Subject(s)
Exanthema , Polyarteritis Nodosa , Skin Ulcer , Humans , Polyarteritis Nodosa/diagnosis , Polyarteritis Nodosa/drug therapy , Polyarteritis Nodosa/complications , Skin Ulcer/etiology , Skin Ulcer/diagnosis , Skin Ulcer/pathology , Treatment Outcome , Exanthema/etiology , Exanthema/diagnosis , Skin/pathology , Biopsy , Female , Male , Immunosuppressive Agents/therapeutic useSubject(s)
Piperidines , Protein Kinase Inhibitors , Pyrimidines , Humans , Pyrimidines/administration & dosage , Pyrimidines/therapeutic use , Pyrimidines/adverse effects , Piperidines/administration & dosage , Treatment Outcome , Protein Kinase Inhibitors/administration & dosage , Protein Kinase Inhibitors/adverse effects , Female , Male , Middle Aged , Administration, Cutaneous , Aged , Skin Ulcer/drug therapy , Skin Ulcer/diagnosis , Janus Kinase Inhibitors/administration & dosage , Janus Kinase Inhibitors/therapeutic useABSTRACT
ABSTRACT: Clinically amyopathic dermatomyositis (CADM) is a rare subtype of dermatomyositis that presents with cutaneous features and no muscle involvement. This case report describes a 26-year-old woman with recurrent and multiple digital ulcerations coinciding with the start of winter each year. There was no evidence of myopathy, and antibody testing yielded negative results. A diagnosis of CADM was ultimately made based on clinicopathologic correlation. The patient's ulcers demonstrated excellent response to a combination therapy of hydroxychloroquine and potent topical and systemic steroids. Herein, the authors discuss the pathologic and immunologic characteristics of CADM.
Subject(s)
Dermatomyositis , Fingers , Skin Ulcer , Humans , Dermatomyositis/complications , Dermatomyositis/diagnosis , Dermatomyositis/drug therapy , Female , Adult , Skin Ulcer/diagnosis , Skin Ulcer/etiology , Skin Ulcer/drug therapy , Hydroxychloroquine/therapeutic use , Treatment OutcomeSubject(s)
Fever , Headache , Humans , Fever/etiology , Male , Headache/etiology , Skin Ulcer/etiology , Skin Ulcer/diagnosis , Skin Ulcer/pathology , Middle AgedSubject(s)
Malignant Atrophic Papulosis , Penile Diseases , Skin Ulcer , Humans , Male , Penile Diseases/diagnosis , Penile Diseases/pathology , Skin Ulcer/diagnosis , Skin Ulcer/pathology , Skin Ulcer/etiology , Malignant Atrophic Papulosis/diagnosis , Malignant Atrophic Papulosis/pathology , Malignant Atrophic Papulosis/complications , Middle Aged , Pain/etiology , Pain/diagnosisABSTRACT
A man with a history of polysubstance use presents with new bullae on his bilateral lower extremities. What is your diagnosis?
Subject(s)
Thigh , Humans , Blister/pathology , Blister/etiology , Blister/diagnosis , Skin Ulcer/pathology , Skin Ulcer/diagnosis , Skin Ulcer/etiology , Male , Female , Middle AgedABSTRACT
Cytomegalovirus (CMV) infection is common and often self-limited. Reactivation results in a variety of disease presentations, especially in the setting of immunocompromise. While cutaneous manifestations of systemic CMV infection are rare, dermatologic manifestations of CMV are increasingly reported with a wide morphologic spectrum clinically. Three male patients, with untreated human immunodeficiency virus (HIV), penile lichenoid dermatitis treated with long-term topical and intralesional corticosteroids, and metastatic Merkel cell carcinoma on immune checkpoint inhibitor therapy, each presented with isolated cutaneous ulcers. The ulcers were located on the perianal skin, glans of the penis, and distal thumb. In each case, nonspecific histopathologic features were seen. However, very rare dermal cytomegalic cells with nuclear and cytoplasmic inclusions were present and highlighted with an immunohistochemical stain for CMV. Isolated ulcers due to CMV infection may occur in the setting of systemic or localized immunosuppression. A high index of suspicion is needed upon histopathologic evaluation, as few cytomegalic cells may be present and accurate diagnosis is crucial for prompt and appropriate clinical management.
Subject(s)
Cytomegalovirus Infections , Humans , Cytomegalovirus Infections/pathology , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Infections/virology , Male , Middle Aged , Cytomegalovirus/isolation & purification , Aged , Skin Ulcer/pathology , Skin Ulcer/virology , Skin Ulcer/diagnosis , Immunocompromised Host , HIV Infections/complications , HIV Infections/diagnosis , Skin Diseases, Viral/pathology , Skin Diseases, Viral/diagnosis , Skin Diseases, Viral/virologyABSTRACT
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients. We conducted a cross-sectional analysis of AGGF1 levels in sera from 60 SSc patients and 19 healthy controls with enzyme-linked immunosorbent assay. Serum AGGF1 levels in SSc patients were significantly higher than those in healthy individuals. In particular, diffuse cutaneous SSc patients with shorter disease duration had higher levels compared to those with longer disease duration and limited cutaneous SSc patients. Patients with higher serum AGGF1 levels had a higher incidence of digital ulcers, higher modified Rodnan Skin Scores (mRSS), elevated serum Krebs von den Lungen-6 (KL-6) levels, C-reactive protein levels, and right ventricular systolic pressures (RVSP) on the echocardiogram, whereas they had reduced percentage of vital capacity (%VC) and percentage of diffusing capacity of the lungs for carbon monoxide (%DLCO) in pulmonary functional tests. In line, serum AGGF1 levels were significantly correlated with mRSS, serum KL-6 and surfactant protein D levels, RVSP, and %DLCO. These results uncovered notable correlations between serum AGGF1 levels and key cutaneous and vascular involvements in SSc, suggesting potential roles of AGGF1 in SSc pathogenesis.
Subject(s)
Angiogenic Proteins , Mucin-1 , Humans , Male , Female , Middle Aged , Cross-Sectional Studies , Adult , Mucin-1/blood , Angiogenic Proteins/blood , Scleroderma, Systemic/blood , Scleroderma, Systemic/complications , Scleroderma, Systemic/immunology , Case-Control Studies , Aged , C-Reactive Protein/analysis , Skin/pathology , Vital Capacity , Skin Ulcer/blood , Skin Ulcer/etiology , Skin Ulcer/diagnosis , Skin Ulcer/pathology , Severity of Illness IndexSubject(s)
Azetidines , Hydroxychloroquine , Purines , Pyrazoles , Sulfonamides , Humans , Pyrazoles/adverse effects , Pyrazoles/therapeutic use , Hydroxychloroquine/therapeutic use , Hydroxychloroquine/adverse effects , Sulfonamides/therapeutic use , Sulfonamides/adverse effects , Azetidines/therapeutic use , Azetidines/adverse effects , Purines/adverse effects , Purines/therapeutic use , Male , Lipodystrophy/drug therapy , Lipodystrophy/diagnosis , Skin Ulcer/drug therapy , Skin Ulcer/diagnosis , Drug Therapy, CombinationABSTRACT
BACKGROUND: CCD presents as non-caseating granulomas within the skin at a site distant from the GI tract. CCD is a debilitating extraintestinal sequela of CD that can sometimes precede its GI manifestations. In the absence of GI symptoms, the histopathologic and clinical features of CCD can present as a variety of inflammatory skin conditions that can range from ruptured follicle-associated granulomas to cutaneous ulcerations. While a variety of therapeutic options for patients with CCD and concurrent luminal CD have been described in the literature, there is no standard treatment algorithm for the management of refractory CCD with limited or covert GI involvement. CASE REPORT: The authors discuss the case of a 33-year-old female who presented to the wound care clinic with multiple "knife-edged" cutaneous ulcerations involving the intertriginous spaces, found to be consistent with CCD. Her original cutaneous symptoms and diagnosis manifested with minimal GI involvement and responded to IVIG treatment. CONCLUSIONS: This case supports the inclusion of CCD in the differential diagnosis in patients with knife-edged granulomatous skin lesions in intertriginous locations. This clinical condition may present in the setting of no or limited GI symptoms. The management of CCD and a proposed treatment algorithm are also presented.
Subject(s)
Crohn Disease , Skin Ulcer , Humans , Female , Crohn Disease/complications , Crohn Disease/diagnosis , Crohn Disease/therapy , Adult , Skin Ulcer/pathology , Skin Ulcer/diagnosis , Skin Ulcer/therapy , Skin Ulcer/etiology , Diagnosis, Differential , Treatment Outcome , Granuloma/pathology , Granuloma/diagnosis , Granuloma/therapy , Immunoglobulins, Intravenous/therapeutic useSubject(s)
Skin Ulcer , Humans , Male , Skin Ulcer/pathology , Skin Ulcer/diagnosis , Female , Diagnosis, Differential , ChildABSTRACT
Calciphylaxis is a rare and devastating condition found almost exclusively in patients with end-stage renal disease. Nonuremic calciphylaxis, an even more rare diagnosis, occurs in patients with preserved kidney function. We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of this case report is to raise awareness of calciphylaxis as a differential diagnosis for chronic necrotic skin ulcers, especially in patients with preserved renal function and those on warfarin therapy.
Subject(s)
Calciphylaxis , Skin Ulcer , Humans , Female , Ulcer , Calciphylaxis/complications , Calciphylaxis/diagnosis , Skin Ulcer/diagnosis , Skin Ulcer/etiology , Diagnosis, Differential , LegABSTRACT
INTRODUCTION: Kodamaea ohmeri is an emerging fungus recognised as an important pathogen in immunocompromised hosts, responsible for life-threatening infections. CASE PRESENTATION: We describe a case of a 69-year-old immunocompetent man with a long history of leg skin ulcers infected by K. ohmeri. This is the first case of leg wounds infected by K. ohmeri in an immunocompetent patient. The infection was successfully treated with voriconazole 200 mg daily. CONCLUSION: Though rare, K. ohmeri should be considered in patients with skin ulcers that are poorly responsive to medical treatment, even if not immunocompromised.
Subject(s)
Antifungal Agents , Leg Ulcer , Voriconazole , Humans , Aged , Male , Antifungal Agents/therapeutic use , Voriconazole/therapeutic use , Leg Ulcer/drug therapy , Leg Ulcer/microbiology , Leg Ulcer/diagnosis , Leg Ulcer/pathology , Immunocompetence , Skin Ulcer/drug therapy , Skin Ulcer/microbiology , Skin Ulcer/pathology , Skin Ulcer/diagnosis , Skin Ulcer/etiologyABSTRACT
At present, there are no standardized guidelines for determining patient eligibility for pyoderma gangrenosum (PG) clinical trials. Thus, we aim to determine which clinical features, histopathological features, or laboratory features should be included in active ulcerative PG clinical trial eligibility criteria for treatment-naïve patients and patients already treated with immunomodulating medications (treatment-exposed patients). This study employed 4 rounds of the Delphi technique. Electronic surveys were administered to 21 international board-certified dermatologists and plastic surgeon PG experts (June 2022-December 2022). Our results demonstrated that for a patient to be eligible for a PG trial, they must meet the following criteria: (i) presence of ulcer(s) with erythematous/violaceous undermining wound borders, (ii) presence of a painful or tender ulcer, (iii) history/presence of rapidly progressing disease, (iv) exclusion of infection and other causes of cutaneous ulceration, (v) biopsy for H&E staining, and (vi) a presence/history of pathergy. These criteria vary in importance for treatment-naïve versus treatment-exposed patients. Given the international cohort, we were unable to facilitate live discussions between rounds. This Delphi consensus study provides a set of specific, standardized eligibility criteria for PG clinical trials, thus addressing one of the main issues hampering progress toward Food and Drug Administration approval of medications for PG.
Subject(s)
Clinical Trials as Topic , Consensus , Delphi Technique , Patient Selection , Pyoderma Gangrenosum , Humans , Pyoderma Gangrenosum/drug therapy , Pyoderma Gangrenosum/diagnosis , Eligibility Determination/standards , Skin Ulcer/etiology , Skin Ulcer/diagnosis , Skin Ulcer/pathology , Skin Ulcer/drug therapy , Biopsy , Skin/pathology , Skin/drug effectsABSTRACT
Epidemics of yaws-like cutaneous ulcers are regularly documented in children in the tropics. They occur mainly in poor and remote communities without access to health facilities. The integration of molecular tools into yaws control efforts has made it possible to describe Haemophilus ducreyi (HD) as a major cause of cutaneous ulcers. The objective of this study was to determine the prevalence of HD as cause of cutaneous ulcers, investigate its presence in asymptomatic individuals and identify associated risk factors. A cross-sectional study was conducted in yaws endemic districts of Cameroon. Participants included people presenting yaws-like ulcers and asymptomatic individuals. Swab samples were collected from each participant and tested for HD and Treponema pallidum (TP) using an established qPCR method. Additionally, demographic, habitat, proximity, and hygiene characteristics were collected using a structured questionnaire. A total of 443 individuals participated in the study, including 271 ulcer cases and 172 asymptomatic contacts. The prevalence of HD in ulcers was 30.3% (Confidence Interval (CI) 95% [24.8-35.7]) and the prevalence of asymptomatic HD carriage was 8.6% (CI95% [4.5-12.9]). TP was also detected in our sample among ulcer cases but in lower proportion (5.2% CI95% [2.5-7.8]) compared to HD. The adjusted logistic regression model showed that women were as much at risk of having HD cutaneous ulcer as men regardless of age. Physical proximity to a confirmed ulcer case was the major factor identified favouring HD transmission. HD ulcers were more likely to be present on Bantu individuals compared to Baka as well as HD colonization. These findings highlight HD as the most common cause of cutaneous ulcers in yaws-endemic communities in Cameroon. The exact implications of detecting HD on intact skin are not yet clear. Further studies are needed to understand the significance of this carriage in the spread dynamics of the disease.
Subject(s)
Chancroid , Haemophilus ducreyi , Skin Ulcer , Yaws , Male , Child , Humans , Female , Ulcer/epidemiology , Ulcer/etiology , Yaws/diagnosis , Cameroon/epidemiology , Prevalence , Cross-Sectional Studies , Skin Ulcer/epidemiology , Skin Ulcer/diagnosis , Treponema pallidum , Risk Factors , Chancroid/epidemiology , Chancroid/diagnosisABSTRACT
The Chembio DPP (Dual Path Platform) Syphilis Screen & Confirm kit (https://chembio.com) is a rapid serologic test that can be used to diagnose yaws. We evaluated its capacity to detect patients with ulcers that tested PCR positive for Treponema pallidum subsp. pertenue. DPP detected 84% of ulcers that were positive by PCR.