[Biochemical markers of myocardium damage in children with cardiomyopathy.]

The article presents the results of studies of 104 patients with cardiomyopathy hospitalized in the cardiorheumatological departments of the Republican Specialized Scientific and Practical Medical Center of Pediatrics in Tashkent and the Republican Children's Multidisciplinary Medical Center of the Republic of Karakalpakstan. An analysis of the results of the study showed that in children with cardiomyopathy there is an increase in the level of tissue (LDH, CPK) and cardiospecific (CPK-MB) enzymes, regardless of the region of residence and the form of the disease, which indicate myocardial dysfunction. Therefore, these enzymes can be regarded as highly specific biochemical markers of myocardial damage, and an increase in their activity can be used as criteria for the diagnosis of heart disease. Of the biochemical parameters, a reliable prognostic criterion for the development and outcome of cardiomyopathy is a progressive increase in the level of endothelin with increasing duration of the disease.

[Contribution of common factors to the pathogenesis of maxillodental abnormalities in children]. / Rol' obshchikh faktorov v patogeneze razvitiia deformatsii zubocheliustnoi sistemy u detei.

Results of complex investigation of 64 children with dento-maxillary deformations are presented. Anamnestic data of mothers and children were analyzed. Examinations by different specialists--pediatrician, orthopedician, nephrologist revealed latent and severe diseases and functional disorders of the gastrointestinal tract, central and autonomic nervous system, kidneys causing metabolic disorders particularly mineral metabolism disturbances. The authors suggest joining all the deformations in a group of "dismetabolic" ones and to develop methods of treatment in collaboration with different specialists.

[Evaluation of maxillodental status of children with gastrointestinal diseases]. / Otsenka sostoianiia zubocheliustnoi sistemy u detei s patologiei zheludochno-kishechnogo trakta.

One hundred and thirty three children aged 1 to 15 years with gastrointestinal diseases were studied. The authors found changes of the dentomaxillary system condition in all the patients. The changes were more frequently observed in gall bladder diseases and chronic hepatitis. In under 7 year old children pathologic changes in the hard dental tissues predominated, while at the age of 7 to 11 years deformation of the jaws did. The severity of pathological changes of the dentomaxillary system depended on the duration of gastrointestinal diseases. One to eleven year old children may be assigned to the risk group for the development of jaw deformations. Deformations were more pronounced in subjects with physical development retardation.

[Effectiveness of a new Soviet drug Benzonal, inductor of microsomal enzymes of the liver, in the complex treatment of hemolytic disease of newborn]. / Effektivnost' primeneniia novogo otechestvennogo induktora mikro- somal'nykh fermentov pecheni benzonala v kompleksnoi terapii hemoliticheskoi bolezni novorozhdennykh.

The effects of benzonal on the course of neonatal hemolytic disease due to the Rhesus factor-conflict was studied in comparison with that of phenobarbital. Dynamic follow-up of infants in the early neonatal period showed benzonal to produce a more pronounced hypobilirubinemic effect which was manifested as a prompter disappearance of skin jaundice and lower percentages of complications. By depressing the activity of organospecific enzymes and lowering the serum biliary acid levels, benzonal promotes normalization of the metabolic shifts present in neonatal hemolytic disease. The findings make it possible to recommend the new inductor of microsomal liver enzymes benzonal as part of the combined therapy of neonatal hemolytic disease.