Oxidative and genotoxic effect of piperazine on Galleria mellonella (Lepidoptera: Pyralidae) hemolymph.

Recently, there are many studies suggesting antibacterial, antifungal, and anthelmintic agents as alternative chemicals to insecticides. In this study, the oxidative and genotoxic effect of Piperazine, a clinically important hexahydropyrazine anthelmintic, on Galleria mellonella L. hemolymph tissue by adding artificial diet were investigated. Galleria mellonella larvae were reared until 7th larval stage in artificial diet containing 0.001, 0.01, 0.1, and 1 g piperazine per 100 g of diet. Using hemolymph collected from 7th-instar larvae, the amount of lipid peroxidation final product malondialdehyde (MDA), protein oxidation product protein carbonyl (PCO), and detoxification enzymes glutathione S-transferase (GST) and cytochrome P450 monooxygenase (cyt P450) activity, comet assay were measured. According to the results obtained, when the piperazine high concentrations tested with the control group were compared, statistically significant differences were found in MDA, PCO content, cyt P450, GST activity, and comet assay in the hemolymph of the insect. While MDA content was 0.01 ± 0.0021 nmol/mg protein in the control group, this amount increased approximately 2-fold at the highest concentration (0.0231 ± 0.0050 nmol/mg protein). On the other hand, when the control group and the highest piperazine concentration were compared in the GST and cyt P450 activity, it was determined that there was a statistically significant increase. We obtained similar results in comet assay and micronucleus formation data. This study showed that the tested piperazine concentrations caused significant changes in the detoxification capacity, oxidative stress, and genotoxic markers in the insect's hemolymph tissue.

The diagnostic utility of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) in identification of gifted children.

Accurate assessment and early identification of gifted children is of great importance in terms of providing them with educational programs tailored for their abilities in specific areas. Individually administered intelligence tests are widely used to identify gifted children, and an above-average level of intellectual capacity is generally accepted as the main criterion for giftedness. This study aimed to investigate the utility of the Turkish version of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) to distinguish gifted children from non-gifted children. For this purpose, 201 gifted children and 201 non-gifted children were included in the study. To be able to determine the predictive power of the WISC-IV index and subtest scores, logistic regression analyses were performed. Results indicated that the Perceptual Reasoning Index, Working Memory Index, and Processing Speed Index ​​scores (except Verbal Comprehension Index score), and all subtest scores significantly predicted giftedness. Furthermore, correct classification rates among gifted children were 93% for index scores and 97% for subtest scores. The findings of this study suggest that intelligence scores obtained from the WISC-IV have a diagnostic utility and provide valid and reliable results in identifying gifted children.

Confirmatory Factor Analyses of the Turkish Version of the WISC-IV in Non-clinical Sample: Validation of the Wechsler and CHC Models with Core and Supplemental Subtests.

Objective: In this study, the validities of the 4-factor structure and the Cattell-Horn-Carroll (CHC) theory-based models of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) were investigated by confirmatory factor analyses (CFA) in a Turkish non-clinical sample (n= 793). Methods: Several models were examined and compared using CFA. Results: Results revealed that both the 4-factor structure and the CHC-based 5 factor model were supported. However, both Wechsler and CHC bifactor models did not provide the best explanation of WISC-IV's factor structure. Across all models, while the common variance was mostly explained by general intelligence, it was least explained by the group factor in the CHC bifactor model. Conclusion: Consequently, the factor structure of the WISC-IV Turkish is more suitable for higher-order (indirect hierarchical) models than bifactor models. In addition to the Wechsler 4-factor model, the WISC-IV also measured crystallized ability (Gc), visual processing (Gv), fluid reasoning (Gf), working memory capacity (Gwm), and processing speed (Gs). In particular, either separating Gf and Gv or combining them as the Perceptual Reasoning Index (PRI) provided a meaningful explanation. The Arithmetic subtest had significant cross-loadings. For children in Turkey, this subtest appears a reflection of Gwm and Gc in both Wechsler and the CHC higher-order models.

[Comparing Two Editions of Wechsler Intelligence Scales and Assessing Reading Skills in Children with Attention Deficit and Hyperactivity Disorder]. / Dikkat Eksikligi Hiperaktivite Bozuklugu'nda Wechsler ocuklar Iin Zekâ Ölegi'nin Iki Sürümünün Karsilastirilmasi ve Okuma Becerilerinin Degerlendirilmesi.

OBJECTIVE: This study aimed to examine the cognitive profiles of children with Attention Deficit and Hyperactivity Disorder (ADHD) with the Wechsler Intelligence Scales for Children-Revised (WISC-R) and the Wechsler Intelligence Scales for Children-Fourth Edition (WISC-IV), the latter of which was recently standardized in Turkey. In addition, the reading abilities and intelligence scores of these children were also investigated. METHODS: A total of 48 children with ADHD between the ages of 6 and 16 years who were outpatients in Mus State Hospital were included in this study. The children were administered the WISC-R, the WISC-IV, and the Oral Reading Skills and Reading Comprehension Test (ORCT). RESULTS: There were no significant differences between the WISC-R IQ scores and WISC-IV index scores. Moreover, reading comprehension skills (derived from ORCT scores) were predicted with significant accuracy by both the WISC-R Verbal IQ and the WISC-IV WMI (Working Memory Index). CONCLUSION: Results of this study suggest that the WISC-R and the WISC-IV scale are not sufficient for obtaining a specific cognitive profile for ADHD - there is no significant difference between them. However, the four-factor structure of the WISC-IV is believed to provide more specific information. In addition, results of this study related to reading skills indicate that the importance of reading skills should not be overlooked when assessing children with ADHD.

[Analyzing the Wechsler Intelligence Scale for Children-Revised (WISC-R) in Children With Attention Deficit and Hyperactivity Disorder: Predictive Value of Subtests, Kaufman, and Bannatyne Categories]. / Dikkat Eksikligi Hiperaktivite Bozuklugu Bulunan Çocuklarda Wechsler Çocuklar Için Zekâ Ölçegi Gözden Geçirilmis Formunun (WÇZÖ-R) Incelenmesi: Alt Testlerin, Kaufman ve Bannatyne Siniflamalarinin Yordama Gücü.

OBJECTIVE: The aim of this study is to evaluate the predictive value of intelligence quotients scores (IQs), subtests of Wechsler Intelligence Scale for Children-Revised (WISC-R) and Kaufman's and Bannatyne's categories scores which are the sums of subtests of WISC-R in attention deficit hyperactivity disorder (ADHD). Another aim is to examine the difference of some neurocognitive skills between the children with ADHD and their unaffected peers by WISC-R subtests. METHOD: WISC-R's subtest and IQ scores, and scores of Kaufman's and Bannatyne's categories of the children who were diagnosed with only ADHD were compared with the same scores of the children who were in healthy control group (N= 111) and were in ADHD with co morbidity group (N= 82). RESULTS: It was found that the subtest scores (vocabulary, comprehension, digit span, picture completion and block design) of the children with only ADHD and ADHD with comorbidity were significantly lower than healthy group. It was observed that subtests of comprehension (Wald= 5.47, df= 1, p=0.05), digit span (Wald= 16.79, df= 1, p=0.001) and picture completion (Wald= 5.25, df= 1, p=0.05) predicted significantly ADHD. In addition, the categories of freedom from distractibility (Wald= 8.22, df= 1, p=0.01) and spatial abilities (Wald= 12.22, df= 1, p<0.0001) were predictive for ADHD in this study. CONCLUSION: Problem solving abilities in social processes, auditory short-term memories, visual-spatial abilities and visual configuration abilities of the children with ADHD was observed to be lower than their healthy peers. It was thought that in WISC-R's profile analysis, the categories of freedom from distractibility and spatial abilities can be distinctive in ADHD diagnose.

Trauma-related psychiatric comorbidity of somatization disorder among women in eastern Turkey.

OBJECTIVE: This study sought to determine the trauma-related psychiatric comorbidity of somatization disorder among women who applied to an outpatient psychiatric unit of a general hospital in eastern Turkey. METHODS: Forty women with somatization disorder and 40 non-clinical controls recruited from the same geographic region participated in the study. Somatization disorder and posttraumatic stress disorder (PTSD) sections of the Structured Clinical Interview for DSM-IV (including its criterion A traumatic events checklist), Dissociative Disorders Interview Schedule, Dissociative Experiences Scale (Taxon), Hamilton Depression Rating Scale, and Childhood Abuse and Neglect Questionnaire were administered to all participants. RESULTS: A significant proportion of the women with somatization disorder had the concurrent diagnoses of major depression, PTSD, dissociative disorder, and borderline personality disorder. Women with somatization disorder reported traumatic experiences of childhood and/or adulthood more frequently than the comparison group. A significant proportion of these patients reported possession and/or paranormal experiences. Binary logistic regression analysis demonstrated that current major depression, being married, total number of traumatic events in adulthood, and reports of possession and/or paranormal experiences were independent risk factors for somatization disorder diagnosis. CONCLUSIONS: Among women with endemically high exposition to traumatic stress, multiple somatic complaints were in a significant relationship with major depressive disorder and lifelong cumulative traumatization. While accompanying experiences of possession and paranormal phenomena may lead to seeking help by paramedical healers, the challenge of differential diagnosis may also limit effective service to this group of somatizing women with traumatic antecedents and related psychiatric comorbidities.

Relationships between cognitive appraisals of adolescents with OCD and their mothers.

OBJECTIVE: Our aim was to investigate cognitive models of OCD via the influence of mothers' cognitive appraisals on children's cognitions and OCD symptoms. METHOD: Our sample consisted of 21 adolescents with OCD, their mothers and 27 parent-child dyads for control group without OCD. Subjects with OCD and their mothers were administered The Beck Depression Inventory (BDI), The Thought-Action Fusion Scale (TAFS), The White Bear Suppression Inventory (WBSI), The Padua Inventory-Revised (PI-R) and The Penn Inventory of Scrupulosity (PIOS). RESULTS: While the BDI (t=2.18, p<0.05) and TAF Morality (t=2.18, p<0.05) scores of the mothers of OCD subjects were significantly higher than the mothers of control subjects, the comparisons for the PI, TAF likelihood and PIOS scores of groups were not significant. Intradyadic correlation revealed significant relationships for PI-Rumination, PI-Checking and WBSI scales between the scores of parent and child in OCD dyads, (respectively, r=0.49, P=0.11; r=0.37, P=0.045; and r=0.47, P=0.014). There was no significant relationship in the control group. CONCLUSION: Our results partially supported that mothers' cognitive appraisals are associated with the cognitive appraisal of adolescents. A cognitive intradyadic interaction between mother and child might be more likely in the presence of OCD in adolescents.

Relationship of burnout with personality, alexithymia, and coping behaviors among physicians in a semiurban and rural area in Turkey.

This present study aimed to assess levels of burnout, to investigate the extent to which personal characteristics and coping behaviors are related to burnout, and to establish the predictors of burnout among physicians in a semiurban and rural area. A sample of 139 physicians was assessed using the Maslach Burnout Inventory, Eysenck Personality Questionnaire, Toronto Alexithymia Scale, and Ways of Coping Inventory. The level of burnout was found to be moderately higher than those reported among urban physicians. A forward stepwise multiple regression analysis indicated that neuroticism, occupation (specialist vs general practitioner), helpless, self-confident, and social support seeking approaches were predictors of burnout. The results showed that burnout was negatively related with problem-focused copping strategies, and positively with emotion-focused coping strategies. Fostering problem-focused coping strategies in physicians might be useful in the reduction of burnout.

[The impact of compulsory health service on physicians and burnout in a province in Eastern Anatolia]. / Dogu Anadolu Bölgesi'nde Yer Alan Bir Ilde Devlet Hizmet Yükümlülügü'nün Hekimler Üzerindeki Etkileri ve Tükenmislik.

OBJECTIVE: The Compulsory Health Service (CHS) for physicians has been in place since 2005. The aim of this study was to investigate the impact of the CHS on physicians and the factors associated with burnout. METHOD: The sample group consisted of all physicians working within the province of Mus in this cross-sectional, descriptive, epidemiological study. All participants were assessed using the Maslach Burnout Inventory (MBI), the Beck Depression Inventory, the Job Satisfaction Scale (JSS), the Satisfaction with Life Scale, the Professional Quality of Life Scale (ProQOL) and the General Health Questiannaire-12, along with a detailed sociodemographic and professional data form. RESULTS: A total of 139 physicians participated in this study, and 100 of them (71%) were fulfilling the CHS. Physicians who fulfilled the CHS were found to have lower levels of job satisfaction and professional quality of life. They also had higher levels of depression, general psychiatric symptoms, and psychological stress. The relationships between the level of burnout in physicians fulfilling the CHS and the scores from the scales used in the study were statistically significant except those between MBI-Personal Accomplishment, JSS, and ProQOL-Compassion Fatigue subscales. The extent of depressive symptoms and the daily number of patients were predictors of all three subscales of burnout. Job satisfaction was a predictor of both emotional exhaustion and depersonalization, while life satisfaction was a predictor of emotional exhaustion, and gender was a predictor of personal accomplishment. CONCLUSION: The level of burnout among physicians who had fulfilled the CHS was high. The factors and predictors associated with burnout were discussed.

Relations between childhood traumatic experiences, dissociation, and cognitive models in obsessive compulsive disorder.

OBJECTIVE: Previous studies have indicated that obsessive compulsive disorder (OCD) is associated with childhood traumatic experiences and higher levels of dissociation. Dissociative tendency may arise when individual attempt to incorporate adverse experiences into cognitive schema. METHODS: We investigated the possible links among childhood trauma, dissociation, and cognitive processes. We evaluated 95 patients with OCD using the Beck Depression Inventory (BDI), Thought-Action Fusion Scale (TAFS), Metacognitions Questionnaire (MCQ-30), White Bear Suppression Inventory (WBSI), Dissociative Experiences Scale (DES), and Childhood Trauma Questionnaire (CTQ-28). RESULTS: The CTQ-28 total scores were not associated with Y-BOCS total, Y-BOCS insight, BDI, TAFS, MCQ-30, and WBSI scores. The TAFS Total, MCQ-30, WBSI, and BDI scores were significantly associated with DES scores. Regression analysis revealed that MCQ-30 and WBSI scores significantly predicted the DES scores. CONCLUSIONS: These results suggest that in spite of pathological connotation of dissociative experiences, dissociation may primarily constitute a cognitive trait which is strongly associated with cognitive processes.