Motor cortex single-neuron and population contributions to compensation for multiple dynamic force fields.

To elucidate how primary motor cortex (M1) neurons contribute to the performance of a broad range of different and even incompatible motor skills, we trained two monkeys to perform single-degree-of-freedom elbow flexion/extension movements that could be perturbed by a variety of externally generated force fields. Fields were presented in a pseudorandom sequence of trial blocks. Different computer monitor background colors signaled the nature of the force field throughout each block. There were five different force fields: null field without perturbing torque, assistive and resistive viscous fields proportional to velocity, a resistive elastic force field proportional to position and a resistive viscoelastic field that was the linear combination of the resistive viscous and elastic force fields. After the monkeys were extensively trained in the five field conditions, neural recordings were subsequently made in M1 contralateral to the trained arm. Many caudal M1 neurons altered their activity systematically across most or all of the force fields in a manner that was appropriate to contribute to the compensation for each of the fields. The net activity of the entire sample population likewise provided a predictive signal about the differences in the time course of the external forces encountered during the movements across all force conditions. The neurons showed a broad range of sensitivities to the different fields, and there was little evidence of a modular structure by which subsets of M1 neurons were preferentially activated during movements in specific fields or combinations of fields.

Colored context cues can facilitate the ability to learn and to switch between multiple dynamical force fields.

We tested the efficacy of color context cues during adaptation to dynamic force fields. Four groups of human subjects performed elbow flexion/extension movements to move a cursor between targets on a monitor while encountering a resistive (Vr) or assistive (Va) viscous force field. They performed two training sets of 256 trials daily, for 10 days. The monitor background color changed (red, green) every four successful trials but provided different degrees of force field context information to each group. For the irrelevant-cue groups, the color changed every four trials, but one group encountered only the Va field and the other only the Vr field. For the reliable-cue group, the force field alternated between Va and Vr each time the monitor changed color (Vr, red; Va, green). For the unreliable-cue group, the force field changed between Va and Vr pseudorandomly at each color change. All subjects made increasingly stereotyped movements over 10 training days. Reliable-cue subjects typically learned the association between color cues and fields and began to make predictive changes in motor output at each color change during the first day. Their performance continued to improve over the remaining days. Unreliable-cue subjects also improved their performance across training days but developed a strategy of probing the nature of the field at each color change by emitting a default motor response and then adjusting their motor output in subsequent trials. These findings show that subjects can extract explicit and implicit information from color context cues during force field adaptation.