Enhanced Adsorption of Textile Dyes by a Novel Sulfonated Activated Carbon Derived from Pomegranate Peel Waste: Isotherm, Kinetic and Thermodynamic Study.

The rapid growth of the dye and textile industry has raised significant public concerns regarding the pollution caused by dye wastewater, which poses potential risks to human health. In this study, we successfully improved the adsorption efficiency of activated carbon derived from pomegranate peel waste (PPAC) through a single-step and surface modification approach using 5-sulfonate-salicylaldehyde sodium salt. This innovative and effective sulfonation approach to produce sulfonated activated carbon (S-PPAC) proved to be highly effective in removing crystal violet dye (CV) from polluted water. The prepared PPAC and S-PPAC were characterized via FESEM, EDS, FTIR and BET surface area. Characterization studies confirmed the highly porous structure of the PPAC and its successful surface modification, with surface areas reaching 1180.63 m2/g and 740.75 m2/g for the PPAC and S-PPAC, respectively. The maximum adsorption capacity was achieved at 785.53 mg/g with the S-PPAC, an increase of 22.76% compared to the PPAC at 45 °C. The isothermic adsorption and kinetic studies demonstrated that the adsorption process aligned well with the Freundlich isotherm model and followed the Elovich kinetic model, respectively. The thermodynamic study confirmed that the adsorption of CV dye was endothermic, spontaneous and thermodynamically favorable onto PPAC and S-PPAC.

Activated Carbon-Incorporated Tragacanth Gum Hydrogel Biocomposite: A Promising Adsorbent for Crystal Violet Dye Removal from Aqueous Solutions.

Biomaterials-based adsorbents have emerged as a sustainable and promising solution for water purification, owing to their eco-friendly nature and remarkable adsorption capacities. In this study, a biocomposite hydrogel was prepared by the incorporation of activated carbon derived from pomegranate peels (PPAC) in tragacanth gum (TG). The hydrogel biocomposite (PPAC/TG) showed a porous structure, a negative surface charge at a pH of more than 4.9, and good stability in aqueous media. The adsorption properties of the PPAC/TG hydrogel biocomposite were assessed for the removal of crystal violet dye (CV) from aqueous solutions using a batch adsorption. The equilibrium adsorption data followed the Sips isotherm model, as supported by the calculated R2 (>0.99), r-χ2 (<64), and standard error values (<16). According to the Sips model, the maximum values of the adsorption capacity of PPAC/TG were 455.61, 470.86, and 477.37 mg/g at temperatures of 25, 30, and 35 °C, respectively. The adsorption kinetic of CV onto the PPAC/TG hydrogel biocomposite was well described by the pseudo-second-order model with R2 values more than 0.999 and r-χ2 values less than 12. Thermodynamic studies confirmed that the CV dye adsorption was spontaneous and endothermic. Furthermore, the prepared hydrogel exhibited excellent reusability, retaining its adsorption capacity even after being used more than five times. Overall, this study concludes that the prepared PPAC/TG exhibited a significant adsorption capacity for cationic dyes, indicating its potential as an effective and eco-friendly adsorbent for water treatment.

Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents.

The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, 1H and 13C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.

Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives.

A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.