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1.
Cureus ; 16(7): e63725, 2024 Jul.
Article in English | MEDLINE | ID: mdl-39100058

ABSTRACT

Burkitt lymphoma is an aggressive B-cell non-Hodgkin lymphoma (NHL). Primary CNS lymphoma (PCNSL) is a rare disease, and the subtype of Burkitt lymphoma presenting as a sole CNS lesion is an even rarer diagnosis. Acute sudden blindness is a rare presenting symptom of PCNSL or NHL in general. We present an interesting case of a four-year-old boy with dysmorphic features whose visual examination showed a sudden bilateral loss of vision. There was bilateral eye proptosis and complete ptosis. Extraocular muscles were fixed straight. The pupils were fixed and mid dilated bilaterally and there was grade 3/4 papilledema in both eyes. Neuroimaging showed a mass in the base of the skull, extending to orbits and sinuses. A cervical biopsy of the enlarged lymph nodes was taken and a histopathological diagnosis of Burkitt lymphoma was made. Genetic analysis showed a GNB1 mutation, and the patient was diagnosed with Kabuki syndrome by a pediatrician, based on characteristic dysmorphic features. Treatment with steroids and chemotherapy was initiated.

2.
Cureus ; 13(1): e12638, 2021 Jan 11.
Article in English | MEDLINE | ID: mdl-33489628

ABSTRACT

Background Pterygium is an important public health problem. The prevalence rates of this disease varies widely from 1.2% to 23.4%. Aim To determine the prevalence rates and the associated risk factors of pterygium in the high-altitude area - Ta'if city, Saudi Arabia. Material and method A cross-sectional study was carried out from September 2018 till September 2019 at the ophthalmology outpatient clinics of King Abdul-Aziz Specialist Hospital, Ta'if area. Results Prevalence rate of pterygium in the high-altitude area, Ta'if city, Saudi Arabia was 2.4%. It is significantly higher in older patients belonging to the age group of more than 40 years. As for gender, it was significantly higher in male patients compared to females (2.6% vs. 1.9%). Pterygium prevalence was significantly higher among patients with outdoor occupations compared to indoor occupations (2.9% vs. 2.1%), and among patients with sunlight exposure during daily activities for more than 5 hours (2.6% vs. 2%) (p =< 0.05). Conclusion The overall incidence of pterygium in Al-Ta'if area, Saudi Arabia, was 2.4% but still lower than overall worldwide incidence (10.2%). There was an increased incidence of pterygium with age, high-altitude areas, rural areas, outdoor occupations, which is directly proportional to dose of sunlight exposure. Furthermore, smoking might be reported as a protective factor against pterygium.

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