Targeting the FGFR Pathway in Patients with Advanced Solid Tumors.

In the phase II FUZE trial targeting the FGFR pathway, Debio 1347 showed limited antitumor activity and manageable toxicity in patients with advanced solid tumors. Results from transcriptomic-based analysis enhanced our understanding of the genomic landscape of FGFR fusion-driven tumors, informing clinical trial design and generating hypotheses for resistance mechanisms.

Talazoparib for the treatment of prostate cancer.

INTRODUCTION: Around 25% of patients with advanced prostate cancer harbor alterations in the homologous recombination/DNA damage repair (HRR) pathway. Inhibiting poly (ADP-ribose) polymerase (PARP) in these patients leads to synthetic lethality, making PARP inhibitors (PARPi), including talazoparib, a promising treatment for metastatic castration-resistant prostate cancer (mCRPC) and potentially for metastatic hormone-sensitive prostate cancer (mHSPC). AREAS COVERED: This article examines the mechanism of action, chemical properties, pharmacokinetics, pharmacodynamics, and clinical safety and efficacy data of different PARPis, including talazoparib in prostate cancer. It reviews the TALAPRO-1 and TALAPRO-2 clinical trials and the ongoing TALAPRO-3 trial. EXPERT OPINION: Despite recent therapeutic advancements, mCRPC remains a lethal disease. Androgen receptor pathway inhibitors (ARPIs) are approved for patients with mCRPC and mHSPC, yet most patients first receive these agents in the castration-resistant setting. Real-world data indicate that around half of patients with mCRPC do not receive subsequent lines of therapy, underscoring the efficacy of upfront combination therapies. The combinations of ARPI plus PARPi are indicated for patients with mCRPC harboring HRR mutations, though identifying these patients is challenging due to limited genomic testing. Further research and improved access to genomic testing are essential to optimize treatment strategies.

Evaluation of scientific reliability and quality of YouTube videos on cancer and nutrition.

OBJECTIVES: YouTube is a video-sharing platform used by ∼2 billion people per month, and videos are watched in high numbers in the medical field. In this study, we aimed to evaluate the scientific reliability and the relationship between the quality and popularity of the most watched YouTube videos on cancer and nutrition. METHODS: YouTube videos were evaluated independently by two oncologists. The video quality was evaluated according to the internationally valid medical video or document evaluation scores: DISCERN score, modified DISCERN score, Journal of the American Medical Association score, and Global Quality Scale score. RESULTS: Forty-six (58%) of the videos were uploaded to the platform by physicians or dietitians. Although 29 videos (36%) recommended a uniform diet, 51 videos (64%) had food suggestions that could be added to the diet. The most recommended foods were cruciferous (n = 16 [20%]; broccoli and cauliflower) and berries (n = 12% [15%]; strawberries, blueberries, and raspberries). When the video quality was evaluated according to the DISCERN score, only 17 (21%) videos were evaluated as good or excellent. There was a strong negative correlation between the DISCERN score and the number of video views and likes (r = -0.426; P < 0.001 and r = -0.226; P = 0.017, respectively). CONCLUSIONS: Videos about cancer and nutrition were highly watched, but the overall quality and reliability were low. Although the source of the information presented and its deficiencies and sometimes misleading statements were found, it was determined that the videos with less reliability were watched more. There is a need to produce quality content on YouTube or similar platforms.

Greater financial toxicity correlates with increased psychological distress and lower quality of life among Turkish cancer patients.

PURPOSE: This study aims to investigate the factors that influence financial toxicity and its effects on both quality of life and psychological distress in Turkish cancer patients. METHODS: Data from 400 cancer patients receiving chemotherapy at a public university in Turkey was analyzed. The Comprehensive Score for Financial Toxicity (COST), Patient Health Questionnaire for Depression and Anxiety (PHQ-4), and Functional Assessment of Cancer Therapy-General (FACT-G) were used to measure financial toxicity, psychological distress, and health quality of life, respectively. RESULTS: Patients' median COST score was 22 (SD = 10.1; range: 1-44) and was consistent with mild financial toxicity. Financial toxicity was associated with lower education level (p < 0.001), lower monthly income (p < 0.001), being a woman (p = 0.021), living in another city (p = 0.012), and previous cancer surgery (p = 0.02). A negative and statistically significant correlation was found between financial toxicity and quality of life (r = - 0.139; p = 0.005) and psychological distress (r = - 0.398; p < 0.001). CONCLUSION: This investigation demonstrated that financial toxicity was a significant determinant of quality of life and psychological distress.