1.
Chem Pharm Bull (Tokyo)
; 68(10): 996-1000, 2020.
Article
in English
| MEDLINE
| ID: mdl-32999152
ABSTRACT
This study describes the novel utility of cyclic sulfamidite as a simultaneous protecting group for 1,2- or 1,3-amino alcohols. An exceptionally mild and neutral condition for the removal of the cyclic sulfamidite was developed. The deprotection condition demonstrated a broad range of functional-group compatibility, including a substrate bearing a Z-enyne structure without any loss of double-bond stereochemistry.