Therapeutic efficacy of isavuconazole and potassium iodide in a cat with refractory sporotrichosis.

A seven-month-old, male, domestic short-hair cat was presented with nodular and ulcerative lesions, as well as respiratory signs, caused by Sporothrix brasiliensis infection. Owing to lack of response to oral itraconazole and potassium iodide, isavuconazole was substituted for itraconazole, leading to clinical cure after three months of treatment without adverse effects.

Un chat domestique mâle à poil court de 7 mois est présenté avec des lésions nodulaires et ulcéreuses, ainsi que des signes respiratoires, causés par une infection à Sporothrix brasiliensis. En raison de l'absence de réponse à l'itraconazole oral et à l'iodure de potassium, l'isavuconazole est substitué à l'itraconazole, ce qui conduit à une guérison clinique après 3 mois de traitement sans effets indésirables.

Um gato doméstico de pelo curto de sete meses de idade foi apresentado com lesões nodulares e ulcerativas, bem como sintomas respiratórios, causados por infecção por Sporothrix brasiliensis. Devido à pobre resposta ao tratamento com itraconazol oral e iodeto de potássio, itraconazol foi substituído por isavuconazol, levando à cura clínica após três meses de tratamento, sem efeitos adversos.

Un gato doméstico de pelo corto, macho, de 7 meses de edad, se presentó con lesiones nodulares y ulcerativas, así como signos respiratorios, causados por infección por Sporothrix brasiliensis. Ante la falta de respuesta a itraconazol y yoduro potásico orales, se sustituyó itraconazol por isavuconazol, con curación clínica tras 3 meses de tratamiento sin efectos adversos.

Systemic sporotrichosis in an alcoholic patient

Abstract A 44-year-old male patient presented with nodules that evolved with inflammation, following drainage of seropurulent secretion and ulceration. The patient had a 6 year-history of alcohol addiction and reported contact with cats. At the physical examination, the patient had skin-colored and erythematous nodules, and ulcers covered with thick, blackened crusts on the face, trunk and limbs. A culture of a nodule fluid revealed growth of Sporotrix sp. He also had pulmonary involvement and therefore the disease was classified as systemic sporotrichosis, a rare form that usually affect patients infected with HIV. Chronic alcohol abuse was considered the factor of immunosuppression for the patient.

Systemic sporotrichosis in an alcoholic patient.

A 44-year-old male patient presented with nodules that evolved with inflammation, following drainage of seropurulent secretion and ulceration. The patient had a 6 year-history of alcohol addiction and reported contact with cats. At the physical examination, the patient had skin-colored and erythematous nodules, and ulcers covered with thick, blackened crusts on the face, trunk and limbs. A culture of a nodule fluid revealed growth of Sporotrix sp. He also had pulmonary involvement and therefore the disease was classified as systemic sporotrichosis, a rare form that usually affect patients infected with HIV. Chronic alcohol abuse was considered the factor of immunosuppression for the patient.

Esporotricose: aspectos clínico-laboratoriais e epidemiológicos observados no Instituto de Infectologia Emlíio Ribas em 12 anos (1989-2000)

A Esporotricose é a doença causada pelo fungo Sporothrix schenchkii, usualmente adquirido por inoculação em atividade profissional ou de lazer, causando uma doença geralmente restrita ao tecido subcutâneo e raramente disseminada para outros órgãos como gânglios linfáticos, pulmões, etc. Apresentamos estudo dos casos atendidos no Instituto de Infectologia Emílio Ribas em 12 anos (1989-2000). Foram obtidos 11 casos de esporotricose, sem diferença significativa entre os sexos e com predomínio dos indivíduos com idade acima dos 30 anos e da forma clínica subcutânea fixa. Os fatores predisponentes associados foram a atividade profissional (lavradores e florista), residência na zona rural e a co-infecção pelo HIV. o principal diagnóstico diferencial foi eito com a Leishmaniose Cutâneo-Mucosa. Os casos foram tratados com Anfotericina B, Iodeto de Potássio ou Itraconazol, sendo que para estes dosi últimos houve necessidade de retratamento com Anfotericina B.