Indomethacin for heterotopic ossification prophylaxis following surgical treatment of elbow trauma: a randomized controlled trial.

BACKGROUND: Heterotopic ossification is a frequent complication following surgical treatment of elbow trauma. The use of indomethacin to prevent heterotopic ossification is reported in the literature; however, its effectiveness is controversial. The purpose of this randomized, double-blind, placebo-controlled study was to determine whether indomethacin is effective in reducing the incidence and severity of heterotopic ossification after surgical management of elbow trauma. METHODS: Between February 2013 and April 2018, 164 eligible patients were randomized to receive postoperative indomethacin or placebo medication. The primary outcome was the incidence of heterotopic ossification on elbow radiographs at 1-year follow-up. Secondary outcomes included the Patient Rated Elbow Evaluation score, Mayo Elbow Performance Index score, and Disabilities of the Arm, Shoulder and Hand score. Range of motion, complications, and nonunion rates were also obtained. RESULTS: At 1-year follow-up, there was no significant difference in the incidence of heterotopic ossification between the indomethacin group (49%) and the control group (55%) (relative risk, 0.89; P = .52). There were no significant differences in postoperative Patient Rated Elbow Evaluation, Mayo Elbow Performance Index, and Disabilities of the Arm, Shoulder and Hand scores or range of motion (P = .16). The complication rate was 17% in both the treatment and control groups (P > .99). There were no nonunions in either group. CONCLUSION: This Level I study demonstrated that indomethacin prophylaxis against heterotopic ossification in the setting of surgically treated elbow trauma was not significantly different from placebo.

Does body mass index affect the rate of adverse outcomes in total hip and knee arthroplasty? A retrospective review of a total joint replacement database

Background: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are reliable surgical options to treat pain and disability resulting from degenerative conditions around the hip and knee. Obesity is a modifiable risk factor that contributes to significant morbidity. The purpose of this study was to retrospectively compare outcomes in primary hip and knee arthroplasty for patients with increased body mass index (BMI) and those with normal BMI, using data from the registry of the Alberta Bone and Joint Health Institute (ABJHI). Methods: We retrospectively reviewed the data compiled in the ABJHI registry between March 2010 and July 2016. We reviewed outcomes with respect to length of stay, discharge destination, 30-day readmission, postoperative infection, postoperative transfusion requirements, postoperative adverse events and in-hospital postoperative mechanical complications. Results: A total of 10 902 patients (6076 women, 4826 men) who underwent THA and 16 485 patients (10 057 women, 6428 men) who underwent TKA were included in the study. For both THA and TKA, patients with increased BMI had an increased number of in-hospital medical events, had an increased rate of deep infection, were less likely to be discharged home (p < 0.001) and had decreased transfusion requirements (p < 0.001) than patients whose weight was in the normal range. Increased BMI increased the rate of 30-day readmission and length of stay in the THA cohort but not in the TKA cohort. Increased BMI had no effect on acute postoperative dislocation or periprosthetic fractures. Patients with a BMI of 30 kg/m2 or greater required a THA 1.7 years earlier than patients of normal weight, patients whose BMI was 35 kg/m2 or greater required a THA 3.4 years earlier, and patients whose BMI was 40 kg/m2 or greater required a THA 5.8 years earlier. In the TKA cohort, patients with a BMI of 30 kg/m2 or greater required a TKA 2.7 years earlier than patients whose weight was in the normal range, patients with a BMI of 35 kg/m2 or greater required a TKA 4.6 years earlier, and patients whose BMI was 40 kg/m2 or greater required a TKA 7.6 years earlier. Conclusion: Our study quantifies the effects of obesity in primary hip and knee arthroplasty. It provides a greater understanding of the risks in the obese population when contemplating joint arthroplasty.

Contexte: La prothèse totale de la hanche (PTH) et la prothèse totale du genou (PTG) sont des options chirurgicales fiables pour traiter la douleur et l'invalidité résultant de maladies dégénératives de la hanche et du genou. L'obésité est un facteur de risque modifiable qui contribue significativement à la morbidité. Le but de cette étude était de comparer de manière rétrospective le résultat des interventions primaires pour prothèses de la hanche et du genou selon que les patients avaient un indice de masse corporelle (IMC) normal ou élevé à partir des données du registre de l'Alberta Bone and Joint Health Institute (ABJHI). Méthodes: Nous avons analysé de manière rétrospective les données compilées par le registre de l'ABJHI entre mars 2010 et juillet 2016. Nous avons passé en revue les paramètres suivants : durée du séjour hospitalier, destination post-congé, réadmissions dans les 30 jours, infections postopératoires, besoins transfusionnels postopératoires, complications postopératoires et complications mécaniques postopératoires perhospitalières. Résultats: En tout, 10 902 patients (6076 femmes, 4826 hommes) ayant subi une PTH et 16 485 patients (10 057 femmes, 6428 hommes) ayant subi une PTG ont été inclus dans l'étude. Tant pour la PTH que pour la PTG, les patients ayant un IMC élevé ont présenté un plus grand nombre de complications médicales en cours d'hospitalisation; ils ont aussi présenté un nombre plus élevé d'infections profondes, étaient moins susceptibles de pouvoir retourner chez eux au moment de leur congé (p < 0,001) et ont eu moins besoin de transfusions (p < 0,001) comparativement aux patients dont le poids se situait dans l'éventail des valeurs normales. L'IMC élevé a été en corrélation avec une augmentation du taux de réadmission à 30 jours et de la durée du séjour dans la cohorte soumise à une PTH, mais non dans la cohorte soumise à une PTG. L'IMC élevé n'a exercé aucun effet sur la dislocation postopératoire aiguë ou les fractures périprothétiques. Les patients ayant un IMC de 30 kg/m2 ou plus ont eu besoin d'une PTH 1,7 an plus tôt que les patients de poids normal, les patients ayant un IMC de 35 kg/m2 ou plus ont eu besoin d'une PTH 3,4 ans plus tôt, et les patients ayant un IMC de 40 kg/m2 ou plus ont eu besoin d'une PTH 5,8 ans plus tôt. Dans la cohorte soumise à la PTG, les patients ayant un IMC de 30 kg/m2 ou plus ont eu besoin d'une PTG 2,7 ans plus tôt que les patients de poids normal, les patients ayant un IMC de 35 kg/m2 ou plus ont eu besoin d'une PTG 4,6 ans plus tôt, et les patients ayant un IMC de 40 kg/m2 ou plus ont eu besoin d'une PTG 7,6 ans plus tôt. Conclusion: Notre étude quantifie les effets de l'obésité sur le recours aux interventions primaires pour prothèse de la hanche et du genou. Elle permet de mieux comprendre les risques auxquels est exposée la population obèse lorsqu'une intervention pour prothèse articulaire est envisagée.

Does Rehabilitation before Total Knee Arthroplasty Benefit Postoperative Recovery? A Systematic Review.

BACKGROUND: Arthritis is the most common form of joint disease. Total knee arthroplasty (TKA) is the most effective surgical intervention for end-stage knee osteoarthritis. The purpose of this study is to access whether patients who participated in preoperative rehabilitation before primary TKA received any postoperative benefit compared to patients who did not participate in preoperative rehabilitation. MATERIALS AND METHODS: A comprehensive search of Medline, PubMed, Embase, CENTRAL, CINAHL, Ageline, and hand searching references and abstracts was performed. Inclusion criteria included patients undergoing primary and unilateral TKA. Exclusion criteria included patients who have bilateral, unicompartmental, or revision TKA. All studies compared preoperative exercise program versus no preoperative exercise. Outcomes included patients' function, acute care length of stay (LOS), pain, and stiffness. The Western Ontario and McMaster Universities Osteoarthritis Index and 36-Item Short-Form Health Survey functional scales were used to assess these outcomes. Assessment was performed within 3 months of TKA. RESULTS: Of 1347 articles, 1308 studies were excluded during title and abstract screening. Thirty nine articles underwent full-text screening and were narrowed to five studies matching all criteria. Two studies were combined showing a significant decrease in LOS favoring preoperative exercise (-0.93, 95% confidence interval: -1.29, -0.57). There was a lack of evidence to show any difference regarding self-reported function, stiffness, pain, and physical role. CONCLUSION: Preoperative exercise program may be beneficial and is associated with a significant decrease in length of hospital stay. No conclusive evidence can be delineated from the literature with respect to clinical outcome measures. Well-designed randomized trials would strengthen this position.

The effect of humeral polyethylene insert constraint on reverse shoulder arthroplasty biomechanics.

BACKGROUND: There is little information on the effects of altering reverse shoulder arthroplasty (RSA) polyethylene constraint on joint load, load angle and deltoid force. The present biomechanical study aimed to investigate the effects of changing RSA polyethylene constraint on joint load, load angle, deltoid force and range of motion. METHODS: A custom RSA implant capable of measuring forces across the joint with varying polyethylene constraint was tested in six cadaveric shoulders. Standard-, low- and high-constraint (retentive) polyethylene liners were tested, and joint kinematics, loads and muscle forces were recorded. RESULTS: When polyethylene constraint was altered, joint load and load angle during active abduction were not affected significantly (p > 0.19). Additionally, the force required by the deltoid for active abduction was not affected significantly by cup constraint (p = 0.144). Interestingly, active abduction range of motion was also not affected significantly by changes in cup constraint (p > 0.45). CONCLUSIONS: Altering polyethylene cup constraint in RSA to enhance stability does not significantly alter resultant joint loads and deltoid forces. Surprisingly, terminal abduction range of motion was also not significantly different with varying cup constraint, indicating that terminal impingement may be tuberosity related rather than polyethylene.

The effect of fracture comminution on the reliability and accuracy of radial head sizing.

BACKGROUND: Radial head implant sizing can be based on the maximum head diameter (D-MAX), the minimum head diameter (D-MIN), or the articular dish diameter (D-DISH). The purpose of this study was to assess the reliability of the different radial head sizing techniques and to investigate the effect of radial head fracture comminution on measurement accuracy. METHODS: Ten observers measured 11 cadaveric radial heads with 3 radial head features (D-MAX, D-MIN, and D-DISH diameter). Radial heads were then fractured into 2, 3, and 4 parts, and the measurements were repeated. Variability was assessed by intraclass correlation. The measurements were compared with the intact state to assess the effect of radial head fracture comminution on sizing accuracy. RESULTS: D-MAX and D-MIN measurements were the most reliable among all observers (intraclass correlation coefficients, 0.980, 0.973). The D-DISH measurement was less reliable (intraclass correlation coefficient, 0.643). Radial head comminution did not significantly affect the reliability of any measurement (P > .2). Fracture comminution, however, significantly affected measurement accuracy with D-MAX and D-DISH. With fracture comminution, D-MAX underestimated radial head diameter (-0.4 ± 0.3 mm; P < .001), whereas D-DISH overestimated diameter (+0.5 ± 0.4 mm; P < .001). Comminution did not significantly affect D-MIN (-0.1 ± 0.3 mm; P = .13). DISCUSSION: The D-MAX and D-MIN measurements were more reliable than D-DISH for diameter sizing of intact and comminuted radial heads. Overall, increasing comminution did not significantly affect measurement reliability. However, the accuracy of the D-MIN technique was least affected by comminution, suggesting that D-MIN should be used in selecting the diameter of a radial head implant.

Radial head replacement with pyrocarbon prosthesis: early clinical results.

BACKGROUND: Comminuted radial head fractures are challenging to treat with open reduction and internal fixation. Radial head arthroplasty is a favourable technique for the treatment of complex radial head fractures. The purpose of this study was to evaluate the functional and radiological outcomes of radial head arthroplasty using modular pyrocarbon radial head prosthesis. METHODS: We retrospectively reviewed 21 consecutive patients requiring radial head arthroplasty for unreconstructible radial head fractures between July 2003 and July 2009. Patients completed a Short Form-36 (SF-36), the Disabilities of the Arm, Shoulder and Hand questionnaire, and the Mayo Elbow Performance Index. Patients were independently physically examined and their post-operative radiographs were reviewed. RESULTS: Twenty-one patients (nine males and 12 females) were reviewed at a minimum of 12 months follow-up. The mean Disabilities of the Arm, Shoulder and Hand score was 10.8 (0-34.1), mean SF-36 physical score was 76.9 (35-96), mean SF-36 mental score was 83.8 (60-94), and their Mayo Elbow Performance Index score was 86.4 (70-100). Patients maintained 90% of their grip strength when compared with their uninjured arm and had 17.5° of fixed flexion in the affected arm. Radiologically, 14 cases had some degree of post-traumatic osteoarthritis, 12 cases had evidence of heterotrophic ossification, five had some evidence of periprosthetic lucency and three patients were radiologically, but not functionally 'overstuffed'. CONCLUSION: Radial head arthroplasty with pyrocarbon radial head prosthesis is an acceptable option when treating unreconstructable radial head fractures yielding good functional and radiological outcomes.

No association of G-protein-coupled receptor kinase 5 or ß-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort.

AIMS: Takotsubo cardiomyopathy (TC) is an increasingly recognized syndrome in which patients present with chest pain and ST changes, and are observed to have reversible LV apical ballooning in the absence of angiographically significant coronary artery stenosis. Although the pathophysiology remains unclear, the syndrome occurs almost exclusively in women, and is often triggered by stress. Recent small studies have reported association of TC with functional variants in the G-protein-coupled receptor kinase 5 (GRK5) gene, as well as in the ß1-adrenergic receptor (ß1AR) and ß2AR. METHODS AND RESULTS: We tested these associations in a larger cohort of 92 TC patients. In addition we examined for the association of polymorphisms in the oestrogen receptor α (ERα) and catechol-O-methyl transferase (COMT) with the occurrence of TC, by comparing the allele frequency of these variants in the TC cohort with that in previously genotyped large Caucasian cohorts. Ninety-two patients with TC were recruited from four Australian centres; they had an age range of 41-90 years (mean ± SD = 66.3 ± 9) and 89/92 were female. There were no significant differences in allelic frequency in the TC group vs. the historic control database for any of the loci. CONCLUSION: In the largest genotyped TC cohort in the literature, we have found no association of genetic variants in the ERα, ß1AR, ß2AR, or COMT genes, or with the previously implicated GRK5, with occurrence of the syndrome.

Single-level/single-stage debridement and posterior instrumented fusion in the treatment of spontaneous pyogenic osteomyelitis/discitis: long-term functional outcome and health-related quality of life.

STUDY DESIGN: Retrospective study. OBJECTIVE: To support single-level posterior debridement and instrumented interbody fusion as a single-stage procedure for spontaneous pyogenic osteomyelitis/discitis. SUMMARY OF BACKGROUND DATA: The best surgical technique for patients with bacterial spinal infections is still a matter of debate. Recent publications suggest that titanium implants can be used safely in the infectious sites in combination with debridement and antibiotic therapy. METHODS: We retrospectively review patients with spontaneous pyogenic osteomyelitis/discitis in whom medical therapy failed, and they consequently underwent posterior decompression and instrumented fusion. Data was collected regarding demographics, clinical presentation, images and laboratory studies, antibiotic treatment, duration of hospitalization, time to achieve radiologic evidence of fusion, postoperative complications, and neurologic function pre- and postoperatively. Quality of life was measured using the EQ5D questionnaire and level of disability with the Oswestry Disability Index. RESULTS: Nine patients, ranging in age from 41 to79 years, with a Frankel score of D in 7 cases and of E in 2 cases, underwent a single-level/single-stage debridement and posterior instrumented fusion with pedicle screws and an interbody and posterolateral autogenous bone graft. Preoperative neurologic deficits improved in all the cases and solid bone fusion was achieved in all 9 patients at 12 months. The mean follow-up period was 67 months. The infection healed after surgery in all the patients and they did not require a second operation to remove the metal implants. Quality of life assessed with the EQ5D questionnaire showed scores ranging between 0.70 and 1. The median Oswestry Disability Index was 15.5%. CONCLUSIONS: These findings support that debridement and posterior instrumented fusion can be performed as a single-stage procedure with no increase in the recurrence rate or morbidity. The outcome has been satisfactory in our patients in terms of the rate of fusion and quality of life.

Tako-tsubo cardiomyopathy: how stress can mimic acute coronary occlusion.

Tako-tsubo cardiomyopathy (TTC) is an important differential diagnosis of acute coronary occlusive myocardial infarction that should be understood by all clinicians. Although TTC is frequently clinically indistinguishable from acute left anterior descending coronary artery occlusion, it is readily differentiated with coronary angiography. The increasing frequency of acute angiography and revascularisation for patients with acute myocardial infarction has resulted in TTC being far more frequently diagnosed. Most common in postmenopausal women, TTC is frequently precipitated by physical or emotional stress, and after an acute phase during which the patient may be significantly haemodynamically compromised, there is rapid recovery and an excellent prognosis. After diagnosis the patient can be reassured and advised of the low rates of recurrence. Currently, no specific preventive therapy has been proven to be effective.