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Allelic polymorphism C-590T of the gene IL-4 as the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children.

Kens, O; Vishtak, N; Acopyan, H; Bergtravm, V.

Tsitol Genet ; 50(3): 30-5, 2016.

Article in English, Russian | MEDLINE | ID: mdl-30480406

ABSTRACT

Molecular-genetic study of C-590T polymorphic locus of IL-4 gene in 31 children with recurrent episodes of acute obstructive bronchitis and 50 people who constituted the control population-based group has been carried out. It is proved that the presence of this polymorphic locus leads to three-fold increase of the risk of acute obstructive bronchitis recurrent episodes.

Subject(s)

Alleles , Bronchitis/genetics , Genetic Predisposition to Disease , Interleukin-4/genetics , Polymorphism, Single Nucleotide , Respiratory Tract Infections/genetics , Acute Disease , Bronchitis/complications , Bronchitis/immunology , Bronchitis/physiopathology , Case-Control Studies , Child , Child, Preschool , Female , Gene Expression , Genetic Loci , Genetic Markers , Humans , Immunoglobulin E/blood , Immunoglobulin E/genetics , Interleukin-4/immunology , Leukocytes, Mononuclear , Male , Primary Cell Culture , Recurrence , Respiratory Tract Infections/complications , Respiratory Tract Infections/immunology , Respiratory Tract Infections/physiopathology

ABSTRACT

Subject(s)

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