Safety net hospital risk model demonstrates stronger, population-specific applicability in characterizing lung cancer risk.

Background: Determining lung cancer (LC) risk using personalized risk stratification may improve screening effectiveness. While the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) is a well-established stratification model for LC screening, it was derived from a predominantly Caucasian population and its effectiveness in a safety net hospital (SNH) population is unknown. We have developed a model more tailored to the SNH population and compared its performance to the PLCO model in a SNH setting. Methods: Retrospective dataset was compiled from patients screened for LC at SNH from 2015 to 2019. Descriptive statistics were calculated using the following variables: age, sex, race, education, body mass index (BMI), smoking history, personal cancer history, family LC history, chronic obstructive pulmonary disease (COPD), and emphysema. Variables distribution was compared using t- and chi-square tests. LC risk scores were calculated using SNH and PLCO models and categorized as low (scores <0.65%), moderate (0.65-1.49%), and high (>1.5%). Linear regression was applied to evaluate the relationship between models and covariates. Results: Of 896 individuals, 38 were diagnosed with LC. Data reflected the SNH patient demographics, which predominantly were African American (53.5%), current smokers (69.9%), and with emphysema (70.1%). Among the non-LC cohort, SNH model most frequently categorized patients as low risk, while PLCO model most frequently classified patients as moderate risk. Among the LC cohort, there was no significant difference between mean scores or risk stratification. SNH model showed 92.1% sensitivity and 96.8% specificity while PLCO model showed 89.4% sensitivity and 26.1% specificity. Emphysema demonstrated a strong association in SNH model (P<0.001) while race showed no relation. Conclusions: SNH model demonstrated greater specificity for characterizing LC risk in a SNH population. The results demonstrated the importance of study sample representation when identifying risk factors in a stratification model.

Empreendedorismo na Enfermagem em Estomaterapia: Aspectos Potencializadores de Atuação no Mercado de Trabalho / Entrepreneurship in Stomal Therapy Nursing: Potential Aspects of Performance in the Labor Market / Emprendimiento en Enfermería Estomaterápica: Aspectos Potenciales de Desempeño en el Mercado Laboral

Objetivo:Analisar os aspectos potencializadores descritos por enfermeiros estomaterapeutas para realização de atividades empreendedoras. Método: Estudo de natureza qualitativa, do tipo descritivo-exploratório, realizado por meio de entrevista semiestruturada, entre os meses de janeiro e abril de 2020, com 26 estomaterapeutas empreendedores, apoiado na técnica não probabilística conhecida como snowball, ou bola de neve. Os dados coletados foram transcritos de forma integral e, posteriormente, tratados, aplicando-se a técnica de análise temática de conteúdo. Resultados: Foram relacionados temas que perpassaram pela percepção de potencializadores do empreendedorismo na estomaterapia, como a demanda do mercado e o vasto campo empreendedor da especialidade; a experiência clínica; a importância da indicação por outros pacientes e profissionais; a influência das mídias sociais e o sentimento de satisfação com o desenvolvimento da atividade laboral. Conclusão: A análise dos dados permitiu concluir que os potencializadores citados podem ser reflexo da reduzida oferta de serviços públicos especializados à população, ampliando-se a busca por tais especialistas de forma particular, tanto pela indicação de outros pacientes e profissionais quanto pela busca nas mídias sociais, o que expande os campos de atuação do estomaterapeuta e pode trazer maior satisfação com seu trabalho enquanto especialistas

Objective:To analyze the potentiating aspects of entrepreneurial activities described by stomal therapist nurses. Method: Qualitative, descriptive-exploratory study, carried out through semi-structured interviews, between January and April 2020, with 26 enterprising stoma therapists, supported by the non-probabilistic technique known as snowball. The collected data were fully transcribed and subsequently treated, applying the thematic content analysis technique. Results: Topics that pervaded the perception of entrepreneurship potential in stomatherapy were related, such as market demand and the vast entrepreneurial field of the specialty; clinical experience; the importance of indication by other patients and professionals; the influence of social media and the feeling of satisfaction with the development of the work activity. Conclusion: The analysis of the data allowed us to conclude that the cited potentiators may be a reflection of the reduced supply of specialized public services to the population, expanding the search for such specialists in a particular way, both by referring other patients and professionals and by searching through the social media, which expands the fields of action of the stoma therapist and can bring more satisfaction with their work as specialists.

Objetivo:Analizar los aspectos potenciadores de las actividades emprendedoras descritos por enfermeros estomaterapeutas. Método: Estudio cualitativo, descriptivo-exploratorio, realizado a través de entrevistas semiestructuradas, entre enero y abril de 2020, con 26 estomaterapeutas emprendedores, apoyados en la técnica no probabilística conocida como "Bola de Nieve". Los datos recogidos fueron transcritos íntegramente y posteriormente tratados, aplicando la técnica de análisis de contenido temático. Resultados: Se relacionaron temas que impregnaron la percepción de los potenciadores del emprendimiento en estomaterapia, como la demanda del mercado y el vasto campo empresarial de la especialidad, la experiencia clínica, la importancia de la indicación por parte de otros pacientes y profesionales, la influencia de las redes sociales y el sentimiento de satisfacción con lo que haces. Conclusión: El análisis de los datos permite concluir que los citados potenciadores pueden ser reflejo de la reducida oferta de servicios públicos especializados a la población, ampliando de manera particular la búsqueda de estos profesionales, tanto por la derivación de otros pacientes y profesionales como por la búsqueda a través de las redes sociales, que amplían los campos de actuación del profesional y pueden traer más satisfacción con su trabajo como especialistas.

Saberes e Práticas Sobre Prevenção e Tratamento de Queimaduras no Ambiente Domiciliar / Knowledge and Practices About Prevention and Treatment of Burns in the Home Environment / Conocimientos y Prácticas Sobre Prevención y Tratamiento de Quemaduras en el Ambiente Domiciliario

Objetivos:Demonstrar os saberes e as práticas de indivíduos sobre prevenção e tratamento de queimaduras no ambiente domiciliar e descrever o cuidado educativo de enfermagem na prevenção e tratamento de queimaduras no ambiente domiciliar. Método: Pesquisa convergente-assistencial realizada de maneira virtual, no período de junho a agosto de 2021, com pessoas residentes na cidade de Macaé (RJ). Resultados: A pesquisa incluiu 16 participantes, sendo 81,25% (n = 13) do sexo feminino, com idades entre 19 e 59 anos. Na análise das entrevistas, foi possível identificar saberes e práticas equivocados sobre a prevenção e o tratamento de queimaduras, a serem discutidos neste estudo. Conclusão: Embora haja conhecimento acerca dos saberes e práticas adequados sobre prevenção e tratamento de queimaduras no ambiente domiciliar, houve identificação de práticas equivocadas que podem prejudicar o correto tratamento e prevenção de agravos. Os achados deste estudo apontam para a necessidade de construir materiais e de realizar práticas educativas com essa população para reforço de medidas preventivas de queimaduras.

Objectives:To demonstrate the knowledge and practices of individuals on the prevention and treatment of burns in the home environment and to describe the educational nursing care in the prevention and treatment of burns in the home environment. Method: Convergent care research was carried out virtually, from June to August 2021, with people residing in the city of Macaé/RJ, Brazil. Results: The survey included 16 participants, 81.25% (n = 13) female, aged between 19 and 59 years old. In the analysis of the interviews, it was possible to identify mistaken knowledge and practices about the prevention and treatment of burns, to be discussed in this study. Conclusion: Although there is knowledge about adequate knowledge and practices on the prevention and treatment of burns in the home environment, there was identification of wrong practices that can harm the correct treatment and prevention of injuries. The findings of this study point to the need to build materials and carry out educational practices with this population to reinforce preventive measures for burns.

Objetivos:Demostrar los conocimientos y prácticas de los individuos sobre la prevención y tratamiento de quemaduras en el ambiente domiciliario y describir el cuidado educativo de enfermería en la prevención y tratamiento de quemaduras en el ambiente domiciliario. Método: Investigación de Atención Convergente (PCA) realizada virtualmente, de junio a agosto de 2021, con personas residentes en la ciudad de Macaé/RJ. Resultados: La encuesta contó con 16 participantes, 81,25% (n=13) mujeres, con edades entre 19 y 59 años. En el análisis de las entrevistas, fue posible identificar conocimientos y prácticas erróneas sobre la prevención y el tratamiento de las quemaduras, para ser discutidas en este estudio. Conclusión: Si bien existe conocimiento sobre los saberes y prácticas sobre la prevención y tratamiento de quemaduras en el ámbito domiciliario, se identificaron prácticas incorrectas que pueden perjudicar el correcto tratamiento y prevención de lesiones. Los hallazgos de este estudio apuntan para la necesidad de construir materiales y realizar prácticas educativas con esta población para reforzar las medidas preventivas de quemaduras.

Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.

There is a clear clinical overlap between fibromyalgia, myalgic encephalomyelitis, and post-COVID 19 condition. Chronic fatigue, cognitive impairment, and widespread pain characterize these 3 syndromes. A steady line of investigation posits fibromyalgia as stress-evoked sympathetically maintained neuropathic pain syndrome and places dorsal root ganglia dysregulation with the ensuing small fiber neuropathy at the epicenter of fibromyalgia pathogenesis. This article discusses emerging evidence suggesting that similar mechanism may operate in post-COVID 19 condition.

Is Being a Lark Healthier for Patients with Type 1 Diabetes Mellitus?

Background Sleep quality and mood have been evaluated in type 1 diabetic (T1DM) patients, but chronotypes were not studied. Our objectives were to analyze chronotypes, sleep and mood variables and to describe their association with some metabolic variables in this population. Methods An observational, cross-sectional study was performed. Adults with a diagnosis of T1DM were included. We evaluated chronotypes by the Morningness-Eveningness Questionnaires, sleep quality by Pittsburgh Sleep Quality Index (PSQI), excessive daytime sleepiness by Epworth Sleepiness Scale (ESS), symptoms of depression by Patient Health Questionnaire - 9 (PHQ-9) and emotional well-being by Emotional Well Being Index (IWHO-5). A few metabolic variables were included. Results Ninety-five patients participated. The mean age was 38 years old (range 18-70). The average body mass index (BMI) was 24.4 Kg/m 2 (standard deviation [SD]: 4.6). Out of the total sample, 52.6% were males. The Intermediate chronotype was predominant: n = 56 (55%). We found poor quality of sleep in 67.4% of the sample, excessive daytime sleepiness in 14.7%, depressive symptoms in 6.3% by PHQ9 and low perception of well-being by IWHO-5 in 16.8%. Evening chronotype scored worse in sleep quality ( p = 0.05) and had lower well-being ( p = 0.03) compared with the other chronotypes. Higher MEQ values (morningness) correlated with lower height ( p = 0.043), lower values in the PSQI ( p = 0.021); and higher values in emotional well-being ( p = 0.040). Conclusions We found that the predominant chronotype in T1DM was the intermediate. Two-thirds reported poor quality of sleep and 14,7% excessive daytime sleepiness. Possible diagnosis of a depressive disorder in 6.3% and poor self-perception of emotional well-being in 16. 8% were observed. The morning chronotype had significant correlation with better sleep quality and higher scores in emotional well-being.

PsicAP transdiagnostic protocol of group cognitive-behavioral training for emotional disorders in Dominican Republic: a randomized controlled trial protocol.

Emotional disorders (ED) such as anxiety, depression and somatization are extremely prevalent disorders that can affect an individual's quality of life and functionality. Primary Health Care (PHC) is the first place to identify most patients with these conditions. Mental health services in the Dominican Republic, as well as in Latin America and the Caribbean in general, are unable to provide appropriate care for most people with mental disorders. Using evidence-based treatment protocols is also crucial to make progress in helping people with ED. The PsicAP project is a group intervention that uses a transdiagnostic approach and is grounded in cognitive-behavioral techniques. The program is implemented in 7 group sessions, each lasting for one and a half hours. The program has been shown to be effective in reducing clinical symptoms, dysfunction, and in improving quality of life. It is also a non-time-intensive, low-cost treatment that is helpful for addressing EDs in a PHC context. The objective is to bring psychological treatments into PHC facilities of Dominican Republic, making them more accessible for a larger amount of the population.

Sex disparities in lung cancer survival rates based on screening status.

OBJECTIVE: Low dose computed tomography (LDCT) became the standard method for lung cancer (LC) screening in 2013. However, it is unclear whether there are differences in survival rates based on sex and whether the differences depend on screening status. We aimed to evaluate the LC survival rates between females and males based on screening. MATERIAL AND METHODS: This retrospective cohort study examined data from the Boston LC Study (BLCS) between 2013 and 2021. LC screening depends on patients' demographics (age and smoking history) to determine whether a person is a high-risk individual and, therefore, undergo LDCT. Descriptive statistics were calculated for race, age, histology, smoking history, stage, and treatment. These variables' distributions were compared between sex and screening status using t-test and chi-square, respectively. Cox proportional hazards model and Kaplan-Meier curves were used to compare survival between sex and screening. Propensity score matching was applied to account for selection bias in screening when evaluating the association between screening and stage. RESULTS: A total of 1,216 LC patients were identified with a screening incidence of 9.4 %, among whom 56 % were female. Unscreened males had 1.59 times higher risk of mortality than unscreened females (P=.0002) and had a worse 5-year survival (male 50 %; 95 %CI, 0.38,0.6 vs female 70 %; 95 %CI,0.62,0.76). In contrast, there were no significant differences in survival between sexes among screened. In a balanced cohort of screened and unscreened, the odds of being diagnosed at late stages for females and smokers were 1.33 and 2.51 times that of males and nonsmokers; however, there were no statistical significance. CONCLUSION: Unscreened females had a lower risk of mortality and better survival than unscreened males, while among the screened population, there was no difference in the overall survival. These observations demonstrate the influence of sex on survival prognosis in LC when screening is not performed.

Evaluación del estado emocional de personas con diabetes mellitus en la práctica ambulatoria / Evaluation of the emotional state of people with diabetes mellitus in outpatient practice

La aparición de una enfermedad crónica, como la diabetes mellitus (DM), pone a prueba la respuesta del universo físico y psíquico de un individuo. Como objetivo general, se propone evaluar el estado emocional de las personas con DM en la consulta ambulatoria. Como objetivo particular, detectar y monitorear las necesidades psicológicas que deben formar parte integral del cuidado de la DM mediante el uso de métodos validados. El cuestionario WHO-5 se incluye como índice de bienestar general, el PAID-5 revela la existencia de una posible angustia emocional vinculada a la enfermedad, y el PHQ- 9 como índice de depresión. Ante esta situación, el Comité de Aspectos Psicosociales recomienda explorar estos aspectos para optimizar el control y el tratamiento de la enfermedad, proponiendo estas herramientas para que el equipo de salud las emplee en la detección y el reconocimiento del estado emocional de las personas con DM

Occurrence of a chronic disease, such as diabetes, prove the response of the physical and psychic universe of individuals. As a general objective, is proposed to evaluate emotional state of people with diabetes in the outpatient clinic. As principal objective, detection and monitoring the psychological needs should be a main part of diabetes care, using validated tools to evaluate this aspect. WHO-5 questionnaire is included as an index of general well-being, PAID-5, reveals the existence of a possible emotional distress linked to disease, and PHQ-9 is used as an index of depression. At this situation, the Committee on Psycho-Social Aspects recommends explore these psychological aspects, as a way to optimize the control and treatment of disease, and propose the cited tools, to be used by the health team, in detection and recognition of emotional state in people with diabetes.

Desempeño académico de fin de carrera en estudiantes de medicina ante un cambio de plan de estudios en Uruguay: graduación, rezago y becas / Academic performance at the end of the career in medical students during a curriculum change in Uruguay: on time and delayed graduation and scholarships / Desempenho acadêmico de final de curso dos estudantes de medicina diante de uma mudança no plano de estudos do Uruguai: graduação, defasagem e bolsas

La duración de la carrera de medicina en la Universidad de la República, Uruguay, se redujo un año al modificarse el plan de estudios. Estudiantes que cursaron el novel y el antiguo plan rindieron sincrónicamente un concurso previo a la práctica preprofesional en 2015, graduándose simultáneamente. Este trabajo indagó sobre las potenciales derivaciones de cursar uno u otro plan, como forma de obtener insumos para la evaluación del plan de estudios actual y de los programas de becas de apoyo estudiantil, a fin de proyectar estrategias de mejora. Se realizó un estudio retrospectivo cuantitativo analizando el desempeño, la retención y el rezago estudiantil en relación con el plan cursado, atributos sociodemográficos y el usufructo de becas. Los graduados con rezago tuvieron peor desempeño al final de la carrera que los graduados en tiempo, independientemente del plan. El rezago se asoció al perfil sociodemográfico. El 23.7% de los graduados usufructuó alguna beca durante su carrera. Los becados presentaron niveles educativos parentales inferiores y procedieron en mayor proporción del interior del país que el total de graduados. Se concluye que: a) la desvinculación y el rezago académico tienen lugar en ambos planes; b) cursar con rezago se asocia a un peor desempeño en etapas finales de la carrera, vinculándose con el perfil sociodemográfico y no con cursar un plan de estudios u otro y c) las políticas institucionales de becas remedian parcialmente este hecho favoreciendo la retención y graduación.

At the Universidad de la República, Uruguay, the medical career duration was reduced as a consequence of a curriculum renovation. Students who attended the novice and the prior curriculum synchronously took a pre-practice contest in 2015, graduating simultaneously. This work investigated the potential derivations of taking the previous or the new curriculum and to obtain inputs for the evaluation of the current curriculum and student support scholarship programs in order to project improvement strategies. A quantitative retrospective study was carried out analyzing student performance, retention and delayed graduation in relation to the curriculum taken, sociodemographic attributes and the use of scholarships. Regardless of the curriculum, those with a delayed graduation showed lower results than those who graduated in time. Delayed graduation was associated with the sociodemographic profile. A 23.7% of the graduates used a scholarship at some point in their career. The scholarship recipients presented lower parental educational levels and came in a greater proportion from the interior of the country than the total number of graduates. It was concluded that: a) dropout and academic delay occur at both curriculums; b) obtaining a degree with a delay is associated with worse performance in the final career stages, being linked to the sociodemographic profile and not to taking one study plan or another and c) institutional scholarship policies partially solve baseline inequities, favoring retention and graduation.

A duração do curso de medicina da Universidade da República, Uruguai, foi reduzida em um ano como consequência da modificação do plano de estudos. Os alunos que pegaram o novato e o plano antigo de forma síncrona realizaram um concurso anterior a prática pré-profissional em 2015, graduando-se simultaneamente. Este trabalho investigou as possíveis derivações da adoção de um ou outro plano, como forma de obter informaçoes para a avaliação do atual plano de estudos e programas de bolsas de apoio ao estudante, a fim de projetar estratégias de melhoria. Realizou-se um estudo quantitativo retrospectivo analisando desempenho, retenção e defasagem dos alunos em relação ao plano realizado, atributos sociodemográficos e utilização de bolsas. Os graduados com defasagem alcançaram resultados significativamente mais baixos do que os graduados no prazo, independentemente do plano. A defasagem foi associada ao perfil sociodemográfico. Vinte e três por cento dos egressos utilizaram bolsa durante a curso. Os bolsistas apresentavam pais com menor nível educativo e vinham em maior proporção do interior do país do que o total de diplomados. Conclui-se que: a) o desistência e a defasagem acadêmica ocorrem em ambos os planos; b) a defasagem está associado a um pior desempenho nas fases finais da curso, estando vinculado ao perfil sociodemográfico e não à realização de um ou outro plano de estudos e ao perfil sociodemográfico e não de um ou outro plano de estudos e c) as políticas institucionais de bolsas sanam parcialmente este fato, favorecendo a retenção e a graduação.

Evaluación del estado emocional de personas con diabetes mellitus en la práctica ambulatoria / Evaluation of the emotional state of people with diabetes mellitus in outpatient practice

Resumen La aparición de una enfermedad crónica, como la diabetes mellitus (DM), pone a prueba la respuesta del universo físico y psíquico de un individuo. Como objetivo general, se propone evaluar el estado emocional de las personas con DM en la consulta ambulatoria. Como objetivo particular, detectar y monitorear las necesidades psicológicas que deben formar parte integral del cuidado de la DM mediante el uso de métodos validados. El cuestionario WHO-5 se incluye como índice de bienestar general, el PAID-5 revela la existencia de una posible angustia emocional vinculada a la enfermedad, y el PHQ-9 como índice de depresión. Ante esta situación, el Comité de Aspectos Psicosociales recomienda explorar estos aspectos para optimizar el control y el tratamiento de la enfermedad, proponiendo estas herramientas para que el equipo de salud las emplee en la detección y el reconocimiento del estado emocional de las personas con DM.

Abstract Occurrence of a chronic disease, such as diabetes, prove the response of the physical and psychic universe of individuals. As a general objective, is proposed to evaluate emotional state of people with diabetes in the outpatient clinic. As principal objective, detection and monitoring the psychological needs should be a main part of diabetes care, using validated tools to evaluate this aspect. WHO-5 questionnaire is included as an index of general well-being, PAID-5, reveals the existence of a possible emotional distress linked to disease, and PHQ-9 is used as an index of depression.

Changes in social functioning and engagement during canine-assisted intervention for children with neurodevelopmental disorders in the context of an early intervention service.

PURPOSE: The objectives were to evaluate the feasibility of early implementation of a canine-assisted intervention (CAI) for children with neurodevelopmental disorders, and to determine the changes in social functioning and in engagement experienced by the participants. MATERIALS AND METHODS: A CAI consisting of 24 sessions was piloted in an intra-subject quasi-experimental longitudinal design. The outcome measures were the Assessment of Communication and Interaction Skills (ACIS) and Individual Child Engagement Record-Revised (ICER-R). RESULTS: No adverse events or side-effects were noted. The sample consisted of 44 participants (median age 37 months). A total of 33 children (75%) attended all sessions. Main results showed that after completing the intervention, the overall ACIS score improved significantly (p < 0.001); the effect size was large. There was a significant improvement in the scales of the ICER-R from baseline to the final assessment: overall engagement (p < 0.001), frequency of repetitive behaviours (p < 0.001), frequency of interaction between the child and adults (p < 0.001), and the quality of this interaction (p < 0.001); the effect sizes ranged from medium to large. CONCLUSIONS: The early application was feasible. The results in the areas of social functioning and engagement suggest that this CAI may be a useful complementary strategy in early therapeutic intervention with these children. WHAT THIS PAPER ADDS?: The results of implementation of a canine-assisted intervention (CAI) at an early therapeutic intervention unit for children with neurodevelopmental disorders are not known. This research supported the feasibility and positive impact of a CAI in a population consisting of children with neurodevelopmental disorders in the earliest stages of their life, with similar proportions of participants with global developmental delay and autism spectrum disorder. The study was pioneering in the development of this form of actions in an early intervention service for children with these health conditions. The intervention appears feasible and the results extend the existing evidence base for this intervention modality. The findings suggest significant improvements of a medium to large size in the domains of communication skills and social relations, engagement levels, frequency and quality of interaction with adults and repetitive behaviours after 12 and 24 weekly CAI sessions.

Ruxolitinib as a treatment strategy for SARS-CoV-2 pneumonia: clinical experience in a real-world setting.

INTRODUCTION: Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) infection is characterised by a viral phase and a severe pro-inflammatory phase. The inhibition of the JAK/STAT pathway limits the pro-inflammatory state in moderate to severe COVID-19. METHODOLOGY: We analysed the data obtained by an observational cohort of patients with SARS-CoV-2 pneumonia treated with ruxolitinib in 22 hospitals of Mexico. The applied dose was determined based on physician's criteria. The benefit of ruxolitinib was evaluated using the 8-points ordinal scale developed by the NIH in the ACTT1 trial. Duration of hospital stay, changes in pro-inflammatory laboratory values, mortality, and toxicity were also measured. RESULTS: A total of 287 patients were reported at 22 sites in Mexico from March to June 2020; 80.8% received ruxolitinib 5 mg BID and 19.16% received ruxolitinib 10 mg BID plus standard of care. At beginning of treatment, 223 patients were on oxygen support and 59 on invasive ventilation. The percentage of patients on invasive ventilation was 53% in the 10 mg and 13% in the 5 mg cohort. A statistically significant improvement measured as a reduction by 2 points on the 8-point ordinal scale was described (baseline 5.39 ± 0.93, final 3.67± 2.98, p = 0.0001). There were 74 deaths. Serious adverse events were presented in 6.9% of the patients. CONCLUSIONS: Ruxolitinib appears to be safe in COVID-19 patients, with clinical benefits observed in terms of decrease in the 8-point ordinal scale and pro-inflammatory state. Further studies must be done to ensure efficacy against mortality.

Singulto persistente en dos pacientes con infección por SARS-CoV-2: reporte de casos y revisión de la literatura / Persistent Singult in Two Patients with SARS- CoV-2 Infection: Case Report and Literature Review

Resumen En la actual pandemia por COVID-19, se han descrito manifestaciones poco frecuentes como la rabdomiólisis y la encefalomielitis aguda. Una de las presentaciones atípicas del SARS-CoV-2, es el singulto, que son contracciones repetitivas involuntarias de los músculos intercostales y del diafragma, cuyo origen puede ser gastrointestinal, neurogénico o infeccioso por tuberculosis e influenza, entre otros. En el presente reporte se describen los casos de 2 pacientes cuyo síntoma principal para el diagnóstico de infección por SARS-CoV-2 fue el singulto, asociado con un patrón de afección pulmonar bilateral; a propósito de los casos, se incluye una revisión en la literatura de diferentes pacientes y de los factores relacionados en cada uno.

Abstract In the current COVID-19 pandemic, unusual manifestations such as rhabdomyolysis and acute encephalomyelitis have been described. One of the atypical presentations of COVID-19 is hiccups, which are involuntary repetitive contractions of the intercostal muscles and diaphragm, whose origin can be gastrointestinal, neurogenic, or infectious due to tuberculosis, influenza, among others. This report describes the cases of two patients in whom the main symptom for the diagnosis of SARS-CoV-2 infection, was hiccups associated with a pattern of bilateral pulmonary involvement; a review of the literature is included.

Prescription profile in patients with SARS-CoV-2 infection hospitalised in Aragon, Spain.

INTRODUCTION: On 14 March 2020, a state of alarm was declared in Spain because of the pandemic of coronavirus disease (COVID-19). After 12 weeks from the beginning of the pandemic, the number of confirmed cases stoods at 5781 in Aragon: 46% hospitalised, 5% admitted to intensive care unit, and 15% died. The absence of controlled trials in SARS-CoV-2 infection and the fast progression of the disease has promoted the use of treatments with unproven potential benefit. The objective of this study is to define the prescription profile in patients with SARS-CoV-2 infection hospitalised in Aragon, Spain during the pandemic and its adaptation to the official recommendations. PATIENTS AND METHODS: Descriptive retrospective study of the consumption and inpatient dispensation of drugs in a sample of COVID-19 infected inpatients (with positive PCR test result) admitted to hospitals of Aragon, between 1 March and 8 May 2020. Data were collected by an inpatient dispensation software program. RESULTS: 1482 positive COVID-19 patients were analysed: 54.9% male, median age 75 years (IQR 62-85); 12% were admitted to the intensive care unit. Median prescription: 13 active ingredients per patient (IQR 9-19). 73% (1093 patients) received hydroxychloroquine, lopinavir/ritonavir, or azithromycin, 81% as combination therapy. 4.3% (52) received other antivirals. 46% received corticosteroids (84% methylprednisolone, 8.7% dexamethasone) and 2.2% tocilizumab. DISCUSSION: At the time of the study period there was not enough quality evidence to issue a recommendation on any treatment. There are several clinical trials ongoing to clarify what is the best treatment for patient with SARS-CoV-2 infection.

O cenário das ligas acadêmicas de estomaterapia no Brasil / The scenario of academic stomatherapyleagues in Brazil / El escenario de las ligas académicas de estomaterapia en Brasil

A busca pelo aprofundamento em áreas específicas tem crescido substancialmente na formação profissional, com o intuito de investigar e compartilhar conhecimentos, em conjunto com a participação ativa em atividades práticas, de modo a preservar a indissociabilidade do tripé ensino-pesquisa-extensão1. Por meio dessa percepção, adotaram-se estratégias que promovessem imersão e articulação do conhecimento entre teoria e prática, mediante a criação de Ligas Acadêmicas (LA), que consistem em organizações caracterizadas por estatuto próprio, isenta de fins lucrativos, compostas por acadêmicos e orientadas por profissionais integrantes de determinadas instituições, de forma extracurricular.

The search for deepening in specific areas has grown substantially in professional training, in order to investigate and share knowledge, together with active participation in practical activities, in order to preserve the inseparability of the teaching-research-extension tripod1. Through this perception, strategies were adopted that promote immersion and articulation of knowledge between theory and practice, through the creation of Academic Leagues (AL), which consist of organizations characterized by their own statute, exempt from profit, composed of academics and oriented by professionals who are members of certain institutions, in an extracurricular manner.

A inclusão da pessoa com deficiência no ensino superior: trajetória de implantação da comissão permanente UFRJ-Macaé acessível e inclusiva / The inclusion of person with disabilitie in higher education: trajectory of implantation of ufrj-macaé permanent commission accessible and inclusive

Objetivo: apresentar as experiências do processo de implantação até as ações recentes da Comissão Permanente UFRJ-MACAÉ Acessível e Inclusiva, da UFRJ-Campus Macaé Professor Aloísio Teixeira. Métodos: O estudo apresenta um relato de experiências vividas por membros da CPAI, no período entre o segundo semestre de 2016 e 2019. Para a estruturação deste relato, foram reunidas as memórias dos encontros, atas de reuniões da CPAI, publicações de matérias referentes a CPAI tanto na mídia impressa como digital. Resultados: Foram identificados quatro aspetos relevantes: História da consolidação das instâncias voltadas às pessoas com deficiência na UFRJ; Implantação da CPAI; Entrada dos estudantes com deficiência na UFRJ-Campus Macaé; Ações da CPAI. Considerações finais: A CPAI tem realizado ações que propiciam um frequente diálogo sobre a acessibilidade e inclusão de estudantes com deficiência, sendo relevante para a atenção a estes no âmbito do ensino superior, por muitas vezes acessível apenas para uma parcela da população com deficiência.

Independence in Daily Activities after Stroke among Occupational Therapy Patients and Its Relationship with Unilateral Neglect.

More research is needed to better understand the impact of occupational therapy (OT) in stroke patients and syndromes of unilateral neglect (UN) and anosognosia. A prospective, observational, longitudinal design was conducted on a sample of 27 OT patients. The objectives were to examine: (1) the presence of UN and anosognosia; (2) the functional outcomes; and (3) the association of UN at baseline with functional status at discharge from OT. The outcomes were Barthel (functional independence) and the Rivermead Mobility Index (RMI). The baseline proportion of participants with UN was 33% according to the Star Cancellation Test (STC), and 48.1% according to the Catherine Bergego Scale (CBS) therapist-version. There was a significant difference between the therapist and participant-rated CBS scores (p = 0.004). Functional independence improved significantly between the initial and final assessments (p < 0.001); the effect size (r) was large (r = 0.61). There was a significant improvement in RMI scores (p < 0.001), which was large in size (r = 0.59). Both the STC and CBS-therapist scores were significantly correlated with the Barthel (p < 0.001, p = 0.005, respectively) and with the RMI (p = 0.004, p = 0.028, respectively). The participants substantially enhanced their functional status skills. UN and anosognosia were common problems, and neglect was associated with worse OT program outcomes.

Estilos de aprendizaje de estudiantes de fisioterapia de cursos básicos y prácticas formativas de una universidad en Colombia / Learning styles of physiotherapy students of core courses and practical training in a university in Colombia

OBJETIVO: Caracterizar los estilos de aprendizaje de 2grupos de estudiantes de fisioterapia de una universidad en Santiago de Cali Valle (Colombia). MATERIAL Y MÉTODOS: Estudio descriptivo, transversal y correlacional, con 198 estudiantes que cursaban la carrera de fisioterapia, quienes respondieron, previo consentimiento informado, preguntas sociodemográficas y el cuestionario de Felder y Silverman, para identificar las preferencias en los estilos de aprendizaje. RESULTADOS: La distribución de los estilos de aprendizaje fue similar en los 2grupos estudiados: predominaron los estilos activo, sensorial, visual y secuencial. Se encontró significación estadística entre la dimensión de percepción y los estudios secundarios de la madre (p < 0,05). De igual manera ocurrió con la dimensión tipo de información y nivel de formación básico de los estudiantes: el 100% de los estudiantes son sensitivos (p < 0,05). CONCLUSIONES: Existe predominio por los aprendizajes prácticos, el trabajo en equipo, el avance paso a paso de manera lineal y la percepción de la información en formato visual. El nivel educativo de la madre tiene una asociación con la forma de percibir la información de los estudiantes. La intensidad de preferencia por los estilos en cada dimensión fue equilibrada, lo que permite que puedan desarrollar cierto grado de flexibilidad cognitiva al momento de desarrollar los aprendizajes

OBJECTIVE: To describe the learning style of 2groups of physiotherapy students from a university in Cali, Colombia, according to their level of training, in order to establish guidelines for pedagogical and didactic guidance to teachers and the institution. MATERIAL AND METHODS: Descriptive, cross-sectional and correlational study, in which 198 students participated in the physiotherapy course at 2levels of training, respondents informed consent, demographic questions and the Felder and Silverman questionnaire consisting of 44 questions grouped into 4dimensions, which allow to identify the preferences in learning styles. RESULTS: The distribution of preference of styles was similar in the 2groups studied, in which active lifestyles predominated, including sensory, visual and sequential. Statistical significance was found between the size of perception and secondary studies of the mother (P<.05). The same happened with the dimension type of information and level of training of students, 100% of the students are sensitive (P<.05). CONCLUSIONS: There is predominance by the practical programming, teamwork, step-by-step forward in a linear fashion, and the perception of information in visual formats. The educational level of the mother has a partnership with the way they perceive the information from students. The intensity of preference for the styles in each dimension was balanced, which allows them to develop some degree of cognitive flexibility when developing the programming

Evaluación de la funcionalidad del eje hipotálamo-hipófiso-adrenal a través del test de respuesta del cortisol al despertar en pacientes con diabetes mellitus tipo 1 con y sin depresión: Estudio Multicéntrico Argentino (EMA-1) / Evaluation of the hypothalamo-pituitary-adrenal axis using the cortisol awakening response test in patients with type 1 diabetes mellitus with and without depression: Multicenter Argentine Study (EMA-1)

Introducción: la depresión (DP) tiene una alta prevalencia en pacientes con diabetes mellitus tipo 1 (DM1) y se asocia a repercusiones clínicas negativas como mayor morbimortalidad cardiovascular y complicaciones crónicas. Existen pocos estudios publicados sobre la funcionalidad del eje hipotálamo-hipófiso-adrenal (H-H-A) en DM1 con DP, y la relación entre la DP y el test de respuesta del cortisol al despertar (RCD) con el control glucémico (CG). Objetivos: analizar la funcionalidad del eje H-H-A a través de la evaluación del RCD en pacientes con DM1 (PD1) con y sin DP. Como objetivos secundarios, conocer la prevalencia de DP en PD1 y ver si existe relación entre el RCD y CG, y entre DP y CG. Materiales y métodos: estudio observacional, prospectivo, de corte transversal, multicéntrico, nacional. Se incluyeron PD1 mayores de 18 años; se utilizó cuestionario Patient Health Questionnaire-9 (PHQ-9) para diagnóstico de DP. Se tomaron muestras de cortisol salival al despertar y a los 30 minutos (RCD), y se consideró RCD bloqueado si el valor de cortisol de los 30 minutos no aumentaba más del 50% del basal. Además se tomaron muestras de sangre en ayunas para medir glucemia, fructosamina y HbA1c. Resultados: se incluyeron 79 pacientes, 39% hombres, edad promedio 38±15 años, duración de la diabetes de 16±13 años; 53% casados/en pareja y 87% con ingresos económicos estables. El 68% de los PD1 presentó el RCD bloqueado. En PD1 con DP el 85% presentó el RCD bloqueado vs el 60% en los no deprimidos y dicha diferencia fue marginalmente significativa (p=0,05). La prevalencia de DP fue de 39%. No se encontró ninguna relación significativa entre RCD bloqueado y control glucémico (p>0,05). Los PD1 con DP moderada-severa presentaron un peor control glucémico en relación a los PD1 sin depresión (evaluado por glucemia mayor de 120 mg/dl, fructosamina mayor de 285 umol/l; p<0,05) y la relación no fue significativa para HbA1c aunque mostró una tendencia. Conclusiones: en pacientes con DM1 y DP se halló el RCD bloqueado en un alto porcentaje. Dado que la DP se asocia a mayor morbimortalidad cardiovascular, podría utilizarse el test de RCD como biomarcador de DP, y podría servir para estratificar esta sub-población de alto de riesgo. La depresión moderada-severa se asoció a peor control glucémico, por lo tanto, diagnosticar y tratar adecuadamente la DP en PD1 podría contribuir a prevenir la aparición o progresión de complicaciones crónicas.

Introduction: depression (DP) has a high prevalence in patients with type 1 diabetes mellitus (DM1) and is associated with negative clinicals consequences like more cardiovascular morbimortality and chronic complications. There are few studies published about the dysregulation of hypothalamopituitary-adrenal axis (H-P-A) in DM1 with DP and the relation between DP and the Cortisol Awakening Response Test (CAR) with the glycemic control (GC). Objectives: examine the functionality of the H-P-A axis using the Cortisol Awakening Response Test (CAR), in patients with DM1 (PD1) with and without DP. Determine the prevalence of DP in PD1 and examine if there is any relation between CAR and GC and DP and poorer GC. Materials and methods: observational, prospective, national, multicenter study. Patients with DM1, older than 18 years old; Patient Health-9 questionnaire (PHQ-9) was used to diagnose DP and 2 samples of salivary cortisol, and blood samples for glycemia, glycated albumin and Hba1c. Results: 79 patients with DM1 (PD1) were included, 39% male, mean age 38± 15 years old, an average of 16±13 years evolution of diabetes; 53 % married/couple and 87 % have a regular incomes. 68% of PD1 presented CAR blunted. In PD1 with DP 85% has CAR blunted versus 60% in those without DP, and this difference was marginally significant (p=0.05). The prevalence of DP was 39%. No significant relation was found between CAR blunted and glycemic control (p>0.05).PD1 with Moderate-severe DP showed worse metabolic control than the PD1 without DP (evaluated by glycemia higher than 120 mg/dl, glycated albumin higher than 285 umol/l); p<0.05) and the relation was not significant with HbA1c but it showed a trend. Conclusions: patients with DM1 and DP presented a high prevalence of CAR blunted. DP is related with higher cardiovascular morbi-mortality, thus CAR would be useful as a biomarker of DP and would be used to stratify this population of high risk. DP moderate-severe was related to worse glycemic control, hence diagnose and treat correctly DP in PD1 would contribute to prevent the onset or the evolution of chronic complications.