ABSTRACT
PURPOSE: To assess the impact of thinness on the outcome of the percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A matched case-control study was performed using a prospectively collected database of all patients who underwent PCNL between June 2011 and October 2021. The patients were stratified into two groups according to their phenotypic characteristics, arbitrarily defined according to their body mass index (BMI): <0kg/m2 (Group 1, very thin patients, G<20) and ≥25 kg/m2 (Group 2, non-thin patients, G≥25). Patients were randomly matched based on Guy's Stone Score (GSS) according to case complexity at a ratio of 1:3. RESULTS: A total of 204 patients were enrolled in this study: 51 patients (G<20) and 153 controls (G≥25). Complications occurred in 15.2% of the patients, with 5.4% of these complications classified as major complications (Clavien grade ≥ 3). According to complications there were no significant differences between the groups. The overall complication rates were 17.6% in the G<20 and 14.4% in the G≥25 (p = 0.653). The major complication rates were 3.9% in the G<20 and 5.8% in the G≥25 (p=0.429). No differences in transfusion or urinary fistula rates were found. CONCLUSIONS: In this study, very thin patients were not at a higher risk of complications when submitted to PCNL than in those with a BMI of ≥25 kg/m2. Apparently, this technique can be used in these patients, just as it is used in any other type of patient, independently of their BMI.
Subject(s)
Body Mass Index , Kidney Calculi , Nephrolithotomy, Percutaneous , Postoperative Complications , Humans , Female , Male , Case-Control Studies , Nephrolithotomy, Percutaneous/adverse effects , Nephrolithotomy, Percutaneous/methods , Middle Aged , Postoperative Complications/etiology , Adult , Risk Factors , Kidney Calculi/surgery , Thinness/complications , Prospective Studies , Treatment Outcome , Risk Assessment , AgedABSTRACT
INTRODUCTION: Endoscopic Combined Intrarenal Surgery (ECIRS) has emerged as a promising technique for the management of large and complex kidney stones, potentially offering advantages over traditional Percutaneous Nephrolithotomy (PCNL). This study aims to evaluate best practices, outcomes, and future perspectives associated with ECIRS. MATERIALS AND METHODS: A comprehensive PubMed search was conducted from 2008 to 2024, using MESH terms and the following key words: "ECIRS" and "Endoscopic Combined Intrarenal Surgery" The search yielded 157 articles, including retrospective cohort studies, two randomized controlled trials (RCTs), and four meta-analyses comparing ECIRS with PCNL. Most important findings were summarized regarding indications, patient positioning, kidney access, tract size, surgical outcomes, and complications. RESULTS: ECIRS demonstrated higher stone-free rate, lower complication rate, and a reduced need for multiple procedures compared to traditional PCNL. Additionally, ECIRS has the potential to integrate new technologies to further enhance outcomes. CONCLUSION: ECIRS demonstrates significant advantages in the management of large kidney stones. Future research should focus on well-designed RCTs to provide robust evidence of its efficacy, safety, and cost-effectiveness, potentially establishing ECIRS as the first option treatment for complex kidney stones.
Subject(s)
Endoscopy , Kidney Calculi , Humans , Endoscopy/adverse effects , Endoscopy/economics , Endoscopy/methods , Kidney Calculi/economics , Kidney Calculi/surgery , Nephrolithotomy, Percutaneous/adverse effects , Nephrolithotomy, Percutaneous/economics , Nephrolithotomy, Percutaneous/methods , Treatment OutcomeABSTRACT
PURPOSE: Vacuum-assisted mini-percutaneous nephrolithotomy (vmPCNL) is being increasingly adopted due to its faster operating times and lower incidence of postoperative infectious complications (IC), however, studies have been limited by small sample sizes. We hypothesize that vmPCNL is an efficacious treatment for renal stone disease with acceptable stone-free rates (SFR) and low incidence of IC. The objectives of this study were to measure SFR three months after surgery, determine the factors influencing SFR, and determine the rates of postoperative IC after vmPCNL. MATERIALS AND METHODS: Seven hundred and sixty seven patients underwent vmPCNL for the treatment of renal stones > 20 mm at a single institution. Patients underwent postoperative computed tomography at three months to assess SFR. Postoperative fever and SIRS/Sepsis were recorded for individual patients. Multivariate logistics regression was performed to assess predictors of SFR. RESULTS: The SFR was found to be 73.7% at three months. Stone burden (OR 0.39, 95% CI [0.33-0.46]) and age (OR 1.03, 95% CI [1.01-1.04]) emerged as statistically significant predictors of SFR on multivariate analysis. 5.5% of patients experienced postoperative fever, while 2.9% experienced SIRS/Sepsis. CONCLUSIONS: This is the largest continuous cohort of patients to undergo vmPCNL for stone disease and demonstrates that vmPCNL is safe and efficacious, with an SFR of 74% at three months. The incidence of postoperative fever and SIRS/Sepsis is 5.5% and 2.9% respectively. Further randomized studies with large sample sizes are required to ascertain the rates of these complications in comparison to conventional approaches.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Humans , Kidney Calculi/surgery , Male , Female , Nephrolithotomy, Percutaneous/methods , Nephrolithotomy, Percutaneous/adverse effects , Middle Aged , Adult , Treatment Outcome , Vacuum , Postoperative Complications/etiology , Aged , Tomography, X-Ray Computed , Operative Time , Retrospective Studies , Fever/etiology , Risk Factors , Young AdultABSTRACT
PURPOSE: to identify risk factors for urinary septic shock in patients who underwent percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: Data from PCNL procedures performed between January 2009 and February 2020 were retrospectively analyzed. The study included all patients over 18 years old with kidney stones larger than 15 mm who underwent PCNL. Patients who underwent mini-PCNL or combined surgeries, such as ureteroscopy or bilateral procedures, were not included in the study. Logistic regression was conducted to determine the risk factors for urinary septic shock within 30 days post-operation in patients who underwent PCNL. RESULTS: Urinary septic shock was observed in 8 out of the 1,424 patients analyzed (0.56%). The presence of comorbidities, evaluated using the Charlson Comorbidity Index (CCI) (OR 1.46 [CI 95% 1.15-1.86], p=0.01), larger stones (41.0 mm [IQR 30.0-47.5 mm] vs. 24.0 mm [IQR 17.0-35.0 mm], OR 1.03 [CI 95% 1.01-1.06], p=0.04), and a positive preoperative urine culture (OR 8.53 [CI 95% 1.71-42.45], p < 0.01) were shown to significantly increase the risk of postoperative urinary septic shock. Patients with a CCI > 2, larger stones (≥ 35 mm), and a positive preoperative urine culture were at even higher risk of urinary septic shock (OR 15.40 [CI 95% 1.77-134.21], p=0.01). CONCLUSION: Patients with larger stones, positive preoperative urine culture, and a higher CCI are at risk for urinary septic shock after PCNL. These findings are of utmost importance for optimizing the perioperative care of these patients to prevent life-threatening complications.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Postoperative Complications , Shock, Septic , Humans , Shock, Septic/etiology , Nephrolithotomy, Percutaneous/adverse effects , Female , Male , Risk Factors , Retrospective Studies , Middle Aged , Kidney Calculi/surgery , Adult , Postoperative Complications/etiology , Aged , Logistic ModelsABSTRACT
INTRODUCTION: The optimal temperature of irrigation solution in patients undergoing PCNL is still unclear. Accordingly, this study aims to investigate the effects of different irrigation solution temperatures (cold/room temperature irrigation fluid versus warm/body temperature fluid). Our primary endpoint was hypothermia rate. Secondary outcomes were shivering rate, mean temperature decrease, mean patient final temperature, blood loss, and operative time. EVIDENCE ACQUISITION: This systematic review was conducted in accordance with PRISMA guidelines. Multiple databases were searched in November 2023. Among 299 studies screened, eight were selected for full-text review, resulting in four randomized clinical trials that fit inclusion criteria and desired outcomes. Studies selection and data extraction were performed by multiple reviewers and a random-effects model was used for pooling of data. EVIDENCE SYNTHESIS: The primary outcome, hypothermia rate, showed a significant statistical difference between groups, occurring less frequently in the experimental group (35-37 ºC) than in the cold/room temperature irrigation group (RR 0.64;95%CI 0.46, 0.89; P<0.008; I2=33%). Secondary outcomes such as shivering rate (RR 0.46; 95%CI 0.31, 0.67; P<0.0001; I2=0%) and mean final temperatures (MD 0.43; 95%CI 0.12, 0.75; I2=82%) also showed statistically significant differences between groups, favoring the irrigation with heated fluid. CONCLUSIONS: There was a decreased rate of hypothermia and shivering among patients undergoing PCNL with warm irrigation fluid. Mean final temperatures were also higher in the experimental group. As to blood loss, mean hemoglobin decrease showed no statistically significant difference between groups, prompting further investigation of the influence of Irrigation solution temperature on blood loss volume.
Subject(s)
Nephrolithotomy, Percutaneous , Postoperative Complications , Temperature , Therapeutic Irrigation , Humans , Hypothermia/etiology , Nephrolithotomy, Percutaneous/adverse effects , Nephrolithotomy, Percutaneous/methods , Postoperative Complications/etiology , Postoperative Complications/epidemiology , Randomized Controlled Trials as Topic , Shivering , Therapeutic Irrigation/adverse effects , Therapeutic Irrigation/methodsABSTRACT
BACKGROUND: Success rates in endourological procedures, notably percutaneous nephrolithotomy (PCNL) and ureteroscopy (URS), have demonstrated suboptimal outcomes, leading to more reinterventions and radiation exposure. Recently, the use of intraoperative computed tomography (ICT) scans has been hypothesized as a promising solution for improving outcomes in endourology procedures. With this considered, we conducted a comprehensive systematic review and meta-analysis encompassing all available studies that evaluate the impact of the use of intraoperative CT scans on surgical outcomes compared to conventional fluoroscopic-guided procedures. METHODS: This systematic review was conducted in accordance with PRISMA guidelines. Multiple databases were systematically searched up to December of 2023. This study aimed to directly compare the use of an ICT scan with the standard non-ICT-guided procedure. The primary endpoint of interest was success rate, and the secondary endpoints were complications and reintervention rates, while radiation exposure was also evaluated. Data extraction and quality assessment were performed following Cochrane recommendations. Data was presented as an Odds ratio with 95%CI across trials and a random-effects model was selected for pooling of data. RESULTS: A comprehensive search yielded 533 studies, resulting in the selection of 3 cohorts including 327 patients (103 ICT vs 224 in non-ICT). Primary outcome was significantly higher in the experimental group versus the control group (84.5% vs 41.4% respectively, 307 patients; 95% CI [3.61, 12.72]; p<0.00001; I2=0). Reintervention rates also decreased from 32.6% in the control to 12.6% in the ICT group (OR 0.34; 95%CI [0.12,0.94]; p =0.04; I2= 48%), whereas complication rates did not exhibit significant differences. Radiation exposure was also significantly reduced in two of the included studies. CONCLUSION: This meta-analysis highlights a favorable outcome with intraoperative CT scan use in PCNL procedures, showing a considerable increase in SFR when compared to standard fluoroscopy and nephroscopy. Despite limited studies, our synthesis underscores the potential of ICT scans to significantly reduce residual stones and their consequences for endourology patients, as reinterventions and follow-up ionizing radiation studies.
Subject(s)
Nephrolithotomy, Percutaneous , Tomography, X-Ray Computed , Ureteroscopy , Humans , Tomography, X-Ray Computed/methods , Nephrolithotomy, Percutaneous/methods , Nephrolithotomy, Percutaneous/adverse effects , Ureteroscopy/methods , Ureteroscopy/adverse effects , Kidney Calculi/surgery , Kidney Calculi/diagnostic imaging , Intraoperative Care/methods , Treatment Outcome , Fluoroscopy/methods , Radiation Exposure/analysisABSTRACT
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is considered the gold standard treatment for kidney stones greater than 20 mm. However, retrograde intrarenal surgery (RIRS) may achieve the same stone-free rate with repeated procedures, and potentially fewer complications. This study aimed to compare the efficacy and safety of PCNL and two-staged RIRS. EVIDENCE ACQUISITION: We conducted a systematic search in PubMed, Embase, Scopus, Cochrane, and Web of Science for studies comparing PCNL and RIRS for kidney stones greater than 20mm. The primary outcome is stone-free rate (SFR) of PCNL and RIRS (repeated once if needed). Secondary outcomes were SFR of PCNL versus RIRS (single procedure), operative time, hospital stay, need for auxiliary procedures, and complications. We performed a subgroup analysis for randomized trials, non-randomized trials, and patients with solitary kidney. We performed a trial sequential analysis for the main outcome. EVIDENCE SYNTHESIS: We included 31 articles, with 1987 patients in the PCNL and 1724 patients in RIRS. We confirmed the traditional result that after a single procedure PCNL has a higher SFR. We also found that comparing the SFR of PCNL and RIRS, repeated up to two times if needed, no difference in SFR was observed. Surprisingly, only 26% (CI95 23%-28%) of the patients required a second RIRS. In the trial sequential analysis, the last point of the z-curve was within futility borders. We observed that PCNL has a higher incidence of complications (RR=1.51; CI95 1.24, 1.83; P<0.0001; I2=28%), specifically CD2 (RR=1.82; CI95 1.30, 2.54; P=0.0004; I2=26%) and longer hospital stay (MD 2.57; 2.18, 2.96; P<0.00001; I2-98%). No difference was observed regarding operative time. CONCLUSIONS: RIRS repeated up to two times is equivalent to PCNL in terms of the SFR and may have the same safety.
Subject(s)
Kidney Calculi , Lithotripsy , Nephrolithotomy, Percutaneous , Nephrostomy, Percutaneous , Solitary Kidney , Humans , Nephrolithotomy, Percutaneous/adverse effects , Nephrolithotomy, Percutaneous/methods , Nephrostomy, Percutaneous/methods , Kidney Calculi/surgery , Solitary Kidney/therapyABSTRACT
PURPOSE: The aim of this study is to perform a high-quality meta-analysis using only randomized controlled trials (RCT) to better define the role of postoperative antibiotics in patients undergoing percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A literature search for RCTs in EMBASE, PubMed, and Web of Science up to May 2023 was conducted following the PICO framework: Population-adult patients who underwent PCNL; Intervention-postoperative antibiotic prophylaxis until nephrostomy tube withdrawal; Control-single dose of antibiotic during the induction of anesthesia; and Outcome-systemic inflammatory response syndrome (SIRS) or sepsis and fever after PCNL. The protocol was registered on the PROSPERO database (CRD42022361579). We calculated odds ratios (OR) and 95% confidence intervals (CI). A random-effects model was employed, and the alpha risk was defined as < 0.05. RESULTS: Seven articles, encompassing a total of 629 patients, were included in the analysis. The outcome of SIRS or sepsis was extracted from six of the included studies, while the outcome of postoperative fever was extracted from four studies. The analysis revealed no statistical association between the use of postoperative antibiotic prophylaxis until nephrostomy tube withdrawal and the occurrence of SIRS/sepsis (OR 1.236, 95% CI 0.731 - 2.089, p=0.429) or fever (OR 2.049, 95% CI 0.790 - 5.316, p=0.140). CONCLUSION: Our findings suggest that there is no benefit associated with the use of postoperative antibiotic prophylaxis until nephrostomy tube withdrawal in patients undergoing percutaneous nephrolithotomy (PCNL). We recommend that antibiotic prophylaxis should be administered only until the induction of anesthesia in PCNL.
Subject(s)
Antibiotic Prophylaxis , Nephrolithotomy, Percutaneous , Postoperative Complications , Sepsis , Systemic Inflammatory Response Syndrome , Humans , Nephrolithotomy, Percutaneous/adverse effects , Nephrolithotomy, Percutaneous/methods , Antibiotic Prophylaxis/methods , Postoperative Complications/prevention & control , Systemic Inflammatory Response Syndrome/prevention & control , Systemic Inflammatory Response Syndrome/etiology , Sepsis/prevention & control , Sepsis/etiology , Risk Factors , Anti-Bacterial Agents/therapeutic use , Anti-Bacterial Agents/administration & dosage , Randomized Controlled Trials as Topic , Fever/etiologyABSTRACT
OBJECTIVE: To assess safety, urinary symptoms, and feasibility of JJ stent removal with exteriorized threads through the percutaneous tract after percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: Prospective, transversal, comparative, experimental, randomized 1-to-1 cohort study in 52 patients who underwent "tubeless" PCNL from October 2020 to November 2022. Group A with threads through the urethra and Group B through the percutaneous tract. The validated USSQ (Ureteral Stent Symptom Questionnaire) was applied in the Urology office a week after the procedure, and the JJ stent was withdrawn by pulling the threads. Hemoglobin and urine culture, and pre- and post-surgery were evaluated. RESULTS: There is a statistically significant difference in favor of group B when comparing urinary symptoms (p = 0.008), body pain (p = 0.009), and general condition (p = 0.042), mainly for non-urgency incontinence, frequency of analgesic use, and dysuria. There were significant differences between groups (p = 0.028, p = 0.026, p = 0.027, respectively). There is no association with urinary infections (p = 0.603) nor an increased risk of bleeding (p = 0.321). CONCLUSION: The removal of the JJ stent with exteriorized threads through the percutaneous tract after PCNL in the office is a feasible and safe procedure if it is removed before 8 days and has better tolerance regarding the urinary symptoms.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Nephrostomy, Percutaneous , Humans , Nephrolithotomy, Percutaneous/adverse effects , Nephrolithotomy, Percutaneous/methods , Kidney Calculi/etiology , Nephrostomy, Percutaneous/methods , Cohort Studies , Prospective Studies , Stents/adverse effects , Treatment OutcomeABSTRACT
PURPOSE: This study aims to evaluate the safety and efficacy of ultrasound-guided balloon dilation compared to non-balloon dilation for percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A systematic review and meta-analysis were conducted by searching PubMed, EMBASE, and the Cochrane Library. Results were filtered using predefined inclusion and exclusion criteria as described and meta-analysis was performed using Review Manager 5.4 software. RESULTS: A total of six studies involving 1189 patients who underwent PCNL were included. The meta-analysis results demonstrated that compared to non-balloon dilation, balloon dilation was associated with reduced haemoglobin drop [mean difference (MD) = -0.26, 95% CI = -0.40 ~ -0.12, P = 0.0002], decreased transfusion rate [odds ratio (OR) = 0.47, 95% CI = 0.24 ~ 0.92, P = 0.03], shorter tract establishment time (MD = -1.30, 95% CI = -1.87 ~ -0.72, P < 0.0001) and shorter operation time (MD = -5.23, 95% CI = -10.19 ~ -0.27, P = 0.04). CONCLUSIONS: Overall, ultrasound-guided balloon dilatation offered several advantages in PCNL procedures. It facilitated faster access establishment, as evidenced by shorter access creation time. Additionally, it reduced the risk of kidney injury by minimizing postoperative haemoglobin drop and decreasing the need for transfusions. Moreover, it enhanced the efficiency of surgery by reducing the operation time. However, it is important to note that the quality of some included studies was subpar, as they did not adequately control for confounding factors that may affect the outcomes. Therefore, further research is necessary to validate and strengthen these findings.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Nephrostomy, Percutaneous , Humans , Nephrolithotomy, Percutaneous/methods , Dilatation , Kidney , Kidney Calculi/surgery , Ultrasonography, Interventional , Hemoglobins , Nephrostomy, Percutaneous/methods , Treatment OutcomeABSTRACT
Objetivo: Describir las prácticas de médicos especialistas en urología e infectología con práctica clínica en Colombia para el manejo de la bacteriuria asintomática (BA) preoperatoria de pacientes candidatos a cirugía de cálculos urinarios. Método: Estudio de corte transversal, con recolección de datos por medio de instrumento tipo encuesta, diligenciada por especialistas en urología e infectología en Colombia. Se excluyeron las encuestas con respuestas incompletas o participantes con práctica clínica fuera de Colombia. El análisis estadístico se realizó en SPSS v25.0. Se consideró significativa una p < 0,05. Resultados: Se incluyeron 187 participantes, 85% urólogos y 15% infectólogos. La conducta prequirúrgica más frecuente en el manejo de la BA preoperatoria fue iniciar tratamiento antibiótico dirigido por urocultivo 72 horas antes del procedimiento quirúrgico y llevar al paciente a cirugía dentro de los siguientes tres días. Se evidenciaron diferencias en la práctica clínica (uso de antibiótico postoperatorio, tratamiento de la BA en pacientes con derivación urinaria, tiempo de validez del urocultivo preoperatorio, recomendación de diferir procedimiento hasta tener urocultivo negativo) según la especialidad y el volumen asistencial. Conclusiones: Se ha identificado heterogeneidad en el manejo de la BA previo a cirugía endourológica en Colombia. Se abre una oportunidad para desarrollar recomendaciones colombianas para el manejo de la BA preoperatoria en urolitiasis
Objective: To describe practices from Colombian specialists in urology and infectology for the handling of preoperative asymptomatic bacteriuria (AB) in patients that are candidates for endourological surgery of urolithiasis. Method: Cross-sectional study, with data collection through a survey-type instrument completed by specialists in urology and infectology in Colombia. Surveys with incomplete responses or participants with clinical practice outside of Colombia were excluded. Statistical analysis was performed in SPSS v25.0. A p < 0.05 was considered significant. Results: One hundred eighty-seven participants were included, of which 85% were urologists and 15% were infectologists. The most frequent presurgical behavior in the management of preoperative AB was to start targeted antibiotic treatment 72 hours before the procedure and take the patient to surgery within the next three days. Differences were evident in clinical practice (use of postoperative antibiotics, treatment of AB in patients with urinary diversion, validity period of the preoperative urine culture, recommendation to defer the procedure until a negative urine culture is obtained) depending on the specialty and surgical or clinical volume. Conclusions: The present study has identified heterogeneity in the management of AB prior to endourological surgery in Colombia. An opportunity opens up for the development of Colombian recommendations for the management of preoperative AB in urinary lithiasi
Subject(s)
Humans , General Surgery , Bacteriuria , Urine , Urology , Infectious Disease Medicine , Cross-Sectional Studies , Clinical Clerkship , Lithotripsy, Laser , Antibiotic Prophylaxis , Urolithiasis , Nephrolithotomy, PercutaneousABSTRACT
PURPOSE: To investigate the risk factors associated with adverse outcomes in patients with residual stones after percutaneous nephrolithotomy (PCNL) and to establish a nomogram to predict the probability of adverse outcomes based on these risk factors. METHODS: We conducted a retrospective review of 233 patients who underwent PCNL for upper urinary tract calculi and had postoperative residual stones. The patients were divided into two groups according to whether adverse outcomes occurred, and the risk factors for adverse outcomes were explored by univariate and multivariate analyses. Finally, we created a nomogram for predicting the risk of adverse outcomes in patients with residual stones after PCNL. RESULTS: In this study, adverse outcomes occurred in 125 (53.6%) patients. Multivariate logistic regression analysis indicated that the independent risk factors for adverse outcomes were the diameter of the postoperative residual stones (P < 0.001), a positive urine culture (P = 0.022), and previous stone surgery (P = 0.004). The above independent risk factors were used as variables to construct the nomogram. The nomogram model was internally validated. The calculated concordance index was 0.772. The Hosmer-Lemeshow goodness-of-fit test was performed (P > 0.05). The area under the ROC curve of this model was 0.772. CONCLUSIONS: Larger diameter of residual stones, positive urine culture, and previous stone surgery were significant predictors associated with adverse outcomes in patients with residual stones after PCNL. Our nomogram could help to assess the risk of adverse outcomes quickly and effectively in patients with residual stones after PCNL.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Urinary Calculi , Humans , Nephrolithotomy, Percutaneous/adverse effects , Nomograms , Kidney Calculi/surgery , Kidney Calculi/etiology , Urinary Calculi/etiology , Risk Factors , Retrospective Studies , Treatment OutcomeABSTRACT
OBJECTIVE: The aim of this study was to identify predictive factors for complications after percutaneous nephrolithotomy. METHODS: We prospectively analyzed patients who underwent percutaneous nephrolithotomy from June 2011 to October 2018. The association of preoperative and intraoperative factors with the presence of complications was assessed using univariate and multivariate analyses. The significance level was set at p<0.05. RESULTS: A total of 1,066 surgeries were evaluated, and the overall complication rate was 14.9%. In all, 105 (9.8%) surgeries were performed in the prone position, and 961 (90.2%) were performed in the supine position. Univariate analysis demonstrated that surgical position, upper pole puncture, surgical time, number of tracts, and Guys Stone Score were associated with complications. In multivariate analyses, prone position (odds ratio [OR] 2.10; p=0.003), surgical time ≥90 min (OR 1.76; p=0.014), upper pole puncture (OR 2.48; p<0.001), and Guys Stone Score 3 or 4 (OR 1.90; p=0.033) were independent predictive factors for complications after percutaneous nephrolithotomy. CONCLUSION: Performing percutaneous nephrolithotomy in the supine position, in under 90 min, and avoiding upper pole punctures may reduce complications during the treatment of large kidney stones.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Nephrostomy, Percutaneous , Male , Humans , Nephrolithotomy, Percutaneous/adverse effects , Nephrostomy, Percutaneous/adverse effects , Treatment Outcome , Kidney Calculi/surgery , Kidney Calculi/complications , Patient Positioning/adverse effects , Prone Position , Supine Position , Retrospective Studies , Postoperative Complications/etiologyABSTRACT
PURPOSE: The aim of this meta-analysis is to assess the efficacy of extended dose of preoperative antibiotics to reduce infectious risk in patients undergoing percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A literature search for prospective case-control studies or randomized controlled trials was done. PICO framework was used. POPULATION: adult patients that underwent to PCNL; Intervention: extended dose preoperative antibiotic prophylaxis before PCNL; Control: short dose preoperative antibiotic prophylaxis before PCNL; and Outcome: systemic inflammatory response syndrome (SIRS) or sepsis, fever after PCNL and positive intraoperative urine and stone culture. This meta-analysis was registered in PROSPERO database under the number: CRD42022359589. RESULTS: Three RCT and two prospective studies (475 patients) were included. SIRS/sepsis outcome was retrieved from all studies included. Seven days preoperative oral antibiotics for PCNL was a protective factor for developing SIRS/sepsis (OR 0.366, 95% CI 0.234 - 0.527, p < 0.001). There was no statistical association between seven-day use of antibiotics and fever (OR 0.592, 95% CI 0.147 - 2.388, p = 0.462). Patients who received seven days preoperative antibiotics had lower positive intraoperative urine culture (OR 0.284, 95% CI 0.120 - 0.674, p = 0.004) and stone culture (OR 0.351, 95% CI 0.185 - 0.663, p = 0.001) than the control group. CONCLUSION: one week of prophylactic oral antibiotics based on local bacterial sensitivity pattern plus a dose of intravenous antibiotics at the time of surgery in patients undergoing PCNL reduces the risk of infection.
Subject(s)
Kidney Calculi , Nephrolithotomy, Percutaneous , Nephrostomy, Percutaneous , Sepsis , Adult , Humans , Nephrolithotomy, Percutaneous/adverse effects , Anti-Bacterial Agents/therapeutic use , Prospective Studies , Nephrostomy, Percutaneous/adverse effects , Kidney Calculi/surgery , Systemic Inflammatory Response Syndrome/drug therapy , Systemic Inflammatory Response Syndrome/etiology , Postoperative Complications/etiologyABSTRACT
RESUMEN La nefrolitotomía percutánea es un procedimiento estandarizado para el tratamiento de la litiasis renal. El objetivo de esta comunicación fue describir las complicaciones que más incidieron en los pacientes que fueron atendidos en el Hospital Universitario Clínico-Quirúrgico «Arnaldo Milián Castro¼, en el servicio de Urología, de enero de 2015 a diciembre de 2019, a los cuales se les realizó nefrolitotomía percutánea, así como el tratamiento que recibieron y su evolución. Este estudio mostró bajo índice de complicaciones, lo que guarda relación con el poco tiempo utilizado para realizar esta técnica. Esto resultó beneficioso ya que contribuyó a la corta estadía hospitalaria y disminuyó el consumo de materiales e insumos médicos. También representa un gran logro para los médicos y sobre todo para el paciente, el cual puede recuperarse en un menor período de tiempo y vincularse rápidamente a su vida diaria.
ABSTRACT Percutaneous nephrolithotomy is a standardized procedure for the treatment of kidney stones. The objective of this communication was to describe complications, treatment and evolution of patients who underwent a percutaneous nephrolithotomy in the Urology service at "Arnaldo Milián Castro" Clinical and Surgical University Hospital from January 2015 to December 2019. This study showed a low rate of complications, which is related to the short time used to perform this technique. This was beneficial since it contributed to the short hospital stay and decreased the consumption of medical materials and supplies. It also represents a great achievement for doctors and above all for the patients, who can recover in a shorter period of time and be quickly returned to their daily life.