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1.
Noro Psikiyatr Ars ; 60(3): 283-287, 2023.
Article in English | MEDLINE | ID: mdl-37645084

ABSTRACT

Since December 2020, a significantly higher number of people worldwide have been vaccinated for coronavirus disease 2019 (COVID-19). Neurological complications have been reported after these vaccines, although a definitive causal relationship has not been proven in the available literature. We describe a 51-year-old man presenting with anti-glutamic acid decarboxylase (anti-GAD) antibody positive autoimmune encephalitis with progressive cognitive impairment and behavioral abnormalities, presenting shortly after the second dose of mRNA COVID-19 vaccine, possibly representing a serious vaccine-related adverse event. Response to high-dose steroid and intravenous immunoglobulin treatment was positive. As many people around the world have been vaccinated against COVID-19, this case shows that autoimmune encephalitis and even anti-GAD antibody positive autoimmune encephalitis can develop as a side effect after this new vaccine, but with early diagnosis and appropriate treatment, the clinic can have a good prognosis. Observational studies with large numbers of patients are needed to explain causality.

2.
Mult Scler Relat Disord ; 77: 104880, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37459716

ABSTRACT

BACKGROUND: Follow-on disease modifying therapies (FO-DMTs) do not always require Phase III studies. There are concerns that cheaper FO-DMTs are only used to reduce healthcare costs. However, the well-being of people with MS (pwMS) should be a priority. We aimed to evaluate the efficacy, safety and treatment satisfaction of one of the FO- Fingolimod (FTY) used in Turkey with the approval of Turkish Ministry of Health. METHODS: PwMS under FTY were recruited from 13 centers and real-world data and answers of satisfaction and adherence statements of pwMS on FTY treatment were analyzed. RESULTS: Data of 239 pwMS were obtained. The duration of FTY treatment was 2.5 ± 0.8 (1-4) years in pwMS who were included in the study and whose treatment continued for at least one year. Significant decreases in annual relapse rate (p < 0.001), Expanded Disability Status Scale (p < 0.001) and neuroimaging findings (p < 0.001) were observed. While 64% of the patients were satisfied and 71.5% were found to adherent with this FO-FTY. CONCLUSION: This multicenter retrospective study found that the efficacy, safety and treatment adherence of a prescribed FO-FTY were consistent with the results of real-world studies. Studies including real-world data may provide guidance to address issues related to FO-FTY use.


Subject(s)
Multiple Sclerosis, Relapsing-Remitting , Multiple Sclerosis , Humans , Fingolimod Hydrochloride/adverse effects , Multiple Sclerosis/drug therapy , Immunosuppressive Agents/therapeutic use , Retrospective Studies , Patient Reported Outcome Measures , Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging , Multiple Sclerosis, Relapsing-Remitting/drug therapy
4.
Int J Nurs Pract ; 29(5): e13168, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37243487

ABSTRACT

AIM: This study's aim is to develop and psychometrically assess the Sickness Presenteeism Scale-Nurse. BACKGROUND: Evaluation of the effects of sickness presenteeism on nurses' performance and productivity is important for healthcare quality. DESIGN: This was an instrument development and validation study. METHODS: Scale items were created based on literature review and qualitative research. Data were collected from 619 nurses between October and December 2021. The factor structure of the scale was determined by explanatory and confirmatory factor analysis performed with different sample groups. Convergent and discriminant validity were investigated, and reliability was evaluated with Cronbach's α values, adjusted item-total correlation, composite-reliability and split-half reliability. RESULTS: Explanatory factor analysis showed that Sickness Presenteeism Scale-Nurse consisted of four sub-dimensions and 21 items and explained 57.9% of the total variance. This factor structure was confirmed by confirmatory factor analysis. The convergent and discriminant validity was confirmed. The total Cronbach's α value of the scale was calculated as 0.928, with Cronbach's α values of the sub-dimensions calculated as 0.815-0.903; composite reliability values were calculated as 0.804-0.903. CONCLUSIONS: The Sickness Presenteeism Scale-Nurse is a valid and reliable measurement instrument that can be used to evaluate the effect of nurses' sickness presenteeism behaviour on job performance.


Subject(s)
Presenteeism , Quality of Health Care , Humans , Psychometrics/methods , Reproducibility of Results , Factor Analysis, Statistical , Surveys and Questionnaires
5.
Noro Psikiyatr Ars ; 60(1): 23-27, 2023.
Article in English | MEDLINE | ID: mdl-36911568

ABSTRACT

Introduction: Fingolimod is the first oral immunomodulatory treatment used as secondary care therapy in the treatment of multiple sclerosis for the last 10 years. The objective of our study is to reveal the experiences of the first generic fingolimod active ingredient treatment in different centers across Turkey. Method: The first generic fingolimod efficacy and safety data of patients followed-up in 29 different clinical multiple sclerosis units in Turkey were analyzed retrospectively. Data regarding efficacy and safety of the patients were transferred to the data system both before the treatment and on the 6th, 12th and 24th month following the treatment. The data were analyzed using the IBM SPSS 20.00. P value of <0.05 was considered to be statistically significant. Results: A total of 508 multiple sclerosis patients, 331 of whom were women, were included in the study. Upon comparing the Expanded Disability Status values before and after the treatment, a significant decrease was observed, especially at month 6 and thereafter. Since bradycardia occurred in 11 of the patients (2.3%), the first dose had to be longer than 6 hours. During the observation of the first dose, no issues that could prevent the use of the drug occured. Side effects were seen in 49 (10.3%) patients during the course of fingolimod treatment. Respectively, the most frequent side effects were bradycardia, hypotension, headache, dizziness and tachycardia. Conclusion: The observed results regarding efficacy and safety were similar to clinical trial data in the literature and real life data in terms of the first equivalent with fingolimod active ingredient.

6.
J Child Health Care ; 27(4): 667-679, 2023 12.
Article in English | MEDLINE | ID: mdl-36349442

ABSTRACT

Aim of this study was to develop a patient satisfaction scale for needs and expectations of pediatric surgery patients and to propose a new measurement tool in this field. Population of study consisted of all patients between May 2018 and February 2020 at a pediatric surgery service of a university hospital in Turkey. A pool of 70 items was prepared for scale. Two items were removed in line with expert opinions and suggestions. As a result of content validity and test application, 36 items were removed, and scale was revised. Data were transferred to SPSS Statistics 23 and AMOS 22 program. After evaluating scope validity of scale, Content Validity, Structural Validity, Exploratory Factor Analysis, and finally Reliability Analysis were examined. As a result of the analyses, 32 items with eight sub-dimensions were obtained from scale. Eight-factor scale explained 60.42% of total variance. Cronbach Alpha internal consistency of scale was found to be 0.88. Item factor loads of scale were created and the reliability of scale were obtained at desired level. The scale is suitable for patients aged 6 to 18 years old.


Subject(s)
Patient Satisfaction , Child , Humans , Adolescent , Reproducibility of Results , Turkey , Surveys and Questionnaires , Psychometrics/methods
7.
J Patient Saf ; 18(7): e1102-e1108, 2022 10 01.
Article in English | MEDLINE | ID: mdl-35533000

ABSTRACT

BACKGROUND: Error reporting is vital for the prevention of medical errors. Despite the importance of error reporting, underreporting of medical errors is a common reality in many countries. Therefore, barriers to error reporting and reporting systems are a constantly evolving field of research. For this reason, studies on medical error reporting and reporting systems should be evaluated multidimensionally. AIM: The aim of this study is to evaluate the global research on medical error reporting and reporting systems through bibliometric analysis to obtain a structured macroscopic overview of the features and developments. METHODS: A bibliometric analysis of 1464 publications from 1970 to 2021 was performed to map the literature of medical error reporting and assess the structure of the scientific community. RESULTS: After 2000, the number of publications increased annually until a maximum of 2020 was reached. The International Journal for Quality in Health Care and the Journal of Patient Safety have been the most productive journals when it comes to publishing on the subject. Trend topics of keyword plus have changed over time. The United States (1399), England (580), and Australia (478) are the 3 nations with the highest number of publications. On the other hand, it is seen that the subject has yet to be discussed in a few developing or underdeveloped countries. CONCLUSIONS: This bibliometric analysis shows that the number of publications and authors and cross-country cooperation are low regarding error reporting. The low number of publications and the lack of cooperation, especially in developing countries, reveal the importance of global cooperation.


Subject(s)
Bibliometrics , Publishing , Australia , Humans , Medical Errors , Medication Errors , United States
8.
Mult Scler Relat Disord ; 63: 103880, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35613508

ABSTRACT

BACKGROUND: Difficulties of self-management in people with MS (pwMS) is considered as one of the most important factors contributing to low rehabilitation efficacy, more severe long-term complications and increase in healthcare costs. Despite the emergence of research in the last decade documenting causes, types, and course of cognitive difficulties in MS disease subtypes, limited evidence is available in the literature for direct comparison of self-management and cognitive deficits. In this study we aimed to investigate the relationship between cognitive performance and self-management in pwMS. METHODS: PwMS who applied to neurology out-patient clinics of seven different centers were included into study. Multiple Sclerosis Self-Management Scale- Revised (MSSM-R) was used for the assessment of self-management behaviors and Multiple Sclerosis inventory cognition scale (MUSIC) was used for the assessment of cognitive performance and fatigue. RESULTS: In this study, 194 (144 female and 50 male) pwMS participated (mean age = 38.9 years). The course of the disease was RRMS in 173 patients and mean EDSS was 2.0. 68.5% of the participants were married, 32.5% were employed, and 57.2% had secondary education. The MSSM-R mean score of the study group was 42.6 ± 10.4 (1-81). There was a positive correlation between MSSM-R and MUSIC-cog scores (r = 0.21, p = 0.003). A hierarchical multiple regression revealed that income level (ß = 0.196, t = 2.692, p = 0.008) and cognitive performance (ß = 0.167, t = 2.063, p = 0.041) together with control variables (gender, age, educational status, employment status, duration of disease, EDSS and fatigue) explained 5.5% of the variance in self-management. CONCLUSION: Cognitive performance is a predictor of self-management in pwMS. Better self-management behavior is also related with employment and income level in pwMS. Studies evaluating patients' cognitive abilities and evaluating the effectiveness of adapted self-management training programs are needed.


Subject(s)
Cognition Disorders , Multiple Sclerosis , Self-Management , Adult , Cognition , Cognition Disorders/complications , Fatigue/complications , Fatigue/therapy , Female , Humans , Male , Multiple Sclerosis/complications , Multiple Sclerosis/psychology , Multiple Sclerosis/therapy
9.
Noro Psikiyatr Ars ; 59(1): 33-37, 2022.
Article in English | MEDLINE | ID: mdl-35317509

ABSTRACT

Introduction: The aim of this study was to form the Turkish adaptation of the SCOPA-SleepScale to be used in evaluating sleep quality in individuals with Parkinson's disease and to test its psychometric properties. Method: Data for this methodological study was collected between May and December 2017 in the neurology outpatient clinic of a hospital through face to face interviews with patients with a diagnosis of Parkinson's disease. The sample of the study consisted of 105 patients of 18 years of age and above with no additional neurological diseases who volunteered for the study. The SCOPA Sleep Scale was translated into Turkish through translation and back translation, and expert views were taken to test content validity. The reliability analyses of the scale were performed using item- total score correlations, test-retest correlations, and internal consistency. Exploratory factor analyses were conducted for construct validity and the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were applied for criterion validity. The appropriateness of data for factor analysis was examined using the Kaiser-Meyer-Olkin (KMO) and Bartlett's tests. Results: The factor loads of the SCOPA Sleep Scale varied between 0.743 and 0.901, and the Turkish version of the scale exhibited a two factor structure in compliance with the original scale. The Cronbach`s alpha coefficient was found 0.907 for the nighttime sleep sub-dimension and 0.906 for the daytime sleepiness sub-dimension. In the test-retest evaluation, a correlation of 0.948 was obtained in the nighttime sleep sub-dimension of the scale and a correlation of 0.956 was obtainedin the daytime sleepiness sub-dimension of the scale. The nighttime sleep sub-dimension of the scale showed a positive correlation with PSQI, while the daytime sleepiness sub-dimension showed a positive correlation with ESS. Conclusion: The Turkish form of the SCOPA Sleep Scale is a valid and reliable tool to evaluate the sleep quality of individuals with Parkinson's disease.

10.
Neurol Sci ; 43(3): 1799-1807, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34331157

ABSTRACT

INTRODUCTION: Alzheimer's disease (AD), and idiopathic Parkinson's disease (IPD) are the neurodegenerative diseases of the central nervous system (CNS). Cognitive impairment is on the forefront in AD. However, IPD is a movement disorder. Inflammation was suggested to have an effect in the pathophysiology of these two diseases. Neutrophil-lymphocyte ratio (NLR) was shown to be a possible marker showing the peripheral inflammation. We aimed to investigate the NLR of patiens with the diagnosis of AD, and IPD, and individuals with no neurodegenerative disease. MATERIALS AND METHODS: A total of 100 patients with the diagnosis of IPD, and 94 with diagnosis of AD, and 61 healthy controls were included into the study. All the demographic, clinical, and laboratory data were retrospectively obtained from the hospital automated database system. RESULTS: The NLR in the IPD group was found statistically significantly higher compared with the control group and the AD group (p < 0.001, p = 0.04, respectively). The age-adjusted values were statistically analyzed because of age difference. No statistically significant difference was detected between AD and control groups in terms of NLR (p = 0.6). The age-adjusted NLR value in the Parkinson's group was found significantly higher compared to the control group (p = 0.02) and Alzheimer's group (p = 0.03). DISCUSSION: Chronic inflammation has an important role in the emergence and progression of the chronic neurodegenerative diseases of the CNS. Our results show that the inflammation in the peripheral blood in IPD was more significant compared with the inflammation in AD.


Subject(s)
Neurodegenerative Diseases , Neutrophils , Central Nervous System , Humans , Inflammation , Lymphocytes , Neurodegenerative Diseases/diagnosis , Retrospective Studies
11.
Int J Nurs Knowl ; 33(3): 196-206, 2022 Jul.
Article in English | MEDLINE | ID: mdl-34693654

ABSTRACT

BACKGROUND: Evidence-based nursing and its practices are increasing rapidly in the health and nursing literature. A holistic image of evidence-based nursing research is needed to address evidence-based studies and available information on nursing. AIM: The aim of this study was to evaluate evidence-based nursing-related research with bibliometric analysis in order to provide a structured macroscopic overview of its features and advances. METHODS: A bibliometric analysis of 4,159 publications from 1995 to 2021 was performed to map the literature of evidence-based nursing studies and assess the structure of the scientific community. The studies' publication output and growth trend, authors and collaborations, publishing journals, terms, current trends, subject categories, global distribution and collaboration, and the authors' average number of citations were all assessed. RESULTS: It was found that the number of evidence-based nursing publications increased until 2016, reaching the publication peak (n = 369), after which they began to decline. Most studies on the topic (n = 543) have been published in the journal Worldviews on Evidence-Based Nursing. Evidence-based knowledge, dissemination, implementation, implementation barriers, and implementation and training curricula in particular fields have all evolved over time as the key concepts of research. The United States (6,218), Australia (1,247), and England (790) are the three nations with the highest number of publications. On the other hand, it is seen that the subject has yet to be discussed in a few developing or underdeveloped countries. CONCLUSIONS: In the last 12 years, evidence-based nursing has been a comprehensive area of research. In comparison with the research areas in its field, it can be speculated that it has a more practical focus. It was determined that the authors' keywords primarily began with research implementation, practice development, and knowledge utilization over time, and then evolved to specific areas, educational areas, process applications, and important current topics such as Covid19.


Subject(s)
COVID-19 , Nursing Research , Bibliometrics , Evidence-Based Nursing , Humans , Knowledge , United States
12.
Perspect Psychiatr Care ; 58(3): 1103-1111, 2022 Jul.
Article in English | MEDLINE | ID: mdl-34218449

ABSTRACT

PURPOSE: This study aimed to determine the relationship between nursing students' professional attitudes and caring behaviors. DESIGN AND METHODS: The research is a cross-sectional, descriptive, and correlational study. The study was conducted with 202 nursing students. The participation rate was 95%. FINDINGS: The total Instrument of Professional Attitude for Student Nurses mean score was 106.708 ± 20.24 and the Caring Behaviors Inventory-24 mean score of the nursing students was 5.23 ± 0.88. A positive weak correlation was found between total Instrument of Professional Attitude for Student Nurses scores and sub-dimension scores, and Caring Behaviors Inventory-24 total scores of nursing students (p < .05). PRACTICE IMPLICATIONS: The present study has demonstrated that the professional attitudes of students positively affect caring behaviors.


Subject(s)
Students, Nursing , Attitude , Attitude of Health Personnel , Cross-Sectional Studies , Humans , Surveys and Questionnaires
13.
Ther Apher Dial ; 26(1): 191-196, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34018667

ABSTRACT

This prospective study compared methods using both arterial and venous needles with back eyes with those using only arterial needle with back eye for arteriovenous fistula cannulation. Sixty-one patients receiving hemodialysis (HD) via an arteriovenous fistula were evaluated. All patients underwent arteriovenous fistula puncture using only arterial needle with back eye in first 3 months and both arterial and venous needles with back eyes in following 3 months. Arterial and venous pressures, blood flow velocities, total blood volume cleared, and Kt/V values were compared. Mean blood flow velocity, arterial pressure, Kt/V, and cleared total blood volume values were higher and venous pressure was lower in patients who underwent cannulation using both needles with back eyes than in those with only the arterial needle with back eye. For arteriovenous fistula cannulation, using both arterial and venous needles with back eyes provides adequate HD more successfully.


Subject(s)
Arteriovenous Shunt, Surgical/instrumentation , Arteriovenous Shunt, Surgical/methods , Needles , Punctures/instrumentation , Punctures/methods , Renal Dialysis/methods , Equipment Design , Female , Humans , Male , Middle Aged , Prospective Studies
14.
Nurse Educ Today ; 109: 105244, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34952303

ABSTRACT

BACKGROUND: In healthcare services, nurses' roles and practices make them an integral component of the change process. Therefore, nurses should prepare for their change-creating roles during their education. However, little research regarding change management and the change creation process of nursing students is found in the literature. OBJECTIVES: To identify the needs of undergraduate nursing students when initiating change in practice and to reveal their experiences during the planning and implementation process of change projects. DESIGN: A descriptive, qualitative design using focus group was conducted. PARTICIPANTS: The study includes third-year undergraduate nursing students enrolled in a nursing school in Turkey and were enrolled in the Management in Nursing and Clinical Practices courses. METHODS: Six focus group were conducted with a total of 28 nursing students. Data were collected over one semester via a semi-structured form. The data were analyzed using thematic content analysis. RESULTS: Regarding the change management experiences of the participants, five main themes ("changing world, changing necessities," "view from the perspective of change," "discovering resistance," "developing motivation against resistance," and "change in the perception of change"), and nine sub-themes were determined. CONCLUSIONS: As a result of their change management experiences, nursing students might better contribute to the quality of patient care, think more critically and have more autonomy. Therefore, change process management should be extensively included in nursing education and should be systematically monitored.


Subject(s)
Education, Nursing, Baccalaureate , Education, Nursing , Students, Nursing , Change Management , Humans , Qualitative Research , Schools, Nursing
15.
Mult Scler Relat Disord ; 53: 103039, 2021 Aug.
Article in English | MEDLINE | ID: mdl-34087686

ABSTRACT

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease and acute exacerbations are also a part of the clinical course. The presence of the disease and relapses cause stress in people with MS (pwMS). For this reason, stress coping strategies of the patients are important in reducing perceived stress. Our aim in this study is to evaluate which strategies pwMS use during the COVID-19 pandemic, the effect of the strategies on perceived stress, their relationship with relapses and their role on quality of life (QoL). METHODS: An online form including Perceived Stress Scale (PSS; 10 items), Coping with Experienced Problems Scale (Brief-COPE; 28 items) and SF-12 were sent to 340 pwMS under our follow-up. RESULTS: During the COVID-19 pandemic, we found that the patients used the strategies of turn to religion, planning and acceptance at a high rate. PSS score was high in 23 (11.2%) of the patients. The patients with low perceived stress used the acceptance strategy more (P=0.008). We found a negative correlation between physical component summary (PCS) of SF-12 and denial (r=-0.2, p<0.001) and distraction (r =-0.1, p=0.04). A negative correlation was found between mental component summary (MCS) of SF-12 and behavioral disconnection (r=-0.2, p=0.006). There was a positive correlation between MCS and humor (r=0.1, p=0.04), use of instrumental support (r=0.2, p=0.009), planning (r=0.1, p=0.04), and positive reframing (r=0.2, p=0.002). CONCLUSION: PwMS have been successful in coping with stress in the first half of the pandemic with the combination of emotional and problem-focused strategies. Acceptance strategy was highly adopted by patients with low PSS, and the tendency to use the active coping strategy together with the acceptance strategy was high in patients without relapses. Adoption to emotional strategies may have prevented the severe deterioration in QoL in this study group in the early period of Covid-19 pandemic.


Subject(s)
COVID-19 , Multiple Sclerosis , Adaptation, Psychological , Humans , Multiple Sclerosis/epidemiology , Pandemics , Quality of Life , SARS-CoV-2 , Stress, Psychological/epidemiology , Surveys and Questionnaires
16.
Int Urol Nephrol ; 53(6): 1059-1065, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33620664

ABSTRACT

PURPOSE: Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that involves different neurological areas. In addition to lower urinary tract symptoms (LUTS), sexual dysfunction (SD), and psychopathological effects, MS sometimes seriously impairs the quality of life (QoL). We hypothesize that the pelvic floor exercise program (PFEP) could improve bladder, sexual function, depression, and QoL in MS patients. METHODS: Patients diagnosed with MS completed the Incontinence Questionnaire Short Form (ICIQ-SF), the Beck Depression Inventory (BDI), the Multiple Sclerosis Quality of Life-54 (MSQoL-54) questionnaire, and either the Female Sexual Function Index (FSFI) or the Sexual Health Inventory for Men (SHIM). Maximum bladder volumes (MBV) and post-voiding residual (PVR) volumes were measured using ultrasonography. The patients who regularly completed the PFEP for 12 weeks were asked to fill out the questionnaires again, and their MBV and PVR were remeasured. RESULTS: Seventy-two patients with relapsing-remitting multiple sclerosis (RRMS) were included in the study. Forty-two (58.3%) RRMS patients reached the end of the study. The patients' post-PFEP average MBV statistically increased (p = 0.01). In contrast, no statistically significant difference was found in the PVR (p = 0.2). After exercise, the FSFI values in women increased (p = 0.02), and ICIQ-SF and BDI values in all the RRMS patients statistically decreased (p = 0.004, p = 0.01, respectively), but there was no improvement in the MSQoL-54 score (p > 0.05). CONCLUSION: PFEP, which causes a reduction in LUTS by enhancing the MBV of RRMS patients, can be seen as an investment in the future in terms of reducing depression in MS patients and preventing or delaying SD in women.


Subject(s)
Exercise Therapy , Multiple Sclerosis/complications , Pelvic Floor , Sexual Dysfunction, Physiological/etiology , Sexual Dysfunction, Physiological/therapy , Urinary Incontinence/etiology , Urinary Incontinence/therapy , Adult , Aged , Female , Humans , Male , Middle Aged , Quality of Life
17.
Microsc Res Tech ; 84(6): 1172-1180, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33340178

ABSTRACT

The present study focuses on the quantitative phase imaging of erythrocytes with the aim to compare the morphological differences between epilepsy patients under antiepileptic treatment, who have no other disease which may affect the erythrocyte morphology, and the healthy control group. The white light diffraction phase microscopy (WDPM) has been used to obtain the interferogram of the erythrocyte surfaces. The continuous wavelet transform with Paul wavelet has been chosen to calculate the surface profiles from this interferogram image. For the determination of alteration in morphology, besides WDPM, erythrocyte surfaces have been investigated by light microscope and scanning electron microscope. In this way, it has been possible to see the difference in terms of precision and implementation between the most commonly used methods with regard to the quantitative phase imaging. Erythrocytes from all the samples have been examined and displayed in both two- and three-dimensional way. We have observed that erythrocytes of patients with effective antiepileptic blood levels were more affected in morphology than healthy subjects. When we compared the erythrocyte morphological changes of patients who received monotherapy or polytherapy, no difference was observed. In conclusion, antiepileptic drugs (AEDs) cause red blood cell (RBC) morphological changes and a combined usage of WDPM with Paul wavelet and light microscopy methods are very convenient for studying the erythrocyte morphologies on multiple patients.


Subject(s)
Epilepsy , Anticonvulsants/therapeutic use , Epilepsy/drug therapy , Erythrocytes , Humans , Microscopy , Microscopy, Electron, Scanning
18.
Pak J Med Sci ; 36(2): 10-15, 2020.
Article in English | MEDLINE | ID: mdl-32063923

ABSTRACT

OBJECTIVE: The purpose of this quasi-experimental study was to developing web-based, anonymous reporting system to increase reporting of medication errors, blood transfusion errors and patient falls in pediatric units and to compare the computerized system with the written system already in use at the institution. METHODS: This study was conducted in all pediatric units of a research hospital. All physicians and nurses working in these units agreed to participate in the study. All units were visited to introduce the new reporting system. The number and quality of the reports sent on the new system in years 2014 and 2015 were compared to the reports sent the previous year using the written system. RESULTS: There was considerable increase in rates of reporting: 234% increase in medication error reporting rate, and 100% increase in the reports of blood transfusion errors. One of the most important results of this study that near-miss errors were not reported at all while the written system of the study institution was being used, whereas it was the most commonly reported type of errors in the electronic error reporting system. CONCLUSION: The web-based reporting system, which makes reporting easy, promoted the development of safety culture among doctors and nurses in common language.

19.
Balkan Med J ; 36(3): 174-178, 2019 05 10.
Article in English | MEDLINE | ID: mdl-30582321

ABSTRACT

Background: It is well known that axonal degeneration plays a role in disability in patients with multiple sclerosis, and synaptopathy has recently become an important issue. Aims: To investigate the possible roles of selected synaptic and presynaptic membrane protein genetic polymorphisms (VAMP2, SNAP-25, synaptotagmin, and syntaxin 1A) in patients with multiple sclerosis. Study Design: Case-control study. Methods: A total of 123 patients with multiple sclerosis and 192 healthy controls were included. The functional polymorphisms of specific SNARE complex proteins (VAMP2, synaptotagmin XI, syntaxin 1A, and SNAP-25) were analyzed by polymerase chain reaction. Results: Significant differences were detected in the genotype and allele distribution of 26-bp Ins/Del polymorphisms of VAMP2 between patients with multiple sclerosis and control subjects; Del/Del genotype and Del allele of VAMP2 were more frequent in patients with multiple sclerosis (p=0.011 and p=0.004, respectively). Similarly, Ddel polymorphism of SNAP-25 gene C/C genotype (p=0.059), syntaxin 1A T/C and C/C genotypes (p=0.005), and synaptotagmin XI gene C allele (p=0.001) were observed more frequently in patients with multiple sclerosis. CC, syntaxin rs1569061 1A gene for 33-bp promoter region TC haplotypes, and synaptotagmin XI gene were found to be associated with an increased risk for multiple sclerosis (p=0.012). Similarly, GC haplotype for rs3746544 of SNAP-25 gene and rs1051312 of SNAP-25 gene were associated with an increased risk for multiple sclerosis (p=0.022). Conclusion: Genetic polymorphisms of SNARE complex proteins, which have critical roles in synaptic structure and communication, may play a role in the development of multiple sclerosis.


Subject(s)
Multiple Sclerosis/blood , Polymorphism, Genetic/genetics , SNARE Proteins/analysis , Adolescent , Adult , Case-Control Studies , Female , Humans , Male , Middle Aged , Multiple Sclerosis/genetics , Polymerase Chain Reaction/methods , SNARE Proteins/blood , Synaptosomal-Associated Protein 25/analysis , Synaptosomal-Associated Protein 25/blood , Synaptotagmins/analysis , Synaptotagmins/blood , Turkey , Vesicle-Associated Membrane Protein 2/analysis , Vesicle-Associated Membrane Protein 2/blood
20.
Acta Paul. Enferm. (Online) ; 31(5): 525-534, 2018. tab
Article in Portuguese | LILACS, BDENF - Nursing | ID: biblio-973415

ABSTRACT

Resumo Objetivo: O objetivo deste estudo foi descrever os pontos de vista de estudantes de doutorado em enfermagem antes do início e durante o doutorado sobre mudanças no planejamento da carreira e prioridades de pesquisa. Métodos: O estudo foi de natureza qualitativa, tendo sido realizado com 16 entrevistas no Instituto de Ciências da Saúde, Faculdade de Enfermagem. Foram realizadas entrevistas individuais com 16 estudantes de doutorado matriculados em diferentes especialidades acadêmicas. Após as entrevistas, as gravações de áudio foram primeiramente transcritas e depois categorizadas. Os dados foram submetidos a análise de conteúdo. Resultados: Após análise de conteúdo, três temas principais ("mudanças no planejamento da carreira", "prioridades de pesquisa" e "desenvolvimento") e seis categorias foram formuladas a partir dos dados obtidos. Os participantes afirmaram ter consciência de ter feito várias mudanças nos planos de carreira ao iniciar seu projeto de doutorado, e o trabalho no projeto mudou o desenvolvimento profissional e melhorou as habilidades acadêmicas. Conclusão: Nossos resultados indicam que os estudantes de doutorado devem ser apoiados para serem eficazes na carreira, e a formação no período pós-doutoral também deve ser apoiada. Políticas efetivas em relação ao aperfeiçoamento de enfermeiros doutorandos também devem ser desenvolvidas e implementadas com base em evidências sólidas da utilidade desses suportes.


Resumen Objetivos: El objetivo de este estudio fue describir los puntos de vista de estudiantes de doctorado en enfermería sobre cambios en la planificación de la carrera y prioridades de investigación antes del inicio y durante el doctorado. Métodos: El estudio fue de naturaleza cualitativa, habiendo sido realizado con 16 entrevistas en el Instituto de Ciencias de la Salud, Facultad de Enfermería. Se realizaron entrevistas individuales con 16 estudiantes de doctorado matriculados en diferentes especialidades académicas. Después de las entrevistas, las grabaciones de audio fueron transcritas, en primer lugar, y luego categorizadas. Los datos fueron sometidos a análisis de contenido. Resultados: Después del análisis de contenido y, a partir de los datos obtenidos, se formularon tres temas principales ("cambios en la planificación de la carrera", "prioridades de investigación" y "desarrollo") y seis categorías. Los participantes afirmaron tener conciencia de haber hecho varios cambios en los planes de carrera al iniciar su proyecto de doctorado: el trabajo en el proyecto cambió el desarrollo profesional y mejoró las habilidades académicas. Conclusión: Nuestros resultados indican que los estudiantes de doctorado deben ser apoyados para ser eficaces en la carrera, igualmente, también es necesario apoyar la formación en el período postdoctoral. Las políticas efectivas en relación con el perfeccionamiento de enfermeros doctorandos también deben ser desarrolladas e implementadas con base en evidencias sólidas de la utilidad de esos soportes.


Abstract Objective: The aim of this study was to describe the views of nursing doctoral student before beginning and during training doctoral programs about career planning changes and research priorities. Methods: The study was of qualitative design. The study was carried out with 16 interviews with Health Sciences Institute Faculty of Nursing. Individual interviews were with 16 doctoral students enrolled in different academic specialties following the interviews, the audio recordings were first transcribed and then categorized. The data were analyzed by content analysis. Results: Data was analyzed by content analysis and then three main themes, namely "changes in career planning," "research priorities," and "development," and six categories were formulated from the data obtained. The participants stated that upon starting their doctoral program, they were aware that they had made various changes in their career plans also doctoral program had affected their professional development and improved their transferable skills. Conclusion: This study's results suggest that doctoral students should be supported so that they can be effective in their careers, and that post-doctoral education should also be supported. Effective policies concerning the improvement of doctoral nurses should also be developed and implemented based on evidence demonstrating the usefulness of these supports.


Subject(s)
Humans , Male , Female , Adult , Perception , Research , Students, Nursing , Career Choice , Education, Nursing, Graduate , Epidemiology, Descriptive , Interviews as Topic , Evaluation Studies as Topic
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