ABSTRACT
The use of a lymphocyte transformation test (LTT) to provide evidence of allergic contact dermatitis was investigated. The haptens studied were alantolactone and isoalantolactone, two moderate allergens from Inula helenium L., a decorative and medicinal plant. Only alantolactone showed a significant response in vivo and in vitro in mice sensitized epicutaneously, without using Freund's complete adjuvant. Isoalantolactone did not show any sensitizing capacity in the murine model studied. The comparison of in vitro lymphocyte proliferation and in vivo allergenic capacity showed a good correlation and clearly demonstrates that, of the two sesquiterpene lactones, alantolactone is the better sensitizer.
Subject(s)
Dermatitis, Allergic Contact/etiology , Sesquiterpenes/immunology , Animals , Cross Reactions , Disease Models, Animal , In Vitro Techniques , Lactones , Lymphocyte Activation , Male , Mice , Mice, Inbred BALB C , Mice, Inbred DBA , Sesquiterpenes, Eudesmane , Species SpecificityABSTRACT
We present a very typical case of pseudo-xanthoma elasticum (PXE) with very remarkable cutaneous lesions, a great number of angioid streaks and, at the moment, with no involvement of the peripheral vascular system. From a genetic standpoint, we believe it must be considered as recessive Type I. An X-ray microanalysis was performed showing intense Ca and P deposits in the affected areas as well as complete absence of Si.
Subject(s)
Pseudoxanthoma Elasticum/diagnosis , Adult , Angioid Streaks/etiology , Elastic Tissue/chemistry , Electron Probe Microanalysis , Fundus Oculi , Humans , Male , Pseudoxanthoma Elasticum/pathologyABSTRACT
We communicate a case of pressure sore (decubitus ulcer) treated with 20% topic benzoyl peroxide in O/W emulsion with very satisfactory results. This substance feeds hyperbaric oxygen. Benzoyl peroxide also has antimicrobial, antipruriginous and antifungal properties all of them contributing to shorten the evolution of the lesions.
