Comparing the photocatalytic activity of TiO2 at macro- and microscopic scales.

This study focuses on the characterization of photocatalytic TiO2 coatings using Kelvin probe force microscopy. While most photocatalytic experiments are carried out at a macroscopic scale, Kelvin probe force microscopy is a microscopic technique that is surface sensitive. In order to link microscale results to macroscopic experiments, a simple method to establish the relation between Kelvin probe force microscopy and electrochemical measurements is presented by the calibration of a reference sample consisting of epitaxial deposited Cu-Ni-Au that is used as a transfer standard. The photocatalytic properties of TiO2 at macro- and microscopic scales are investigated by comparing photocatalytic degradation of acetone and electrochemical experiments to Kelvin probe force microscopy. The good agreement between the macro- and microscopic experiments suggests that Kelvin probe force microscopy can be a valuable tool towards the understanding, standardization and design of TiO2-based solutions in photocatalytic applications.

Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats.

Since strontium (Sr) is known for its anabolic and anticatabolic effect on bone, research has been focused on its potential impact on osseointegration. The objective of this study was to investigate the performance of nanotopographic implants with a Sr-functionalized titanium (Ti) coating (Ti-Sr-O) with respect to osseointegration in osteoporotic bone. The trial was designed to examine the effect of sustained-release characteristics of Sr in poor-quality bone. Three Ti-Sr-O groups, which differed from each other in coating thickness, Sr contents, and Sr release, were examined. These were prepared by a magnetron sputtering process and compared to uncoated grade 4 Ti. Composition, morphology, and mechanical stability of the coatings were analyzed, and Sr release data were gained from in vitro washout experiments. In vivo investigation was carried out in an osteoporotic rat model and analyzed histologically, 6 weeks and 12 weeks after implantation. Median values of bone-to-implant contact and new bone formation after 6 weeks were found to be 84.7% and 54.9% (best performing Sr group) as compared to 65.2% and 23.8% (grade 4 Ti reference), respectively. The 12-week observation period revealed 84.3% and 56.5% (best performing Sr group) and 81.3% and 39.4% (grade 4 Ti reference), respectively, for the same measurements. The increase in new bone formation was found to correlate with the amount of Sr released in vitro. The results indicate that sputtered nanostructured Ti-Sr-O coatings showed sustained release of Sr and accelerate osseointegration even in poor-quality bone, and thus, may have impact on practical applications for medical implants.

Enhanced osseointegration of endosseous implants by predictable sustained release properties of strontium.

UNLABELLED: Studies have shown that strontium (Sr) incorporated into surfaces may enhance osseointegration. Thus, we suggested that a sustained Sr release from implant surfaces could improve bone healing. This study verifies and further investigates the effect of a novel Ti-Sr-O functionalized implant surface prepared from a magnetron co-sputtering platform with a continuous release of Sr. MATERIALS AND METHODS: Four experimental Ti-Sr-O groups, which differed from each other in Sr contents and pre-wash procedures, were tested. Implants were prepared with a Ti-Sr-O coating by means of magnetron co-sputtering and compared to Grade 4 titanium. Composition, morphology and mechanical stability were analyzed; Sr-release data were gained from in vitro washout experiments. In vivo investigations were carried out in a rat model and analyzed histologically regarding bone-to-implant contact and new bone formation 30 days after implantation. RESULTS: Structural differences were detected between the two basis Ti-Sr-O coatings with 6.7 at.% and 8.9 at.% Sr, respectively. Different release profiles were observed with 8.9 at.% Sr coating exhibiting the highest long-term release of Sr. Median values of new bone formation and bone-to-implant contact was found to be 60.1% and 91.6%, respectively, for the best group compared to 16.6% and 70.6% for the Grade 4 titanium reference. The increase in new bone formation was found to correlate with the amount of Sr released in vitro. CONCLUSION: The results show that sputtered Ti-Sr-O coatings with sustained release of Sr may improve osseointegration, and could thus have impact on practical applications for medical implants.