ABSTRACT
INTRODUCTION: von Willebrand factor (vWf) is thought to mediate binding of tumour cells to platelets and to favour their systemic spreading capacity. Platelets involved in tumour angiogenesis are capable of releasing vascular endothelial growth factor (VEGF). Hence, levels of vWf and VEGF may correlate with cancer stage. The objectives are determine the impact of surgery and chemotherapy on vWf and VEGF in colorectal cancer (CRC) patients. MATERIAL AND METHODS: Twenty healthy volunteers (group 1), 14 patients with locally advanced CRC (group 2) and 12 patients with metastatic CRC (group 3) were enrolled. Blood samples were taken at recruitment in group 1, and before and after surgery and chemotherapy in groups 2 and 3, respectively. Blood levels of vWf, VEGF, platelet count, C-reactive protein (CRP), ceruloplasmin and carcinoembrionary antigen (CEA) were measured. RESULTS: At baseline, group 3 showed higher concentrations of vWf than the other groups (p<0.05). In group 2, vWf became elevated 40% post-surgery (p=0.016), independently of changes in CRP or ceruloplasmin. In group 3, chemotherapy caused a 42% reduction in VEGF (p=0.015). CONCLUSIONS: There was a strong correlation between higher vWf levels and more advanced CRC stage at diagnosis. These levels were elevated post-surgery in patients with locally advanced CRC. Chemotherapy significantly decreased VEGF in metastatic CRC patients before CEA showed any significant change.
Subject(s)
Colorectal Neoplasms/blood , Colorectal Neoplasms/therapy , Vascular Endothelial Growth Factor A/blood , von Willebrand Factor/analysis , Adolescent , Adult , Aged , Aged, 80 and over , Colorectal Neoplasms/pathology , Female , Humans , Male , Middle AgedABSTRACT
Introduction. von Willebrand factor (vWf) is thought to mediate binding of tumour cells to platelets and to favour their systemic spreading capacity. Platelets involved in tumour angiogenesis are capable of releasing vascular endothelial growth factor (VEGF). Hence, levels of vWf and VEGF may correlate with cancer stage. The objectives are determine the impact of surgery and chemotherapy on vWf and VEGF in colorectal cancer (CRC) patients. Material and methods. Twenty healthy volunteers (group 1), 14 patients with locally advanced CRC (group 2) and 12 patients with metastatic CRC (group 3) were enrolled. Blood samples were taken at recruitment in group 1, and before and after surgery and chemotherapy in groups 2 and 3, respectively. Blood levels of vWf, VEGF, platelet count, C-reactive protein (CRP), ceruloplasmin and carcinoembrionary antigen (CEA) were measured. Results. At baseline, group 3 showed higher concentrations of vWf than the other groups (p<0.05). In group 2, vWf became elevated 40% post-surgery (p=0.016), independently of changes in CRP or ceruloplasmin. In group 3, chemotherapy caused a 42% reduction in VEGF (p=0.015). Conclusions. There was a strong correlation between higher vWf levels and more advanced CRC stage at diagnosis. These levels were elevated post-surgery in patients with locally advanced CRC. Chemotherapy significantly decreased VEGF in metastatic CRC patients before CEA showed any significant change
No disponible
Subject(s)
Male , Female , Adult , Aged , Middle Aged , Humans , Vascular Endothelial Growth Factor A/blood , von Willebrand Factor/analysis , Colorectal Neoplasms/blood , Colorectal Neoplasms/therapy , Colorectal Neoplasms/pathologyABSTRACT
BACKGROUND: There is some dispute about the role of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) consumption on the prevention of coronary heart disease. The aim of this study was to analyze the relationship between n-3 PUFA and fish consumption and the risk of a first acute myocardial infarction (AMI) in a low risk population from Navarre (Spain). METHOD: A hospital-based case-control study was conducted in Pamplona (Spain). We included 171 patients (81% males, age < 80 years) who were admitted with a first acute myocardial infarction and 171 age, gender and hospital-matched controls were selected. A validated semi-quantitative food frequency questionnaire was administered and face-to-face interviews were performed. Conditional logistic regression modeling was used to take into account potential confounders. RESULTS: Adjusted odds ratio (OR) and 95% confidence intervals (CI) for the second and third tertile of n-3 PUFA intake were 0.44 (95% CI, 0.21-0.91) and 0.47 (95% CI, 0.22-1.00), respectively. Trend test was not statistically significant. Adjusted OR and 95% CI for the second and third tertile of fish consumption were 0.40 (95% CI, 0.19-0.83) and 0.42 (95% CI, 0.19-0.93), respectively. Additional adjusting for n-3 PUFA led to a non-significant association between fish consumption and AMI. CONCLUSIONS: This study reveals a protective effect of n-3 PUFA and fish consumption against AMI. Our results suggest that a threshold exists in the quantitative dose-response relationship between fish intake and AMI.
Subject(s)
Fatty Acids, Omega-3/therapeutic use , Myocardial Infarction/epidemiology , Myocardial Infarction/prevention & control , Case-Control Studies , Female , Humans , Male , Middle Aged , Risk FactorsABSTRACT
FUNDAMENTO: Existen dudas acerca del posible papel protector del consumo de pescado y ácidos grasos omega-3 en la prevención de la enfermedad coronaria. El objetivo del presente estudio ha sido analizar la relación entre el consumo de ácidos grasos omega-3 y de pescado y el riesgo de un primer infarto agudo de miocardio (IAM) en una población española de bajo riesgo. MÉTODO: Se realizó un estudio de casos y controles emparejados de base hospitalaria en Navarra. Se eligieron 171 casos incidentes (81 por ciento varones, < 80 años) ingresados por un primer episodio de IAM, y se emparejaron por sexo, edad y hospital con 171 controles. Se administraron cuestionarios semicuantitativos de frecuencia de consumo de alimentos previamente validados y se realizaron entrevistas protocolizadas y estructuradas. La asociación entre el consumo de pescado o de ácidos grasos omega-3 y el riesgo de un primer IAM se calculó mediante un análisis multivariante de regresión logística condicional. Se ajustó por posibles factores de confusión. RESULTADOS: Las odds ratios (OR) ajustadas e intervalos de confianza (IC) del 95 por ciento para el segundo y tercer tercil de ingestión de ácidos grasos omega-3 fueron 0,44 (IC del 95 por ciento, 0,210,91) y 0,47 (IC del 95 por ciento, 0,22-1,00). El test de tendencia lineal no fue estadísticamente significativo. Las OR ajustadas e IC del 95 por ciento para el segundo y tercer tercil de ingestión de pescado y otros alimentos de origen marino fueron 0,40 (IC del 95 por ciento, 0,19-0,83) y 0,42 (IC del 95 por ciento, 0,19-0,93). Tras un ajuste adicional por omega-3, desaparecía la significación estadística para la asociación entre consumo de pescado e infarto de miocardio. CONCLUSIONES: El estudio encontró un efecto protector de la ingestión de ácidos grasos omega-3 y pescado frente al IAM. Nuestros resultados indican que existe un valor umbral a partir del cual ya no aumenta más la protección que puede derivarse del consumo de pescado (AU)
