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Leuk Lymphoma ; 58(9): 1-13, 2017 09.
Article in English | MEDLINE | ID: mdl-28571489

ABSTRACT

Expression of thioredoxin-1 (TXN) and CXCL9 is not restricted to THRLBCL macrophages, but may be observed in histiocytes and neoplastic (HRS) cells of EBV + mixed cellularity (MC) classical Hodgkin lymphoma (cHL) and nodular lymphocyte predominant HL. We aimed to validate and extend the above observations in 174 cHL patients evaluating the immunohistochemical expression of TXN, CXCL9 and IFN-γ. HRS-cell CXCL9 expression was higher in latent membrane protein-1 (LMP1)+, MC and Stage IV. TXN and CXCL9 expression by cHL histiocytes was more frequent in LMP1+, MC and older patients (only for CXCL9). TXN expression by HRS cells (≥80%) was independently associated with better failure-free survival. In conclusion, markers of TCHRLBCL histiocytes (TXN, CXCL9), as well as IFN-γ are also expressed by histiocyte subsets and neoplastic cells of cHL. The expression of some of them is more prominent in EBV + MC, but not restricted to this subtype. The prognostic implication of TXN needs further evaluation.


Subject(s)
Chemokine CXCL9/genetics , Hodgkin Disease/genetics , Interferon-gamma/genetics , Macrophages/metabolism , Thioredoxins/genetics , Adolescent , Adult , Aged , Chemokine CXCL9/metabolism , Female , Gene Expression , Histiocytes/metabolism , Histiocytes/pathology , Hodgkin Disease/metabolism , Hodgkin Disease/mortality , Hodgkin Disease/pathology , Humans , Immunohistochemistry , Interferon-gamma/metabolism , Male , Middle Aged , Neoplasm Staging , Prognosis , Proportional Hazards Models , Thioredoxins/metabolism , Tumor Microenvironment , Young Adult
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