[use of a Staphylococcus bacterial vaccine in pediatric patients with chronic sinusitis]. / Uso de vacuna bacteriana de Staphylococcus en pacientes pediátricos con sinusitis crónica.

INTRODUCTION: The antigenic extracts of bacterial vaccine (Staphylococcus aureus) they increase the phagocitosis, the immunoglobulins concentrations and they help in the immunologic response. OBJECTIVE: To determine the effectiveness of the bacterial vaccine in patient pediatric with chronic sinusitis. MATERIAL AND METHOD: Through a prospective, observational, descriptive and logitudinal study 50 patients were studied with clinical and radiological diagnosis of chronic sinusitis in the period of May from 1997 to July of 1998; they talked to three outlines of antibiotics, they were made studies of cytology hematic, of snot, perspired pharyngeal and immunoglobulin determination and x-rays of breasts paranasals. The extract of 0.1 ml was applied twice up to 0.5 ml per week, subcutaneous trial during eight months, with pursuit of six months and control of cytology hematic, as well as immunoglobulin determination. RESULTS: 82% (41) of the patients they improved and nine (18%) they persisted with symptoms, of these five required the antimicrobials prescription, three tonsillectomi. There was an immunoglobulin increment, mainly of the IgA and IgG in 38 (76%) patient.

Uso de vacuna bacteriana de Staphylococcus en pacientes pediátricos con sinusitis crónica / Use of Staphylococcus bacterial vaccine in pediatric patients with chronic synusitis

Introducción. Los extractos antigénicos de vacuna bacteriana (Staphylococcus aureus) incrementan la fagocitosis, las concentraciones de inmunologlobulinas y ayudan en la respuesta inmunológica. Objetivo. Determinar la eficacia de la vacuna bacteriana en pacientes pediátricos con sinusitis crónica. Material y método. A través de un estudio prospectivo, observacional, descriptivo y longitudinal se estudiaron 50 pacientes con diagnóstico clínico y radiológico de sinusititis crónica en el periodo de mayo de 1997 a julio de 1998; se trataron con tres esquemas de antibióticos, se les efectuaron estudios de citología hemática, de moco, exudado faríngeo y determinación de inmunoglobulinas y radiografías de senos paranasales. Se aplicó el extracto de 0.1 ml hasta 0.5 ml dos veces por semana, vía subcutánea durante ocho meses, con seguimiento de seis meses y control de citología hemática, así como determinación de inmunoglobulinas. Resultados. 82 por ciento (41) de los pacientes mejoraron y nueve (18 por ciento) persistieron con síntomas, de éstos cinco requirieron la prescripción de antimicrobianos, tres amigdalectomía. Hubo un incremento de inmunoglobulina, principalmente de la IgA e IgG en 38 (76 por ciento) pacientes

Nonspecific enhancers of resistance in man.

Nonspecific enhancers of resistance may include (1) viral interference, (2) interferon, (3) interferon inducers, (4) bacterial interference, (5) bacterial products such as Coley's "toxins," endotoxins, or staphylococcal, BCG, and Corynebacterium parvum vaccines, (6) transfer factor, and (7) well-defined chemicals such as dinitrochlorbenzene, levamisole, and vitamin C. These are discussed only as they have been applied to man to learn whether or not they have enhanced his ability to resist infections and growth of tumors. Preliminary studies suggest that a variety of relatively safe and effective nonspecific enhancers may soon be available for clinical use.

Some observations on filariasis in British Guiana and its treatment

The pathological manifestations of parasitization by Wucheria bancrofti appear to result from a combination of three causes namely: (a) an allergic reaction to the parasite evidenced by oedema, urticaria and itching of the skin with occasionally arthritis and synovitis. (b) invasion of the oedematous and devitalized tissues by pathogenic micro-organisms. (c) lymphatic obstruction caused by the parasite itself and partly by a reactive fibrosis. Treatment by streptococcal vaccines is useful but symptoms recur sooner or later. Treatment of the allergic symptoms by desensitization with extracts of Dirofilaria immitis may be helpful. Treatment by a combination of vaccines and desensitizing extracts promises to be of value in amelioration of symptoms, prevention of attacks and prevention of elephantiasis (Summary)