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1.
PLoS One ; 18(11): e0294643, 2023.
Article in English | MEDLINE | ID: mdl-38032868

ABSTRACT

In the realm of music information retrieval, similarity-based retrieval and auto-tagging serve as essential components. Similarity-based retrieval involves automatically analyzing a music track and fetching analogous tracks from a database. Auto-tagging, on the other hand, assesses a music track to deduce associated tags, such as genre and mood. Given the limitations and non-scalability of human supervision signals, it becomes crucial for models to learn from alternative sources to enhance their performance. Contrastive learning-based self-supervised learning, which exclusively relies on learning signals derived from music audio data, has demonstrated its efficacy in the context of auto-tagging. In this work, we propose a model that builds on the self-supervised learning approach to address the similarity-based retrieval challenge by introducing our method of metric learning with a self-supervised auxiliary loss. Furthermore, diverging from conventional self-supervised learning methodologies, we discovered the advantages of concurrently training the model with both self-supervision and supervision signals, without freezing pre-trained models. We also found that refraining from employing augmentation during the fine-tuning phase yields better results. Our experimental results confirm that the proposed methodology enhances retrieval and tagging performance metrics in two distinct scenarios: one where human-annotated tags are consistently available for all music tracks, and another where such tags are accessible only for a subset of music tracks.


Subject(s)
Music , Skin Neoplasms , Humans , Affect , Benchmarking , Databases, Factual , Information Storage and Retrieval
2.
PLoS One ; 15(7): e0233755, 2020.
Article in English | MEDLINE | ID: mdl-32628677

ABSTRACT

Systems biology aims at holistically understanding the complexity of biological systems. In particular, nowadays with the broad availability of gene expression measurements, systems biology challenges the deciphering of the genetic cell machinery from them. In order to help researchers, reverse engineer the genetic cell machinery from these noisy datasets, interactive exploratory clustering methods, pipelines and gene clustering tools have to be specifically developed. Prior methods/tools for time series data, however, do not have the following four major ingredients in analytic and methodological view point: (i) principled time-series feature extraction methods, (ii) variety of manifold learning methods for capturing high-level view of the dataset, (iii) high-end automatic structure extraction, and (iv) friendliness to the biological user community. With a view to meet the requirements, we present AGCT (A Geometric Clustering Tool), a software package used to unravel the complex architecture of large-scale, non-necessarily synchronized time-series gene expression data. AGCT capture signals on exhaustive wavelet expansions of the data, which are then embedded on a low-dimensional non-linear map using manifold learning algorithms, where geometric proximity captures potential interactions. Post-processing techniques, including hard and soft information geometric clustering algorithms, facilitate the summarizing of the complete map as a smaller number of principal factors which can then be formally identified using embedded statistical inference techniques. Three-dimension interactive visualization and scenario recording over the processing helps to reproduce data analysis results without additional time. Analysis of the whole-cell Yeast Metabolic Cycle (YMC) moreover, Yeast Cell Cycle (YCC) datasets demonstrate AGCT's ability to accurately dissect all stages of metabolism and the cell cycle progression, independently of the time course and the number of patterns related to the signal. Analysis of Pentachlorophenol iduced dataset demonstrat how AGCT dissects data to identify two networks: Interferon signaling and NRF2-signaling networks.


Subject(s)
Gene Expression , Software , Systems Biology/methods , Wavelet Analysis , Algorithms , Animals , Cell Cycle/genetics , Computational Biology/methods , Datasets as Topic , Gene Expression Regulation/drug effects , Liver/drug effects , Liver/metabolism , Markov Chains , Mice , Pentachlorophenol/pharmacology , Pentachlorophenol/poisoning , Random Allocation , Saccharomyces cerevisiae/cytology , Saccharomyces cerevisiae/genetics , Saccharomyces cerevisiae/metabolism , Systems Biology/statistics & numerical data
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