graft between July 2019 and April 2020 were included. Patients were divided into two randomized groups. The amount of graft to be harvested was according to surgical needs. The patients were asked about pain according to the visual analogue scale in the first, third and sixth months after surgery, always requesting that the most painful side be identified. RESULTS: a total of 44 patients (n = 23 right crest, n = 21 left crest) were analyzed. Most patients were unable to identify the side from which the bone graft was harvested, with a statistically significant difference (p-value 0.0001). CONCLUSION: iliac crest bone graft harvesting is an effective and safe procedure that improves the rates of fusion without increasing the patient's morbidity.

INTRODUCCIÓN: la fusión espinal es utilizada para tratar, entre otras patologías, las enfermedades degenerativas discales. El injerto óseo autólogo de cresta ilíaca es el estándar de oro para aumentar las probabilidades de fusión; sin embargo, no está exento de complicaciones. OBJETIVOS: investigar si los pacientes a los que se les recolecta injerto de cresta ilíaca posterior y son cegados al lado del sitio donante, pueden identificar de qué lado se tomó dicho injerto y si la intensidad de este dolor está en relación con la cantidad de injerto obtenido. MATERIAL Y MÉTODOS: trabajo prospectivo, experimental, aleatorizado y comparativo, simple ciego. Se incluyeron pacientes adultos operados entre Julio de 2019 hasta Abril de 2020, a los cuales se les realizó una cirugía primaria de artrodesis lumbar posterolateral abierta instrumentada, con colocación de injerto óseo autólogo de cresta ilíaca. Se dividió a los pacientes en dos grupos aleatorizados. La cantidad de injerto a recolectar fue de acuerdo a las necesidades quirúrgicas. Se interrogó por el dolor según escala visual analógica al primer, tercer y sexto mes de la cirugía, siempre solicitando que se identifique el lado más doloroso. RESULTADOS: se analizaron 44 pacientes (n = 23 cresta derecha, n = 21 cresta izquierda). La mayoría de los pacientes no lograron identificar el lado del cual se obtuvo el injerto óseo, con una diferencia estadística ampliamente significativa (p = 0.0001). CONCLUSIÓN: la obtención de injerto óseo de cresta ilíaca es un procedimiento efectivo y seguro, que mejora las probabilidades de fusión sin aumentar la morbilidad del paciente.

Injerto de cresta ilíaca como cirugía de revisión de Latarjet fallida por inestabilidad glenohumeral en deportistas / Iliac crest graft for previous failed Latarjet surgery with glenohumeral instability in athletes

Introducción: El objetivo de este estudio es reportar los resultados funcionales, el retorno al deporte, la tasa de consolidación y las complicaciones en deportistas jóvenes con una cirugía de Latarjet previa fallida, tratados con injerto autólogo de cresta ilíaca.Materiales y métodos: entre el 2017 y el 2020, se operaron en nuestra institución doce pacientes con inestabilidad glenohumeral recurrente luego de una estabilización previa fallida con cirugía de Latarjet, con injerto autólogo de cresta ilíaca como cirugía de revisión. La evaluación funcional se realizó con el score de Rowe, la escala visual análoga (EVA) y el score de ASOSS. Evaluamos el porcentaje de retorno al deporte, el nivel alcanzado y el tiempo que tardaron los deportistas en volver a competir. La consolidación ósea y la posición adecuada del injerto se analizó en todos los casos con radiografías de hombro frente y perfil y tomografía axial computada con reconstrucción 3D. Se registraron las complicaciones y las revisiones.Resultados: el seguimiento promedio fue de 42.6 meses (rango 24 a 92 meses). El score de Rowe, la EVA y el ASOSS mejoraron significativamente luego de la cirugía (p <0.1). Nueve pacientes retornaron al deporte, ocho de ellos al mismo nivel. El injerto óseo consolidó en todos los pacientes. No hubo recurrencias. No se reportaron complicaciones.Conclusión: el injerto autólogo de cresta ilíaca es una opción válida para el tratamiento de deportistas con inestabilidad glenohumeral recurrente luego de una estabilización previa fallida con cirugía de Latarjet. Nivel de Evidencia: IV

Introduction: The purpose of this study was to report the functional results, return to sport, consolidation rate and complications in young athletes with a previous failed Latarjet surgery, treated with an autologous iliac crest graft.Materials and methods: between 2017 and 2020, twelve patients with recurrent glenohumeral instability were operated on at our institution after previous failed stabilization with Latarjet surgery with autologous iliac crest graft as revision surgery. Functional evaluation was performed with the Rowe score, the VAS, and the ASOSS score. We evaluated the percentage of return to sport, the level reached, and the time it took the athletes to compete again. Bone consolidation and the adequate position of the graft were evaluated in all cases with front and profile X-rays of the shoulder and computed tomography with 3D reconstruction. Complications and revisions were recorded.Results: the average follow-up was 42.6 months (range 24 to 92 months). The Rowe score, visual analog scale, and ASOSS were significantly improved after surgery (p <0.1). Nine patients returned to sport, eight of them at the same level. The bone graft consolidated in all patients. There were no recurrences. No complications were reported.Conclusion: autologous iliac crest grafting is a valid option for the treatment of athletes with recurrent glenohumeral instability after previous failed stabilization with a Latarjet procedure. Level of Evidence: IV

Donor Site Morbidity of Nonvascularized Bone Graft: A Systematic Review

ABSTRACT Objective: To evaluate the donor site morbidity of iliac and fibular nonvascularized bone graft after mandibular resection. Material and Methods: This study was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in PubMed, Proquest, Science Direct, and Ebsco. A total of 12 studies met the criteria of studies in humans using iliac and fibular nonvascularized bone grafts in mandibular reconstruction after mandibular resection. Results: A greater proportion of patients received iliac nonvascularized bone graft (88.9%) than fibular nonvascularized bone graft (11.1%). Of the 385 cases of iliac bone graft, 153 cases (40%) experienced complications at the iliac donor site, whereas in 48 cases of fibular bone graft, two (4%) experienced complications at the donor site. Hemorrhage, bone fracture, infection requiring debridement, and hematoma were the major complications. Conclusion: The morbidity rate of the nonvascularized bone graft donor site of the fibula (4%) tended to be lower than that of the ilium (40%). Patient age and defect size were not significantly correlated with the occurrence of morbidity donor sites in either the ilium or fibula.

A systematic review and meta-analysis of fusion rate enhancements and bone graft options for spine surgery.

Our study aimed to evaluate differences in outcomes of patients submitted to spinal fusion using different grafts measuring the effectiveness of spinal fusion rates, pseudarthrosis rates, and adverse events. Applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, this systematic review and meta-analysis identified 64 eligible articles. The main inclusion criteria were adult patients that were submitted to spinal fusion, autologous iliac crest (AIC), allograft (ALG), alloplastic (ALP; hydroxyapatite, rhBMP-2, rhBMP-7, or the association between them), and local bone (LB), whether in addition to metallic implants or not, was applied. We made a comparison among those groups to evaluate the presence of differences in outcomes, such as fusion rate, hospital stay, follow-up extension (6, 12, 24, and 48 months), pseudarthrosis rate, and adverse events. Sixty-four studies were identified. LB presented significantly higher proportions of fusion rates (95.3% CI 89.7-98.7) compared to the AIC (88.6% CI 84.8-91.9), ALG (87.8% CI 80.8-93.4), and ALP (85.8% CI 75.7-93.5) study groups. Pseudarthrosis presented at a significantly lower pooled proportion of ALG studies (4.8% CI 0.1-15.7) compared to AIC (8.6% CI 4.2-14.2), ALP (7.1% CI 0.9-18.2), and LB (10.3% CI 1.8-24.5). ALP and AIC studies described significantly more cases of adverse events (80 events/404 patients and 860 events/2001 patients, respectively) compared to LB (20 events/311 patients) and ALG (73 events/459 patients). Most studies presented high risk-of-bias scores. Based on fusion rates and adverse events proportions, LB showed a superior trend among the graft cases we analyzed. However, our review revealed highly heterogeneous data and a need for more rigorous studies to better address and assist surgeons' choices of the best spinal grafts.

Morbilidad de la zona dadora de injerto óseo autólogo de cresta ilíaca por vía posterior: Análisis de dos técnicas quirúrgicas / Autologous donor site morbidity after posterior iliac crest bone harvest. Comparative analysis of two surgical techniques

Introducción: El injerto óseo autólogo tomado de la cresta ilíaca posterior para artrodesis de columna presenta ventajas: es osteogénico, osteoinductor y osteoconductor, y sus desventajas son ofrecer una cantidad limitada y las complicaciones del sitio dador (8-39%), como dolor de la zona dadora, lesión neurovascular y fracturas de pelvis. Los objetivos de este estudio fueron comparar la toma de injerto cortico-esponjoso de cresta ilíaca posterior mediante técnica con escoplo gubia frente a la toma con cureta; evaluar las complicaciones intraoperatorias y posoperatorias; cuantificar la cantidad recolectada y graduar el dolor en la zona dadora. Materiales y Métodos: Estudio prospectivo aleatorizado de 34 pacientes consecutivos para artrodesis posterolateral de columna torácica y lumbosacra (26 mujeres y 8 hombres, de entre 15 y 79 años de edad). Se los dividió en dos grupos: grupo 1, cureta y grupo 2, escoplo gubia. Se evaluaron el peso obtenido, el tiempo requerido y las complicaciones. Resultados: Grupo 1: 19 pacientes (14 mujeres y 5 hombres). Se requirieron, en promedio, 9.94 min para obtener 9,26 g. En el primer control, 13 pacientes presentaron un valor 1; 5, un valor 2 y uno, un valor 3. En el tercer control, 15 tuvieron un puntaje 1; 2, un puntaje 2 y 2, un puntaje 3. Grupo 2: 15 pacientes (12 mujeres y 3 hombres). Se tomaron 11,26 g en 8,6 min. En puntaje de dolor en el primer control fue: 10 pacientes con un valor 1; 2, con un valor 2 y 3, con un valor 3, todos tuvieron un puntaje 1 en el tercer control. Conclusiones: La toma de injerto de cresta ilíaca posterior utilizando escoplo gubia es más rápida, recolecta más injerto y provoca menos dolor a los 60 días. Nivel de Evidencia: II

Introduction: The autologous bone graft harvested from the posterior iliac crest for spinal fusion presents osteogenic, osteoinductive and osteoconductive advantages; however, its disadvantages include a limited amount of available material and an incidence of donor site complications ranging from 8% to 39%, including donor site pain, neurovascular injury and pelvic fractures. Objectives: To compare the posterior iliac crest corticoancellous harvest using a chisel-gouge approach versus a curette approach; to evaluate intra-operative and post-operative complications; to quantify the harvested bone; to grade donor site pain. Materials and Methods: Prospective randomized study in 34 consecutive patients for posterolateral fusion of the thoracic and lumbosacral spine; 26 women and 8 men, between 15 and 79 years of age. Subjects were divided into two groups. Group 1: curette approach; and Group 2: chiselgouge approach. The evaluation included: the amount of bone harvested, the time required and complications. Results: Group 1: 19 patients, 14 women and 5 men. The procedure lasted an average of 9.94 min, and the harvested material averaged 9.26 g. Denis Pain Scale scores at the first follow-up survey: 13 patients scored 1; 5 scored 2; 1 scored 3. Denis Pain Scale scores at the third follow-up survey: 15 patients scored 1; 2 scored 2; 1 scored 3. Group 2: 15 patients, 12 women and 3 men. The procedure lasted an average of 8.6 min, and the harvested material averaged 9.26 g. Denis Pain Scale scores at their first follow-up: 10 patients scored 1; 2 scored 2; 3 scored 3. At the third follow-up, all patients scored 1. Conclusions: We observed that the posterior iliac crest graft harvested using the chisel-gouge approach is faster, provides more graft and results in less pain at 60 days. Level of Evidence: II

Injertos óseos en el fisurado labio-alvéolo-palatino (FLAP): casos clínicos / Bone grafts in the cleft lip and palate (CLP) patient: clinical cases

Objetivo: mostrar el tratamiento que realizamos en comunicaciones a nivel del reborde alveolar en los FLAP, tanto para pacientes con fisura unilateral como bilateral, realizados con cresta ilíaca tomada del paciente y basados en nuestra experiencia de más de 40 años. Casos clínicos: nuestro protocolo está dentro de lo que es el tratamiento que proponemos para FLAP, ortopédico y quirúrgico, teniendo en cuenta el crecimiento y desarrollo del maxilar superior, realizando dentro de éste lo que son las periostioplastías y los injertos óseos, con el correspondiente seguimiento de pacientes en el tiempo. Conclusión: se realiza un protocolo adecuado para cada paciente, para realizar el cierre de la comunicación bucosinusal, teniendo siempre en cuenta el crecimiento y desarrollo de cada paciente y no un tiempo fijo en general para todos ellos. Nos diferenciamos de otras personas que lo hacen en forma sistemática en tiempos quirúrgicos preestablecidos, igual para todos los pacientes (AU)

Customizable template technique to harvest iliac crest bone graft for reconstructions of mandibular defects. / Técnica de template customizável para remoção de enxerto ósseo de crista ilíaca para reconstruções de defeitos mandibulares.

Bone graft harvesting from the anterior iliac crest is a good option for reconstructing mandibular defects after trauma or other diseases. In order to achieve optimal clinical results in reconstructive surgeries with bone grafts, accurate preoperative planning and prestigious surgical technique are paramount. Therefore, this paper describes the use of a customizable template that is indicated for obtaining free iliac bone block for immediate or late mandibular reconstructions following marginal or segmental defects. The template is based on a piece of malleable metal obtained from an aluminum beverage can. It is used transoperatively to demarcate the bone graft donor site, being especially useful because of the limited access to the inner table of the anterior ilium. The described customizable template has been shown as a useful tool to easily determine the size of the bone block to be harvested from the iliac region, improving surgical time and preventing removal of insufficient bone graft.

A remoção de enxerto da crista ilíaca anterior é uma boa opção para a reconstrução de defeitos mandibulares após ressecções por trauma ou outras doenças. Para obtenção de resultados clínicos de excelência em cirurgias reconstrutivas com enxertos ósseos, um planejamento pré-operatório preciso e uma refinada técnica cirúrgica são essenciais. Portanto, este artigo descreve o uso de um template customizável, que é indicado para obter bloco de osso ilíaco livre para reconstruções mandibulares imediatas ou tardias após defeitos marginais ou segmentares. O template é baseado em um fragmento de metal maleável obtido de uma lata de bebida de alumínio. Ele é utilizado no transoperatório para demarcar o sítio doador do enxerto ósseo e é especialmente útil devido ao acesso limitado à cortical interna da crista ilíaca. O template customizável tem se mostrado uma ferramenta de fácil aplicação para determinar o tamanho do bloco de enxerto a ser coletado da região ilíaca, otimizando o tempo cirúrgico e evitando a remoção insuficiente de enxerto ósseo.

Técnica de template customizável para remoção de enxerto ósseo de crista ilíaca para reconstruções de defeitos mandibulares / Customizable template technique to harvest iliac crest bone graft for reconstructions of mandibular defects

RESUMO A remoção de enxerto da crista ilíaca anterior é uma boa opção para a reconstrução de defeitos mandibulares após ressecções por trauma ou outras doenças. Para obtenção de resultados clínicos de excelência em cirurgias reconstrutivas com enxertos ósseos, um planejamento pré-operatório preciso e uma refinada técnica cirúrgica são essenciais. Portanto, este artigo descreve o uso de um template customizável, que é indicado para obter bloco de osso ilíaco livre para reconstruções mandibulares imediatas ou tardias após defeitos marginais ou segmentares. O template é baseado em um fragmento de metal maleável obtido de uma lata de bebida de alumínio. Ele é utilizado no transoperatório para demarcar o sítio doador do enxerto ósseo e é especialmente útil devido ao acesso limitado à cortical interna da crista ilíaca. O template customizável tem se mostrado uma ferramenta de fácil aplicação para determinar o tamanho do bloco de enxerto a ser coletado da região ilíaca, otimizando o tempo cirúrgico e evitando a remoção insuficiente de enxerto ósseo.

ABSTRACT Bone graft harvesting from the anterior iliac crest is a good option for reconstructing mandibular defects after trauma or other diseases. In order to achieve optimal clinical results in reconstructive surgeries with bone grafts, accurate preoperative planning and prestigious surgical technique are paramount. Therefore, this paper describes the use of a customizable template that is indicated for obtaining free iliac bone block for immediate or late mandibular reconstructions following marginal or segmental defects. The template is based on a piece of malleable metal obtained from an aluminum beverage can. It is used transoperatively to demarcate the bone graft donor site, being especially useful because of the limited access to the inner table of the anterior ilium. The described customizable template has been shown as a useful tool to easily determine the size of the bone block to be harvested from the iliac region, improving surgical time and preventing removal of insufficient bone graft.

Atrophic Maxilla Reconstruction With Autogenous Iliac Graft and Guided Dental Implants.

Oral rehabilitation with osseointegrated implants is frequently the best alternative for replacement of lost teeth. Several techniques and materials allow achievement of excellent function and esthetics. In the case of maxillary or mandibular atrophy, extensive grafting may be necessary before implants can be properly placed. This is a case of maxillary reconstruction with autogenous iliac crest bone grafts, followed by placement of guided implants. After integration of the grafts, planning and insertion of implants allowed installation of an implant-supported prosthesis, recovering the morphology, function, and esthetics.

Clear cell odontogenic carcinoma of the mandible: a treatment strategy.

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates of cells with eosinophilic cytoplasm. The patient, a 62-year-old Caucasian woman, presented an intraosseous lesion in the mandibular symphysis. A clinical examination revealed a discrete volumetric increase with a hard consistency, palpable to extraoral and intraoral examinations. Imaging studies revealed an extensive radiolucent area, without defined limits, extending from the region of the right second premolar to the left canine. Incisional biopsy analysis indicated a diagnosis of CCOC. The treatment proposed was segmental resection of the mandible with a safety margin. After six months without recurrence, definitive mandibular reconstruction was performed using an iliac crest graft, followed by rehabilitation with implant-supported denture after five months. After three years of post-resection follow-up, the patient has shown no evidence of recurrence or metastasis. She continues to be under follow-up. To conclude, CCOC must be considered a malignant tumor with aggressive behavior. Previous studies have shown that resection with free margins is a treatment with a lower rate of recurrence. Nevertheless, long-term follow-up is necessary for such patients.

Radiographic analysis of dental implant extensions using bone grafts on dogs.

BACKGROUND: Despite the wide use of dental implants they can bring inconveniences, as the moment one reaches osseointegration, these can no longer be extended. Therefore, if a problem occurs regarding its positioning, the options open are substitution or burial of the implant. With implant substitution, there exists the risk of local bone loss and/or future loss of the new implant. PURPOSE: This study proposes a new device (implant extender) for extending the dental implant. The feasibility of this technique is verified through installing dental implant extensions onto the humerus bone of dogs with autogenous bone grafts. MATERIALS AND METHODS: Implants of 3.3 mm in diameter by 6 mm in length and implant extensions with a 3.3 mm diameter and 2.2 mm length were installed onto humerus of 4 healthy dogs, using an autogenous bone graft in a block made from ilium. The biomechanical percussion tests were performed on the implant extensions and then the implant-extension sets were removed for radiographic analysis. RESULTS: In the biomechanical percussion, none of the extensions present clinical mobility. As for the x-rays, these were analyzed by 20 professionals, who concluded that there was a 100% success rate with bone formation around the implants, 74.1% for bone neoformation of the implant extensions, and 80.1% referring to the adaptation of the implant extension. DISCUSSION AND CONCLUSION: Bone formation occurred in every installed dental implant. In most cases, there occurred bone neoformation of the extensions and adaptation of the extension/implant set, according to the x-ray analysis performed by the evaluators. An absence of clinical mobility in the extensions was also observed. Although the results were promising, these techniques still need to be researched in humans, as an alternative for reducing elongated prosthetic crowns or poorly installed implants, as well as the modification of the type of implants among other applications.

Clear cell odontogenic carcinoma of the mandible: a treatment strategy

Abstract Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates of cells with eosinophilic cytoplasm. The patient, a 62-year-old Caucasian woman, presented an intraosseous lesion in the mandibular symphysis. A clinical examination revealed a discrete volumetric increase with a hard consistency, palpable to extraoral and intraoral examinations. Imaging studies revealed an extensive radiolucent area, without defined limits, extending from the region of the right second premolar to the left canine. Incisional biopsy analysis indicated a diagnosis of CCOC. The treatment proposed was segmental resection of the mandible with a safety margin. After six months without recurrence, definitive mandibular reconstruction was performed using an iliac crest graft, followed by rehabilitation with implant-supported denture after five months. After three years of post-resection follow-up, the patient has shown no evidence of recurrence or metastasis. She continues to be under follow-up. To conclude, CCOC must be considered a malignant tumor with aggressive behavior. Previous studies have shown that resection with free margins is a treatment with a lower rate of recurrence. Nevertheless, long-term follow-up is necessary for such patients.

Rapid Prototyping as an Auxiliary in Mandibular Reconstructions.

The reconstruction of mandible is a challenge with regard to aesthetic and reconstructive demands. The etiology of mandibular fractures is variable, trauma, pathology, bone infections. There are many materials that provide an excellent form of rehabilitation for these defects, where the autogenous graft presents important characteristics that favor a greater success rate. Furthermore, the rapid prototyping method is quite interesting, because it brings a series of advantages to the surgeon, like reducing the operative time, among others. The purpose of the present article is to describe a clinical case of a patient with mandible bone defect caused by gunshot perforation, treated through iliac crest bone graft with planning through rapid prototyping. The mandibular reconstruction can present a real challenge for the surgeon. Biomodels should be required in complex cases because they help to decrease surgical time and to increase the predictability of the procedure.

Delayed union of humeral shaft fractures: comparison of autograft with and without platelet-rich plasma treatment: a randomized, single blinded clinical trial.

INTRODUCTION: Despite an adequate orthopedic treatment with functional bracing, some patients develop a delayed union in humeral shaft fractures. The objective of the present study was to determine the bone consolidation time among patients with delayed union of diaphyseal humeral fractures who were managed with locking compression plate (LCP) fixation combined with an iliac crest autograft using platelet-rich plasma (PRP) as a co-adjuvant. MATERIALS AND METHODS: This study was a controlled, randomized, experimental, longitudinal, comparative, prospective, blind clinical trial. Patients diagnosed with delayed union of a diaphyseal humeral fracture with at least 4 months of evolution were treated with an open reduction and LCP osteosynthesis combined with an iliac crest autograft. The experimental group also received PRP. The patients were assessed radiographically until 36 weeks of evolution. RESULTS: A total of 16 patients were included. Both groups had similar demographic characteristics. The patients treated with PRP had an earlier beginning of bone consolidation. Furthermore, these same patients exhibited bone consolidation at 19.9 weeks, on average, in contrast to 25.4 weeks in the control group. CONCLUSIONS: The use of PRP promotes earlier bone consolidation in patients with delayed union of the humeral shaft.

Off-Label Use of Bone Morphogenetic Protein 2 in the Reconstructions of Mandibular Continuity Defects.

This paper describes 3 patients of off-label use of bone morphogenetic protein 2 (rhBMP-2) in the reconstruction of mandibular continuity defects. In the first patient, rhBMP-2 was associated with iliac crest bone graft for late mandibular reconstruction after resection of osteosarcoma. In the 2 other patients, rhBMP-2 was used alone. In 1 patient the mandibular continuity defect was due to resection for treatment of osteomyelitis and in the other patient a continuity defect was created by unsuccessful osteogenic distraction for correction of mandibular hypoplasia. Despite the good results in those patients, the off-label use of rhBMP-2 is associated with increased rate of complications, so more studies are needed to assess the predictability of the use of rhBMP-2 in mandibular continuity defects. Therefore, at the moment the off-label use of rhBMP-2 should be restricted to complicated bone defects in which the conventional alternatives of reconstruction were unsuccessful.

Autogenous non-vascularized bone graft in segmental mandibular reconstruction: a systematic review.

The restoration of mandibular bone defects with non-vascularized bone grafts depends on the diagnosis, anatomical site, extent of the defect, and the patient's age, as well as the surgeon's experience. The aim of this study was to perform a systematic literature review on mandibular reconstruction for segmental mandibular bone defects using non-vascularized bone grafts to answer the following question: Is there scientific evidence to support the use of this technique? The initial literature search in PubMed, Scopus, and Cochrane databases identified 862 articles. Of these, 25 were included in the final review. These articles encompassed 926 procedures with non-vascularized bone grafts; 76.1% were from the iliac crest. Benign tumours were the major cause of these defects (56.8%), and 44.7% of defects were located in the lateral mandibular area. Although this technique showed a high occurrence of complications (290 in 873 patients, some with more than one complication), these did not account for treatment failure. The restoration of bone defects due to malignant tumours treated with radiation therapy had lower success rates, and these appear to be a contraindication for the technique. Although standardized randomized controlled clinical studies are needed to obtain better clinical evidence for treatment choices in general, the use of non-vascularized bone grafts for mandibular reconstruction showed an 87.6% success rate in this review.

Effect of maxillary alveolar reconstruction on nasal symmetry of cleft lip and palate patients: a study comparing iliac crest bone graft and recombinant human bone morphogenetic protein-2.

BACKGROUND: Recombinant human bone morphogenetic protein (rhBMP)-2 has been used in some craniofacial centers worldwide. However, its influence on nasal morphology is unknown. Thus, the objective of this investigation was to assess the effect of maxillary alveolar reconstruction on nasal position and symmetry in unilateral complete cleft lip patients who underwent traditional iliac crest bone grafting transferring versus reconstruction using rhBMP-2. METHODS: Nineteen unilateral complete cleft lip patients were randomly divided into two groups. In group 1, patients underwent traditional iliac crest bone grafting transferring (n = 11) and in group 2, patients underwent alveolar reconstruction using collagen matrix with lyophilized rhBMP-2 (n = 8). Computerized tomography (CT) imaging was performed preoperatively and at 6 months postoperatively using a previously standardized protocol. Linear distances using anatomic landmarks were performed using tridimensional CT data reformatted by the OsiriX(®) software. Quantitative and qualitative measurements to assess intra- and inter-group nasal position modifications were performed. RESULTS: Intra-group pre- and postoperative comparisons showed significant differences (p < 0.05) in two linear measurements of group 1, while group 2 did not present a difference (p > 0.05). Group 2 presented significant postoperative enhancement (p < 0.05) in the quantitative nasal symmetry in one measurement. Qualitative analysis showed postoperative nasal symmetry enhancement in 75% of the measurements of group 2 and 36% of group 1. There was no statistically significant difference in the inter-group comparisons. CONCLUSIONS: Our study demonstrated that both groups showed similar effect on nasal symmetry.

Perioperative and long-term clinical outcomes for bone morphogenetic protein versus iliac crest bone graft for lumbar fusion in degenerative disk disease: systematic review with meta-analysis.

STUDY DESIGN: Systematic review with meta-analysis. OBJECTIVES: To compare the perioperative and long-term postoperative effectiveness of bone morphogenetic protein (BMP) for lumbar arthrodesis in skeletally mature adults with degenerative disk disease (DDD) to that of the current golden standard treatment, iliac crest autologous bone graft (ICBG). SUMMARY OF BACKGROUND DATA: The treatment efficacy of lumbar arthrodesis in DDD is a complex clinical and economic issue for patients and health care providers. METHODS: Comprehensive electronic literature search was performed using following databases: Ovid MEDLINE; Embase; Cochrane Library; Central Register of Controlled Trials (CENTRAL); Database of Abstracts of Reviews of Effects; Methodology Register; Technology Assessment Database; and Economic Evaluation Database. The full year ranges of each database until May of 2012 were included. RESULTS: Eight randomized controlled clinical trials of 383 citations were selected. The included studies involved 1138 participants. The pooled 2-year postoperative clinical outcomes were equivalent in BMP and ICBG groups, and exceeded minimum clinically important differences for Oswestry Disability Index, SF-36 (physical scale), and numeric rating scale (back pain). ICBG was associated with increased pain and complications at the donor site (P<0.01). The pooled average operative time was 21 minutes less in BMP versus ICBG (P<0.001). The pooled rate of additional surgical treatment was 2 times less in the BMP than in the ICBG groups (P=0.006). The pooled risk of nonunion at 24-month follow-up was 2 times less in the BMP than in the ICBG groups (P=0.037), however, this effect was likely biased. CONCLUSIONS: BMP, in particular rhBMP-2, is a good alternative to autogenous bone graft, especially in cases when harvesting of autologous bone is contraindicated or undesirable, operation time is limited, and there are no contraindications for BMP use.However, the current study did not reveal evidence robust enough to develop strong medical recommendations concerning BMP use for lumbar arthrodesis in degenerative disk disease.

Radiographic and functional evaluation of the iliac bone graft in the treatment of adolescent idiopathic scoliosis.

This study aimed to assess the impact of the use of an additional iliac bone graft on functional and radiographic results after thoracic spine arthrodesis with pedicle screws in patients with adolescent idiopathic scoliosis. Participants were divided into two groups: a control group that received only local bone (n=19) and a second group that, in addition to this procedure, received an iliac graft (n=22). The evaluations were performed on preoperative, immediate postoperative, and last follow-up (mean 29.7 months; minimum 12 months). Radiographic evaluations included the loss of correction and the presence of nonunion. The functional outcome was evaluated using the Scoliosis Research Society-30 questionnaire. Surgical complications and the presence of iliac donor site pain were also described. There were no significant differences between groups in the pseudoarthrosis rate, loss of correction over time, and quality of life. We concluded that the addition of bone graft from the iliac yielded no benefit in terms of the fusion rate and functional outcomes. The appropriate facetectomy, bed preparation, and filling with a local bone graft must be adequate to achieve an adequate fusion on surgical treatment of adolescent idiopathic scoliosis.