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Correction to: Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.

Kryl'skii, E D; Razuvaev, G A; Potapova, T N; Akinina, A I; Nihaev, L E.

Bull Exp Biol Med ; 172(1): 111, 2021 Nov.

Article in English | MEDLINE | ID: mdl-34796427

Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.

Kryl'skii, E D; Razuvaev, G A; Potapova, T N; Akinina, A I; Nihaev, L E.

Bull Exp Biol Med ; 171(6): 716-721, 2021 Oct.

Article in English | MEDLINE | ID: mdl-34705173

ABSTRACT

A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.

Subject(s)

Catalase/metabolism , Glutathione Peroxidase/metabolism , Glutathione Reductase/metabolism , Glutathione Transferase/metabolism , Glutathione/metabolism , Parkinson Disease, Secondary/enzymology , Superoxide Dismutase/metabolism , Animals , Antioxidants/metabolism , Brain/drug effects , Brain/enzymology , Brain/pathology , Catalase/genetics , Gene Expression , Glutathione Peroxidase/genetics , Glutathione Reductase/genetics , Glutathione Transferase/genetics , Male , Mitochondria/drug effects , Mitochondria/enzymology , Mitochondria/genetics , Oxidative Stress , Parkinson Disease, Secondary/chemically induced , Parkinson Disease, Secondary/genetics , Parkinson Disease, Secondary/pathology , Rats , Rats, Wistar , Rotenone/toxicity , Superoxide Dismutase/genetics

ABSTRACT

Subject(s)

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