Subject(s)
Bronchiectasis , Glucocorticoids/therapeutic use , Lung , Mycobacterium Infections, Nontuberculous , Nontuberculous Mycobacteria/isolation & purification , Sjogren's Syndrome , Age Factors , Body Mass Index , Bronchiectasis/diagnostic imaging , Bronchiectasis/epidemiology , Bronchiectasis/etiology , Colorado/epidemiology , Comorbidity , Female , Humans , Lung/diagnostic imaging , Lung/microbiology , Male , Middle Aged , Mycobacterium Infections, Nontuberculous/diagnosis , Mycobacterium Infections, Nontuberculous/epidemiology , Mycobacterium Infections, Nontuberculous/physiopathology , Referral and Consultation/statistics & numerical data , Risk Assessment , Risk Factors , Sjogren's Syndrome/complications , Sjogren's Syndrome/epidemiology , Sjogren's Syndrome/therapyABSTRACT
BACKGROUND: Since nontuberculous mycobacterial pulmonary disease (NTM-PD) is a condition with increasing morbidity, a more detailed knowledge of radiological aspects and pulmonary function plays a relevant role in the diagnosis and appropriate therapeutic management of these patients. OBJECTIVES: The purpose of this study was to evaluate changes in lung parenchyma through computed tomography (CT) densitometry and, secondarily, to analyze its correlation with pulmonary function testing (PFT) in patients with NTM-PD. METHODS: This is a cross-sectional study in which 31 patients with NTM-PD and 27 controls matched by sex, age, and body mass index underwent CT pulmonary densitovolumetry and pulmonary function tests including spirometry and body plethysmograph. RESULTS: Based on the total lung volume (TLV) and total lung mass (TLM) measurements, the cumulative mass ratios were calculated for 3% (M3), 15% (M15), 85% (M85), and 97% (M97) of the TLV. We also calculated the complement, which is represented by TLM (100%) minus the mass of 15% (C85) or 3% (C97) of the TLV. Patients with NTM-PD presented lower values of M3 and M15 than controls, with greater significant differences in the apical third and middle third measurements. Compared to controls, patients with NTM-PD showed higher values of C85 and C97, although significant differences were observed only in the basal third measurements. There were negative correlations of total lung capacity with M3 and M15 in the middle third and apical third measurements. There were positive correlations of residual volume and airway resistance with M3 at the apical third measurement. CONCLUSIONS: Patients with NTM-PD show reduced lung mass and increased lung mass in the apical and basal regions of the lungs, respectively. Furthermore, there is a relationship between lung mass measurements and pulmonary function parameters.
Subject(s)
Lung Volume Measurements , Lung/diagnostic imaging , Mycobacterium Infections, Nontuberculous/diagnostic imaging , Case-Control Studies , Cross-Sectional Studies , Female , Humans , Lung/physiopathology , Male , Middle Aged , Mycobacterium Infections, Nontuberculous/physiopathology , Nontuberculous Mycobacteria , Respiratory Function Tests , Tomography, X-Ray ComputedSubject(s)
Bone Marrow Cells/pathology , Macrophages/pathology , Mycobacterium Infections, Nontuberculous/pathology , Adult , Biopsy , Bone Marrow Cells/immunology , Bone Marrow Cells/microbiology , Brazil , Female , Hospitals, Teaching , Humans , Leprosy, Lepromatous/immunology , Leprosy, Lepromatous/microbiology , Leprosy, Lepromatous/pathology , Leprosy, Lepromatous/physiopathology , Macrophages/immunology , Macrophages/microbiology , Mycobacterium Infections, Nontuberculous/immunology , Mycobacterium Infections, Nontuberculous/microbiology , Mycobacterium Infections, Nontuberculous/physiopathology , Mycobacterium leprae/immunology , Mycobacterium leprae/isolation & purification , Pancytopenia/etiology , Skin/immunology , Skin/microbiology , Skin/pathology , Skin/physiopathology , Skin Diseases, Bacterial/immunology , Skin Diseases, Bacterial/microbiology , Skin Diseases, Bacterial/pathology , Skin Diseases, Bacterial/physiopathologySubject(s)
Bacteremia/immunology , Inflammatory Bowel Diseases/immunology , Inflammatory Bowel Diseases/microbiology , Immunocompromised Host , Mycobacterium Infections, Nontuberculous/physiopathology , Mycobacterium Infections, Nontuberculous/immunology , Mycobacterium Infections, Nontuberculous/prevention & control , Lymphadenitis/immunology , Lymphadenitis/microbiology , Environmental Microbiology , Mycobacterium avium subsp. paratuberculosis , Mycobacterium/pathogenicity , Lung Diseases/immunology , Lung Diseases/microbiology , Skin Ulcer/microbiologyABSTRACT
Se hace una revisión de la literatura sobre los más destacados aspectos clínicos y terapéuticos de las microbacteriosis se comunican 44 casos. Diez fueron de las siguientes formas: un caso de linfadenopatía y lesiones esporotricoides por M. Kansasii; un caso por M. marinum y tres por microbacterias no determinadas; unalinfadenopatía, probablemente por M. scrofulaceum; un caso de abscesos por microbacterias y otro de lesión verrugosa; una microbacteriosis cutánea ulcerosa y un caso de microbacteriosis de SIDA, así como una epidemia nosocomial en 34 casos