ABSTRACT
The methanolic crude extract from the roots of Jacquinia flammea showed moderate antifungal activity against dermatophytes and very strong antifungal activity against Colletotrichum gloeosporioides. The bioassay-guided purification of the extract, using a combination of vacuum-liquid chromatography and high performance liquid chromatography, allowed the identification of sakurasosaponin as the main metabolite responsible for the antifungal activity.
Subject(s)
Antifungal Agents/pharmacology , Plant Extracts/pharmacology , Plant Roots/chemistry , Primulaceae/chemistry , Saponins/pharmacology , Antifungal Agents/analysis , Antifungal Agents/chemistry , Arthrodermataceae/drug effects , Chromatography, Liquid , Colletotrichum/drug effects , Methanol , Molecular Structure , Plant Extracts/analysis , Plant Extracts/chemistry , Saponins/analysis , Saponins/chemistryABSTRACT
Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.
