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1.
Khirurgiia (Mosk) ; (7): 130-140, 2024.
Article in Russian | MEDLINE | ID: mdl-39008707

ABSTRACT

We demonstrated successful treatment of patients with complicated central lung cancer, who underwent right upper sleeve lobectomy with carinal resection. We have used the following options for carinal reconstruction: anastomosis of trachea with the left main bronchus and anastomosis of intermediate bronchus with the left main bronchus (clinical case No. 1) or with trachea (clinical case No. 2). Cervicothoracotomy provided correct N-staging and mobilization of trachea with left main bronchus. This approach provided compliance with oncological principles of surgical treatment of lung cancer and significantly reduced tension of anastomosis. These aspects are important for satisfactory immediate functional and oncological results after right upper sleeve lobectomy with carinal resection.


Subject(s)
Bronchi , Lung Neoplasms , Neoplasm Staging , Pneumonectomy , Thoracotomy , Trachea , Humans , Lung Neoplasms/surgery , Pneumonectomy/methods , Male , Trachea/surgery , Thoracotomy/methods , Bronchi/surgery , Middle Aged , Anastomosis, Surgical/methods , Treatment Outcome , Lung/surgery , Lung/diagnostic imaging , Female
2.
Article in English | MEDLINE | ID: mdl-39041591

ABSTRACT

Minimally invasive coronary surgery offers benefits to the patient. Besides the anterior wall, the lateral and inferior walls can be reached through a small thoracotomy with off-pump techniques. Thoracoscopic coronary identification can be very useful in these multivessel procedures. Positioning the heart without cardiopulmonary bypass can be challenging. We describe our technique for off-pump positioning and for grafting the right posterior descending coronary artery.


Subject(s)
Coronary Artery Bypass, Off-Pump , Coronary Vessels , Minimally Invasive Surgical Procedures , Humans , Coronary Artery Bypass, Off-Pump/methods , Minimally Invasive Surgical Procedures/methods , Coronary Vessels/surgery , Thoracotomy/methods , Coronary Artery Disease/surgery , Thoracoscopy/methods , Male
3.
J Cardiothorac Surg ; 19(1): 427, 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38982433

ABSTRACT

INTRODUCTION: Pulmonary regurgitation (PR) remains a common sequela in patients following surgically corrected TOF, and may lead to progressive right ventricle dilatation and dysfunction. The conventional approach of redo-sternotomy for pulmonary valve replacement (PVR) is associated with increased operative time as well as risks of bleeding and injury to the heart and great vessels. Thus, left anterior mini-thoracotomy has become an alternative approach in eliminating the risks of redo-sternotomy in these patients. This series aimed to determine the outcomes of minimally invasive pulmonary valve replacement after surgical TOF correction. METHODS: A retrospective analysis was conducted on 24 patients with severe PR post-surgical TOF correction who underwent left anterior mini-thoracotomy PVR in Penang General Hospital from January 2021 to January 2023. RESULTS: The median age was 23.5 years (I.Q.range 17.6-36.3), with a male:female ratio of 1:4. Majority of patients had mild to moderate symptoms prior to surgery and 19 patients (79.1%) were on regular diuretics medication. All patients had severe free-flow PR with evidence of right ventricular dilatation and dysfunction. Magnetic Resonance Imaging and computed tomography of pulmonary artery were performed prior to surgery. Minimally invasive PVR was performed on all patients via left upper anterior mini-thoracotomy and femoral-femoral bypass without cardioplegic arrest. The operative time and cardiopulmonary bypass time were 208 (I.Q.range 172-324) and 98.6 minutes(I.Q.range 87.4-152.4) respectively. The time to wean off inotropes postoperatively was 6.2 hours (I.Q.range1.4-14.8), and no postoperative arrhythmia and chest re-exploration were reported. Most patients stayed in Intensive Care Unit (ICU) for 10.8 hours (I.Q.range 8.4-36.5), and the total hospital stay was 4.2 days (I.Q.range 3.4-7.6). 2 patients (11.1%) required blood transfusion postoperative. There was no paravalvular leak and no mortality during the follow-up period of up to 28 months. CONCLUSION: Minimally invasive PVR after surgical correction of TOF is a safe alternative to the conventional redo-sternotomy approach in patients with favorable anatomy. This approach is able to reduce the risks associated with redo-sternotomy, particularly bleeding and injury to mediastinal structures, with the additional benefit of expedited recovery and hospital discharge. Our series has shown a safe and efficient approach in these patients with favorable outcomes.


Subject(s)
Heart Valve Prosthesis Implantation , Pulmonary Valve Insufficiency , Tetralogy of Fallot , Thoracotomy , Humans , Male , Female , Tetralogy of Fallot/surgery , Retrospective Studies , Adult , Thoracotomy/methods , Adolescent , Heart Valve Prosthesis Implantation/methods , Young Adult , Pulmonary Valve Insufficiency/surgery , Pulmonary Valve Insufficiency/etiology , Minimally Invasive Surgical Procedures/methods , Pulmonary Valve/surgery , Treatment Outcome
4.
BMC Anesthesiol ; 24(1): 240, 2024 Jul 16.
Article in English | MEDLINE | ID: mdl-39014323

ABSTRACT

INTRODUCTION: Thoracotomy procedures can result in significant pain and cause nausea/vomiting. Glucocorticoids have anti-emetic and analgesic effects due to their anti-inflammatory and nerve-blocking properties. This study investigates the additive effect of local dexamethasone with bupivacaine as sole analgesic medication through a peripleural catheter after thoracotomy. METHOD: The study was conducted as a randomized control trial on 82 patients. Participants were allocated to receive either 2.5 mg/kg of bupivacaine plus 0.2 mg/kg of dexamethasone or 2.5 mg/kg of bupivacaine plus the same amount of normal saline as placebo through a 6 French peripleural catheter implemented above the parietal pleura and beneath the musculoskeletal structure of the chest wall. The primary outcome was the severity of pain 24 h after the operation in the visual analogue scale (VAS) score. Secondary outcomes were the incidence of nausea/vomiting, opioid consumption for pain control, and incidence of any adverse effects. RESULTS: A total of 50 participants were randomized to each group, and the baseline characteristics were similar between the groups. Median of VAS score (6 (3-8) vs. 8 (6-9), p < 0.001), postoperative opioid consumption (9 (36%) vs. 17 (68%) patients, p=0.024), and median length of hospital stay (4 (3-8) vs. 6 (3-12) days, p < 0.001) were significantly lower in the dexamethasone group. However, postoperative nausea/vomiting (p=0.26 for nausea and p=0.71 for vomiting) and surgical site infection (p = 0.55) were similar between the two groups. CONCLUSION: In thoracotomy patients, administering local dexamethasone + bupivacaine through a peripleural catheter can reduce postoperative pain, analgesic consumption, and length of hospital stay. TRIAL REGISTRATION: Iranian Registry of Clinical Trials (IRCT20220309054226N1, registration date: 3/21/2022.


Subject(s)
Anesthetics, Local , Bupivacaine , Dexamethasone , Pain, Postoperative , Thoracotomy , Humans , Dexamethasone/administration & dosage , Dexamethasone/therapeutic use , Thoracotomy/adverse effects , Thoracotomy/methods , Male , Pain, Postoperative/drug therapy , Pain, Postoperative/prevention & control , Female , Bupivacaine/administration & dosage , Middle Aged , Anesthetics, Local/administration & dosage , Anesthetics, Local/therapeutic use , Double-Blind Method , Pain Management/methods , Postoperative Nausea and Vomiting/epidemiology , Adult , Pain Measurement/methods , Analgesics, Opioid/administration & dosage , Analgesics, Opioid/therapeutic use , Aged , Drug Therapy, Combination
5.
Ann Card Anaesth ; 27(3): 193-201, 2024 Jul 01.
Article in English | MEDLINE | ID: mdl-38963353

ABSTRACT

ABSTRACT: With the advancements in regional anesthesia and ultrasound techniques, the use of non-neuraxial blocks like the erector spinae plane block (ESPB) has been increasing in cardiac surgeries with promising outcomes. A total of 3,264 articles were identified through a literature search. Intervention was defined as ESPB. Comparators were no regional technique performed or sham blocks. Four studies with a total of 226 patients were included. Postoperative opioid consumption was lower in the group that received ESPB than the group that did not (weighted mean difference [WMD]: -204.08; 95% CI: -239.98 to -168.19; P < 0.00001). Intraoperative opioid consumption did not differ between the two groups (WMD: -398.14; 95% CI: -812.17 to 15.98; P = 0.06). Pain scores at 0 hours were lower in the group that received ESPB than the group that did not (WMD: -1.27; 95% CI: -1.99 to -0.56; P = 0.0005). Pain scores did not differ between the two groups at 4-6 hours (WMD: -0.79; 95% CI: -1.70 to 0.13; P = 0.09) and 12 hours (WMD: -0.83; 95% CI: -1.82 to 0.16; P = 0.10). Duration of mechanical ventilation in minutes was lower in the group that received ESPB than the group that did not (WMD: -45.12; 95% CI: -68.82 to -21.43; P = 0.0002). Given the limited number of studies and the substantial heterogeneity of measured outcomes and interventions, further studies are required to assess the benefit of ESPB in midline sternotomies.


Subject(s)
Nerve Block , Pain, Postoperative , Paraspinal Muscles , Randomized Controlled Trials as Topic , Humans , Nerve Block/methods , Pain, Postoperative/prevention & control , Paraspinal Muscles/innervation , Analgesia/methods , Treatment Outcome , Perioperative Care/methods , Thoracotomy/methods
6.
Article in English | MEDLINE | ID: mdl-38980286

ABSTRACT

This study elucidates the efficacy and outcomes of a minimally invasive aortic valve replacement via a right anterior mini-thoracotomy, emphasizing its potential to minimize surgical trauma and expedite recovery while maintaining procedural integrity comparable to that of a traditional full sternotomy. This video tutorial demonstrates a successful aortic valve replacement procedure using the right anterior mini-thoracotomy approach, characterized by the absence of sutureless valves and specialized instruments. The detailed surgical procedure includes specific steps to optimize visibility and access through strategic incisions and rib dislocations, adhering to "the box principle" for effective exposure of the aortic valve. This video tutorial suggests that a right anterior mini-thoracotomy is a viable, cost-effective alternative to a conventional sternotomy for aortic valve replacement, offering significant patient benefits without compromising long-term valve function or safety. The broader implications for patient selection and surgical techniques highlight the need for meticulous preoperative planning and anatomical assessment to maximize the potential of a right anterior mini-thoracotomy in clinical practice.


Subject(s)
Aortic Valve , Heart Valve Prosthesis Implantation , Minimally Invasive Surgical Procedures , Thoracotomy , Humans , Thoracotomy/methods , Minimally Invasive Surgical Procedures/methods , Heart Valve Prosthesis Implantation/methods , Aortic Valve/surgery , Male , Female , Aged , Sternotomy/methods , Treatment Outcome , Aortic Valve Stenosis/surgery
7.
ASAIO J ; 70(7): 565-569, 2024 Jul 01.
Article in English | MEDLINE | ID: mdl-38949771

ABSTRACT

National trends show rapid increases in the use of mechanical circulatory support devices (MCSD) over the last 20 years. While current literature has not proven a mortality benefit in cardiogenic shock as a complication of acute myocardial infarction (AMI-CS) with percutaneous MCSD, these devices are vital to maximizing cardiopulmonary parameters for definitive therapy. To minimize complications, many different techniques have been described including a novel off-pump direct apical cannulation for venoarterial-extracorporeal membrane oxygenation (VA-ECMO). This technique allows early ambulation and avoids peripheral artery access complications but has only been described in small case series. Our case series represents the largest summary of patients (50) using this technique and contains the only comparison data to date. Fifty-four percentage of our patients were Society for Cardiovascular Angiography and Interventions (SCAI) stage D and 22% were arrested before cannulation. We achieved flows on average >5 L/min and most patients required biventricular drainage (86%) and an oxygenator (92%). Thirty day survival was 56% and most survivors were bridged to heart transplant (30%). Our most common complication was bleeding (16%). This technique showed significant improvement in ejection fraction (EF), cardiac output/index (CO/CI), and pulmonary artery pressures. This case series demonstrates the safety and efficacy of this novel technique for central cannulation in cardiogenic shock at large scale within a single institution.


Subject(s)
Cannula , Extracorporeal Membrane Oxygenation , Shock, Cardiogenic , Humans , Extracorporeal Membrane Oxygenation/methods , Extracorporeal Membrane Oxygenation/adverse effects , Extracorporeal Membrane Oxygenation/instrumentation , Middle Aged , Male , Female , Shock, Cardiogenic/therapy , Shock, Cardiogenic/surgery , Aged , Thoracotomy/methods , Thoracotomy/adverse effects , Catheterization/methods , Catheterization/adverse effects , Catheterization/instrumentation , Adult , Myocardial Infarction , Heart-Assist Devices/adverse effects
8.
Sci Rep ; 14(1): 17625, 2024 Jul 31.
Article in English | MEDLINE | ID: mdl-39085273

ABSTRACT

Aortic valve replacement (AVR) is a critical procedure for patients with aortic valve diseases. This study compares the effectiveness of three minimally-invasive surgical approaches for AVR: totally thoracoscopic (TT), right anterior mini-thoracotomy, and upper mini-sternotomy. We analyzed retrospective data from 130 patients who underwent one of these surgeries, focusing on various factors such as duration of hospital stay, operation time, times for cardiopulmonary bypass and aortic cross-clamping, postoperative complications, levels of cardiac biomarkers, pain intensity using the Visual Analog Scale, and mid-term survival rates. Results show that while the TT method had the longest operation times, it also had the shortest hospital stays and faster pain reduction post-surgery. Although the TT group initially showed higher cardiac biomarker levels after surgery, these levels normalized by the third day, similar to the other groups. There were no significant differences in mid-term survival and major adverse cardiac and cerebrovascular event (MACCE) rates among the groups. These findings suggest that the TT method, despite longer surgical times, offers a quicker initial recovery, making it a viable option for AVR.


Subject(s)
Aortic Valve , Heart Valve Prosthesis Implantation , Sternotomy , Thoracoscopy , Thoracotomy , Humans , Male , Female , Thoracotomy/methods , Sternotomy/methods , Aortic Valve/surgery , Middle Aged , Aged , Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis Implantation/adverse effects , Retrospective Studies , Thoracoscopy/methods , Treatment Outcome , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Operative Time , Length of Stay , Minimally Invasive Surgical Procedures/methods
9.
Khirurgiia (Mosk) ; (6): 94-99, 2024.
Article in Russian | MEDLINE | ID: mdl-38888025

ABSTRACT

Surgical treatment of chondromyxoid fibroma of ribs is described. The diagnosis was verified after histological analysis. The patient underwent resection of multinodular tumor of anterolateral thoracic wall invading abdominal cavity via thoracoabdominal access. Postoperative period was uneventful. This case demonstrates the need for total en-bloc resection of tumor with surrounding tissues. Surgery is the only effective method for these patients.


Subject(s)
Bone Neoplasms , Fibroma , Ribs , Humans , Ribs/surgery , Fibroma/surgery , Fibroma/diagnosis , Bone Neoplasms/surgery , Bone Neoplasms/diagnosis , Bone Neoplasms/pathology , Treatment Outcome , Male , Thoracic Wall/surgery , Female , Tomography, X-Ray Computed/methods , Adult , Thoracotomy/methods
10.
J Robot Surg ; 18(1): 264, 2024 Jun 25.
Article in English | MEDLINE | ID: mdl-38916783

ABSTRACT

Upper hemi-sternotomy is a common approach for outflow graft anastomosis to the ascending aorta in minimally invasive left-ventricular assist device implantation. Right mini-thoracotomy may also be used, but use of robotic assistance has been reported only anecdotally. The aim of our study was to confirm the feasibility of robotically assisted suturing of the outflow graft anastomosis and to assess performance metrics for the robotic suturing part of the procedure. The procedure was carried out in eight cadaver studies by two surgeons. The assist device pump head was inserted through a left-sided mini-thoracotomy and the outflow graft was passed toward a right-sided second interspace mini-thoracotomy through the pericardium. After placement of a partial occlusion clamp on the ascending aorta, a longitudinal aortotomy was performed and the outflow graft to ascending aorta anastomosis was carried out robotically. The procedure was feasible in all eight attempts. The mean outflow graft anastomotic time was 20.1 (SD 6.8) min and the mean surgeon confidence and comfort levels to complete the anastomoses were 8.3 (SD 2.4) and 6.9 (SD2.2), respectively, on a ten-grade Likert scale. On open inspection of the anastomoses, there was good suture alignment in all cases. We conclude that suturing of a left-ventricular assist device outflow graft to the human ascending aorta is very feasible with good surgeon comfort. Anastomotic times are acceptable and suture placement can be performed with appropriate alignment.


Subject(s)
Anastomosis, Surgical , Cadaver , Feasibility Studies , Heart-Assist Devices , Minimally Invasive Surgical Procedures , Operative Time , Robotic Surgical Procedures , Humans , Robotic Surgical Procedures/methods , Robotic Surgical Procedures/instrumentation , Anastomosis, Surgical/methods , Minimally Invasive Surgical Procedures/methods , Aorta/surgery , Surgeons , Suture Techniques , Prosthesis Implantation/methods , Thoracotomy/methods
11.
J Cardiothorac Surg ; 19(1): 348, 2024 Jun 21.
Article in English | MEDLINE | ID: mdl-38907312

ABSTRACT

BACKGROUND: The incidence of minimally invasive heart surgery via mini-thoracotomy (MT; right anterior thoracotomy) is on the rise, accompanied by an increase in post-MT intercostal nerve neuralgia and the risk of lung herniation through the incision site. While various methods have been proposed to address these issues, none have been commonly effective. In this case report, we attempted to simultaneously address these problems by performing intercostal cryoablation (IC) and mesh repair. CASE PRESENTATION: A 43-year-old male was referred to our hospital for chronic post-thoracotomy neuralgia following heart surgery via MT, involving patch closure of an atrial septal defect and tricuspid annuloplasty. He presented with intercostal nerve neuralgia and lung herniation accompanied by severe pain. Despite medication and lidocaine injections, there was no relief. Consequently, he underwent surgical treatment with IC for chronic MT wound pain and simultaneously underwent mesh repair for a lung hernia. He was discharged from hospital free of complications. Subsequently, he no longer required further pain medication and experienced a favorable recovery. CONCLUSION: Our findings suggest that concurrent IC and mesh repair can effectively relieve chronic post-MT intercostal nerve neuralgia and severe lung herniation pain in patients who underwent MT surgery, leading to a decrease in opioid medication usage.


Subject(s)
Cryosurgery , Herniorrhaphy , Intercostal Nerves , Pain, Postoperative , Surgical Mesh , Thoracotomy , Humans , Male , Adult , Cryosurgery/methods , Thoracotomy/methods , Herniorrhaphy/methods , Intercostal Nerves/surgery , Intercostal Nerves/injuries , Pain, Postoperative/etiology , Lung Diseases/surgery , Lung Diseases/etiology , Neuralgia/etiology , Neuralgia/surgery , Hernia/etiology , Chronic Pain/etiology , Chronic Pain/surgery
12.
J Cardiothorac Surg ; 19(1): 354, 2024 Jun 22.
Article in English | MEDLINE | ID: mdl-38909233

ABSTRACT

BACKGROUND: A left thoracotomy approach is anatomically appropriate for childhood aortic coarctation; however, the pediatric femoral arteriovenous diameters are too small for cardiopulmonary bypass cannulation. We aimed to determine the safety of a partial cardiopulmonary bypass through the main pulmonary artery and the descending aorta in pediatric aortic coarctation repair. METHODS: We retrospectively reviewed 10 patients who underwent coarctation repair under partial main pulmonary artery-to-descending aorta cardiopulmonary bypass with a left thoracotomy as the CPB group. During the same period, 16 cases of simple coarctation of the aorta repair, with end-to-end anastomosis through a left thoracotomy without partial CPB assistance, were included as the non-CPB group to evaluate the impact of partial CPB. RESULTS: The median age and weight at surgery of the CPB group were 3.1 years (range, 9 days to 17.9 years) and 14.0 (range, 2.8-40.7) kg, respectively. Indications for the partial cardiopulmonary bypass with overlap were as follows: age > 1 year (n = 7), mild aortic coarctation (n = 3), and predicted ischemic time > 30 min (n = 5). Coarctation repair using autologous tissue was performed in seven cases and graft replacement in three. The mean partial cardiopulmonary bypass time, descending aortic clamp time, and cardiopulmonary bypass flow rate were 73 ± 37 min, 57 ± 27 min, and 1.6 ± 0.2 L/min/m2, respectively. Urine output during descending aortic clamping was observed in most cases in the CPB group (mean: 9.1 ± 7.9 mL/kg/h), and the total intraoperative urine output was 3.2 ± 2.7 mL/kg/h and 1.2 ± 1.5 mL/kg/h in the CPB and non-CPB group, respectively (p = 0.020). The median ventilation time was 1 day (range, 0-15), and the intensive care unit stay duration was 4 days (range, 1-16) with no surgical deaths. No major complications, including paraplegia or recurrent coarctation, occurred postoperatively during a median observation period of 8.1 (range, 3.4-17.5) years in the CPB group. In contrast, reoperation with recurrent coarctation was observed in 2 cases in the non-CPB group (p = 0.37). CONCLUSIONS: Partial cardiopulmonary bypass through the main pulmonary artery and descending aorta via a left thoracotomy is a safe and useful option for aortic coarctation repair in children.


Subject(s)
Aortic Coarctation , Cardiopulmonary Bypass , Thoracotomy , Humans , Aortic Coarctation/surgery , Retrospective Studies , Cardiopulmonary Bypass/methods , Child, Preschool , Child , Infant , Thoracotomy/methods , Male , Female , Adolescent , Infant, Newborn , Aorta, Thoracic/surgery , Pulmonary Artery/surgery , Treatment Outcome
13.
Eur J Cardiothorac Surg ; 65(5)2024 May 03.
Article in English | MEDLINE | ID: mdl-38745366

ABSTRACT

In the current endovascular era, open surgery through left posterolateral thoracotomy with moderate to deep hypothermic circulatory arrest remains an alternative for treating chronic distal arch or proximal descending aortic diseases, allowing cardiovascular surgeons to definitively repair the aorta in a single stage. When utilizing this approach, this report illustrates an alternative surgical technique for antegrade body perfusion during cooling, antegrade selective cerebral perfusion and rewarming, through a prosthetic graft on the right subclavian artery. This report shows the safety and feasibility of this technique during open distal arch and/or proximal descending aortic surgery through left posterolateral thoracotomy, after shifting the patient from a supine to the right lateral decubitus position.


Subject(s)
Aorta, Thoracic , Cerebrovascular Circulation , Subclavian Artery , Thoracotomy , Humans , Subclavian Artery/surgery , Thoracotomy/methods , Aorta, Thoracic/surgery , Cerebrovascular Circulation/physiology , Male , Perfusion/methods , Aged , Blood Vessel Prosthesis Implantation/methods , Aortic Aneurysm, Thoracic/surgery , Middle Aged
14.
J Int Med Res ; 52(5): 3000605241247656, 2024 May.
Article in English | MEDLINE | ID: mdl-38818531

ABSTRACT

OBJECTIVE: To compare the clinical effects of coronary artery bypass grafting (CABG) between the left anterior small thoracotomy (LAST) and lower-end sternal splitting (LESS) approaches for coronary artery disease. METHODS: In total, 110 patients who underwent LAST from October 2015 to December 2020 in Tianjin Chest Hospital were selected as the observation group. Patients who underwent the LESS approach during the same period were analyzed. The propensity score was calculated by a logistic regression model, and nearest-neighbor matching was used for 1:1 matching. RESULTS: The length of hospital stay and ventilator support time were significantly shorter in the LAST than LESS group. The target vessels in the obtuse marginal branch and posterior left ventricular artery branch grafts were significantly more numerous in the LAST than LESS group, but those in the right coronary artery graft were significantly less numerous in the LAST group. CONCLUSIONS: CABG using either the LAST or LESS approach is safe and effective, especially in low-risk patients. The LAST approach can achieve complete revascularization for multivessel lesions and has the advantages of less trauma and an aesthetic outcome. However, it requires a certain learning curve to master the surgical techniques and has specific surgical indications.


Subject(s)
Coronary Artery Bypass , Coronary Artery Disease , Thoracotomy , Humans , Coronary Artery Bypass/methods , Male , Thoracotomy/methods , Female , Middle Aged , Coronary Artery Disease/surgery , Aged , Length of Stay/statistics & numerical data , Sternum/surgery , Treatment Outcome , Propensity Score , Retrospective Studies
15.
Clin Lung Cancer ; 25(5): 395-406.e5, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38705833

ABSTRACT

BACKGROUND: Immune checkpoint inhibitors have revolutionized non-small cell lung cancer (NSCLC) treatment but may pose greater technical challenges for surgery. This study aims to assess the feasibility and oncological effectiveness of video-assisted thoracoscopic surgery (VATS) for resectable stage III NSCLC after neoadjuvant immunochemotherapy. METHODS: Initial stage IIIA-IIIB NSCLC patients with neoadjuvant immunochemotherapy undergoing either VATS or open lobectomy at 6 medical centers during 2019-2023 were retrospectively identified. Perioperative outcomes and 2-year survival was analyzed. Propensity-score matching (PSM) was employed to balance patient baseline characteristics. RESULTS: Among the total 143 patients, PSM yielded 62 cases each for VATS and OPEN groups. Induction-related adverse events were comparable between the 2 groups. VATS showed a 14.5% conversion rate. Notably, VATS decreased numeric rating scales for postoperative pain, shortened chest tube duration (5[4-7] vs. 6[5-8] days, P = .021), reduced postoperative comorbidities (21.0% vs. 37.1%, P = .048), and dissected less N1 lymph nodes (5[4-6] vs. 7[5-9], P = .005) compared with thoracotomy. Even when converted, VATS achieves perioperative outcomes equivalent to thoracotomy. Additionally, over a median follow-up of 29.5 months, VATS and thoracotomy demonstrated comparable 2-year recurrence-free survival (77.20% vs. 73.73%, P = .640), overall survival (87.22% vs. 88.00%, P = .738), cumulative incidences of cancer-related death, and recurrence patterns. Subsequent subgroup comparisons and multivariate Cox analysis likewise revealed no statistical difference between VATS and thoracotomy. CONCLUSION: VATS is a viable and effective option for resectable stage III NSCLC patients following neoadjuvant immunochemotherapy, leading to decreased surgical-related pain, earlier chest tube removal, reduced postoperative complications, and similar survival outcomes compared to thoracotomy.


Subject(s)
Carcinoma, Non-Small-Cell Lung , Lung Neoplasms , Neoadjuvant Therapy , Neoplasm Staging , Thoracic Surgery, Video-Assisted , Thoracotomy , Humans , Carcinoma, Non-Small-Cell Lung/pathology , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/surgery , Carcinoma, Non-Small-Cell Lung/mortality , Thoracic Surgery, Video-Assisted/methods , Male , Female , Retrospective Studies , Lung Neoplasms/pathology , Lung Neoplasms/drug therapy , Lung Neoplasms/surgery , Lung Neoplasms/mortality , Neoadjuvant Therapy/methods , Middle Aged , Thoracotomy/methods , Aged , China/epidemiology , Pneumonectomy/methods , Survival Rate , Immunotherapy/methods , Follow-Up Studies , East Asian People
16.
Ann Card Anaesth ; 27(1): 10-16, 2024 Jan 01.
Article in English | MEDLINE | ID: mdl-38722115

ABSTRACT

BACKGROUND AND OBJECTIVE: Regional analgesia is effective for post-thoracotomy pain. The primary objective of the study is to compare the intraoperative requirement of isoflurane and fentanyl between general anaesthesia (GA) with epidural analgesia and GA with paravertebral analgesia. METHODS AND MATERIAL: A prospective observational comparative study was conducted on 56 patients undergoing open thoracotomy procedures. The patients were divided into two groups of 28 by assigning the study participants alternatively to each group: Group GAE - received thoracic epidural catheterization with GA, and Group GAP - received ultrasound guided thoracic paravertebral catheterization on the operative side with GA. Intraoperative requirement of isoflurane, fentanyl, postoperative analgesia, stress response, need of rescue analgesics and adverse effects were observed and analysed. RESULTS: 25 patients in each group were included in the data analysis. The intraoperative requirement of isoflurane (32.28 ± 1.88 vs 48.31 ± 4.34 ml; p < 0.0001) and fentanyl (128.87 ± 25.12 vs 157 ± 30.92 µg; p = 0.0009) were significantly less in the GAE group than in the GAP group. VAS scores and need of rescue analgesics and blood glucose levels were not statistically significant during the postoperative period (p > 0.05). The incidence of adverse effects was comparable except for hypotension and urinary retention which were significantly higher in the GAE group. CONCLUSION: GA with epidural analgesia resulted in significant reduction in the intraoperative consumption of isoflurane and fentanyl in comparison to GA with paravertebral analgesia. However, both the techniques were equally effective in the postoperative period.


Subject(s)
Analgesia, Epidural , Anesthesia, General , Fentanyl , Pain, Postoperative , Thoracotomy , Humans , Female , Male , Thoracotomy/methods , Prospective Studies , Middle Aged , Anesthesia, General/methods , Fentanyl/administration & dosage , Analgesia, Epidural/methods , Pain, Postoperative/prevention & control , Pain, Postoperative/drug therapy , Adult , Isoflurane/administration & dosage , Anesthetics, Inhalation/administration & dosage , Analgesics/therapeutic use , Analgesics/administration & dosage , Aged , Nerve Block/methods
17.
J Anesth ; 38(4): 525-536, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38767667

ABSTRACT

PURPOSE: The potential of uniportal video-assisted thoracic surgery (U-VATS) to reduce chronic pain after thoracic surgery (CPTS) compared to open thoracotomy (OT) remains unexplored. This prospective study aims to assess the incidence of CPTS following U-VATS or OT and identify associated risk factors. METHODS: Patients undergoing thoracic surgery were recruited from March 2021 to March 2022, categorized by surgical approach (U-VATS vs. OT). Standard clinical protocols for surgery, anesthesia, and analgesia were followed. Pain symptoms were assessed using the Short-form McGill Pain Questionnaire, with follow-ups up to 6 months. Perioperative factors influencing CPTS at 3 months were analyzed through univariate and multivariate methods. RESULTS: A total of 694 patients were analyzed. Acute pain after thoracic surgery (APTS) was significantly less severe in the U-VATS group (p < 0.001). U-VATS patients exhibited a lower incidence of CPTS at 3 months (63.4% vs. 80.1%, p < 0.001), with reduced severity among those experiencing CPTS (p = 0.007) and a decreased occurrence of neuropathic pain (p = 0.014). Multivariate analysis identified OT incision, moderate to severe APTS (excluding moderate static pain at 24 h postoperative), nocturnal surgery, and lung surgery as risk factors for CPTS. CONCLUSION: This study underscores the potential of U-VATS to reduce both the incidence and severity of CPTS at 3 months compared to OT. Furthermore, it highlights risk factors for CPTS, including OT incision, inadequately managed APTS, lung surgery, and nocturnal surgery. These findings emphasize the importance of considering surgical approach and perioperative pain management strategies to mitigate the burden of CPTS.


Subject(s)
Chronic Pain , Pain, Postoperative , Thoracic Surgery, Video-Assisted , Thoracotomy , Humans , Thoracic Surgery, Video-Assisted/methods , Thoracic Surgery, Video-Assisted/adverse effects , Male , Female , Prospective Studies , Thoracotomy/methods , Thoracotomy/adverse effects , Chronic Pain/epidemiology , Chronic Pain/etiology , Pain, Postoperative/epidemiology , Pain, Postoperative/prevention & control , Middle Aged , Aged , Pain Measurement/methods , Risk Factors , Adult , Cohort Studies , Incidence
18.
Port J Card Thorac Vasc Surg ; 31(1): 23-28, 2024 May 13.
Article in English | MEDLINE | ID: mdl-38743523

ABSTRACT

INTRODUCTION: Myasthenia gravis (MG) is an autoimmune, neurologic disease that causes a wide range of symptoms. While the transsternal, transcervical and thoracotomy approaches are accepted as effective, there is still debate regarding the VATS approach. MATERIALS AND METHODS: We analyzed our center's surgical experience with thymectomy for myasthenia gravis, comparing the results of patients operated on using VATS and more invasive approaches, over a period of 10 years. A search of the department's surgical database for myasthenia gravis cases between January 2010 and January 2021, revealed a total of 40 cases. Twenty-four patients were included in the final analysis and were distributed into two groups: the VATS procedure group (group A) and the open procedure group (group B). The latter included sternotomy, thoracotomy, transcervical and hemiclamshell approaches. Only radical thymectomies were included. The established outcomes were clinical improvement defined as asymptomatic remission, reduction, or discontinuation of the medication necessary to achieve optimal symptom control. RESULTS: The median follow-up time was 27 months (ranging from 4 to 75 months). Videothoracoscopy radical thymectomy was performed on 12 patients. Complete remission with no medication was achieved in 1 case (8.3%), while 2 patients (16.7%) became asymptomatic with reduced medication. An improvement (reduced symptoms or decreased medication) was observed in 8 cases (66.6%). No change in clinical outcome was noted in 1 patient (8.3%). None of the patients reported worsening symptoms. Open thymectomy was performed on 12 patients. Complete remission with no medication was achieved in 1 case (8.3%), while 2 patients (16.7%) became asymptomatic with reduced medication. An improvement was noted in 6 cases (50%). No change in clinical outcome was observed in 3 patients (25%) whereas 2 of them (16.7%) experienced slightly better symptom control but with a significant increase in medication. One patient (8.3%) described the clinical results as without any significant change. None of the patients reported worsening symptoms. CONCLUSION: The videotoracoscopic approach in the treatment of myasthenia gravis is non-inferior compared to the open approach and effective in a long-term follow-up, offering all the additional benefits of less invasive surgery.


Subject(s)
Myasthenia Gravis , Thoracic Surgery, Video-Assisted , Thymectomy , Humans , Myasthenia Gravis/surgery , Thymectomy/methods , Thoracic Surgery, Video-Assisted/methods , Thoracic Surgery, Video-Assisted/adverse effects , Male , Female , Middle Aged , Adult , Retrospective Studies , Treatment Outcome , Aged , Thoracotomy/methods , Thoracotomy/adverse effects , Young Adult
19.
Med Sci Monit ; 30: e943089, 2024 May 10.
Article in English | MEDLINE | ID: mdl-38725228

ABSTRACT

BACKGROUND One-lung ventilation is the separation of the lungs by mechanical methods to allow ventilation of only one lung, particularly when there is pathology in the other lung. This retrospective study from a single center aimed to compare 49 patients undergoing thoracoscopic cardiac surgery using one-lung ventilation with 48 patients undergoing thoracoscopic cardiac surgery with median thoracotomy. MATERIAL AND METHODS This single-center retrospective study analyzed patients who underwent thoracoscopic cardiac surgery based on one-lung ventilation (experimental group, n=49). Other patients undergoing a median thoracotomy cardiac operation were defined as the comparison group (n=48). The oxygenation index and the mechanical ventilation time were also recorded. RESULTS There was no significant difference in the immediate oxygenation index between the experimental group and comparison group (P>0.05). There was no significant difference for the oxygenation index between men and women in both groups (P>0.05). The cardiopulmonary bypass time significantly affected the oxygenation index (F=7.200, P=0.009). Operation methods (one-lung ventilation thoracoscopy or median thoracotomy) affected postoperative ventilator use time (F=8.337, P=0.005). Cardiopulmonary bypass time (F=16.002, P<0.001) and age (F=4.384, P=0.039) had significant effects on ventilator use time. There was no significant effect of sex (F=0.75, P=0.389) on ventilator use time. CONCLUSIONS Our results indicated that one-lung ventilation thoracoscopic cardiac surgery did not affect the immediate postoperative oxygenation index; however, cardiopulmonary bypass time did significantly affect the immediate postoperative oxygenation index. Also, one-lung ventilation thoracoscopic cardiac surgery had a shorter postoperative mechanical ventilation use time than did traditional median thoracotomy cardiac surgery.


Subject(s)
Cardiac Surgical Procedures , One-Lung Ventilation , Thoracoscopy , Thoracotomy , Humans , Male , Female , Thoracotomy/methods , One-Lung Ventilation/methods , Middle Aged , Thoracoscopy/methods , Retrospective Studies , Cardiac Surgical Procedures/methods , Aged , Oxygen/metabolism , Respiration, Artificial/methods , Adult , Cardiopulmonary Bypass/methods , Lung/surgery , Lung/metabolism
20.
BMC Anesthesiol ; 24(1): 159, 2024 Apr 25.
Article in English | MEDLINE | ID: mdl-38664657

ABSTRACT

Serratus posterior intercostal plane block (SPSIPB) is a novel periparavertebral block. It provides anterolateral posterior chest wall analgesia. It is an interfascial plane block, performed under ultrasound guidance, and the visualization of landmarks is easy. It is performed deep into the serratus posterior superior muscle at the level of the third rib. Until now, there have been case reports about the usage of single-shot SPSIPB, but there are no reports about the usage of the block catheterization technique of SPSIPB. Continuous infusion from a catheter of interfascial plane blocks is important for postoperative analgesia management after painful surgeries such as thoracic and cardiac surgeries. Thus, we performed SPSIPB catheterization in a patient who underwent right atrial mass excision with minimally invasive thoracotomy surgery. Here, we present our successful analgesic experience with continuous SPSIPB in this case report.


Subject(s)
Heart Atria , Nerve Block , Pain, Postoperative , Female , Humans , Middle Aged , Heart Atria/surgery , Heart Neoplasms/surgery , Intercostal Nerves , Nerve Block/methods , Pain, Postoperative/drug therapy , Pain, Postoperative/prevention & control , Thoracotomy/methods , Ultrasonography, Interventional/methods
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